Clinical trials: Cerebral Blood Flow
Cerebral Blood Flow
Validation of UK Protocols to Exclude Brain Blood Flow During Normothermic Regional Perfusion (NRP)
This study aims to evaluate both Abdominal Normothermic Regional Perfusion (A-NRP) and Thoracoabdominal-NRP (TA-NRP) techniques, proving that brain blood flow is not resumed during NRP.
- Trial name
- NCT05775263
- Testing
- CT angiogram
- Volunteers
- 10 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Stroke
Blood Flow Regulation and Neuromuscular Function Post-Stroke
The muscles of stroke survivors can fatigue faster compared to muscles in people who have not had a stroke, which can limit how long a person with stroke can perform tasks such as walking.
- Trial name
- NCT06027294
- Testing
- Ischemic Conditioning
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Medical College of Wisconsin
Spinal Cord Injury, Blood Pressure
Treating Cognitive Deficits in Spinal Cord Injury
Multiple studies in the spinal cord injury (SCI) population have documented deficits in learning and memory (LM) and processing speed (PS) that adversely impact daily life and the ability to benefit from rehabilitation.
- Conditions
- Spinal Cord Injury, Blood Pressure, Cerebral Blood Flow, Cognitive Function
- Trial name
- NCT03037879
- Testing
- SPT, SPT Control, mSMT
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Cardiac Arrest, Extracorporeal Circulation
Cytokine Adsorption in Post-cardiac Arrest Syndrome in Patients Requiring Extracorporeal Cardiopulmonary Resuscitation
Almost all patients with refractory cardiac arrest, who are primarily stabilized under ongoing cardiopulmonary resuscitation by transcutaneous implantation of a venoarterial extracorporeal membrane oxygenation system (va-ECMO for…
- Conditions
- Cardiac Arrest, Extracorporeal Circulation, Extracorporeal Membrane Oxygenation, Cytokine Storm
- Trial name
- CYTER (NCT03685383)
- Testing
- Cytosorb removal column in eCPR, standard eCPR (va-ECMO)
- Where
- Germany
- Volunteers
- 41 people
- Sponsor
- University Hospital Freiburg
Major Depression, Anxiety Disorder
Photobiomodulation to Alter Cerebral Blood Flow and to Affect the Emotional Status of Patients With Major Depression
A pilot study to evaluate the ability of photobiomodulation to alter cerebral blood flow in the frontal poles and to affect the emotional status of patients with major depression.
- Conditions
- Major Depression, Anxiety Disorder, Post-Traumatic Stress Disorder, Substance Abuse Disorder
- Trial name
- NCT00961454
- Testing
- Photobiomodulation with a super-luminous light emitting diode
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Ischemic Stroke, Acute, Thrombectomy
CO2 Modulation in Endovascular Thrombectomy for Acute Ischemic Stroke
Acute ischemic stroke due to large vessel occlusion is responsible of cerebral blood flow impairment with a progressive and extensive ischemic process.
- Conditions
- Ischemic Stroke, Acute, Thrombectomy, Anesthesia, General, Cerebrovascular Circulation
- Trial name
- COMET-AIS (NCT05051397)
- Testing
- HYPERCAPNIA, NORMOCAPNIA
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Stroke
Reperfusion Completion Via Local Arterial Infusion of Tenecteplase After Incomplete Mechanical Thrombectomy
To evaluate the efficacy and safety of intra-arterial TNK bridging therapy following incomplete recanalization (2b ≤ eTICI < 3) after mechanical thrombectomy for acute anterior circulation large vessel occlusion.
- Trial name
- RECLAIM-TNK (NCT07471282)
- Testing
- Tenecteplase (0.0938mg/kg)
- Where
- China
- Volunteers
- 344 people
- Sponsor
- Chuansheng Zhao
Ischemic Stroke
iTBS for Acute Ischemic Stroke After Thrombectomy
The goal of this randomized, single-blind, parallel-controlled clinical trial is to evaluate the efficacy and safety of intermittent theta burst stimulation (iTBS) as an adjunctive therapy for acute anterior circulation ischemic…
- Trial name
- NCT06941961
- Testing
- intermittent theta burst stimulation
- Where
- China
- Volunteers
- 178 people
- Sponsor
- Yi Yang
Traumatic Brain Injury
tPBM in Older Adults With Traumatic Brain Injury
The purpose of this study is to evaluate the effect of transcranial photobiomodulation (tPBM) in older patients with chronic traumatic brain injury (TBI).
- Trial name
- NCT06956404
- Testing
- Transcranial photobiomodulator (tPBM)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- NYU Langone Health
Multiple Sclerosis
Cerebral Blood Flow and tDCS
With this study, the investigators will substantiate if regional cerebral blood flow (CBF) is affected by tDCS, assess the amount of CBF change in relation to different currents, and measure differences in regional CBF under…
- Trial name
- NCT04033133
- Testing
- tDCS
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Dementia
EEG Biofeedback to Improve Memory in Adults With Dementia
This study measures whether the symptoms of frontotemporal dementia (FTD) can be successfully treated by (a) biofeedback training to increase brain blood flow, (b) biofeedback to increase the frequency of the brain's dominant…
- Trial name
- QMFFTD (NCT01168466)
- Testing
- QEEG-based Neurofeedback Training
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Quietmind Foundation
Congenital Heart Disease in Children, Extracorporeal Circulation; Complications
Non-invasive Monitoring of Cerebral Autoregulation in Perioperative Neonatal Cardiac Surgery
Cardiac surgery under extracorporeal circulation (ECC) in newborns with congenital heart disease causes significant morbidity and mortality.
- Trial name
- NEMOCARD (NCT04295239)
- Testing
- MRI
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Nantes University Hospital
Magnetic Resonance Imaging, Cerebrovascular Circulation
Brain Blood Vessel Responses to Changes in Blood Flow
Brain blood flow will be measured during a simulated postural change test and while breathing increased levels of carbon dioxide using magnetic resonance imaging.
- Trial name
- NCT06629077
- Testing
- MRI, Prazosin
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Alzheimer Disease
Blood Biomarkers from Internal Jugular Vein for the Diagnosis of Alzheimer's Disease
The goal of this observational study is to explore the diagnostic performance of blood biomarkers from the internal jugular vein for the diagnosis of Alzheimer's disease (AD) in patients with cognitive symptoms or concerns.
- Trial name
- NCT06754254
- Testing
- blood biomarkers from the internal jugular vein
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Stroke, Acute Ischemic
Tirofiban for Successful Endovascular Stroke Thrombectomy
Up to 50% of acute ischemic stroke patients with large vessel occlusion failed to achieve functional independence even after successful reperfusion therapy, a phenomenon that is referred to as "futile recanalization".
- Trial name
- ADJUVANT-2 (NCT06373042)
- Testing
- Intraarterial and intravenous tirofiban
- Volunteers
- 712 people
- Sponsor
- Zhongming Qiu
Hypoxia, Brain
Supplementation of 500mg Trans-resveratrol Within Hypoxic and Normoxic Conditions, in Healthy Humans.
Objectives: Resveratrol, a non-flavonoid polyphenol, has been found to consistently modulate cerebral blood flow (CBF) following oral supplementation.
- Trial name
- NCT03100019
- Testing
- Resveratrol
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Ischemic Stricture of Intestine
Safety and Effectiveness Evaluation of the ISS System in Treatment of Acute Ischemic Stroke
The primary objective of this pilot study is the assessment of the safety of the ISS500 System in patients who have experienced an acute ischemic stroke within the anterior circulation.
- Trial name
- ImpACT-1 (NCT03733236)
- Testing
- ISS Active Stimulation
- Where
- 2 sites in India
- Volunteers
- 98 people
- Sponsor
- BrainsGate
High Altitude Pulmonary Edema
Prevention of High Altitude Pulmonary Edema
A double-blind placebo controlled study To compare the effect of tadalafil and dexamethasone versus placebo on Ppa and pulmonary edema formation in subjects susceptible to HAPE.
- Trial name
- NCT00274430
- Testing
- dexamethasone 8 mg bid, tadalafil 10mg bid
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Multiple Sclerosis
Transcranial Electrical Stimulation in Multiple Sclerosis
First the investigators will examine if the blood flow in the brain is different in patients with Multiple Sclerosis compared to healthy volunteers. HOW? The blood flow of the subjects is imaged by use of a special MRI-technique.
- Trial name
- TEMS (NCT06966128)
- Testing
- transcranial Direct Current Stimulation
- Where
- 2 sites in Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Preeclampsia
Ephedrine, Phenylephrine and Metaraminol Effects on Maternal Cardiac Output, Uterine Blood Flow and Fetal Circulation
It is a prospective clinical trial with random distribution that intends to investigate maternal and fetal effects of ephedrine, phenylephrine and metaraminol during cesarean delivery in patients with pre-eclampsia.
- Trial name
- NCT02245191
- Testing
- Ephedrine, Phenylephrine, Metaraminol
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital