Clinical trials: Cerebral Blood Flow
Amnesia, Dementia
Magnetic Resonance Imaging for the Study of Patients With Neurological Disorders
This study is divided into two parts. The first part of the study will use MRI technology to view the brain structure of patients with neurological disorders and normal volunteers.
- Conditions
- Amnesia, Dementia, Healthy, Nervous System Disease
- Trial name
- NCT00001362
- Where
- United States
- Volunteers
- 830 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cerebral Blood Flow
The Time Effects of a Berry Extract Upon Cerebral Blood Flow.
Berry fruits are widely recognised as natural functional food products. They contain several different phytochemicals which have potential to modulate human health and wellbeing.
- Trial name
- NCT01540123
- Testing
- Berry drink, Control
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Cerebrovascular Disorders
HYPEROXIA Responses and ROS
30 participants (15 males and 15 females) who are ≥18 - ≤ 40 years old and considered healthy will be enrolled into this study to test the role of reactive oxygen species (ROS) in regulating cerebral blood flow (CBF).
- Trial name
- NCT05958303
- Testing
- Antioxidant Cocktail
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Cerebrovascular Circulation
Imaging Study to Compare Effects of Darolutamide and Enzalutamide With Respect to Placebo on the Blood Flow in the Brain in Healthy Male Volunteers.
The current study would investigate the effects of a single dose of darolutamide and enzalutamide compared with placebo and compared to each other on human brain blood flow using arterial spin labeling magnetic resonance imaging…
- Trial name
- NCT03704519
- Testing
- Darolutamide (BAY1841788), Enzalutamide
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Bayer
Obesity
MRI Based Study to Assess Brain-gut Axis in Obesity
The mechanism of neural communication between the brain and gut in the regulation of food intake is complex and not fully understood.
- Trial name
- BGImaging (NCT05437653)
- Testing
- Nutritional Drink A, Nutritional Drink B
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Alzheimer's Disease
Brain Amyloid and Vascular Effects of Eicosapentaenoic Acid
The number of Americans diagnosed with Alzheimer's disease (AD) is expected to triple by 2050. Compared to the general population, Veterans have a greater risk of AD, likely in part due to their increased incidence of traumatic…
- Trial name
- BRAVE-EPA (NCT02719327)
- Testing
- icosapent ethyl (IPE)
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Neuropathic Pain
Structural and Functional Brain Reorganization in Neuropathic Pain: Basal State of Local Cerebral Blood Flow and Functional Connectivity
Neuropathic pain is a medical condition involving allodynia (painful perceptions in response to stimuli that normally are not) and spontaneous pain (occurring at rest, without stimulation).
- Trial name
- CONNECT (NCT02858466)
- Testing
- MRI scan
- Where
- France
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Jugular Venous Blood Flow
Jugular Venous Flow Healthy Volunteers
Our hypothesis is that there will be a decrease in internal jugular venous flow in the park bench position when compared to the supine position.
- Trial name
- NCT02002494
- Testing
- Different positions
- Where
- Canada
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Hypoxia, Hypercapnia
Impact of NOS, COX, and ROS Inhibition on Cerebral Blood Flow Regulation
Elucidating cerebrovascular control mechanisms during physiologic stress may help identify novel therapeutic targets aimed at preventing or reducing the impact of cerebrovascular disease.
- Trial name
- NCT03066115
- Testing
- L-NMMA, Ketorolac, Ascorbic Acid
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Healthy, Aging
Brain Blood Flow: Age and Gender
Baseline cerebral blood flow through the middle cerebral artery (MCA) and cerebral vasodilator response of the MCA to inhaled carbon dioxide (CO2) will be measured in young women, young men, older women, and older men using…
- Trial name
- NCT02840851
- Testing
- MRI, TCD
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Inactivity/Low Levels of Exercise
Handgrip Training and Brain Blood Flow Regulation
This study aims to investigate the effect of isometric handgrip training on brain blood vessel function in physically inactive adults.
- Trial name
- NCT07223645
- Testing
- Handgrip Training
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Florida State University
Cerebrovascular Function, Cognition
Oral Ketone Monoester Supplementation and Resting-state Brain Connectivity
People who report subjective memory complaints have a greater risk of developing dementia. Memory issues may be an early warning sign of dysfunctional cerebral glucose metabolism and cerebral blood flow.
- Trial name
- NCT05992571
- Testing
- β-OHB
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McMaster University
Cerebrovascular Circulation, Cognitive Impairment
Effects of Dietary Nitrate From Vegetable/Fruit Juice on Cerebral Blood Flow Parameters
Nitrate provides the body with an alternative source of Nitric Oxide which plays a large role in promoting blood flow and reducing blood pressure.
- Trial name
- NCT01169662
- Testing
- Vegetable/fruit juice
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Concussion
Vascular Assessment of Regulation Index Arrays Registry
The objective of this patient registry is to collect and analyze physiological data associated with baseline and brain injury identified in standard clinical practice (Normal Values, Recovery Curves, Correlation between Symptoms…
- Trial name
- VARIA (NCT02435082)
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- NeuroChaos Solutions, Inc.
Fabry Disease, Healthy
PET Scans in Normal Volunteers and Patients With Fabry Disease
This study will determine the rate of sugar metabolism in the brain of patients with Fabry disease, a genetic disease of abnormal lipid metabolism.
- Trial name
- NCT00005111
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Obstructive Sleep Apnea, Hypertension
Effect of Selective and Nonselective Cyclooxygenase Enzyme Inhibition on Arterial Blood Pressure and Cerebral Blood Flow With Exposure to Intermittent Hypoxia in Humans
The study has been designed to assess the effect of cyclooxygenase inhibition on blood pressure, cerebral blood flow, ventilation and renal hemodynamics following chronic intermittent hypoxia exposure.
- Conditions
- Obstructive Sleep Apnea, Hypertension, Cardiovascular Diseases, Stroke
- Trial name
- NCT01280006
- Testing
- Intermittent hypoxia, Indomethacin, Celecoxib
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Multiple Sclerosis
Transcranial Electrical Stimulation in Multiple Sclerosis
First the investigators will examine if the blood flow in the brain is different in patients with Multiple Sclerosis compared to healthy volunteers. HOW? The blood flow of the subjects is imaged by use of a special MRI-technique.
- Trial name
- TEMS (NCT06966128)
- Testing
- transcranial Direct Current Stimulation
- Where
- 2 sites in Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
High Blood Pressure
Acupuncture Treatment on Cerebral Blood Flow
Cerebrovascular diseases (CVD) and neurodegenerative diseases (NDD) are both leading causes of death in the United States. Epidemiological data have shown that increased prevalence of hypertension is related to these outcomes.
- Trial name
- Amp-HTN (NCT04346511)
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Oklahoma
Schizophrenia
Brain Blood Flow Changes Elicited by Oxytocin in Volunteers With and Without Schizophrenia
The purpose of this study is to assess how oxytocin delivered intranasally changes regional brain blood flow measured by positron emission tomography (PET) in conjunction with oxygen-15 labeled water in persons with…
- Trial name
- NCT01123317
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Anesthesia, General, Infant
Impact of CO2 on Cerebral Blood Flow in Infants Less Than 6 Months During General Anaesthesia
The study aims at assessing cerebral blood flow variations following expired CO2 variations in anaesthetized infants less than 6 months, during a routine general anesthesia.
- Trial name
- NCT03567031
- Testing
- EtCO2 modification
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital