Clinical trials: Childbirth, open to volunteers
Diabetic Macular Edema
Phase 2 Trial of RGX-314 in Adults With Center Involved - Diabetic Macular Edema (CI - DME)
Phase 2 open label, randomized, active controlled, dose-ranging trial in adults with Center Involved - Diabetic Macular Edema (CI - DME)
- Trial name
- ELAAVATE (NCT06942520)
- Testing
- RGX-314 Dose 1, RGX-314 Dose 2, Aflibercept (2.0 mg)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Sierra Eye Associates
Diabetes
Satisfaction of Specific Modes Related to Physical Activity in People Living With Type 1 Diabetes and Using an Hybrid Closed-loop System
The BF-ACT study is a single-center, non-interventional (RIPH3) descriptive study conducted at CHU Grenoble Alpes. It aims to evaluate the satisfaction of adults with type 1 diabetes using closed-loop insulin delivery systems…
- Trial name
- BF-ACT (NCT07567170)
- Testing
- Questionnar
- Where
- France
- Volunteers
- 900 people
- Sponsor
- University Hospital, Grenoble
Anxiety
An Informative Video About Perineal Tears During Labor for Anxiety Reduction: A Randomized Controlled Trial
This study evaluates the impact of an informative video about perineal tears on maternal anxiety during labor. Perineal trauma during childbirth, especially severe tears such as obstetric anal sphincter injuries (OASIS), is…
- Trial name
- VITAL (NCT07064213)
- Testing
- Behavioral: Educational Video
- Where
- Israel
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Newly Diagnosed MGMT Unmethylated Glioblastoma
D2C7-IT and 2141-V11 in Newly Diagnosed GBM Patients
The purpose of this research study is to determine the safety and efficacy of administering a single intracerebral (within the brain) dose of investigational compounds called D2C7-immunotoxin (IT) and 2141-V11 in residual disease…
- Trial name
- NCT05734560
- Testing
- D2C7-IT, 2141-V11
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Darell Bigner
SMARD1, CMT2S
Gene Therapy for IGHMBP2-Related Diseases
Open-label, single intrathecal injection study of a AAV9 vector carrying the IGHMBP2 gene for IGHMBP2-related diseases.
- Trial name
- NCT05152823
- Testing
- Gene Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Megan Waldrop
Cervical Intraepithelial Neoplasia Grade 1, Human Papillomavirus 16 Infection
Phase I/II Trial of Electroporation-Delivered pBI-4 Vaccine (TriGrid™ PVX4) for Treatment of Women With HPV16-Positive CIN1 or Persistent Infection
The purpose of this study is to evaluate the safety, efficacy, and tolerability of pBI-4, an investigational therapeutic DNA vaccine, in treating adult women with Human Papillomavirus type 16 (HPV16)-positive Grade 1 cervical…
- Trial name
- NCT07809997
- Testing
- pBI-4 Vaccine
- Where
- 2 sites in Taiwan
- Volunteers
- 94 people
- Sponsor
- Chang Gung Memorial Hospital
Very Preterm Infants (<32 Weeks of Gestation)
Administration of Extracellular Vesicles From Donor Human Milk in Preterm Infants
The AdVEMPrem study is exploring whether tiny particles called extracellular vesicles (EVs), which are naturally found in human milk, can help protect very premature babies from serious gut problems such as necrotizing…
- Trial name
- AdVEMPrem (NCT07402083)
- Testing
- Donor human milk extracellular vesicles (DHM-EVs)
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Anesthesia, Postoperative Pain
Lateral QL Block vs Intrathecal Morphine for Cesarean Section
Effective postoperative analgesia after cesarean delivery is essential for maternal recovery, early mobilization, breastfeeding, and maternal-infant bonding.
- Conditions
- Anesthesia, Postoperative Pain, Regional Anesthesia
- Trial name
- NCT07712783
- Testing
- Lateral Quadratus Lumborum Block, ıv morphine PCA, Intrathecal morphine
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Ondokuz Mayıs University
Neonatal Respiratory Distress Syndrome, PreTerm Neonate
MINImising Total Radiation EXposure in Preterm Infants
Being born too early (preterm birth) is the leading cause of death in children world-wide. In Australia, 97% of very preterm babies who are admitted to Neonatal Intensive Care Units need breathing support after birth to survive.
- Trial name
- MINI T-Rex (NCT06975189)
- Testing
- Lung ultrasound group, Standard Care
- Where
- Australia
- Volunteers
- 180 people
- Sponsor
- Western Health, Australia
Infant, Premature, Diseases, Premature Birth of Newborn
Elevated Midline Positioning During Diaper Change in Preterm Infants
Diaper changing is one of the most frequent routine care procedures in the neonatal intensive care unit (NICU) and is known to cause physiological instability and behavioral stress responses in preterm infants.
- Conditions
- Infant, Premature, Diseases, Premature Birth of Newborn, Pain
- Trial name
- NCT07865897
- Testing
- 30-Degree Elevated Midline Positioning, Standard Lateral Position Diaper Change
- Volunteers
- 80 people
- Sponsor
- Akdeniz University
Smart Eyewear
Smart Eyewear to Automatically Detect Drug Delivery Events
This project is designed as a prospective observational study of medication preparation and delivery using a novel wearable data input device to automate detection of drug delivery events in the anesthesia workspace at University…
- Trial name
- NCT05184660
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Washington
Diabete Type 1, Pregnancy Complications
Automated Insulin Delivery Versus Usual Insulin Treatment Modality Before and During Pregnancy in Women With Type 1 Diabetes
A national multi-center open-label randomized controlled trial that investigates whether the use of the automated insulin delivery system CamAPS FX initiated during pregnancy planning or in early pregnancy improves maternal time…
- Trial name
- AID-DM (NCT07240012)
- Testing
- Automated closed-loop insulin delivery
- Where
- 8 sites in Denmark
- Volunteers
- 305 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Birth
Trial of Underwater Birth
Evaluate maternal perinatal outcomes in adult low-risk laboring people randomized to waterbirth compared to those randomized to birth on land.
- Trial name
- TUB (NCT07313319)
- Testing
- Waterbirth
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- University of New Mexico
Gastric Emptying, Caesarean Delivery
Comparison of 'Sip Til Send' Regimens Prior to Elective Caesarean Delivery Using Bedside Gastric Ultrasound
'Sip Til send' is a liberal drinking policy that replaces fasting before a caesarean delivery, meaning that women waiting in hospital can freely drink sips of water until they are called from the ward for their delivery.
- Conditions
- Gastric Emptying, Caesarean Delivery, Pregnancy
- Trial name
- NCT07407530
- Testing
- The carbohydrate group represent the interventional group and will utilise the standard carbohydrate-rich drink, The "water group"
- Where
- 2 sites in Ireland
- Volunteers
- 190 people
- Sponsor
- The Rotunda Hospital
Maternal Health, Pregnancy
Understanding the Role of Doulas in Supporting People With PMADs
Detailed Description The doula-led intervention developed during the first phase of this project will be pilot tested for feasibility.
- Conditions
- Maternal Health, Pregnancy, Delivery, Obstetric, Self Efficacy
- Trial name
- NCT05763537
- Testing
- Standard Doula Care Plus PMAD Intervention, Standard Doula Care
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Montana
Cesarean Section, Surgical Wound Infection
Timing of Cesarean Wound Dressing Removal on Wound Healing in Women With BMI ≥ 30 kg/m²
Cesarean delivery is one of the most common surgical procedures in obstetric care. Women with obesity (body mass index [BMI] of 30 kg/m² or higher) are at increased risk for postoperative wound complications, including surgical…
- Conditions
- Cesarean Section, Surgical Wound Infection, Wound Healing, Obesity
- Trial name
- NCT07846930
- Volunteers
- 726 people
- Sponsor
- Assiut University
Eldery People, Cognitive Decline
Optimizing CNS DHA Delivery in Elderly Adults at Risk for Dementia
The purpose of this placebo-controlled trial is to compare the effects of 24-weeks supplementation with LPC-DHA and TAG-DHA on cerebrospinal fluid and blood DHA levels, as well as biomarkers of central neurodegenerative and…
- Conditions
- Eldery People, Cognitive Decline, Memory Decline, DHA CNS Delivery
- Trial name
- NCT06933095
- Testing
- LPC-EPA+DHA capsules containing omega-3 fatty acids EPA and DHA esterified to lysophosphatidylcholine (LPC-EPA+DHA)(Trade name: Lysoveta)
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- University of Cincinnati
Premature Birth, Premature Infant
Growing Little PEAPODS Study
The goal of this clinical trial is to learn more about how the food and nutrition babies receive while in the Neonatal Intensive Care Unit (NICU) influences their ability to gain weight and fat-free mass, and their future growth…
- Conditions
- Premature Birth, Premature Infant, Premature, Intrauterine Growth Restriction
- Trial name
- NCT06226051
- Testing
- PEAPOD Infant Body Composition measuring device
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Wisconsin, Madison
Preeclampsia, Intrauterine Growth Restriction
sFlt1/PlGF and Planned Delivery to Prevent Preeclampsia at Term.
Preeclampsia (PE) affects ~5% of pregnancies. Although improved obstetrical care has significantly diminished associated maternal mortality, PE remains a leading cause of maternal morbidity and mortality in the world.
- Conditions
- Preeclampsia, Intrauterine Growth Restriction, Maternal Hypertension, Neonatal Outcome
- Trial name
- PE37 (NCT04766866)
- Testing
- sFlt1/PlGF screening in maternal blood at 35 to 36.6 weeks of gestation
- Where
- 21 sites in Belgium, Colombia and 7 more
- Volunteers
- 9,132 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Cesarean Section
Health Education to Reduce Unnecessary Cesarean Section Among Primigravida Women
This study aims to evaluate the Effectiveness of Health Educational Program for Primigravida Women in Reducing the Rate of Unnecessary Cesarean Section. Specific objectives: 1.
- Trial name
- CS (NCT07810751)
- Testing
- Health Educational Program on Modes of Delivery.
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Assiut University
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