Clinical trials: Cerebrospinal Fluid
Multiple Sclerosis
Characterization of White Blood Cells Sub-populations From Multiple Sclerosis Patients.
Multiple sclerosis (MS) is a chronic progressive neurological autoimmune disease, that gradually affects patient's quality of life. There are about 2.5 millions patients world wide, with an increasing cost Burdon.
- Trial name
- NCT03486665
- Testing
- Blood Sampling, CSF Sampling
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bioimmunate
Bacterial Meningitis, Fungal Meningitis
Early Diagnosis of Native and Device-associated Meningitis
Device-associated meningitis is a severe complication after implantation of various central nervous system (CNS) devices such as ventriculoperitoneal (VP) and ventriculoatrial (VA) shunts, external ventricular drains (EVD)…
- Conditions
- Bacterial Meningitis, Fungal Meningitis, Implant Infection
- Trial name
- NCT05146570
- Testing
- D-lactate test, Standard diagnostic tests
- Where
- Germany
- Volunteers
- 842 people
- Sponsor
- Charite University, Berlin, Germany
Breast Cancer, Leptomeningeal Metastasis
Microfluidic Device to Diagnose Leptomeningeal Metastasis in Breast Cancer
This study will prospectively enroll 36 evaluable subjects with breast cancer who are undergoing workup for clinical suspicion of leptomeningeal metastasis (LM).
- Trial name
- NCT02948751
- Testing
- OncoCEE
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Columbia University
Herpesviridae Infection, HTLV-I Infection
Assessment of Patients With Multiple Sclerosis (MS)
Multiple sclerosis (MS) is a disease of the nervous system. The exact cause of MS is unknown, but it is believed to be an autoimmune condition.
- Conditions
- Herpesviridae Infection, HTLV-I Infection, Multiple Sclerosis, Tropical Spastic Paraparesis
- Trial name
- NCT00001156
- Where
- United States
- Volunteers
- 1,388 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Normal Pressure Hydrocephalus
Analysis of Cerebrospinal Fluid Dynamics in Normal Pressure Hydrocephalus
This study aims to evaluate whether phase-contrast magnetic resonance imaging (MRI)-based cerebrospinal fluid (CSF) flow dynamics can improve the diagnosis and prognostic assessment of normal pressure hydrocephalus (NPH).
- Trial name
- NCT07831044
- Testing
- Cerebrospinal fluid drainge
- Where
- South Korea
- Volunteers
- 22 people
- Sponsor
- Chungnam National University Hospital
Cerebrospinal Fluid Shunts
Bedside Ultrasound to Measure Optic Nerve Sheath Diameter in Pediatric CSF Shunts
Bedside ultrasound in the emergency department is useful for quick assessments of patients. One growing use is to measure the optic nerve sheath diameter of patients for whom increased pressure in the head is a concern.
- Trial name
- NCT02776085
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Post-hemorrhagic Hydrocephalus (PHH)
Assessing CSF Flow Dynamics in Pediatric Hemorrhagic Hydrocephalus
The purpose of this study is to evaluate the safety and efficacy of ventricular microdosing of indocyanine green (ICG) in order to assess cerebrospinal fluid (CSF) ventricular dynamics and extracranial CSF outflow using…
- Trial name
- NCT06994949
- Testing
- fCTOT cap, NIRF planar imaging, ICG
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Eva Sevick
Encephalitis
Pharmacokinetic Study of a Single Dose of AVI-4065 in Cerebral Spinal Fluid
AVI-4020 Injection, a phosphorodiamidate Morpholino oligomer (PMO), was found to cross the blood-brain barrier during a study of patients with presumptive West Nile virus disease.
- Trial name
- NCT00381433
- Testing
- AVI-4065 Injection
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Sarepta Therapeutics, Inc.
Alzheimer Disease
Alzheimer Biomarkers on CSF of Elderly Patients Undergoing Surgery
Dementia is a syndrome characterized by cognitive and behavioral impairment in older adults, which usually manifests as memory loss, communication difficulties or changes in mood.
- Trial name
- NCT03977025
- Testing
- Lumbar punction
- Where
- Chile
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Chile
Attention Deficit and Disruptive Behavior Disorder, Attention Deficit Disorder With Hyperactivity
Biological Markers in Attention Deficit/Hyperactivity Disorder (ADHD)
The purpose of this study is to evaluate individuals with Attention Deficit/Hyperactivity Disorder (ADHD) to learn more about the genetics of the disease. This study is part of other ongoing studies of individuals with ADHD.
- Trial name
- NCT00001206
- Where
- United States
- Volunteers
- 347 people
- Sponsor
- National Institute of Mental Health (NIMH)
PCNSL
Bendamustine-based Combination Therapy for PCNSL
This pilot study will i) evaluate the efficacy and the safety of bendamustine-based combination chemotherapy and ii) investigate the pharmacokinetics (PK)of bendamustine in plasma and CSF when given as salvage treatment for…
- Trial name
- NCT03392714
- Testing
- R-B(O)AD
- Where
- South Korea
- Volunteers
- 15 people
- Sponsor
- Chonnam National University Hospital
Ventriculitis, Infectious
Evaluation of a TDM Program for Intensive Care Patients in the Cerebrospinal Fluid
Therapeutic drug monitoring of antibiotics in critically ill patients is a present research topic of the last ten years. Research results have shown subtherapeutic blood concentrations in those patients.
- Trial name
- EMIL (NCT04426383)
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Perinatal Depression, Chronic Pain
CSF/Serum Biomarkers in Predicting PND/Persistent Pain After Cesarean
The aim is to investigate if inflammatory biomarkers in the blood and cerebrospinal fluid (CSF) are associated with the development of perinatal depression and/or persistent pain after cesarean delivery.
- Trial name
- NCT04271072
- Testing
- No intervention
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Duke University
Cardiac Arrest (CA), Hypoxic-Ischemic Brain Injury
Multiomics Profiling of CSF in Cardiac Arrest Survivors
The goal of this observational study is to identify further pathophysiologic mechanism of secondary brain injury following cardiac arrest by using serial multiomics profiling of serum and cerebrospinal fluid (CSF) samples.
- Conditions
- Cardiac Arrest (CA), Hypoxic-Ischemic Brain Injury, Post-Resuscitation Syndrome
- Trial name
- MOPCAS (NCT07090577)
- Where
- South Korea
- Volunteers
- 15 people
- Sponsor
- Chungnam National University Hospital
Dural Sealing
DuraSeal Exact Spine Sealant System Post-Approval Study
This is a non-randomized, post-approval study to further evaluate the rate of post-operative Cerebral Spinal Fluid (CSF) leaks in subjects who undergo a spinal procedure and receive DuraSeal Exact Spine Sealant System.
- Trial name
- DuraSeal PAS (NCT01410864)
- Testing
- DuraSeal Exact Spine Sealant System, Control
- Where
- 36 sites in United States
- Volunteers
- 924 people
- Sponsor
- Integra LifeSciences Corporation
Multiple Sclerosis
SPINCOMS Biomarker Study
To determine if biomarker-based CSF testing is reliably detecting differences between patients with Multiple Sclerosis (MS), different MS-subtypes, and other central nervous system (CNS) diseases.
- Trial name
- SPINCOMS (NCT04496830)
- Where
- United States
- Volunteers
- 161 people
- Sponsor
- Washington University School of Medicine
Cerebrospinal Fluid Leak
Post-market Assessment of Biodesign Dural Repair Grafts
The purpose of this clinical study is to gather post-market clinical evidence on the use of the Biodesign® Dural and Duraplasty Grafts when used as a dura substitute of the dura mater.
- Trial name
- NCT04057157
- Testing
- Biodesign Dural or Duraplasty Repair Grafts
- Where
- 3 sites in United States, Canada and 1 more
- Volunteers
- 128 people
- Sponsor
- Cook Research Incorporated
Alzheimer's Disease
Dose-ranging Safety and Tolerability Study in Subjects ≥60 Years of Age
The study determined the safety of CNP520 in healthy elderly over 3 months. Data relevant for Pharmacokinetic/Pharmacodynamic modeling were obtained in order to define the target dose in subsequent efficacy studies.
- Trial name
- NCT02576639
- Testing
- CNP520
- Where
- 11 sites in United States, Belgium and 3 more
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Alzheimer Disease, Late Onset
Synaptic Injury and Functional Connectivity in Alzheimer's Disease
The purpose of this study is to examine cross-sectional associations between CSF markers of synaptic injury (Ng and SNAP-25) and functional connectivity in default and semantic memory networks using 3T- fMRI in individuals with…
- Trial name
- NCT03300726
- Testing
- CSF analysis, Functional MRI
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Back Pain
Measure of Cerebrospinal Fluid (CSF) Pressure Variation With Patient Positioning
This is a study looking at pressure changes in the fluid that surrounds the spine when a person is positioned in 2-3 different ways.
- Trial name
- NCT00231374
- Testing
- Myelogram
- Where
- United States
- Sponsor
- Emory University