Clinical trials: Chemotherapy Effect
Rectal Cancer, Total Neoadjuvant Treatment
Total Neoadjuvant Therapy and Organ Preservation Versus Surgery for Rectal Cancer.
This study hypothesizes that approximately 50% of rectal cancer patients can preserve their rectum using a watch-and-wait strategy if they achieve a complete or near-complete clinical response to total neoadjuvant therapy (TNT).
- Conditions
- Rectal Cancer, Total Neoadjuvant Treatment, Neoadjuvant Therapy, Radiotherapy
- Trial name
- NCT06758830
- Testing
- Radiation Therapy, Chemoradiotherapy, Consolidation Chemotherapy
- Where
- Lithuania
- Volunteers
- 400 people
- Sponsor
- National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos
Hodgkin Lymphoma, Adult, Cardiovascular Diseases
Physical Capacity in Hodgkin Lymphoma Survivors
The study aims to investigate if physical capacity obtained in the cardiopulmonary exercise test can predict cardiovascular alterations in Hodgkin Lymphoma (HL) Survivors.
- Conditions
- Hodgkin Lymphoma, Adult, Cardiovascular Diseases, Radiation Effect, Chemotherapy Effect
- Trial name
- NCT04636255
- Testing
- Physical Characteristics, Assessment of Heart rate variability, Blood Pressure and Cardiac Autonomic Control
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo General Hospital
Neoplasms, Chemotherapy-induced Nausea and Vomiting
Serious Gaming for Chemotherapy-induced Nausea and Vomiting
The purpose of this study is to examine the effectiveness of a technology-based intervention for managing nausea and vomiting in older adults with cancer.
- Trial name
- NCT05838638
- Testing
- eSSET-CINV
- Where
- 2 sites in United States
- Volunteers
- 610 people
- Sponsor
- University of Central Florida
Cancer Survivorship, Chemotherapy Side Effects
Remote Physical Activity Programming to Improve Outcomes in Cancer Survivors With and Without Type 2 Diabetes
The growing U.S. cancer survivor population is projected to hit 26M by 2040. Chemotherapy represents an effective cancer treatment but can diminish cancer survivors' quality of life-particularly cognitive function-through select…
- Trial name
- CICI-PA (NCT06725953)
- Testing
- Social Cognitive Theory-based, Technology-delivered Physical Activity Program
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Oklahoma
Acute Myeloid Leukemia, Newly Diagnosed
Study of the Effectiveness and Safety of Daunorubicin /Idarubicin ± Silibinin in Treating Newly Diagnosed AML (Non-M3).
Silibinin is the major active component of silymarin, a commonly used hepatoprotective agent. It stabilizes hepatocyte membranes, preserves cellular integrity, and accelerates DNA synthesis in liver cells.
- Conditions
- Acute Myeloid Leukemia, Newly Diagnosed, Chemotherapy Effect
- Trial name
- AML (NCT07561892)
- Testing
- daunomycin/Idarubicin+ Silybinin, daunomycin/Idarubicin
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fujian Medical University Union Hospital
Cancer, Pediatric Cancer
Massage Impact on Sleep in Pediatric Oncology
This study aims to determine the impact of massage therapy for pediatric patients receiving intensive chemotherapy or stem cell transplant (SCT).
- Conditions
- Cancer, Pediatric Cancer, Chemotherapy Effect, Acute Myeloid Leukemia
- Trial name
- NCT06892158
- Testing
- Massage therapy, Standard of care
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- Children's Hospital of Philadelphia
Chemotherapy Induced Alopecia, Chemotherapy Side Effects
Pharmacokinetic Study of DA-020
Pharmacokinetic Study of DA-020
- Trial name
- NCT07402330
- Testing
- DA-020 (0.1%), DA-020 (0.2%), DA-020 (0.5%)
- Where
- 2 sites in Brazil, Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Applied Biology, Inc.
Breast Cancer, Drug-Related Side Effects and Adverse Reactions
Telenursing for the Early Detection and Management of Side Effects Associated With Cyclin-Dependent Kinase Inhibitors in Breast Cancer Patients
This study is a multicenter randomized controlled trial designed to evaluate the effectiveness of a structured telenursing intervention in patients with breast cancer receiving cyclin-dependent kinase (CDK) inhibitor therapy.
- Conditions
- Breast Cancer, Drug-Related Side Effects and Adverse Reactions, Chemotherapy Toxicity, Treatment Adherence
- Trial name
- NCT07524829
- Testing
- Structured Telenursing Follow-up, Standard Nursing Care
- Where
- Italy
- Volunteers
- 124 people
- Sponsor
- Azienda Sanitaria Locale di Asti
Immunotherapy, Gastric Cancer
Multi-omics Sequencing in Neoadjuvant Immunotherapy of Gastrointestinal Tumors
immunotherapy，gastric cancer，rectal cancer，biomark
- Conditions
- Immunotherapy, Gastric Cancer, Rectal Cancer, Chemotherapy Effect
- Trial name
- NCT05515796
- Testing
- Terelizumab (aka Tislelizumab), CapeOx, Trastuzumab
- Where
- China
- Volunteers
- 189 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Intrahepatic Cholangiocarcinoma, Chemotherapy Effect
HAI-Floxuridine, or SIRT, Combined With Gemox For Patients With Intra-Hepatic Cholangiocarcinoma Not Amenable to Resection (TOMCAT)
Patients with intrahepatic cholangiocarcinoma (IHC) have relatively aggressive tumors, and the prognosis for most of these patients is dismal.
- Trial name
- TOMCAT (NCT06313203)
- Testing
- Floxuridine, Selective Internal Radiation Therapy (SIRT)
- Where
- Norway
- Volunteers
- 39 people
- Sponsor
- Oslo University Hospital
Breast Cancer, HER2-positive Breast Cancer
TME Alteration in HER2 Positive Breast Cancer
Evaluate for changes in the tumor microenvironment before/during neoadjuvant chemotherapy and after treatment in patients diagnosed with HER2-positive advanced breast cancer and receiving neoadjuvant cancer therapy and surgery…
- Conditions
- Breast Cancer, HER2-positive Breast Cancer, Chemotherapy Effect
- Trial name
- NCT06533670
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital
Oral Mucositis, Chemotherapy Effect
Photobiomodulation in the Prevention and Management of Oral Mucositis in Children
Oral mucositis (OM) is a frequent, debilitating complication in pediatric oncology that impairs quality of life, nutrition, hydration, and treatment adherence.
- Conditions
- Oral Mucositis, Chemotherapy Effect, Pediatric Cancer
- Trial name
- PBMOM-PEDMX (NCT07372443)
- Testing
- Photobiomodulation, bioadhesive gel
- Volunteers
- 49 people
- Sponsor
- Universidad de Guanajuato
Esophagus Cancer, Esophagogastric Junction Cancer
Chemoradiotherapy in Esophageal or Esophagogastric Junction Cancer
Definitive chemoradiotherapy is the standard of care in unresectable esophageal or esophagogastric cancer. A multidisciplinary approach, including chemotherapy and radiotherapy, is important for these patients.
- Conditions
- Esophagus Cancer, Esophagogastric Junction Cancer, Chemoradiation, Targeted Therapy
- Trial name
- NCT04821778
- Testing
- Radiotherapy, Platinum based chemotherapy, Paclitaxel based chemotherapy
- Where
- 5 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Esophageal Cancer, Chemotherapy Effect
Neoadjuvant Treatment Modalities in Esophageal Cancer
Esophageal cancer is the most prevalent cancer globally with poor survival outcome. The prognosis with surgery alone is poor, accounting for 30-40% of overall survival at 5 year.
- Conditions
- Esophageal Cancer, Chemotherapy Effect, Chemoradiation, Surgery
- Trial name
- NCT04821843
- Testing
- Platinum based chemotherapy, Paclitaxel based chemotherapy, Radiotherpay
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Chemotherapy Effect, Pain Cancer
Effects of Virtual Museum Visit on Pain, Fatigue, and Anxiety in Patients Receiving Chemotherapy
Symptom management is the most important aspect of clinical cancer care. Virtual reality-based interventions can be used to improve cancer patients' experiences with medical treatment, with their distraction-based effects.
- Conditions
- Chemotherapy Effect, Pain Cancer, Fatigue, Anxiety
- Trial name
- NCT06844695
- Testing
- Art Therapy (Virtual Museum Visit)
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Cumhuriyet University
Chemotherapy Effect
Anxiolytic Effects of Socio-aesthetics in Cancer Patients Undergoing Chemotherapy
The purpose of the study is to assess the average of the "State Anxiety" score of the State Trait Inventory Anxiety at the end of the third cycle of chemotherapy compared to the pre-treatment score (inclusion)
- Trial name
- PASITHEA (NCT05649852)
- Testing
- Socio-aesthetic care, Supportive care
- Where
- France
- Volunteers
- 192 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Chemotherapy Side Effects, Machine Learning
Prospective Validation of Machine Learning Model to Predict Platinum Induced Nephrotoxicity in Cancer Patients
This study aims to investigate the utility of predictive models for chemotherapy-induced nephrotoxicity in the Taiwanese cancer population.
- Conditions
- Chemotherapy Side Effects, Machine Learning, Acute Kidney Injury, Acute Kidney Disease
- Trial name
- NCT07114276
- Testing
- Machine learning models predictions of acute kidney injury and acute kidney disease
- Where
- Taiwan
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Taste Disorders, Breast Cancer
Incidence of Dysgeusia in Breast Cancer Patients Undergoing Chemotherapy
The goal of this observational study is to examine how frequently changes in taste occur in people with early-stage breast cancer who receive chemotherapy.
- Conditions
- Taste Disorders, Breast Cancer, Quality of Life, Taste Perception
- Trial name
- GustiAmo (NCT07317752)
- Testing
- Taste Assessment / Nutritional Assessment / Quality of Life Assessment
- Volunteers
- 40 people
- Sponsor
- Azienda Sanitaria Locale CN2 Alba-Bra
Endometrial Cancer, Chemotherapy Effect
Impact of Adjuvant Chemotherapy on the Quality of Life of Patients Treated for Stage II / III Endometrial Cancer
Through this study, The investigator believe to evaluate the impact in terms of overall quality of life of adjuvant chemotherapy in patients with locally advanced endometrial cancer at a distance from their care
- Conditions
- Endometrial Cancer, Chemotherapy Effect, Quality of Life
- Trial name
- EndoQOL (NCT03466788)
- Testing
- Self questionnaires of quality of life and living conditions
- Where
- 5 sites in France
- Volunteers
- 51 people
- Sponsor
- Centre Francois Baclesse
Cancer, Chemotherapy Induced Pain
Effect of Geranium Inhalation Aromatherapy on Pain and Blood Pressure in Cancer Patients Undergoing Chemotherapy
This randomized controlled trial aims to examine the effect of geranium inhalation aromatherapy on pain and blood pressure among Indonesian cancer patients undergoing intravenous chemotherapy.
- Conditions
- Cancer, Chemotherapy Induced Pain, Blood Pressure Changes in Cancer Patients, Chemotherapy Side Effects
- Trial name
- NCT07292844
- Testing
- Geranium Inhalation Aromatherapy
- Where
- Indonesia
- Volunteers
- 90 people
- Sponsor
- Universitas Muhammadiyah Surakarta