Clinical trials: Cathartics
Cathartic Colon
Oral Sulfate Solution (SUPREP) Versus Polyethylene Glycol (PEG) Plus Ascorbic Acid
The aims of the present study is to compare oral sulfate solution (OSS) with low-dose polyethylene glycol plus ascorbic acid (2-L PEG/Asc) for bowel cleansing efficacy.
- Trial name
- NCT02761213
- Testing
- Oral sulfate solution (OSS), 2-L PEG/Asc
- Where
- South Korea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Bo-In Lee
Constipation
Laxative Properties of Microencapsulated Lipid (Constipation Study)
The present study seeks to build on these observations to assess whether in principle, fat containing microcapsules might help patients experiencing constipation in association with weight loss interventions (including GLP-1…
- Trial name
- NCT05324241
- Testing
- Fat Microcapsules
- Where
- Ireland
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Constipation
Acupressure for Constipation in the Elderly
This study will carried out to determine the effect of acupressure applied to Tianshu (ST25), Guanyuan (CV4) and Hegu (LI4) acupuncture points for a total of 6 minutes, two to each point, on the symptoms of constipation in the…
- Trial name
- NCT05805787
- Testing
- Acupressure
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Yalova
Colonoscopy Preparation
PEG Versus PEG+Bisacodyl Versus Sennosides for Colon Cleansing Before Colonoscopy
Background: Polyethylene glycol (PEG) solution has been proven to be effective for large bowel cleansing prior to colonoscopy in children.
- Trial name
- NCT01531140
- Testing
- polyethylene glycol +Bisacodyl, Polyethylene glycol, Sennosides
- Where
- 2 sites in Poland
- Volunteers
- 240 people
- Sponsor
- Medical University of Warsaw
Cathartics, Mobile Applications
Improving Bowel Cleansing With a Smart Phone Application
Getting ready for a colonoscopy is difficult and involves a lot of steps. The information given to patients is very important to adherence to treatment.
- Trial name
- NCT02303743
- Testing
- Smart Phone Application, Written instructions with visual aids
- Volunteers
- 260 people
- Sponsor
- Vicente Lorenzo-Zúñiga García
Colorectal Liver Metastases
Optimised Recovery With Accelerated Nutrition and GI Enhancement
Factors which delay recovery following uncomplicated abdominal surgery include uncontrolled pain, intolerance of diet and poor mobility.
- Trial name
- ORANGE (NCT00538954)
- Testing
- Post operative laxation (Magnesium Oxide), Preoperative metabolic conditioning postoperative nutritional supplementation, Standard ERAS group
- Where
- 2 sites in Netherlands, United Kingdom
- Volunteers
- 64 people
- Sponsor
- University of Edinburgh
Postoperative Ileus
Randomized Clinical Trial of Bisacodyl Versus Placebo on Postoperative Bowel Motility in Elective Colorectal Surgery
Postoperative bowel dysmotility is a frequent condition after colorectal surgery. The influence of colon stimulating laxatives have not been studied.
- Trial name
- NCT00509327
- Testing
- bisacodyl, glucosemonohydricum
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University Hospital, Basel, Switzerland
Constipation, Faecal Impaction
Efficacy and Tolerability of PEG-only Laxative for Fecal Impaction and Chronic Constipation in Children
The aim of this study is to compare the efficacy, tolerability, acceptance and compliance of a PEG-only formulation compared to a reference PEG-EL formulation in resolving faecal impaction and in the treatment of chronic…
- Trial name
- NCT01592734
- Testing
- Polyethylene glycol with electrolytes, Polyethylene glycol
- Volunteers
- 96 people
- Sponsor
- Azienda Policlinico Umberto I
Prostate Cancer, Kidney Cancer
Preop Laxatives in Robotic Urologic Surgery
Minimally-invasive surgery, either laparoscopic or robotic, is commonly used in urology. Several urologic procedures including prostatectomy, radical nephrectomy, and partial nephrectomy are now commonly performed robotically.
- Conditions
- Prostate Cancer, Kidney Cancer, Constipation
- Trial name
- NCT05805436
- Testing
- Polyethylene Glycol 3350
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Chad R. Tracy
Severe Pain
A Non-interventional, Observational Study for Targinact® Treatment in Patients With Severe Pain.
This non-interventional, observational study evaluates the efficacy of Targinact with regard to pain relief in daily clinical practice in Belgium compared to the previous analgesic treatment.
- Trial name
- NCT01983137
- Testing
- Targinact® (oxycodone/naloxone)
- Where
- Belgium
- Volunteers
- 1,338 people
- Sponsor
- Mundipharma CVA
Chronic Constipation
Comparison of TCM and Laxatives for Adults With Chronic Constipation
The purpose of the study is to compare the therapeutic efficacy, safety, cost-effectiveness and maintenance effect between Chinese herbal formula and lactulose on chronic constipation in long-term care.
- Trial name
- NCT00745147
- Testing
- Chinese herbal formula (CCH1), Duphalac
- Where
- Taiwan
- Volunteers
- 93 people
- Sponsor
- National Taiwan University Hospital
Opioid Induced Constipation
To Evaluate Patient Preference of Movantik and Polyethylene Glycol 3350 for Opioid Induced Constipation
The purpose of this study is to determine whether patients with opioid induced constipation prefer treatment with naloxegol (Movantik) or with Polyethylene Glycol 3350.
- Trial name
- NCT03060512
- Testing
- Polyethylene Glycol 3350, Movantik
- Where
- 53 sites in United States
- Volunteers
- 276 people
- Sponsor
- AstraZeneca
Chronic Constipation
Effect to Linaclotide on Colonic Motility
This study aim was to evaluate the effect of Linaclotide, a pharmacological treatment normally used to treat functional constipation or irritable bowel syndrome with predominant constipation, on colonic motility as assessed by…
- Trial name
- NCT06989268
- Testing
- Linaclotide 290 micrograms
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Screening Colonoscopy, Surveillance Colonoscopy
Evaluation of Proposed EZ2go Complete Bowel Cleansing System
This study aims to provide safety and efficacy data comparable to available over-the-counter bowel preparations prior to colonoscopy.
- Conditions
- Screening Colonoscopy, Surveillance Colonoscopy, Colonoscopy
- Trial name
- NCT01838408
- Testing
- Ez2go Complete, LoSo Prep
- Where
- United States
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Borland-Groover Clinic
Chronic Severe Pain
A Non-interventional, Observational Study for Targinact® Treatment in Patients With Chronic Severe Pain
This non-interventional, observational study is set up on request of the Belgian reimbursement authorities and evaluates the efficacy of Targinact with regard to pain relief and constipation in daily clinical practice in Belgium…
- Trial name
- NCT01710904
- Testing
- Targinact® (oxycodone/naloxone)
- Where
- Belgium
- Volunteers
- 68 people
- Sponsor
- Mundipharma CVA
Laxative Compatibility
Sodium Picosulfate Plus Magnesium Citrate Versus Macrogol 4000 in the Bowel Cleansing Procedure: a Comparison of Efficiency and Compatibility
For effective cleansing of the bowel prior to colonoscopy polyethylene glycol (e.g. macrogol) has widely been used in Germany. Usually patients have to drink between 4 an 6 liter of macrogol in a split dose (3 liter on the day…
- Trial name
- NCT01607099
- Testing
- Compatibility
- Where
- Germany
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Adequate Colonoscopy Preparation for Inpatients
Specific Verbal vs. Usual Instructions for Inpatients Undergoing Colonoscopy
To study the impact of providing specific verbal instructions in inpatients (and/or their relatives) undergoing colonoscopy on the quality of bowel preparation.
- Trial name
- NCT02887014
- Testing
- SPECIFIC VERBAL INSTRUCTIONS
- Where
- Greece
- Volunteers
- 300 people
- Sponsor
- Attikon Hospital
Appendicitis, Appendicitis Acute
Clinical Study of PEG Bowel Preparation in Appendectomy Patients
Colonoscopy is a necessary item of physical examination for colorectal cancer. For high-risk groups, annual physical examination is the most effective way of early prevention; At present, a large amount of polyethylene glycol…
- Trial name
- NCT07478029
- Testing
- Bowel Preparation with Polyethylene Glycol (PEG) Laxatives
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Huaping Xie
Constipation
Impact of Laxative Therapy With Lactulose in the Evolution of Organ Dysfunction in Critically Ill Patients.
MAIN FEATURES OF THE STUDY: therapeutic intervention. Constipation is a frequent complication in critical ill patients. The disaccharide lactulose has a laxative osmotic activity.
- Trial name
- NCT01607060
- Testing
- Lactulone
- Where
- Brazil
- Volunteers
- 88 people
- Sponsor
- Federal University of São Paulo
Constipation - Functional, Constipation
A Trial of Actazin Versus PEG 3350 for Maintenance Therapy in Children With Constipation
The goal of this pilot feasibility randomized controlled trial is to determine whether Actazin (kiwifruit extract) is a feasible and effective alternative to polyethylene glycol 3350 (PEG 3350) for maintenance therapy in children…
- Conditions
- Constipation - Functional, Constipation, Constipation Aggravated
- Trial name
- NCT06836024
- Testing
- Actazin chewable tablet, PEG 3350, Chewable Tablet
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Hamilton Health Sciences Corporation