Clinical trials: Central Nervous System Disease
Acromegaly, Excessive Growth Hormone Secretion
Substrate Metabolism and Insulin Sensitivity in Acromegalic Patients Before and After Treatment
The purpose of this study is to investigate the effects of chronic elevated growth hormone on metabolism and insulin sensitivity by studying acromegalic patients before and after treatment.
- Conditions
- Acromegaly, Excessive Growth Hormone Secretion, Insulin Resistance
- Trial name
- NCT00647179
- Testing
- Transsphenoidal adenomectomy
- Where
- Denmark
- Volunteers
- 27 people
- Sponsor
- University of Aarhus
Traumatic Brain Injury (TBI)
Functional Recovery Effect of Bloodletting Puncture at Jing-well Points on Acute Brain Injury Patients
Traumatic brain injury (Traumatic brain injury, TBI) can be derived from various forms of injury, including blunt trauma, penetrating or acceleration/deceleration force caused by head injury.There are some study data show that…
- Trial name
- NCT04930146
- Testing
- acupuncture and bloodletting
- Where
- Taiwan
- Volunteers
- 72 people
- Sponsor
- Chang Gung Memorial Hospital
Parkinson Disease
On-line Cognitive Training for Parkinson's Disease
Application of online cognitive training in patients affected by Parkinson's disease and mild cognitive impairment. The treatment consists of a 6-week on-line cognitive training preceded and followed by neurological…
- Trial name
- NCT04259827
- Testing
- Neuronation, Aspecific online games
- Where
- 2 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Università degli Studi di Brescia
Brain Metastases
Phase 1 Trial for Tumor Treating Field for Drug/Radiation Resistant Brain Metastases
Brain metastasis is a very common disease with poor prognosis, 20% cancer will develop brain metastases(BM), up to 40% by autopsy.
- Trial name
- NCT04967027
- Testing
- ASCLU-300 TTF
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Xiangya Hospital of Central South University
Ischemic Stroke, Acute, Rehabilitation Outcome
Cerebrolysin in Early Stroke Rehabilitation - Tertiary Study
The study evaluates the effect and safety of Cerebrolysin administered during early rehabilitation in patients with moderate neurological impairment after acute ischemic stroke, conducted at the Department of Vascular Neurology…
- Conditions
- Ischemic Stroke, Acute, Rehabilitation Outcome, Cerebrolysin
- Trial name
- NCT07043686
- Testing
- Cerebrolysin treatment, Standard treatment (including neurorehabilitation) of acute ischemic stroke
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Parkinson Disease
The Study is Being Conducted to Evaluate the Safety and Efficacy of XJN010 Nasal Spray in Patients With Parkinson's Disease Experiencing Off Episodes
The study is being conducted to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of XJN010 Nasal Spray in Patients with Parkinson's Disease Experiencing Off Episodes
- Trial name
- NCT07156773
- Testing
- XJN010 Nasal Spray
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Guangzhou Novaken Pharm Co., Ltd.
Hemodialysis Patient, Fatigue
The Effects of an App-based Acupressure on Alleviating Fatigue, Pruritus, and Sleep Quality Among Hemodialysis Patients
Objectives: To evaluate the effectiveness of an app-based self-guided acupressure intervention in alleviating fatigue and pruritus, and in improving sleep quality among hemodialysis patients.
- Trial name
- NCT07259369
- Testing
- app-based acupressure
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- Taipei Medical University
Carotid Artery Stenosis, Carotid Artery Disease
Neuropsychometric Outcome After Carotid Endarterectomy
The purpose of this study is to determine how well patients undergoing carotid endarterectomy will perform on a battery of tests to assess brain function before and after surgery as compared to a control group of patients…
- Conditions
- Carotid Artery Stenosis, Carotid Artery Disease, Transient Ischemic Attack, Stroke
- Trial name
- CEA (NCT00597883)
- Testing
- Carotid endarterectomy, Neurological and neuropsychological evaluations
- Where
- United States
- Volunteers
- 817 people
- Sponsor
- Columbia University
Stroke, Acute
Trunk Rotation And Lateral Flexion Exercises In Stroke Patients
In this study we want to introduce the beneficiary combine effects of chest mobilization and chest physiotherapy exercises by using cough peak flow meter and chest expansion in stroke patients.
- Trial name
- NCT06379854
- Testing
- chest physiotherapy, trunk rotation exercises,deep diaphragmatic also chest physiotherapy
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Riphah International University
Dementia, Alzheimer Disease
Integrating eSAGE With EHR Data Using Machine Learning for the Early Detection and Monitoring of Cognitive Impairment in Individuals
The goal of this observational trial is to leverage the electronic Self-Administered Gerocognitive Examination (eSAGE), a variety of metadata (a set of data that describes and gives information about other data) collected during…
- Conditions
- Dementia, Alzheimer Disease, Mild Cognitive Impairment, Worried Well
- Trial name
- NCT06017505
- Testing
- electronic self administered gerocognitive examination (eSAGE)
- Where
- United States
- Volunteers
- 1,486 people
- Sponsor
- Douglas Scharre
Angelman Syndrome
A Study in Adults and Adolescents With Angelman Syndrome (STARS)
The purpose of the study is to assess the safety and tolerability of oral OV101 (gaboxadol) in adult and adolescent subjects with Angelman syndrome. In addition, several exploratory efficacy outcome measures will be investigated.
- Trial name
- NCT02996305
- Testing
- OV101 Regimen 1, OV101 regimen 2
- Where
- 13 sites in United States, Israel
- Volunteers
- 88 people
- Sponsor
- Healx AI
Parkinson Disease
Pilot Randomized Controlled Trial of Telemedicine for Individuals With Parkinson Disease in a Rural Population
To eliminate barriers (such as travel and cost) to specialized Parkinson disease (PD) care, two movement disorder specialists at the University of Rochester will be providing telemedicine visits for patients with PD who reside in…
- Trial name
- Tele-PD (NCT00668551)
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Rochester
Small Cell Lung Cancer ( SCLC ), Brain Injury
Exploration of Whole-Brain Radiotherapy Combined With PD-1 Inhibitors on Brain Injury
The study aims to enroll the small cell lung cancer(SCLC) who meet the indications for prophylactic cranial irradiation (PCI): patients with limited-stage SCLC who have achieved complete or partial remission after first-line…
- Trial name
- NCT07905937
- Testing
- PD-1 Inhibitor + Chemotherapy+PCI, chemotherapy+PCI
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Guizhou Medical University
Spinal Cord Injury
Preventing Pneumonia and Other Respiratory Problems in Persons With Spinal Cord Injury
It is known that individuals with spinal cord injury are at increased risk for respiratory tract infections like pneumonia. Part of this risk is due to weakened chest and abdominal muscles that are vital to deep breathing and the…
- Trial name
- NCT00448045
- Testing
- Manual and mechanical assisted cough, Incentive spirometry
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Kessler Foundation
Pituitary Neoplasms
Application of Augmented Reality Neuronavigation in Transnasal Endoscopic Skull Base Surgery
"For lesions in the skull base, including meningiomas, chordomas and pituitary tumors, endoscopic surgery has replaced traditional microscopes as the mainstream procedure.
- Trial name
- NCT06282224
- Testing
- Performing endoscopic transnasal skull base surgery with AR-integrated endoscope
- Where
- China
- Volunteers
- 10 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Epilepsy, Stigma
Effects of Podcast Education on Medication Perception, Stigma Level, and Epilepsy Self-management in Epilepsy Patients
Seventy epilepsy patients who presented to Gaziosmanpaşa Training and Research Hospital as outpatients (diagnosed at least 3 months prior, taking at least one medication, and having access to the internet) were randomly assigned…
- Conditions
- Epilepsy, Stigma, Self Management, Drug Therapy
- Trial name
- epilepsy (NCT07090980)
- Testing
- epilepsy education via podcast
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Istanbul Sabahattin Zaim University
Alzheimer Disease
Dose-Escalation Study to Assess the Safety, Tolerability, and Pharmacokinetics of Donepezil From Single Dose of GB-5001 IM Depot and Aricept® Oral Tablets in Healthy Male Volunteers
This study is to evaluate the safety and tolerability of single dose of GB-5001 (donepezil) IM depot in healthy male volunteers.
- Trial name
- NCT05525780
- Testing
- GB-5001, Oral cohort
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- G2GBio, Inc.
Pituitary Tumor
NET-TIME: Inflammatory Tumor Microenvironment in Pituitary Neoplasm
Over the past twenty years, a progressively increasing number of markers biochemical, clinical, imaging, histopathological or genetic have been suggested to attempt to predict aggression and therapeutic outcome, both in secretory…
- Trial name
- NET-TIME (NCT07594262)
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor
Busulfan in Treating Children and Adolescents With Refractory CNS Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the safety of delivering intrathecal busulfan in children and adolescents who…
- Conditions
- Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor, Leukemia, Lymphoma
- Trial name
- NCT00006246
- Testing
- busulfan
- Where
- 8 sites in United States
- Volunteers
- 28 people
- Sponsor
- Pediatric Brain Tumor Consortium
Stroke
Comparison of Effects of Activity Base Therapy vs Strength Training on Gait Performance in Chronic Stroke
Stroke is a leading cause of disability worldwide affecting both male and female especially in older people. Functional independence and locomotion are hampered in stroke, therefore, affecting their quality of life.
- Trial name
- NCT04823546
- Testing
- activity based therapy, Strength Training
- Where
- Pakistan
- Volunteers
- 16 people
- Sponsor
- Riphah International University
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