Clinical trials: Chemoprophylaxis
Malaria
Seasonal Malaria Chemoprevention With or Without Lipid-based Nutrient Supplement in Children Aged 6-59 Months in Mali
SMC LNS Mali is a interventional matched-pair clustered cohort carried out between August and November 2017 in 18 health areas in Kolokani Circle, Koulikoro region, Mali.
- Trial name
- NCT03035305
- Testing
- Lipid-based Nutrient Supplement (LNS), Seasonal malaria chemoprevention
- Where
- Mali
- Volunteers
- 36,717 people
- Sponsor
- Alliance for International Medical Action
Colorectal Cancer (Diagnosis), Adenoma
S-Adenosylmethionine (SAMe) for Chemoprevention of Colorectal Adenomas
This study will enroll a total of 18 patients who have undergone curative surgery for stage I or II colorectal cancer and are planned for post-surgical surveillance without any need for chemotherapy at Cedars-Sinai Medical…
- Trial name
- NCT07582003
- Testing
- S-Adenosylmethionine (SAMe)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Jun Gong, MD
Malaria,Falciparum, Anemia in Children
Comparing Chemoprevention Approaches for School-based Malaria Control
This is an individually randomized, controlled, single blind three arm clinical trial of malaria chemoprevention strategies Arm 1: Intermittent screening and treatment (IST) - students will receive treatment if they have a…
- Trial name
- NCT05244954
- Testing
- Dihydroartemisinin-Piperaquine, Chloroquine
- Where
- Malawi
- Volunteers
- 746 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Malaria,Falciparum, Controlled Human Malaria Infection
Safety and Efficacy of NF135 CPS Immunization
This is an open label, randomized, controlled clinical trial. The primary aim of this project is to determine the safety and tolerability of NF135.C10 sporozoite immunization under chemoprophylaxis against homologous and…
- Conditions
- Malaria,Falciparum, Controlled Human Malaria Infection, Immunization; Infection
- Trial name
- CPS135 (NCT03813108)
- Testing
- CPS-immunization, malaria challenge infection, P. falciparum NF135.C10, malaria challenge infection, P. falciparum NF54
- Where
- Netherlands
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Colorectal Cancer, Colorectal Adenoma
The Colorectal Cancer Chemoprevention Acceleration and Improvement Platform (CRC-CHAMP) Study
The overall goal of this study is to develop a platform for both large-scale chemoprevention trials and real-world chemoprevention studies for colorectal cancer (CRC) prevention.
- Conditions
- Colorectal Cancer, Colorectal Adenoma, Colorectal Adenomatous Polyp
- Trial name
- NCT05402124
- Testing
- acetylsalicylic acid delayed release tablets, 81mg
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Familial Breast Cancer
Specialist Recommendation on FBC (Familial Breast Cancer) Chemoprevention Prescribing
Some women are more likely to get breast cancer as it runs in their family, they are at risk of familial breast cancer. There are medications, called chemoprevention, which may lower their risk of developing breast cancer by a…
- Trial name
- FBC (NCT04058418)
- Testing
- Survey Administration
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Malaria
Safety, Tolerability and Immunogenicity of PfSPZ Vaccine in an Age De-escalation Trial in Equatorial Guinea.
This trial will evaluate the safety, tolerability, and immunogenicity of PfSPZ Vaccine in healthy Equatoguinean adults, adolescents, children and infants who receive doses of 0.9x10^6, 1.8x10^6 or 2.7x10^6 PfSPZ Vaccine via…
- Trial name
- NCT02859350
- Testing
- PfSPZ Vaccine, PfSPZ Challenge (for CHMI), Normal Saline
- Where
- Equatorial Guinea
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Sanaria Inc.
Recurrent Bladder Cancer
Celecoxib in Treating Patients With Bladder Cancer
This randomized phase IIb/III trial is studying celecoxib to see how well it works in preventing disease recurrence in patients who have bladder cancer.
- Trial name
- NCT00006124
- Testing
- celecoxib
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- National Cancer Institute (NCI)
Breast Cancer
Protocol for Women at Increased Risk of Developing Breast Cancer
A pilot study to assess the effects of six months of letrozole on breast tissue risk markers in postmenopausal women on hormone replacement therapy at high risk of developing breast cancer.
- Trial name
- NCT00291135
- Testing
- letrozole
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Carol Fabian, MD
Breast Cancer
Tamoxifen-MRI Study
The project is a double blind, randomized, placebo-controlled phase II chemoprevention trial. Study participants will be randomly assigned to receive either tamoxifen or placebo for one year.
- Trial name
- NCT00295100
- Testing
- Tamoxifen
- Where
- 7 sites in United States, Italy
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Anemia, Malaria
Perennial Malaria Chemoprevention (PMC) in Cameroon
The Plus Project will assess the impact, operational feasibility, efficacy, effectiveness, and cost-effectiveness of PMC. Specifically, the impact evaluation will involve monitoring a passive cohort of all children in the study…
- Trial name
- NCT05889052
- Testing
- Sulfadoxine pyrimethamine
- Where
- Cameroon
- Volunteers
- 2,138 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Hand Laceration, Tendon Involved
Prophylactic Antibiotic Treatment for Hand Lacerations Involving Flexor and/or Extensor Tendon
The investigators assume that simple hand lacerations involving flexors or extensors tendons, do not require prophylactic antibiotic treatment to prevent wound infection.
- Conditions
- Hand Laceration, Tendon Involved, Clean Laceration, No Bone Involved
- Trial name
- NCT01899781
- Testing
- Antibiotic-Cefamezin
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Head and Neck Squamous Cell Carcinoma
Chemoprevention of Head and Neck Squamous Cell Carcinoma (HNSCC) With Valproic Acid
This study evaluates the addition of valproic acid as a chemopreventive drug in head and neck squamous cell carcinoma (HNSCC) patients that do not have signs of recurrence or residual disease.
- Trial name
- GAMA (NCT02608736)
- Testing
- Valproic Acid
- Where
- Brazil
- Volunteers
- 42 people
- Sponsor
- Barretos Cancer Hospital
Inguinal Hernia
Prophylactic Antibiotic Use in Hernioplasty
The purpose of this study is to determine whether prophylactic antibiotic use in inguinal hernioplasty are effective in prevention of infectious complication.
- Trial name
- RCT-herniation (NCT00636831)
- Testing
- Antibiotic: cefazolin Sodium
- Where
- Japan
- Volunteers
- 400 people
- Sponsor
- Nihon University
Surgical Wound Infection, Head and Neck Neoplasms
Prophylactic Antibiotic Duration in Head and Neck Cancer Surgery (PROTECT-HN Trial)
The goal of this clinical trial is to learn whether giving antibiotics for 7 days after surgery, instead of the usual 24 hours, lowers the chance of wound infection in adults having major surgery for mouth or throat cancer.
- Conditions
- Surgical Wound Infection, Head and Neck Neoplasms, Oral Cancer Neoplasms, Pharyngeal Neoplasms
- Trial name
- PROTECT-HN (NCT07851857)
- Testing
- Ampicillin/Sulbactam 24-Hour Postoperative Prophylaxis, Ampicillin/Sulbactam 7-Day Postoperative Prophylaxis
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- AC Camargo Cancer Center
HIV Infections
Emtricitabine/Tenofovir Disoproxil Fumarate for HIV Prevention in Men
The purpose of this study is to determine whether daily use of emtricitabine/tenofovir disoproxil fumarate (FTC/TDF) can prevent HIV infection in men who also receive HIV counseling, condoms, and treatment for other sexually…
- Trial name
- iPrEx (NCT00458393)
- Testing
- daily TDF/FTC
- Where
- 11 sites in United States, Brazil and 4 more
- Volunteers
- 2,499 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria,Falciparum
Association Between Drug Levels, Malaria, and Antimalarial Resistance in the Setting of Seasonal Malaria Chemoprevention
In areas of the Sahel sub-region of Africa with intense seasonal malaria transmission, seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine and amodiaquine (SP+AQ) has become the standard-of-care for the…
- Trial name
- DRUMARS (NCT04969185)
- Where
- 2 sites in Burkina Faso
- Volunteers
- 310 people
- Sponsor
- University of California, San Francisco
Splenectomized Patients
Post Splenectomy Care Assessment and the Role of Patient Education in Its Improvement
The goal of this trial is to evaluate compliance to booster vaccines and chemoprophylaxis in children who underwent a splenectomy and to assess the knowledge regarding this aspect before and after giving education.
- Trial name
- NCT07027371
- Testing
- Health education
- Where
- Egypt
- Volunteers
- 112 people
- Sponsor
- Cairo University
Breast Cancer
Combined Estrogen Blockade of the Breast With Exemestane and Raloxifene in Postmenopausal Women With a History of Breast Cancer Who Have No Clinical Evidence of Disease
The purpose of this research study is to learn about the effects of two drugs when they are given together. The names of the drugs are raloxifene and exemestane. Raloxifene is a drug that is related to estrogen.
- Trial name
- NCT00200174
- Testing
- Raloxifene followed by combination therapy, Exemestane followed by combination therapy
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Malaria, Malnutrition, Child
Assessment of a Combined Strategy of SMC + Nutrients Supplementation to Tackle Malaria and Malnutrition
Malaria and malnutrition represent major public health concerns worldwide especially in Sub-Sahara Africa. Despite implementation of Seasonal Malaria Chemoprophylaxis (SMC), an intervention aimed at reducing malaria prevalence…
- Trial name
- SMC-NUT (NCT04238845)
- Testing
- AQSP Administration, Supplementation with Plumpy'Doz, Supplementation with Vitamin A
- Where
- Burkina Faso
- Volunteers
- 1,059 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche en Sciences de la Sante, Burkina Faso