Clinical trials: Cessation, Smoking
Smoking Cessation
A Study To Evaluate The Efficacy And Safety Of Varenicline Compared To Placebo For Smoking Cessation Through Reduction
This study will determine whether varenicline is safe and helps people to quit smoking through reduction when they are not willing/able to make an abrupt quit attempt.
- Trial name
- NCT01370356
- Testing
- Varenicline Tartrate
- Where
- 65 sites in United States, Australia and 8 more
- Volunteers
- 1,510 people
- Sponsor
- Pfizer
Lung Cancer
A Trial of Placebo Versus Enzastaurin for Lung Cancer Prevention in Former Smokers
To compare the difference of a marker of cellular proliferation in all bronchial biopsy specimens of former smokers stratified by lung cancer risk, collected before and after treatment per patient between the enzastaurin and…
- Trial name
- NCT00414960
- Testing
- Enzastaurin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Eli Lilly and Company
Chronic Obstructive Pulmonary Disease
QVA Mechanistic Efficacy Study (Receptor Effects, Etc)
The purpose of this study was to assess global ventilated lung volume in moderate to severe COPD patients using MRI lung imaging after treatment with QVA149 compared to placebo.
- Trial name
- NCT02634983
- Testing
- QVA149
- Where
- 3 sites in United Kingdom
- Volunteers
- 31 people
- Sponsor
- Novartis Pharmaceuticals
Smoking Cessation
Randomized Trial to Evaluate the Effectiveness of X-22 as a Smoking Cessation Aid
A randomized, active controlled clinical trial in which a total of 216 healthy smokers will be enrolled and followed over approximately 19 weeks.
- Trial name
- NCT01400815
- Testing
- X-22 Smoking Cessation Product, Active Control Cigarettes
- Where
- 3 sites in United States
- Volunteers
- 234 people
- Sponsor
- 22nd Century Limited, LLC
Tobacco Use
A Mobile App Based Cognitive Dissonance Intervention for Smoking Cessation
This research study aims to develop a cognitive dissonance-based mobile app for smoking cessation (Support2Quit) and test the efficacy of the app with 500 adult smokers who express a desire to quit smoking.
- Trial name
- Support2Quit (NCT05797155)
- Testing
- Support2Quit App - Cognitive Dissonance Based Smoking Cessation + Smoking Cessation Tips, Tips for Smoking Cessation App
- Where
- United States
- Volunteers
- 437 people, healthy volunteers welcome
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.
Vaping, E-Cig Use
A Study of Cytisinicline for Vaping Cessation in Adult Smokers
This placebo-controlled Phase 2 study is being conducted at sites within the United States to evaluate the efficacy and safety profile of 3 mg cytisinicline administered TID for 12 weeks for vaping cessation.
- Trial name
- ORCA-V1 (NCT05431387)
- Testing
- cytisinicline, Behavioral support
- Where
- 5 sites in United States
- Volunteers
- 160 people
- Sponsor
- Achieve Life Sciences
Smoking Reduction, Smoking Behaviors
Assessment of the Pivot Breath Sensor: Single-Arm Cohort Study
Prospective open label, single center study enrolling up to 220 participants to evaluate the effect of the Pivot Breath Sensor on a user's attitudes towards quitting smoking and smoking behavior.
- Conditions
- Smoking Reduction, Smoking Behaviors, Smoking, Tobacco, Smoking Cessation
- Trial name
- NCT04133064
- Testing
- Pivot Breath Sensor
- Where
- United States
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- Jennifer Marler, MD
Smoking Cessation
Provoked Craving Relief Study by NRT
This study is designed to assess the ability of the mint nicotine mouth strip to relieve provoked cigarette craving in light smokers compared to nicotine lozenge and nicotine gum.
- Trial name
- NRT (NCT01476202)
- Testing
- nicotine
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Smoking Cessation
Comparison of Pharmacokinetic Profiles of Two Nicotine Gum Formulations
The primary objective of this study is to compare pharmacokinetic (PK) profiles and assess the bioequivalence between the newly developed nicotine gums (2 mg and 4 mg) and the reference nicotine gums (2 mg and 4 mg) in healthy…
- Trial name
- NCT01847443
- Testing
- Nicotine (2 mg), Nicotine (4 mg)
- Where
- United Kingdom
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
COPD
Chronic Obstructive Pulmonary Disease (COPD) Biomarker Identification Study
Chronic obstructive pulmonary disease (COPD) is a common inflammatory disease of the airway affecting approximately 10% of individuals aged 40 years or more with a smoking history.
- Trial name
- NCT01780298
- Where
- United Kingdom
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Nicotine Addiction, Smoking Cessation
Evaluation of a Smoking Cessation Program for Long-Term Abstinence
This observational study evaluates a structured smoking cessation program delivered via weekly group sessions. The primary objective is to assess participant-reported smoking abstinence following completion of the program and at…
- Trial name
- ESCaPe (NCT06746025)
- Testing
- Quit Center cessation program
- Where
- United States
- Volunteers
- 371 people
- Sponsor
- Quit Center LLC
Smoking Cessation
Outcomes From a Mobile Smoking Cessation Program During a Monitoring Period of 6 Months
Prospective, open label, single center clinical study enrolling 260 subjects in a mobile smoking cessation program using a smartphone app and a handheld breath sensor with coaching support over a six month period.
- Trial name
- NCT03295643
- Testing
- Mobile smoking cessation program and CO breath sensor device
- Where
- United States
- Volunteers
- 319 people, healthy volunteers welcome
- Sponsor
- Jennifer Marler, MD
Smoking Cessation
A Study in Healthy Smokers to Investigate the Effect of Food on the Bioavailability of Cytisine in a New Formulation
This will be an open-label, randomised, 2-treatment period, single-dose crossover study to determine the comparative bioavailability and renal elimination following single-dose administration of 3.0 mg cytisine in healthy smokers…
- Trial name
- NCT03509948
- Testing
- cytisine
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- Achieve Life Sciences
Smoking Cessation
Pharmacokinetic Study of 4 mg Nicotine Lozenge.
This is a randomized, single center, open label, single dose, four way crossover study in fasted healthy male subjects to compare the pharmacokinetics of nicotine following administration of 3 prototype 4mg nicotine lozenge to an…
- Trial name
- NCT01669122
- Testing
- nicotine
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Tobacco Dependence
Bioequivalence Between Two New Oral Nicotine Replacement Therapy Products and Nicorette® Microtab
The purpose of this study is to assess the bioequivalence between two new oral nicotine replacement therapy products and Nicorette® microtab.
- Trial name
- NCT01238640
- Testing
- Code STD, Code STE, Nicorette Microtab
- Where
- Sweden
- Volunteers
- 84 people
- Sponsor
- McNeil AB
Malformations
Varenicline Pregnancy Cohort Study
A prospective population-based cohort study to examine whether varenicline use during pregnancy is associated with an increased risk of major congenital malformations in infants above that associated with smoking during pregnancy.
- Trial name
- NCT01290445
- Testing
- varenicline, cigarette smoke from maternal smoking, Non-Exposure
- Volunteers
- 885,185 people
- Sponsor
- Pfizer
Smoking Cessation
A Second Study of Cytisinicline for Smoking Cessation in Adult Smokers
This placebo-controlled Phase 3 study is being conducted at sites within the United States to evaluate 3 mg cytisinicline TID for treatment duration of 42 days/6 weeks and evaluate 3 mg cytisinicline TID for treatment duration of…
- Trial name
- ORCA-3 (NCT05206370)
- Testing
- Cytisinicline, Behavioral support
- Where
- 12 sites in United States
- Volunteers
- 792 people
- Sponsor
- Achieve Life Sciences
Smoking
Efficacy and Safety Study of Nicotine Mint Lozenge (2mg and 4mg) in Smoking Cessation
A multi-center, randomized, double-blind, placebo-controlled, 4-arm clinical study to evaluate efficacy and safety of nicotine lozenge (2mg and 4mg) in smoking cessation in adult cigarette smokers who are motivated to quit…
- Trial name
- NCT00985985
- Testing
- Nicotine
- Volunteers
- 723 people
- Sponsor
- GlaxoSmithKline
Smoking Cessation
A Study in Healthy Volunteers to Investigate the Effect of Food on the Bioavailability of Cytisine
This will be an open-label, randomised, 2-period, single-dose crossover study to determine the comparative bioavailability of cytisine following single-dose administration in healthy male and female subjects under fed and fasted…
- Trial name
- NCT03268343
- Testing
- Cytisine
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Achieve Life Sciences
Chronic Obstructive Pulmonary Disease (COPD)
Aclidinium/Formoterol Fixed Combination Dose Finding Study
The study seeks to determine the optimal dose of the Aclidinium/Formoterol combination for investigation in Phase III clinical trials
- Trial name
- NCT00626522
- Testing
- Aclidinium bromide and formoterol
- Where
- 9 sites in Australia, Czechia and 2 more
- Volunteers
- 808 people
- Sponsor
- AstraZeneca