Clinical trials: Cerebrovascular Circulation
Cerebrovascular Circulation, Cognitive Impairment
Effects of Dietary Nitrate From Vegetable/Fruit Juice on Cerebral Blood Flow Parameters
Nitrate provides the body with an alternative source of Nitric Oxide which plays a large role in promoting blood flow and reducing blood pressure.
- Trial name
- NCT01169662
- Testing
- Vegetable/fruit juice
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Change in Cognitive Function and Fatigue During Extended Performance of the Cognitive Demand Battery (CDB) at 1, 3 and 6 Hours Post Consumption, Change in Long Term Declarative Memory at 1, 3 and 6 Hours Post-intervention.
Plant Based Extracts and Cognition
Acute, randomized, placebo controlled, double blind, 4 arm crossover study to determine the effect of different combinations of plant based extracts on cognitive function and cerebral blood flow.
- Trial name
- CEOPTB (NCT02202629)
- Testing
- Beverage containing plant based extracts
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Cognitive Function, Mood
Effects of Epigallocatechin Gallate (EGCG) in Healthy, Young Adults
Epigallocatechin gallate (EGCG) is the most abundant catechin (sometimes referred to as tea flavonoids) in green tea extract. A review by Nagle et al (2006) identifies that a large amount of research indicates EGCG (amongst other…
- Trial name
- NCT00981292
- Testing
- EGCG
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Vascular Dementia, Subcortical Vascular Dementia
Effect of Zydena (Udenafil) on Cerebral Blood Flow and Peripheral Blood Viscosity
The purpose of this study is to determine whether Zydena (Udenafil) has effect on cerebral blood flow and peripheral blood viscosity in normal and subcortical vascular cognitive impairment subjects.
- Trial name
- SMCZN01 (NCT01466543)
- Testing
- Zydena (Udenafil)
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Multiple Sclerosis, Relapse
Coagulation/Complement Activation and Cerebral Hypoperfusion in Relapsing-remitting Multiple Sclerosis
This is a multi-center, prospective, controlled study. MS patients (1° group: 30 patients in relapse; 2° group: 30 patients in remission) and age/sex-matched healthy controls (3° group: 30 subjects) will be enrolled in the study.
- Trial name
- NCT04380220
- Testing
- Blood samples and processing
- Where
- 3 sites in United States, Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Regina Elena Cancer Institute
Brain Vascular Function, Cerebral Blood Flow
Soy and Brain Vascular Function
Cognitive performance is negatively related to an impaired glucose metabolism, possibly due to impairments in brain vascular function.
- Conditions
- Brain Vascular Function, Cerebral Blood Flow, Glucose Metabolism, Cognitive Performance
- Trial name
- NCT03627637
- Testing
- Soy nuts
- Where
- Netherlands
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Cerebrovascular Circulation
MRI Biomarkers and Exercise
The overall goal of observational study is to examine the age-related and habitual exercise training status-related differences in structural and functional changes in the human brain, detected by magnetic resonance (MR) imaging.
- Trial name
- NCT02729428
- Testing
- MRI
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Cerebrovascular Disorder, Healthy
Magnetic Resonance Imaging Studies of Motor and Thought Processes
Magnetic resonance imaging (MRI) is a diagnostic tool that creates high quality images of the human body without the use of X-ray (radiation).
- Conditions
- Cerebrovascular Disorder, Healthy, Movement Disorder, Nervous System Disease
- Trial name
- NCT00001361
- Where
- United States
- Volunteers
- 610 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cerebral Blood Flow, Cerebral Blood Flow Regulation
The Role of Estrogen and Testosterone in Determining Brain Blood Flow and Metabolic Regulation in Humans
Due to historical exclusion of females from research, there are gaps in the understanding of female physiology, how it differs from males, and how sex-specific hormones contribute.
- Conditions
- Cerebral Blood Flow, Cerebral Blood Flow Regulation, Sex Differences, Exercise
- Trial name
- NCT07212712
- Testing
- GnRH antagonist, Estradiol (E2), Testosterone
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Multiple Sclerosis
Transcranial Doppler in Multiple Sclerosis
The aim of this study is to investigate the potential of Transcranial doppler (TCD) and Near-Infrared Spectroscopy (NIRS), more simple and non-invasive bedside methods than magnetic resonance imaging (MRI), to evaluate changes in…
- Trial name
- TRADOMS (NCT02389426)
- Testing
- TCD baseline, TCD after bosentan administration, NIRS baseline
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Hypoglycemia, Cerebral Blood Flow
External Carotid Blood Flow in Individuals With Post-Bariatric Hypoglycemia
This is a pilot study (small-scale study) that aims to understand more about how blood flow changes in people who have low blood sugar after bariatric surgery (post-bariatric hypoglycemia) compared to those who have had surgery…
- Trial name
- NCT07082478
- Testing
- in-ear device measuring blood flow
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Brain Concussion, Post-Concussion Syndrome
Cerebral Blood Flow Regulation and Concussions
The purpose of this study is to understand how biochemical markers in blood, balance disturbances, and cognitive performance are related to brain blood flow changes after a concussion.
- Trial name
- NCT02754206
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Southern Methodist University
Cerebral Hypoxia
The Effects of Hypobaria vs Hypoxia on Cerebral Functions.
The investigators will investigate the effect of hypobaria and hypoxia on physiological responses such as: oxygen saturation, heart rate, cerebral blood flow, cerebral oxygenation, brain's activity and concentration performance.
- Trial name
- Hypoxia (NCT03303118)
- Testing
- Hypoxia
- Where
- Switzerland
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Fliegerärztliches Institut
Vertebral Artery Dissection, Cerebrovascular Accident
Changes in Cerebral Blood Flow With Spinal Manipulative Therapy vs. Voluntary Motion
The investigators are performing a study to determine whether changes in blood flow occur in the neck and back of the brain following a series of head positions and a manipulation of the upper neck.
- Conditions
- Vertebral Artery Dissection, Cerebrovascular Accident, Cerebrovascular Stroke
- Trial name
- NCT01205490
- Testing
- head positions and spinal manipulation
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Canadian Memorial Chiropractic College
Alzheimer Disease, Dementia
Evaluation of Age- and Alzheimer's Disease-Related Memory Disorder
The purpose of this study is to examine how a part of the brain called the hippocampus contributes to memory changes that occur with aging and Alzheimer's disease (AD). Memory problems are the most important early symptoms of AD.
- Conditions
- Alzheimer Disease, Dementia, Memory Disorder, Healthy
- Trial name
- NCT00029120
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Alzheimer's Disease
Cerebral and Peripheral Perfusion Pilot Study
The purpose of this study is to evaluate the hypothesis that in middle-aged, asymptomatic, adult children of persons with Alzheimer's disease (AD), atorvastatin therapy will beneficially affect mechanisms thought to contribute to…
- Trial name
- CAPP (NCT00751907)
- Testing
- atorvastatin
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Spinal Cord Injury
Impact of Age on Cardiovascular, Cerebrovascular and Cognitive Health in Spinal Cord Injury
As the spinal cord injured population ages, these individuals are being exposed to an increased prevalence of age-associated diseases, which coupled with the secondary complications of the injury may contribute to the reduced…
- Trial name
- NCT01984476
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Cerebrovascular Circulation, Magnetic Resonance Imaging
Brain Blood Flow Responses During Exercise: Younger Cohort
Brain blood flow will be measured during exercise using magnetic resonance imaging.
- Trial name
- NCT06446622
- Testing
- MRI
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Cerebrovascular Circulation, Magnetic Resonance Imaging
Brain Blood Flow Responses During Exercise
Brain blood flow will be measured during exercise using magnetic resonance imaging.
- Trial name
- NCT05864950
- Testing
- MRI
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Aging, Physical Activity
Effects of Regular Exercise on Cerebrovascular Reserve in Older Adults
While it is well established that physical inactivity is a modifiable risk factor for vascular disease and cognitive decline, the mechanism by which exercise exerts its protective effect on the cerebral circulation and cognition…
- Conditions
- Aging, Physical Activity, Cognitive Function
- Trial name
- BIM (NCT03158337)
- Testing
- Aerobic exercise
- Where
- Canada
- Volunteers
- 286 people, healthy volunteers welcome
- Sponsor
- University of Calgary