Clinical trials: Chemotherapy Induced Peripheral Neuropathy
Chemotherapy-induced Peripheral Neuropathy, Onychodystrophy
CIPN-prevention Trial Evaluating the Efficacy of Hand-cooling and Hand-compression
The POLAR study is a monocentric, prospective, randomized, 2-arm study designed to evaluate the effectiveness of compression or hypothermia in preventing higher-grade chemotherapy-induced peripheral neuropathy (CIPN) (Grade > 1…
- Trial name
- POLAR (NCT06541769)
- Testing
- Limb hypothermia, Limb compression
- Where
- Germany
- Volunteers
- 122 people
- Sponsor
- University Hospital Heidelberg
Chemotherapy-induced Peripheral Neuropathy
Role of Curcumin in Paclitaxel Induced PN
Paclitaxel induced peripheral neuropathy is the most common and serious side effect associated with Paclitaxel treatment in breast cancer patients receiving Paclitaxel.
- Trial name
- NCT05966441
- Testing
- Curcumin, Paclitaxel
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Neuralgia, Neuropathic Pain
Safety and Effectiveness of Magnetic Peripheral Nerve Stimulation for the Treatment of Chemotherapy Induced Neuropathy
Assess the safety and effectiveness of Axon Therapy in the treatment of chemotherapy-induced neuropathy
- Conditions
- Neuralgia, Neuropathic Pain, Chemotherapy-induced Peripheral Neuropathy
- Trial name
- mPNS-CH (NCT05935956)
- Testing
- Magnetic Peripheral Nerve Stimulation
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- NeuraLace Medical, Inc.
Neuropathic Pain, Chemotherapy Effect
Prevention of Paclitaxel-induced Neuropathic Pain in Patients With Planned Paclitaxel Chemotherapy (PrevTel)
Phase IIa clinical trial will be conducted with patients requiring in-label paclitaxel-chemotherapy due to ovarian or breast cancer.
- Trial name
- PrevTel (NCT05322889)
- Testing
- Telmisartan tablets
- Where
- Germany
- Volunteers
- 35 people
- Sponsor
- Dr. Frank Behrens
Chemotherapy-induced Peripheral Neuropathy
Understanding and Preventing Cortical Mechanisms of Chemotherapy-induced Peripheral Neuropathy
Cohort 1: To track the onset and progression of a condition called chemotherapy-induced peripheral neuropathy (CIPN). Cohort 2: To track the onset and progression of a condition called chemotherapy-induced peripheral neuropathy…
- Trial name
- NCT06389721
- Testing
- Electroencephalogram (EEG)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer, Peripheral Neuropathy Due to Chemotherapy
Evaluation of the Effect of Amantadine in the Prevention of Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer Patients
This randomized, controlled, open-label trial will evaluate the efficacy and safety of amantadine, an NMDA receptor antagonist with antioxidant and anti-inflammatory properties, in preventing paclitaxel-induced peripheral…
- Conditions
- Breast Cancer, Peripheral Neuropathy Due to Chemotherapy, VAS Score
- Trial name
- NCT07889115
- Testing
- Amantadine (oral)
- Volunteers
- 80 people
- Sponsor
- Al-Azhar University
Chemotherapy-induced Peripheral Neuropathy
Efficacy of Peri-neural Platelet Rich Plasma Injection in Treatment of Chemotherapy Induced Peripheral Neuropathy
This study aims to show the efficacy and safety of ultra-sound guided peri-neural platelet rich injection in treatment of chemotherapy induced peripheral neuropathy.
- Trial name
- NCT05348408
- Testing
- platelet rich plasma
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- South Egypt Cancer Institute
Peripheral Nervous System Diseases
A Study to Investigate the Safety and Efficacy of Ricolinostat
This is a double-blind, placebo-controlled study during which patients will receive ricolinostat or placebo.
- Trial name
- NCT05229042
- Testing
- Ricolinostat
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Beijing 3E-Regenacy Pharmaceuticals Co., Ltd.
Chemotherapy-induced Peripheral Neuropathy
Cannabinoids for Taxane Induced Peripheral Neuropathy
Taxane-induced peripheral neuropathy (TIPN) affects a significant number of women undergoing breast cancer treatment. Some patients may need to shorten their course of treatment, and do not receive the full benefit of…
- Trial name
- NCT03782402
- Testing
- Cannabinoids
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- New York State Psychiatric Institute
CIPN - Chemotherapy-Induced Peripheral Neuropathy, Pain
Scrambler Therapy With Duloxetine-based Usual Care vs Duloxetine-based Usual Care for Chemotherapy-induced Peripheral Neuropathy.
The investigators hypothesize that Scrambler therapy with duloxetine, compared to duloxetine-based usual care, will result in greater improvement in CIPN as measured by the BPI-Short Form.
- Trial name
- NCT06914557
- Testing
- Scrambler Therapy, Questionnaire and Physical Exam
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Fox Chase Cancer Center
Breast Cancer, Peripheral Neuropathy
Role of Silymarin in Chemotherapy Toxicity and Cognition Improvement in Breast Cancer Patients
Aim of the work This study aims to evaluate the possible beneficial role of silymarin in attenuating both doxorubicin related cardiac and hepatic toxicities and paclitaxel associated peripheral neuropathy and improving cognitive…
- Conditions
- Breast Cancer, Peripheral Neuropathy, Cardiac Toxicities, Hepatic Toxicity
- Trial name
- NCT05595109
- Testing
- Silymarin
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Tanta University
Chemotherapy-induced Peripheral Neuropathy
Memantine XR and Pregabalin for Chemotherapy-Induced Peripheral Neuropathy
Study is designed to assess the efficacy and safety of memantine XR and pregabalin in reducing neuropathic pain in patients with chemotherapy-induced peripheral neuropathy (CIPN) caused by prior treatment with any chemotherapy as…
- Trial name
- NCT03709888
- Testing
- Memantine XR-pregabalin combination therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Saint John's Cancer Institute
CIPN, Chemotherapy-induced Peripheral Neuropathy
Transauricular Vagus Nerve Stimulation in the Treatment of Chemotherapy-induced Peripheral Neuropathy
Chemotherapy induced peripheral neuropathy is common in tumor patients receiving chemotherapy. Nowaday, CIPN is mainly treated with drugs, but the therapeutic effect is not satisfactory.
- Trial name
- NCT05434403
- Testing
- Vagus nerve stimulation
- Where
- China
- Volunteers
- 26 people
- Sponsor
- Peking University People's Hospital
Pediatric Cancer, Pediatric Brain Tumor
Playful Sensorimotor Training in Pediatric Brain Tumor Patients
Chemotherapy-induced peripheral neuropathy (CIPN) is a highly prevalent and clinically relevant side-effect of cancer treatment.
- Conditions
- Pediatric Cancer, Pediatric Brain Tumor, Chemotherapy-induced Peripheral Neuropathy, Sensorimotor Polyneuropathy
- Trial name
- RESET (NCT03334162)
- Testing
- Sensorimotor training
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Basel
Breast Cancer, Chemotherapy Induced Peripheral Neuropathy
Objective Evaluation of Paclitaxel/Docetaxel-induced Neuropathy in Breast Cancer Patients
The purpose of this prospective, non-interventional study is to perform neurological and cognitive assessment of breast cancer patients who receive standard of care single agent weekly paclitaxel docetaxel chemotherapy to…
- Conditions
- Breast Cancer, Chemotherapy Induced Peripheral Neuropathy, Paclitaxel Induced Neuropathy
- Trial name
- NCT03872141
- Testing
- Quantitative measures of reduction in Chemotherapy Induced Neuropathy (CIPN) and Cognitive Impairment (CICI) in patients with stage I-III breast cancer
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Yale University
Peripheral Neuropathy Due to Chemotherapy
Medical Device for Oxaliplatin-Induced Neuropathy in Gastrointestinal Cancer Patients
This is an observational study related to a medical device designed for the prevention of oxaliplatin-induced peripheral neuropathy (OIPN) in patients with gastrointestinal cancer.
- Trial name
- NCT06873360
- Testing
- Clinical interviews with patients and Usability interviews and glove testing.
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Corporacion Parc Tauli
Breast Cancer
"Electro Acupuncture in the Treatment and Management of Chemotherapy Induced Peripheral Neuropathy"
To evaluate the effectiveness of Electro acupuncture (EA) for treatment of persistent painful CIPN symptoms in patients with stages 1-3 breast cancer treated with docetaxel chemotherapy 6 months prior
- Trial name
- NCT02821442
- Testing
- Acupuncture
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Manitoba
Chemotherapy Induced Peripheral Neuropathy (CIPN)
Electrical Stimulation and Chemotherapy Induced Peripheral Neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) implies sensory or deficits pain, loss of motor functions and impaired proprioception which in turn may affect balance and fine motor skills.
- Trial name
- NCT02088996
- Testing
- longwave diathermy on high power and interferential therapy, longwave diathermy on low power
- Where
- Sweden
- Volunteers
- 70 people
- Sponsor
- Uppsala University
Chemotherapy-Induced Peripheral Neuropathy, Hematopoietic and Lymphoid Cell Neoplasm
PEA for the Relief of Chemotherapy-Induced Peripheral Neuropathy
This phase II trial tests whether PEA works to relieve the symptoms of chemotherapy-induced peripheral neuropathy in patients with cancer.
- Conditions
- Chemotherapy-Induced Peripheral Neuropathy, Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
- Trial name
- NCT05246670
- Testing
- Palmidrol, Quality-of-Life Assessment
- Where
- 10 sites in United States
- Volunteers
- 88 people
- Sponsor
- Academic and Community Cancer Research United
Chemotherapy-induced Peripheral Neuropathy, Colorectal Cancer
Hand-Foot Exercises for Chemotheraphy Induced Peripheral Neuropathy Pain, Falls and Quality of Life in Colorectal Cancer
Colorectal cancer is the 4th most common cancer in the world among all cancer types. Chemotherapy-induced peripheral neuropathy is a common and serious side effect caused by chemotherapeutic agents, especially platinum analogues…
- Trial name
- NCT05873829
- Testing
- Hand-foot exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Gulhane Training and Research Hospital