Clinical trials: Cerebral Infarction
Aphasia, Stroke
Transcranial Magnetic Stimulation + Language Therapy to Treat Mild Aphasia
The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with Speech-Language Therapy (SLT) is an effective treatment for mild aphasia in persons with chronic stroke.
- Conditions
- Aphasia, Stroke, Aphasia Following Cerebral Infarction, Aphasia, Acquired
- Trial name
- TMS (NCT06842745)
- Testing
- Transcranial Magnetic Stimulation (TMS), Speech-Language Therapy (SLT)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Pennsylvania
Acute Ichemic Stroke, Anterior Cerebral Artery Stroke
Safety and Efficacy of Baricitinib After Endovascular Treatment in Acute Anterior Circulation Large Vessel Occlusion: A Multicenter, Randomized Controlled Clinical Trial
The primary purpose of this study is to evaluate the efficacy and safety of Baricitinib combined with endovascular therapy in patients with acute anterior circulation large vessel occlusion, to address futile recanalization with…
- Conditions
- Acute Ichemic Stroke, Anterior Cerebral Artery Stroke, Baricitinib
- Trial name
- NCT07449910
- Testing
- 2mg Baricitinib, 4mg Baricitinib, Guideline-based therapy
- Where
- China
- Volunteers
- 750 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Stroke, Chronic Stroke
Psychedelic Healing: Adjunct Therapy Harnessing Opened Malleability
The main purpose of the current studies is to evaluate the safety and tolerability of psilocybin in patients with chronic stroke.
- Conditions
- Stroke, Chronic Stroke, Intracerebral Haemorrhage, Intracerebral Haemorrhage (ICH)
- Trial name
- PHATHOM (NCT07053917)
- Testing
- Psilocybin (Usona Institute)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Symptomatic Cerebral Infarction
Evaluate the Frequency of Fatigue After Cerebral Infarction
Cerebral infarction is a type of stroke that can lead to sometimes disabling sequelae. Among these sequelae, fatigue is frequently reported by patients.
- Trial name
- Fatigue AVC (NCT03288090)
- Testing
- FSS: Fatigue Severity Scale, Neuropsychological evaluation battery, Other functional scores
- Where
- France
- Volunteers
- 126 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Calcified Cerebral Embolism
Calcified Cerebral Embolism: a Descriptive Study in a Large Single Center Cohort
Calcified cerebral embolism (CCE) is a relatively rare but underdiagnosed cause of infarction. CCE diagnosis is made by CT. Radiological characteristics of CCE have been reported in small case series.
- Trial name
- CCE Cohorte (NCT06309069)
- Testing
- None, purely observational study
- Where
- France
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Aphasia Following Cerebral Infarction
Application of Cerebellar tDCS in Aphasia
The goal of this clinical trial is to learn if adding brain stimulation (cerebellar anodal tDCS) helps a computer-based therapy improve word-finding in Cantonese-speaking adults with aphasia after stroke.
- Trial name
- NCT07353879
- Testing
- anodal right posterolateral cerebellar high-definition tDCS, computerized visual speech perception naming intervention
- Where
- 2 sites in Hong Kong
- Volunteers
- 6 people
- Sponsor
- The University of Hong Kong
Stroke, Hemiplegia
The Efficacy & Safety of rTMS for Upper-limb Motor Function Recovery in Subcortical and Brainstem Stroke
The purpose of this study is to evaluate the efficacy and safety of repetitive transcranial magnetic stimulation applied with an electromagnetic therapy stimulator 'ALTMS-A' for upper-limb motor function recovery with the sham…
- Conditions
- Stroke, Hemiplegia, Subcortical Infarction
- Trial name
- NCT05535504
- Testing
- Low-frequency rTMS (experimental)
- Where
- 2 sites in South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Bundang Hospital
Cerebral Infarction, Brain Ischemia
Japan Alteplase Clinical Trial (J-ACT): Efficacy and Safety Study of Tissue Plasminogen Activator (Alteplase) for Ischemic Stroke
Based on previous studies comparing Duteplase[a recombinant tissue plasminogen activator (rt-PA) very similar to alteplase] doses, we performed a clinical trial with 0.6mg/kg, which is lower than the internationally approved…
- Trial name
- NCT00147316
- Testing
- Alteplase
- Where
- Japan
- Volunteers
- 103 people
- Sponsor
- Tanabe Pharma Corporation
Stroke
Post-marketing Clinical Study of Alteplase for Acute Ischemic Stroke （Japan Alteplase Clinical Trial Ⅱ：J-ACT Ⅱ）
The purpose of this study is to confirm the efficacy and safety of intravenously administered alteplase in patients with acute ischemic stroke based on the rate of recanalization assessed by magnetic resonance angiography (MRA)…
- Trial name
- NCT00412867
- Testing
- Alteplase
- Where
- Japan
- Volunteers
- 58 people
- Sponsor
- Tanabe Pharma Corporation
Death, Myocardial Infarction
A Trial Evaluating Vitamin D Normalization on Major Adverse Cardiovascular-Related Events Among Myocardial Infarction Patients
This study evaluates whether achieving 25-hydroxyvitamin D (25[OH] Vit D) levels (>40 ng/mL) among myocardial infarction patients will result in a reduction of cardiovascular-related adverse events.
- Conditions
- Death, Myocardial Infarction, Cerebral Vascular Accident, Heart Failure Hospitalization
- Trial name
- TARGET-D (NCT02996721)
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 634 people
- Sponsor
- Intermountain Health Care, Inc.
Ischemic Stroke, Acute, Thrombolysis
Endovascular Treatment With or Without Preceding Intravenous Tenecteplase (TNK) in Patients With Late-window acUte Ischemic Stroke Due to Middle Cerebral Artery Occlusion
The purpose of this study is to investigate the safety and efficacy of endovascular treatment with or without preceding intravenous Tenecteplase in patients with late-window (4.5-24 hours of symptom onset) acute ischemic stroke…
- Conditions
- Ischemic Stroke, Acute, Thrombolysis, Endovascular Treatment
- Trial name
- TNK-PLUS (NCT06221371)
- Testing
- Tenecteplase, direct EVT
- Where
- 21 sites in China
- Volunteers
- 391 people
- Sponsor
- Beijing Tiantan Hospital
Intracranial Hemorrhages, Acute Ischemic Stroke
AI Assisted Reader Evaluation in Acute Computed Tomography (CT) Head Interpretation
This study has been added as a sub study to the Simulation Training for Emergency Department Imaging 2 study (ClinicalTrials.gov ID NCT05427838).
- Conditions
- Intracranial Hemorrhages, Acute Ischemic Stroke, Hydrocephalus, Cerebral Infarction
- Trial name
- AI-REACT (NCT06018545)
- Testing
- Ground truthing, Reading
- Where
- 4 sites in United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust
Ischemic Stroke, Atrial Fibrillation
Cardiac Assessment for Recurrent Stroke Risk Evaluation in Atrial Fibrillation
Background Atrial fibrillation (AF) is the most common cardiac arrhythmia, affecting up to 10% of the elderly. Ischemic stroke is the main complication of AF and cardioembolism is one of the leading causes of ischemic stroke…
- Conditions
- Ischemic Stroke, Atrial Fibrillation, Cerebrovascular Disorders, Brain Diseases
- Trial name
- CARE-AF (NCT06954610)
- Testing
- No intervention
- Where
- Switzerland
- Volunteers
- 500 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cerebral Infarction
Research on Binaural Synchronous Vagus Nerve Regulation of Sensorimotor Disorders After Cerebral Infarction
The aim of this study is to determine the efficacy and safety of binaural synchronous vagus nerve regulation in the treatment of patients with sensory and motor dysfunction after cerebral infarction through a randomized…
- Trial name
- NCT07081568
- Testing
- transcutaneous auriculai vagus nerve stimulation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Nanchang University Affiliated Rehabilitation Hospital
Stroke, Acute Stroke
Stroke Recovery Initiative - Registry for Stroke Research Studies
The Stroke Recovery Initiative is a nation-wide participant recruitment registry that connects people who have had a stroke with researchers who are working to develop new approaches to improve recovery after stroke.
- Conditions
- Stroke, Acute Stroke, Ischemic Stroke, Hemorrhagic Stroke
- Trial name
- NCT03318432
- Where
- United States
- Volunteers
- 60,000 people
- Sponsor
- University of California, San Francisco
Stroke, Brain Infarction
Intervention Effectiveness Towards Improving Physical and Mental Health for Post-stroke Patients.
This was a multi-intervention randomized controlled trial that aimed to develop a management pattern for stroke survivors. The program consisted of monitoring the recovery process, early detecting the physical and mental…
- Conditions
- Stroke, Brain Infarction, Brain Ischemia, Cerebral Infarction
- Trial name
- NCT04941482
- Testing
- Periodic health check program for post-stroke, Guiding the appropriate rehabilitation exercises, Motivational Interviewing
- Where
- Vietnam
- Volunteers
- 92 people
- Sponsor
- Hanoi Medical University
Stroke, Stroke, Ischemic
Evaluation of Low Dose Colchicine and Ticagrelor in Prevention of Ischemic Stroke in Patients With Stroke Due to Atherosclerosis
REDUCING INFLAMMATION IN ISCHEMIC STROKE WITH COLCHICINE, AND TICAGRELOR IN HIGH-RISK PATIENTS-EXTENDED TREATMENT IN ISCHEMIC STROKE.
- Conditions
- Stroke, Stroke, Ischemic, Atherosclerosis, Myocardial Infarction
- Trial name
- RIISC-THETIS (NCT05476991)
- Testing
- Colchicine 0.5 MG, Ticagrelor 90mg, Aspirin 75-300mg
- Where
- France
- Volunteers
- 2,800 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cerebral Infarction
Observation of the Therapeutic Effect of Fire Needle on Upper Limb Function in Stroke Patients
Objective: To explore the clinical efficacy of different needling strategies with moxibustion needles on upper limb function in post-stroke patients.
- Trial name
- NCT07140406
- Testing
- conventional rehabilitation training, conventional acupuncture, Acupuncture with the milli-needle fire-puncture on flexor muscle groups
- Where
- China
- Volunteers
- 105 people
- Sponsor
- Qilu Hospital of Shandong University
Severe Cerebral Edema Following Large Hemispheric Infarction
The Efficacy and Safety of HRS8179 in Severe Cerebral Edema Following Large Hemispheric Infarction
The study is being conducted to evaluate the efficacy, and safety of HRS8179 injection in preventing and treating severe cerebral edema after large area cerebral infarction in the cerebral hemisphere
- Trial name
- NCT06732648
- Testing
- HRS8179 injection, HRS8179 blank preparation.
- Where
- China
- Volunteers
- 725 people
- Sponsor
- Beijing Suncadia Pharmaceuticals Co., Ltd
Cerebral Infarction, TIA
Early Rivaroxaban for Acute Ischemic Stroke or TIA Patients With Atrial Fibrillation
Anticoagulant treatment for non-valvular atrial fibrillation (AF) associated with cerebral infarction/ TIA is one of the recognized treatment of stroke prevention.
- Trial name
- ERSAF (NCT03749057)
- Testing
- Rivaroxaban
- Where
- China
- Volunteers
- 400 people
- Sponsor
- General Hospital of Shenyang Military Region