Clinical trials: Chest Injury Trauma
Thoracic Injuries
Evaluation of the GORE Conformable TAG® for Treatment of Traumatic Transection
TAG 08-02 is a prospective, multicenter, single-arm study to evaluate the use of the CTAG Device in traumatic transection of the descending thoracic aorta.
- Trial name
- NCT00917852
- Testing
- Gore Conformable TAG Thoracic Endoprosthesis
- Where
- 26 sites in United States
- Volunteers
- 51 people
- Sponsor
- W.L.Gore & Associates
Stable Angina Pectoris
Prevalence and Prognostic Value of Unrecognized Myocardial Injury in Stable Coronary Artery Disease (PUMI)
This study includes patients with stable coronary artery disease without previously known myocardial infarction, and investigates the prevalence of clinically unrecognized myocardial damage and its prognostic implication.
- Trial name
- PUMI (NCT01257282)
- Where
- 6 sites in Sweden
- Volunteers
- 275 people
- Sponsor
- Uppsala University
Lung Injury
Acute Lung Injury After Aortic Valve Surgery
The purpose of this prospective, randomized clinical trial is to understand and measure lung injuries caused by CPB in aortic valve surgery.
- Trial name
- NCT01184313
- Testing
- aortic valve surgery with CPB
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- University of Oulu
Spinal Cord Injury (SCI)
Trunk Balance and Functional Independence in Individuals With SCI
This study investigates the relationship between trunk balance, position sense, wheelchair skills, and functional independence in individuals with thoracic spinal cord injury.
- Trial name
- SCI (NCT06612112)
- Testing
- No Interventions
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Afyonkarahisar Health Sciences University
Acute Respiratory Distress Syndrome, Acute Lung Injury
Early Low Dose Steroid Therapy of Acute Respiratory Distress Syndrome
The purpose of this study is to determine whether the 2mg/kg administration of corticosteroids, in the form of methylprednisolone sodium succinate, in early phase acute respiratory distress syndrome after thoracic surgery, will…
- Conditions
- Acute Respiratory Distress Syndrome, Acute Lung Injury, Postoperative Complications
- Trial name
- NCT00290602
- Testing
- Methylprednisolone sodium succinate
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- National Cancer Center, Korea
Radiation Induced Lung Injury (RILI)
Hyperpolarized 129Xe Magnetic Resonance Imaging for Evaluation of Radiation-Induced Lung Injury in Subjects Undergoing Thoracic Irradiation
The purpose of this work is to perform hyperpolarized (HP) 129Xe MRI in human subjects undergoing thoracic radiation therapy (RT), both before, during and following RT.
- Trial name
- RILI (NCT03431129)
- Testing
- Hyperpolarized gas and proton lung MRI
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- The Hospital for Sick Children
Spinal Cord Injury
Modified Yoga for Pulmonary Function and Quality of Life in Spinal Cord Injury Patients
This pilot interventional study evaluated whether adding wheelchair-adapted Modified Yoga Therapy to conventional physical rehabilitation could improve pulmonary function, respiratory muscle strength, and quality of life in…
- Trial name
- Leave blank (NCT07842003)
- Testing
- Conventional Physical Rehabilitation Therapy, Modified Yoga Therapy
- Where
- India
- Volunteers
- 29 people
- Sponsor
- Government (CL&SC) Spine Institute and Hospital, Ahmedabad
Lung Cancer
Phase II Evaluation of Exhaled Nitric Oxide (NO)
The goal of this clinical research study is to learn if the level of nitric oxide you breathe out may relate to the amount of breathing complications that you may experience due to radiation treatment.
- Trial name
- NCT01392144
- Testing
- Nitric oxide breath test, Questionnaires
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- M.D. Anderson Cancer Center
Unstable Angina, Coronary Artery Bypass Graft
Comparison Between Lidocaine, Dexmedetomidine, and Their Combined Infusion in Subjects Undergoing Coronary Artery Bypass Graft
The aim of the present study is to compare the antiarrhythmic and myocardial protective effect between lidocaine, dexmedetomidine, and their combined infusion in subjects undergoing coronary artery bypass graft.
- Conditions
- Unstable Angina, Coronary Artery Bypass Graft, Dexmedetomidine, Lidocaine
- Trial name
- NCT01688648
- Testing
- Lidocaine infusion, Dexmedetomidine infusion
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Samsung Medical Center
Acute Respiratory Distress Syndrome (ARDS), Extracorporeal Membrane Oxygenation
Personalized Ventilator Settings for Patients on ECMO
While mechanical ventilation can be used to sustain life in those with lung injury, it, can further worsen lung injury or prevent lung healing resulting in high morbidity and mortality as seen in Acute Respiratory Distress…
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Extracorporeal Membrane Oxygenation, Respiratory Failure Patients Treated With ECMO, Respiratory Failure, ICU
- Trial name
- PEEPECMO (NCT07673250)
- Testing
- Personalized Positive End-Expiratory Pressure (PEEP)
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of California, San Diego
Critically Ill, Acute Lung Injury
Respiratory Mechanics and Pleural Effusion
The investigators aim to compare the respiratory mechanics in acute lung injury (ALI)/acute respiratory diseases syndrome (ARDS) patients with and without pleural effusion.
- Conditions
- Critically Ill, Acute Lung Injury, ARDS
- Trial name
- NCT00258518
- Testing
- mechanical ventilation/CT Scan
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Policlinico Hospital
Hiv, Lung Injury
Effects of Using E-Cigarettes on Lungs in People With HIV (HBS Ancillary)
This is an ancillary study, thus participants will be recruited from participants in the HBS Study. This project acutely assesses the role of the e-cigarettes and vaping on lung health.
- Trial name
- HBS Ancillary (NCT04794543)
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Pennington Biomedical Research Center
CoronaVirus Induced Disease-2019 (COVID-19)
Study of Oral Ibrutinib Capsules to Assess Respiratory Failure in Adult Participants With Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and Pulmonary Injury
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Lung failure is the main cause of death related to COVID-19 infection.
- Trial name
- iNSPIRE (NCT04375397)
- Testing
- Ibrutinib
- Where
- 9 sites in United States
- Volunteers
- 46 people
- Sponsor
- AbbVie
Thoracic Spine Fracture, Concomitant Sternal Fracture
The Unstable Thoracic Cage Injury
Analysis of patient data and computed tomography scan of polytraumatized patients thoracic spine fractures A concomitant sternal fracture was identified an indicator for an unstable thoracic spine fracture
- Trial name
- NCT02514993
- Volunteers
- 130 people
- Sponsor
- BG Unfallklinik Murnau
Coronary Syndrome, Acute, Myocardial Infarction
Rapid or Ultra-rapid Diagnosis of Myocardial Infarction Using High-Sensitivity Cardiac Troponin on Hospital Presentation
People with chest pain are often tested for a heart attack using a blood test called high-sensitivity cardiac troponin (hs-cTn). Traditionally, this blood test is repeated 3 hours after the first sample.
- Conditions
- Coronary Syndrome, Acute, Myocardial Infarction, Coronary Artery Disease, Cardiovascular Diseases
- Trial name
- DanRUSH (NCT07727135)
- Testing
- 0/3-hour high-sensitivity cardiac troponin algorithm, 0/1-hour high-sensitivity cardiac troponin algorithm
- Where
- 11 sites in Denmark
- Volunteers
- 28,000 people
- Sponsor
- Herlev and Gentofte Hospital
Kidney Injury Following Open-Chest Cardiac Surgery
A Phase 2b Dose Finding Study of RMC-035 in Participants Undergoing Open-chest Cardiac Surgery
The goal of this clinical trial is to identify the optimal dose of RMC-035 for protection of long-term renal function in adult patients undergoing cardiac surgery who are at high risk of kidney injury.
- Trial name
- POINTER (NCT06475274)
- Testing
- RMC-035
- Where
- 19 sites in Canada, Czechia and 2 more
- Volunteers
- 170 people
- Sponsor
- Guard Therapeutics AB
Pneumoconiosis
Potential of Deep Learning in Assessing Pneumoconiosis Depicted on Digital Chest Radiography
Pneumoconiosis is relatively prevalent in low/middle-income countries, and it remains a challenging task to accurately and reliably diagnose pneumoconiosis.
- Trial name
- NCT04963348
- Testing
- convolutional neural networks (CNNs)
- Volunteers
- 1,881 people
- Sponsor
- Peking University Third Hospital
Hypotension, Hemodynamic Instability
The "Hypotension Prediction Index" in Patients Undergoing Lung Surgery
The "Hypotension Prediction Index (HPI)" was established by the Edwards Lifescience Company (Irvine, California, USA) and is CE certified.
- Conditions
- Hypotension, Hemodynamic Instability, Renal Failure, Myocardial Injury
- Trial name
- NCT04149314
- Testing
- HPI based hemodynamic optimization algorithm
- Where
- Germany
- Volunteers
- 142 people
- Sponsor
- University of Giessen
Rib Fracture Multiple, Pain, Chest
RIB PAIN (Rib Fractures Treated With Parental Analgesia With Infused LidocaiNe)
Traumatic rib fractures (RF) are a relatively common occurrence in patients of all ages, with a 10% incidence in all trauma patients and are associated with significant morbidity and mortality.
- Conditions
- Rib Fracture Multiple, Pain, Chest, Pain, Acute, Respiratory Failure
- Trial name
- RIB PAIN (NCT03770208)
- Testing
- Intervention: Lidocaine
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- Western University, Canada
Cardiogenic Shock, Malignant Arrhythmias
The Caribbean Registry of Extracorporeal Membrane Oxygenation (ECMO) From the University Hospital in Martinique
The project's main goal is to collect baseline clinical and procedural data as well as to assess clinical outcomes for all patients undergoing VV, VA or VAV ECMO implantation in the French West Indies and Guiana.
- Conditions
- Cardiogenic Shock, Malignant Arrhythmias, Ischemic or Valvular Heart Failure, Drepanocytosis and Thoracic Syndrome
- Trial name
- NCT07351435
- Volunteers
- 1,200 people
- Sponsor
- University of Genova