Clinical trials: Central Nervous System Sensitization, open to volunteers
Widspread Chronic Pain, Fibromyalgia
The Effect of Vagus Nerve Stimulation on Pain and Functional Activities in Individuals With Chronic Widespread Pain
The goal of this clinical trial is to examine the effect of vagus nerve stimulation (VNS) on chronic, widespread pain in adults.
- Trial name
- NCT07080749
- Testing
- Vagal nerve stimulation through deep exhalation exercise, Vagal nerve stimulation through ear electrical stimulation, No intervention (observational study)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of North Georgia
Chronic Pain
The Effect of Pain Education Group Therapy and Its Impact on Chronic Pain, Kinesiophobia, and Physical Activity
The goal of this clinical trial is to learn if pain knowledge group intervention among chronic pain patients would influence their level of physical activity, pain intensity, depression, kinesiophobia and central sensitization.
- Trial name
- NCT07491549
- Testing
- pain education
- Where
- Estonia
- Volunteers
- 50 people
- Sponsor
- University of Tartu
Endometriosis, Pelvic Pain
Estradiol-mediated Inflammation and Central Sensitization in the Pathophysiology of Endometriosis-associated Pelvic Pain
The purpose of this study is to better understand how hormone suppression with Relugolix Combination-Therapy (CT) affects pelvic pain, inflammation, and pain sensitivity in women with moderate-to-severe endometriosis associated…
- Trial name
- NCT07100782
- Testing
- Relugolix CT
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of Michigan
Chronic Nonspecific Low Back Pain
Is Central Sensitization a Prognostic Indicator in Chronic Nonspecific Low Back Pain?
This observational study will examine whether signs of increased sensitivity in the nervous system at the beginning of the study are associated with short-term clinical outcomes in adults with chronic nonspecific low back pain.
- Trial name
- NCT07826546
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Mardin Artuklu University
Ankylosing Spondylitis, Peripheral Neuropathies
Assessment of Peripheral Neuropathy in Ankylosing Spondylitis
investigators hypothesized that peripheral neuropathy in ankylosing spondylitis is associated with higher disease activity, greater central sensitization, worse functional impairment, and poorer quality of life.
- Trial name
- NCT07641920
- Testing
- Nerve conduction study
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Assiut University
Thoracic Outlet Syndrome
Motivational Interviewing in Thoracic Outlet Syndrome
The goal of this clinical trial is to learn if motivational interviewing (MI) works to improve symptoms in people with thoracic outlet syndrome (TOS).
- Trial name
- NCT07668206
- Testing
- Motivational Interviewing, Home Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Hacettepe University
Fibromyalgia
Fibromyalgia Response With Esreboxetine Evaluated Using a Randomized Withdrawal Research Design
The study is a Phase 3, double-blind, placebo-controlled, randomized withdrawal study to assess the efficacy and safety of AXS-14 in the management of fibromyalgia.
- Trial name
- FORWARD (NCT07398417)
- Testing
- AXS-14 (Esreboxetine)
- Where
- 53 sites in United States
- Volunteers
- 620 people
- Sponsor
- Axsome Therapeutics, Inc.
Lipedema
Pain, Central Sensitization, and Misophonia in Lipedema
Lipedema is a chronic condition that predominantly affects women and is characterized by disproportionate, usually symmetrical accumulation of subcutaneous fat, particularly in the hips and legs.
- Trial name
- NCT07849634
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Gaziantep City Hospital
Plaque Psoriasis, Fibromyalgia
Prevalence of Fibromyalgia in Patients With Plaque Psoriasis
This observational study aims to determine how common fibromyalgia syndrome and central sensitization are in adults with plaque psoriasis compared to healthy individuals.
- Trial name
- NCT07773766
- Volunteers
- 110 people
- Sponsor
- Assiut University
Chronic and Episodic Headache, Headache Disorders
PERSONOLOGICAL STRUCTURE, COGNITIVE FUNCTIONS AND CENTRAL SENSITIZATION IN HEADACHE
Headache, in its episodic and chronic forms, cannot be considered solely as an isolated neurological symptom, but as a complex condition of a bio-psycho-social nature.
- Trial name
- AURA (NCT07268768)
- Testing
- Neuropsychological assessment
- Where
- Italy
- Volunteers
- 64 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Neuropathic Pain, Central Sensitization
Neuropathic Characteristics of Subacromial Pain Syndrome
This single-center observational study aims to investigate neuropathic pain descriptors and their relationship with central sensitization in patients diagnosed with subacromial pain syndrome (SAPS) who have had shoulder pain for…
- Conditions
- Neuropathic Pain, Central Sensitization, Subacromial Pain Syndrome
- Trial name
- NCT07057128
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Izmir City Hospital
Myofascial Pain Syndrome - Neck
Agreement Between CSI and IASP Pain Classification in Chronic Cervical Myofascial Pain
This study aims to investigate how closely two approaches to assessing pain-related characteristics agree in adults with chronic cervical myofascial pain syndrome (chronic neck pain associated with painful muscle trigger points).
- Trial name
- NCT07904364
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Mardin Artuklu University
Shoulder
Device-Assisted Balance Training for People With Shoulder Impingement
This randomized controlled study will examine whether adding device-assisted balance training to conventional physiotherapy improves symptoms related to increased pain sensitivity, shoulder pain, shoulder function, and balance in…
- Trial name
- NCT07917689
- Testing
- Balance exercise protocol, Conventional exercise protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Istanbul Gedik University
Fibromyalgia Syndrome, Central Sensitisation
Investigation of the Relationship Between Central Sensitization and Balance in Fibromyalgia
The aim of the study is to investigate the relationship between central sensitization parameters and changes in static and dynamic balance in patients with fibromyalgia.
- Conditions
- Fibromyalgia Syndrome, Central Sensitisation, Postural Balance
- Trial name
- NCT06851091
- Testing
- Biodex Balance System, Pressure Pain Threshold (PPT) Measurement with Algometer, Conditioned Pain Modulation (CPM)
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Knee Osteoarthritis
Functional Capacity Differences in Knee Osteoarthritis With Similar Pain Severity
People with knee osteoarthritis may have similar levels of pain but very different abilities to walk, rise from a chair, and perform daily activities.
- Trial name
- NCT07869680
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Mardin Artuklu University
Chronic Pain, Central Sensitisation
The Effect of Griffonia Simplicifolia on Pain Intensity, Central and Peripheral Sensitization, Painmodulation in Healthy Volunteers
This planned study is based on a randomized, placebo-controlled cross-over design. Griffonia simplicifolia contains the serotonin-precursor 5-hydroxytryptophan (5-HTP), an endogenous amino acid.
- Conditions
- Chronic Pain, Central Sensitisation, Peripheral Sensitization, Neuroinflammatory Response
- Trial name
- NCT06893822
- Testing
- Griffonia simplicifolia
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Chronic Pain, Central Sensitisation
Effect of Boswellia Serrata on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Volunteers
This planned study is based on a randomized, placebo-controlled cross-over design. Boswellic acids, the triterpenes found in the gum resins of Boswellia serrata (family: Burseraceae), are traditionally used in the Indian…
- Conditions
- Chronic Pain, Central Sensitisation, Peripheral Sensitization, Neuroinflammatory Response
- Trial name
- BSPP (NCT07109843)
- Testing
- Boswellia serrata extract
- Where
- Austria
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Chronic Plaque-type Psoriasis
Serum Substance P, Neuropathic Pain, and Central Sensitization Across Treatment Groups in Chronic Plaque Psoriasis
The goal of this observational study is to better understand whether blood levels of Substance P are related to pain, itching, altered pain sensations, central sensitization, psoriasis severity, and quality of life in adults with…
- Trial name
- NCT07844772
- Testing
- IL-17 Inhibitor Therapy, Conventional Systemic Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Istanbul Training and Research Hospital
Rotator Cuff Tears
Effect of Central Sensitization on Response to Physical Therapy in Patients With Partial Supraspinatus Tear
This prospective observational study aims to investigate whether central sensitization influences the response to physical therapy in patients with partial supraspinatus tendon tears.
- Trial name
- NCT07664137
- Testing
- Standard Physical Therapy and Rehabilitation
- Volunteers
- 60 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Non-specific Chronic Low Back Pain, Central Sensitization
Exercise Interventions for Overweight Men With Chronic Low Back Pain
This randomized controlled trial aims to compare the effectiveness of motor control exercise, aerobic walking exercise, and muscle strengthening exercise in overweight male adults with non-specific chronic low back pain and…
- Trial name
- MAMS-CLBP (NCT07688564)
- Testing
- Motor Control Exercise, Aerobic Walking Exercise, Muscle Strengthening Exercise
- Where
- Saudi Arabia
- Volunteers
- 156 people
- Sponsor
- Universiti Sains Malaysia