Clinical trials: Chest Pain
Unstable Angina, Myocardial Infarction
SYNERGY: Open Study of Enoxaparin Versus Unfractionated Heparin in Patients With Acute Coronary Syndromes
Patients experiencing a mild heart attack will receive one of two medications which thin the blood to discern which is superior.
- Conditions
- Unstable Angina, Myocardial Infarction, Myocardial Ischemia
- Trial name
- NCT00043784
- Testing
- enoxaparin
- Where
- United States
- Volunteers
- 8,000 people
- Sponsor
- Sanofi
Thoracotomy
Association of Intravenous Ketamine With Thoracic Epidural Analgesia: Effects on Pain and Respiratory Function Following Thoracotomy.
Thoracotomy for lung resection is deemed painful. Ketamine is now a renewed interest in preventing acute postoperative pain. A previous study performed in the service testing the association ketamine/morphine versus morphine PCA…
- Trial name
- NCT00726258
- Testing
- ketamine
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Generalized Anxiety Disorder, Chest Pain
Patient-centered Treatment of Anxiety After Low-Risk Chest Pain in the Emergency Room
The goal of this research is to compare the benefits and risks of three anxiety treatments that are pragmatic, graduated in the level of resource intensity, and have demonstrated efficacy and feasibility for real world adoption.
- Conditions
- Generalized Anxiety Disorder, Chest Pain, Panic
- Trial name
- PACER (NCT04811521)
- Testing
- Primary care follow-up, Online Self-Administered Anxiety Management Program plus Peer Support Guidance, Therapist-Administered Cognitive Behavioral Therapy
- Where
- 5 sites in United States
- Volunteers
- 375 people
- Sponsor
- Indiana University
Chest Pain, Acute Coronary Syndrome
Magnetocardiography in the Accurate Identification of Myocardial Infarction
Magnetocardiography (MCG) is a promising noninvasive and accurate method for detecting myocardial infarction. Although progress has been made in this area, there is a lack of studies using up-to-date examination instruments for…
- Conditions
- Chest Pain, Acute Coronary Syndrome, Myocardial Infarction
- Trial name
- NCT05896826
- Testing
- Magnetometer
- Where
- China
- Volunteers
- 3,841 people, healthy volunteers welcome
- Sponsor
- Qilu Hospital of Shandong University
Sickle Cell Disease
A Phase 1 Study of Continuous Intravenous L-citrulline During Sickle Cell Pain Crisis or Acute Chest Syndrome
Sickle cell disease is a genetic red blood cell disorder characterized by vaso-occlusion from sickling of red blood cells, that can lead to pain or organ complications such as acute chest syndrome.
- Trial name
- NCT02697240
- Testing
- Intravenous citrulline
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Mississippi Medical Center
Angina Pectoris
Treatment of Refractory Angina Pectoris by Shock Wave Therapy
The purpose of this study is to determine that extracorporeal shock wave therapy (ESWT) is safe and effective for the treatment of refractory angina pectoris.
- Trial name
- NCT00776568
- Testing
- Extra-corporeal shockwave, Anti-hypertensive drugs
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Universal Research Group
RATS Surgery, Thymectomy
Serratus Posterior Superior Intercostal Plane Block in Robotic-Assisted Thymectomy
This study aims to assess the effectiveness of the Serratus Posterior Superior Intercostal Plane Block (SPSIP Block) for postoperative pain control, reducing opioid analgesic consumption, minimizing postoperative respiratory…
- Conditions
- RATS Surgery, Thymectomy, Locoregional Anesthesia, Postoperative Pain Management
- Trial name
- SPRATS (NCT06545409)
- Testing
- Ultrasound-guided Serratus Posterior Superior Intercostal Plane Block performed with 0.25% bupivacaine
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Coronary Artery Disease
Non-contrast Cardiac CT as a Risk Stratification Tool in Patients With Non-cardiac Chest Pain
Background: Only around 20% of all patients seen in hospital with suspected Acute Coronary Syndrome will have Acute Myocardial Infarction.
- Trial name
- NCT02422316
- Testing
- Non-contrast Cardiac CT scan
- Where
- Denmark
- Volunteers
- 248 people
- Sponsor
- University of Southern Denmark
Noncardiac Chest Pain, Panic Attack
Validation of the Panic Screening Score in Patient With Unexplained Chest Pain
Panic-like anxiety ( panic attacks with or without panic disorder), a highly treatable condition, is the most prevalent condition associated with unexplained chest pain in the emergency department.
- Trial name
- NCT02405052
- Testing
- No intervention
- Where
- Canada
- Volunteers
- 3,000 people
- Sponsor
- CISSS de Chaudière-Appalaches
Chest Pain, Emergencies
RCT aiTriage Chest Pain Risk Stratification
Chest pain is one of the most common reasons people visit the Emergency Department (ED). While most cases are not serious, a small number may lead to life-threatening heart problems, known as Major Adverse Cardiac Events (MACE).
- Trial name
- NCT07074808
- Testing
- aiTriage risk score
- Where
- 2 sites in Singapore
- Volunteers
- 1,120 people
- Sponsor
- Singapore General Hospital
Chest Wall Tumor, Reconstructive Surgical Procedure
Chest Wall Reconstruction Cohort
Chest wall reconstruction following tumor or infection-related resections remains a challenging aspect of thoracic surgery, requiring restoration of structural stability and preservation of respiratory mechanics.
- Conditions
- Chest Wall Tumor, Reconstructive Surgical Procedure, Malignancy
- Trial name
- NCT07338006
- Testing
- chest wall reconstruction
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- University of Health Sciences Lahore
Complex Regional Pain Syndromes
Sympatholytic Effects of High Thoracic Erector Spinae Plane Block: Changes in Optic Nerve Sheath Diameter
The thoracic erector spinae plane (ESP) block is suggested to potentially affect the stellate ganglion, a key component of the sympathetic nervous system, thereby influencing autonomic functions.
- Trial name
- NCT06468384
- Testing
- thoracic erector spinae plane (ESP) block
- Volunteers
- 15 people
- Sponsor
- Pamukkale University
Low Back Pain, Postural
Effects of Lumbal Lordosis and Thoracic Kyphosis Angles on Muscle Activations
When the thoracic kyphosis and lumbar lordosis are within a normal range of angular values back pain is less likely to occur. Angular modifications in the physiological curvatures of this sagittal plane have been shown to…
- Trial name
- NCT05748548
- Testing
- Thoracic kyphosis- Lumbal Lordosis angle measurement, Back Muscle Endurance Test - Sorenson Test, Surface EMG activation
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Ankara Yildirim Beyazıt University
Post Acute Coronary Syndrome, Myocardial Ischemia
Efficacy and Safety of Aliskiren and Valsartan Versus Placebo in Patients Stabilized Following an Acute Coronary Syndrome
The purpose of this study is to test the hypothesis that the inhibition of the renin-angiotensin-aldosterone system (RAAS) with the angiotensin receptor blocker valsartan or the renin antagonist aliskiren will improve ventricular…
- Trial name
- NCT00409578
- Testing
- Aliskiren 300 mg, Valsartan 320 mg, Aliskiren/valsartan 300/320 mg
- Where
- 11 sites in United States, Belgium and 9 more
- Volunteers
- 1,101 people
- Sponsor
- Novartis
Asthma Attack, Asthma in Children
The Effect of Nebulization Positions in Asthmatic Children
The purpose of this study was to establish the effect on pulse rate, oxygen saturation, respiratory rate, pain and anxiety levels of Fowler's and the forward-leaning positions during nebulization in children experiencing asthma…
- Conditions
- Asthma Attack, Asthma in Children, Asthma Acute, Asthma
- Trial name
- NCT05318885
- Testing
- A Randomized Controlled Study
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people
- Sponsor
- Istanbul University - Cerrahpasa
Chest Pain, Stable Angina Pectoris, CCS Class I to III
Randomized Evaluation of Patients With Stable Angina Comparing Diagnostic Examinations
This randomized, controlled, diagnostic, multicenter trial will compare two diagnostic imaging pathways--coronary computed tomography angiography (CCTA) and single photon emission tomography (SPECT) myocardial perfusion imaging…
- Conditions
- Chest Pain, Stable Angina Pectoris, CCS Class I to III, Angina Equivalent, Coronary Artery Disease
- Trial name
- RESCUE (NCT01262625)
- Testing
- CCTA, SPECT MPI/ICA
- Where
- 3 sites in United States
- Volunteers
- 1,050 people
- Sponsor
- American College of Radiology
Pain, Postoperative, Neuropathic Pain
Midline Versus Dorsolateral Spinal Cord Stimulation for Post-surgical Neuropathic Pain
The goal of this interventional study is to learn if dorsolateral spinal cord stimulation (DL-SCS) can treat focal post-surgical, medically refractory neuropathic pain.
- Trial name
- MIDL-SCS (NCT06390150)
- Testing
- Spinal Cord Stimulator
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Nova Scotia Health Authority
Coronary Heart Disease, Stable Angina Pectoris
Studies of Traditional Chinese Medicine Clinical Efficacy Evaluation Index
The purpose of the trial is to take stable angina pectoris of coronary heart disease (CHD) as examples to build a standard evaluation system for efficacy of traditional Chinese medicine (TCM). 1.
- Trial name
- NCT01502943
- Testing
- Louxiangdan Tongxin granules, Chixiangshen Tongxin granules, Western basis treatment
- Where
- 10 sites in China
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Liaoning University of Traditional Chinese Medicine
Microtia, Microtia, Congenital
Study of Analgesic Efficacy of Nerve Blocks on Otoplastic Surgery
Background: Children with microtia complain of severe postoperative pain during early postoperative days after rib cartilage harvest for auricular reconstruction.
- Trial name
- NCT04192708
- Testing
- intercostal nerve block under direct vision, intercostal nerve block under ultrasound guidance, paravertebral block under ultrasound guidance
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Acute Coronary Disease, Angina Unstable
Clopidogrel Optimal Loading Dose Usage to Reduce Recurrent EveNTs/Optimal Antiplatelet Strategy for InterventionS
The purpose of this study is to evaluate whether a higher dosage of clopidogrel with aspirin (two doses) will decrease the risk of ischemic complications (cardiac death (CV death), myocardial infarction (MI), stroke) after a…
- Trial name
- CURRENT/OASIS7 (NCT00335452)
- Testing
- Clopidogrel, acetylsalicyclic acid (ASA)
- Where
- 38 sites in United States, Argentina and 36 more
- Volunteers
- 25,086 people
- Sponsor
- Sanofi