Clinical trials: Chest Pain
STEMI - ST Elevation Myocardial Infarction
Use of the Methoxyflurane as Pain-killer in the Prehospital Management of Acute Myocardial Infarction
Chest pain is the main symptom of acute myocardial infarction. A precocious analgesic treatment is justified by patient's comfort and unfavorable hemodynamic consequences of persistent pain.
- Trial name
- MAMI (NCT07445737)
- Testing
- Methoxyflurane, Morphine
- Where
- France
- Volunteers
- 700 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiac Amyloidosis, Chest Pain
CHEST-CA: Study of Chest Pain and Hidden Cardiac Amyloidosis
The objective of this observational, prospective study is to determine the prevalence of Cardiac Amyloidosis (CA) in males over the age of 65 who experience chest pain but show no signs of coronary artery disease (CAD).
- Trial name
- CHEST-CA (NCT07435168)
- Testing
- Screening thourgh examinations including bonescintigraphy
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Coronary Artery Disease, Chest Pain
Artificial Intelligence Stress Echo (FINESSE) Project
The goal of this observational study is to learn whether combining stress echocardiography (stress echo) results with routine clinical information can better predict important heart outcomes in adults (18+) with chest pain who…
- Conditions
- Coronary Artery Disease, Chest Pain, Myocardial Ischemia, Angina Pectoris
- Trial name
- FINESSE (NCT07432620)
- Testing
- Dobutamine Stress Echocardiography
- Where
- United Kingdom
- Volunteers
- 2,281 people
- Sponsor
- Milton Keynes University Hospital NHS Foundation Trust
Funnel Chest, Pectus Excavatum
Intraoperative Cryoanalgesia Versus Thoracic Epidural Block in MIRPE (Minimally Invasive Repair of Pectus Excavatum)
The main objective of this study is to compare epidural blockade with cryoanalgesia of the intercostal nerves as an analgesic method in the postoperative period of minimally invasive repair of pectus excavatum (MIRPE).
- Conditions
- Funnel Chest, Pectus Excavatum, Postoperative Pain After Video Assisted Thoracic Surgery, Postoperative Pain
- Trial name
- FROZEN MIRPE (NCT07431632)
- Testing
- Cryotherapy, Epidural
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo
Acute Coronary Syndrome Without ST Elevation on Electrocardiogram
Calibration Study PREDICT - Prehospital Triage for Suspected Acute Coronary Syndrome Without ST-segment Elevation
The PREDICT calibration study is a prospective, non-interventional trial aiming to adapt and calibrate the ACS-Pathfinder algorithm for prehospital triage of patients with suspected non-ST-elevation acute coronary syndrome…
- Trial name
- PREDICT (NCT07419139)
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Leipzig Heart Science gGmbH
Cardiovascular Diseases, Ischaemic Heart Disease
Machine Learning in Quantitative Stress Echocardiography
Greater diagnostic accuracy is required to find out who is at risk of a heart attack as this can reduce the requirement of more invasive downstream tests and thereby improve the patient experience and also reduce their exposure…
- Trial name
- MLQSE (NCT04193475)
- Testing
- Analysis
- Where
- United Kingdom
- Volunteers
- 1,250 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Gastrointestinal Diseases, Chest Pain
Virtual Reality for Non-cardiac Chest Pain
The purpose of this study is to determine if virtual reality (VR) will improve symptoms in non-cardiac chest pain (NCCP).
- Trial name
- NCT06262126
- Testing
- Virtual Reality
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Trauma, Rib Fractures
Percutaneous Cryoablation of Intercostal Nerves for the Treatment of Rib Fractures
The goal of this double blinded randomized control trial is to learn if percutaneous cryoablation of traumatic rib fractures improves outcomes.
- Conditions
- Trauma, Rib Fractures, Chest Wall Disorder, Respiratory Insufficiency
- Trial name
- NCT06533904
- Testing
- Percutaneous Cryoablation of Intercostal Nerves, Multi-modal pain regimen
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Chest Pain
Early Warning and Classification Model for Acute Non-traumatic Chest Pain
Acute non-traumatic chest pain is one of the common causes of presentation in emergency patients, but the causes of acute non-traumatic chest pain are complex, the severity of the condition varies greatly, and the specificity of…
- Trial name
- NCT06196307
- Testing
- Clinical evaluation, laboratory and cardiac imaging results, medication, surgery, and any hospitalization
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Xiao-nan He
Acute Coronary Syndrome, High-Risk Chest Pain
BREVOC Study: Exhaled VOCs for High-Risk Chest Pain in the ED
Study Objectives 1. Screening and identification of diagnostic biomarkers: To establish the exhaled volatile organic compound (VOC) profile of patients with acute high-risk chest pain and to differentiate high-risk chest pain…
- Conditions
- Acute Coronary Syndrome, High-Risk Chest Pain, Volatile Organic Compounds
- Trial name
- BREVOC (NCT07379567)
- Testing
- observational study
- Volunteers
- 6,000 people
- Sponsor
- Qilu Hospital of Shandong University
Chest Pain, Emergency Medicine
A Study to Assess the Accuracy of Magnetocardiography (MCG) to Diagnose True Ischemia in Patients With Chest Pain in the ED
The purpose of the research is to see if patients that come to the Emergency Department with chest pain can be more accurately and more quickly diagnosed by magnetocardiography (MCG) to see if their chest pain is caused by…
- Trial name
- MCG (NCT05809648)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Mayo Clinic
Chest Wall Tumor, Reconstructive Surgical Procedure
Chest Wall Reconstruction Cohort
Chest wall reconstruction following tumor or infection-related resections remains a challenging aspect of thoracic surgery, requiring restoration of structural stability and preservation of respiratory mechanics.
- Conditions
- Chest Wall Tumor, Reconstructive Surgical Procedure, Malignancy
- Trial name
- NCT07338006
- Testing
- chest wall reconstruction
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- University of Health Sciences Lahore
Chest Pain, Emergencies
RCT aiTriage Chest Pain Risk Stratification
Chest pain is one of the most common reasons people visit the Emergency Department (ED). While most cases are not serious, a small number may lead to life-threatening heart problems, known as Major Adverse Cardiac Events (MACE).
- Trial name
- NCT07074808
- Testing
- aiTriage risk score
- Where
- 2 sites in Singapore
- Volunteers
- 1,120 people
- Sponsor
- Singapore General Hospital
Chest Pain, Shortness of Breath
Leveraging Exercise Stress Echocardiography for Heart Failure With Preserved Ejection Fraction
The purpose of this study is to find out if additional images taken during a stress echocardiogram study and risk score calculation will help the doctor determine if shortness of breath or chest pain are caused by stiff heart…
- Trial name
- NCT06927973
- Testing
- Echocardiogram
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Duke University
Myocardial Infarction, Angina, Unstable
Advantageous Predictors of Acute Coronary Syndromes Evaluation (APACE) Study
The triage of patients with suspected acute coronary syndrome in the emergency room is a time-consuming diagnostic challenge. Therefore high sensitive early markers for myocardial damage are needed for more rapidly rule out of…
- Trial name
- APACE (NCT00470587)
- Where
- 13 sites in Czechia, Italy and 3 more
- Volunteers
- 10,000 people
- Sponsor
- University Hospital, Basel, Switzerland
The Effects of Virtual Reality on Pain and Anxiety Levels During Chest Tube Removal
The Effect of Virtual Reality
Chest tubes are routinely required during cardiothoracic procedures in open-heart surgeries. Postoperatively, these tubes are typically removed within 24-48 hours, and the removal process often causes patients to experience…
- Trial name
- NCT07283172
- Testing
- Virtual Reality
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Giresun University
Chest Pain, Acute Coronary Syndrome
AI-Assisted Interpretation of Cardiac CT in the Emergency Department
" This prospective, pragmatic, randomized controlled trial is designed to evaluate the impact of an artificial intelligence (AI)-based coronary computed tomography angiography (CCTA) interpretation tool (Angiomics) on emergency…
- Conditions
- Chest Pain, Acute Coronary Syndrome, Coronary Artery Disease
- Trial name
- NCT07235657
- Testing
- Angiomics AI-based Coronary CT Interpretation Tool, Standard CCTA Interpretation without AI
- Where
- South Korea
- Volunteers
- 530 people
- Sponsor
- Yonsei University
Physicians, Awareness
Physicians' Awareness of ECG Abnormalities Linked to Acute Ischemic Chest Pain
This study aims to investigate physicians' awareness regarding patients presenting with potential acute ischemic chest pain. It focuses on various electrocardiogram (ECG) patterns requiring prompt catheter lab activation for…
- Conditions
- Physicians, Awareness, ECG Abnormalities, Acute Ischemic Chest Pain
- Trial name
- NCT06836466
- Testing
- Google Form-based questionnaire
- Where
- Egypt
- Volunteers
- 640 people
- Sponsor
- Tanta University
Acute Chest Pain
Intravenous Hydromorphone for the Treatment of Acute Pain
To observe the efficacy and safety of hydromorphone in the treatment of acute chest pain, and to explore the potential advantages of hydromorphone for analgesia in patients with acute chest pain, so as to provide more theoretical…
- Trial name
- NCT06949059
- Testing
- Hydromorphone
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Coronary Artery Disease, Myocardial Infarction
Clinical Evaluation of Radiation Reduction for Optimized Safety
The primary objective of this study is to determine whether a reduced radiation protocol (RRP) in which angiograms are acquired at ultralow radiation doses and then processed using spatiotemporal enhancement software can produce…
- Conditions
- Coronary Artery Disease, Myocardial Infarction, Coronary Disease, Coronary Stenosis
- Trial name
- CERROS (NCT06348875)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Angiowave Imaging