Clinical trials: Cervical Cancer Prevention
Esophageal Cancer, Head and Neck Cancer
Early Detection of Esophageal Squamous Cancer With the Capsule Sponge Device
Esophageal squamous cell carcinoma accounts for ~90% of the nearly half-million annual incident cases of esophageal cancer worldwide.
- Conditions
- Esophageal Cancer, Head and Neck Cancer, Squamous Cell Carcinoma
- Trial name
- ANGELA (NCT06418516)
- Testing
- Capsule-sponge
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Centre of Postgraduate Medical Education
Metastatic Colorectal Cancer, Metastatic Head and Neck Cancer
Prophylaxis of Magnesium-rich Mineral Water to Prevent Hypomagnesemia Induced by an Anti-EGFR (OPTIMAG)
Anti-EGFR (Epidermal Growth Factor Receptor) therapies, namely cetuximab and panitumumab, have become standards in the management of metastatic colorectal and head and neck cancers.
- Trial name
- OPTIMAG (NCT03146338)
- Testing
- Magnesium-rich mineral water (Rozana)
- Where
- 12 sites in France
- Volunteers
- 106 people
- Sponsor
- Weprom
Leukoplakia, Oral
Oral Potentially Malignant Disorders: Comparison Between Surgical Treatment and Wait and See Approach
This research protocol is comparing the effectiveness of surgical excision to the "wait and see" approach for the management of oral leukoplakia and erythroleukoplakia in prevention of oral squamous cell carcinoma onset.
- Trial name
- NCT04858100
- Testing
- Surgical excision of the lesion, Wait and see approach
- Where
- 2 sites in Italy
- Volunteers
- 310 people
- Sponsor
- University of Milan
Breast Carcinoma, Head and Neck Carcinoma
StrataXRT for the Prevention and Treatment of Radiation Dermatitis in Breast Cancer or Head and Neck Cancer Patients
This clinical trial studies the effect of StrataXRT in preventing and treating radiation dermatitis in breast cancer or head and neck cancer patients. Radiotherapy is often associated with multiple side effects.
- Conditions
- Breast Carcinoma, Head and Neck Carcinoma, Radiation-Induced Dermatitis
- Trial name
- NCT05073172
- Testing
- Calendula Ointment, Petrolatum-Mineral Oil-Lanolin-Ceresin Ointment, Polyethylene Glycol Hydrogel
- Where
- United States
- Sponsor
- OHSU Knight Cancer Institute
Head and Neck Cancer
Parotid-gland Stem-cell Sparing Intensity-modulated Radiotherapy
Rationale: Radiation-induced parotid gland dysfunction, often leading to xerostomia is the most-frequently occurring side-effect with a major impact on patient-reported quality of life after radiotherapy for head and neck cancer…
- Trial name
- SCS-IMRT (NCT01955239)
- Testing
- Intensity-modulated Radiotherapy
- Where
- Netherlands
- Volunteers
- 106 people
- Sponsor
- University Medical Center Groningen
Head Cancer, Neck Cancer
Laser Therapy for the Prevention of Radiodermatitis in Head and Neck Patients
Up to 90% of the radiotherapy patients will develop a certain degree of skin reaction at the treated area, also known as radiodermatitis (RD).
- Trial name
- DERMISHEAD (NCT02738268)
- Testing
- Low-level laser therapy
- Where
- 2 sites in Belgium
- Volunteers
- 46 people
- Sponsor
- Hasselt University
Erythroplakia, Hyperplasia
Metformin Hydrochloride in Preventing Oral Cancer in Patients With an Oral Premalignant Lesion
This phase IIa trial studies how well metformin hydrochloride works in preventing oral cancer in patients with an oral premalignant lesion (oral leukoplakia or erythroplakia).
- Conditions
- Erythroplakia, Hyperplasia, Oral Cavity Carcinoma, Oral Leukoplakia
- Trial name
- NCT02581137
- Testing
- Laboratory Biomarker Analysis, Metformin Hydrochloride
- Where
- 4 sites in United States, Canada
- Volunteers
- 26 people
- Sponsor
- National Cancer Institute (NCI)
Cervical Cancer
Game Changers for Cervical Cancer Prevention
This randomized controlled trial will evaluate Game Changers for Cervical Cancer Prevention (GC-CCP) for increasing cervical cancer (CC) screening advocacy among intervention recipients (index participants) towards female social…
- Trial name
- GC-CCP (NCT06010160)
- Testing
- Game Changers for Cervical Cancer Prevention
- Where
- Uganda
- Volunteers
- 936 people, healthy volunteers welcome
- Sponsor
- RAND
Ototoxic Hearing Loss
Intratympanic N-Acetylcysteine for Prevention of Cisplatin-induced Ototoxicity.
Although many intratympanic agents have been attempted, N-Acetylcysteine (NAC) appears to be the most promising and is a powerful, commonly used anti-oxidant.
- Trial name
- NCT04291209
- Testing
- N-Acetyl Cysteine
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Sunnybrook Health Sciences Centre
Human Papillomavirus Infection, Human Papillomavirus-Related Cervical Carcinoma
Comparing One or Two Doses of the Human Papillomavirus Vaccine for the Prevention of Human Papillomavirus Infection, ESCUDDO Study
This phase IV trial investigates whether one dose of a human papillomavirus vaccine works as well as two doses in preventing human papillomavirus (HPV) infection. Certain types of HPV cause almost all cases of cervical cancer.
- Trial name
- ESCUDDO (NCT03180034)
- Testing
- Diphtheria Toxoid/Tetanus Toxoid/Acellular Pertussis Vaccine Adsorbed, Questionnaire Administration, Recombinant Human Papillomavirus Bivalent Vaccine
- Where
- Costa Rica
- Volunteers
- 27,945 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Human Papilloma Virus Infection, Carcinoma in Situ of Uterine Cervix
Community-Driven Cervical Cancer Prevention in Western Kenya
There are many challenges to implementation of cervical cancer prevention in resource-limited countries, despite evidence based screening and treatment strategies.
- Trial name
- NCT02124252
- Testing
- Community-based testing with standard linkage to care, Community-based HPV testing with enhanced linkage to care
- Where
- Kenya
- Volunteers
- 7,200 people, healthy volunteers welcome
- Sponsor
- Duke University
Cervical Cancer
Acceptability of Human Papillomavirus (HPV) Self-sampling Tools for Cervical Cancer Prevention
The proposed study aims to increase HPV screening behaviors in Jamaican women by examining the acceptability of HPV Deoxyribonucleic Acid (DNA) self-sampling tools, and to determine the most culturally appropriate and effective…
- Trial name
- NCT03613493
- Testing
- HPV self-sampling kit, Culturally-targeted Fear Appeal Message, Fear Appeal Message
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- University of Miami
Papillomavirus Infections, Uterine Cervical Neoplasms
Improving HPV Vaccination Coverage Among Adolescent Girls in Mali and Côte d'Ivoire Through Community Health Worker Follow-up
The goal of this trial is to learn if a community health worker (CHW) follow-up program can improve HPV vaccination coverage among adolescent girls in Mali and Côte d'Ivoire.
- Trial name
- NCT07807202
- Testing
- HPV vaccination pro-active community-based follow-up model, Standard community mobilization
- Where
- 2 sites in Côte d’Ivoire, Mali
- Volunteers
- 17,188 people
- Sponsor
- Arsène Brunelle Sandie
Head and Neck Cancer
Efficacy of Prophylactic Treatment With Antibiotics During Concomitant Chemoradiotherapy in Patients With Head and Neck Cancer to Prevent Aspiration Pneumonia
Patients with locally advanced head and neck cancer treated with chemo-radiotherapy have (during and shortly after this treatment) a high risk of developing pneumonia by aspiration.
- Trial name
- PANTAP (NCT01598402)
- Testing
- amoxicillin/clavulanic acid suspension
- Where
- 6 sites in Netherlands
- Volunteers
- 106 people
- Sponsor
- Radboud University Medical Center
Cervical Cancer
HPV Self-sampling to Improve Access to Cervical Cancer Screening for Persons With HIV and/or Underserved Individuals
The objective of this study is to evaluate self-collection of vaginal samples for HPV testing as an alternative cervical cancer screening strategy for persons with HIV and/or limited access to care.
- Trial name
- ACCESS (NCT05528237)
- Testing
- Flocked swab paired with Roche Cobas 4800
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV (Human Immunodeficiency Virus), HPV
Feasibility Study Comparing Use of One Or Two Probes for Thermal Ablation Among Screen Positive Women Living With HIV in C1001P-CS2 Kenya
Cervical cancer disproportionately affects women in low- and middle-income countries (LMICs), particularly women living with HIV (WLWH) who have a 6-fold increased risk of cervical cancer compared to women in the general…
- Conditions
- HIV (Human Immunodeficiency Virus), HPV, Cervical Precancer
- Trial name
- NCT07468695
- Testing
- Thermal ablation (TA) with 1 probe, Thermal ablation (TA) with 2 probes
- Where
- Kenya
- Volunteers
- 300 people
- Sponsor
- Fred Hutchinson Cancer Center
Cervical Dysplasia
Effect of a Childcare Resource on Cervical Cancer Prevention
Aim 1: Determine the prevalence of unmet childcare needs among women with abnormal cervical cancer screening and establish the relevance of childcare as a social determinant of health in the context of cervical dysplasia.
- Trial name
- NCT06086054
- Testing
- Navigation and EMR referral to childcare facility
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Nasopharyngeal Carcinoma (NPC), CTIT-Chemotherapy Induced Thrombocytopenia
A Clinical Study of Hetrombopag for Prevention of Thrombocytopenia Induced by Gemcitabine Plus Cisplatin in the Treatment of Nasopharyngeal Carcinoma
This study is a single-arm, exploratory, self-controlled clinical trial for the prevention of thrombocytopenia induced by gemcitabine plus cisplatin in the treatment of nasopharyngeal carcinoma.
- Trial name
- NCT07252375
- Testing
- herombopag olamine tablets
- Volunteers
- 35 people
- Sponsor
- Fujian Cancer Hospital
Radiodermatitis, Radiation Toxicity
A Novel Skin Barrier Protectant for Acute Radiodermatitis
Acute radiodermatitis (ARD) is a distressing and painful skin reaction that occurs in 95% of the patients undergoing radiotherapy (RT).
- Conditions
- Radiodermatitis, Radiation Toxicity, Radiation Dermatitis, Skin Diseases
- Trial name
- CASP-ORL (NCT04593914)
- Testing
- Cavilon Advanced Skin Protectant
- Where
- 2 sites in Belgium
- Sponsor
- Jessa Hospital
Head and Neck Neoplasm, Trismus
Randomized Study Regarding Preventive Jaw- and Swallowing Intervention for Patients With Head and Neck Cancer
The study includes patients with tumors of the oropharynx, larynx and hypopharynx scheduled to receive radiotherapy with curative intent (+/- chemotherapy).
- Conditions
- Head and Neck Neoplasm, Trismus, Deglutition Disorders
- Trial name
- HNC (NCT04005521)
- Testing
- Preventive intervention
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Sahlgrenska University Hospital