Clinical trials: Cataract Surgery
Ocular Inflammation
Comparison Study of ISV-303 to Durasite Vehicle in Cataract Surgery Subjects
The purpose of this study is to evaluate the ocular safety, tolerability and efficacy of topical administration of ISV-303 compared with Durasite Vehicle.
- Trial name
- NCT01808547
- Testing
- ISV-303, DuraSite Vehicle
- Volunteers
- 268 people
- Sponsor
- Sun Pharmaceutical Industries Limited
Refractive Errors
Measurement of Refractive SE Following Implantation of LS313 MF30 IOL
This Study determines the most precise method for measuring post-operative refraction following implantation of the asymmetric multifocal LS-313 MF30 comparing the results of Refraction of the different Autorefractor Keratometers…
- Trial name
- NCT03292614
- Testing
- Measurements of the postoperative refraction
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Dietrich-Bonhoeffer-Klinikum
Dry Eye Syndromes
Effect of Cequa Treatment on Accuracy of Pre-operative Biometry & Higher Order Aberrations in Dry Eye Patients Undergoing Cataract Surgery
The purpose of this study is to examine the effect of Cequa treatment on the accuracy of pre-operative biometry and on corneal higher-order aberrations (HOAs) in cataract patients who have signs of dry eye disease.
- Trial name
- NCT04342988
- Testing
- Cequa
- Where
- 3 sites in United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Research Insight LLC
Open-angle Glaucoma
Safety and Efficacy of the GTS400 Stent in Conjunction With Cataract
To evaluate the safety and efficacy of the Glaukos Trabecular Micro-Bypass Stent Model GTS400 in conjunction with cataract surgery, compared to cataract surgery only, in subjects with mild to moderate open angle glaucoma.
- Trial name
- NCT00721968
- Testing
- Glaucoma Stent Surgery (GTS400 Stent), cataract surgery alone
- Volunteers
- 62 people
- Sponsor
- Glaukos Corporation
Cataract
Acular LS vs. Nevanac in Post op Inflammation Following Cataract Surgery
The purpose of this study is to compare the clinical outcomes, safety and efficacy in patients randomized to receive either ketorolac or nepafanac following cataract surgery.
- Trial name
- NCT00348582
- Testing
- Ketorolac, Nepafenac
- Where
- United States
- Sponsor
- Innovative Medical
Aphakia, Presbyopia
Contralateral Claims Study of Clareon Vivity Pro
The purpose of this study is to test new versions of Clareon Vivity Pro intraocular lenses (IOLs) by comparing them to currently marketed IOLs.
- Trial name
- NCT07484191
- Testing
- Clareon Vivity Pro IOL, Clareon Vivity IOL, TECNIS PureSee IOL
- Where
- 7 sites in Australia
- Volunteers
- 165 people
- Sponsor
- Alcon Research
Cataract, Presbyopia
Non-comparative Study to Assess the Visual Performances and Safety of a Progressive Multifocal Intraocular Lens
This is an interventional, non-controlled, multicenter international trial with a prospective design on one cohort of patients.
- Trial name
- PSM15 (NCT02838004)
- Testing
- IOL MINI WELL READY
- Where
- Germany
- Volunteers
- 77 people
- Sponsor
- SIFI SpA
Cataract
Clobetasol Propionate Ophthalmic Nanoemulsion 0.05% for the Treatment of Inflammation and Pain Associated With Cataract Surgery (CLOSE-1)
Cataract surgery is one of the most common surgical procedures performed worldwide. In fact, in 2017, 3.8 million cataracts procedures were performed in the US.
- Trial name
- CLOSE-1 (NCT04246801)
- Testing
- Clobetasol propionate, Vehicle
- Where
- 22 sites in United States
- Volunteers
- 250 people
- Sponsor
- Salvat
Ocular Inflammation and Pain
Efficacy and Safety of APP13007 for Treatment of Inflammation and Pain After Cataract Surgery
This Phase 3 study will evaluate APP13007 in comparison to the matching vehicle placebo in a randomized, parallel-group, double-masked fashion.
- Trial name
- NCT04739709
- Testing
- APP13007, 0.05%
- Where
- 35 sites in United States, Puerto Rico
- Volunteers
- 378 people
- Sponsor
- Formosa Pharmaceuticals, Inc.
Cataract
A Study of Cataract Surgery With the Femtosecond Laser
The purpose of this study is to evaluate the feasibility of using the Femtosecond Laser System to perform surgical maneuvers during cataract extraction surgery.
- Trial name
- NCT00922571
- Testing
- FS Laser Surgery, FS Laser System
- Volunteers
- 100 people
- Sponsor
- Abbott Medical Optics
Cataract Extraction
Hydrophilic Acrylic Intraocular Lens
The purpose of this study is to evaluate the safety and efficacy of Hydrophilic Acrylic Intraocular Lens after cataract surgery
- Trial name
- NCT00708331
- Testing
- 2 HEMA Hydrophilic Acrylic Intraocular Lens
- Where
- 9 sites in United States
- Sponsor
- EyeKon Medical, Inc.
Cataract, Astigmatism
Evaluation of the Accuracy & Safety of the LaserArcs Nomogram
Evaluation of the Accuracy and Safety of the LaserArcs Femtosecond Cataract Surgery Arcuate Incision Nomogram in Patients Undergoing Cataract Surgery and Astigmatism Reduction
- Trial name
- NCT05278442
- Testing
- LaserArc
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Research Insight LLC
Cataract, Astigmatism
Astigmatism Correction With Intrastromal Arcuate Incisions in Eyes Undergoing Cataract Surgery With Femtosecond Laser Using the Cassini Ambient With Iris Registration (ARCUATAS)
This is an observational, prospective follow-up post-marketing study of CE marked medical devices aimed at treating astigmatism in patients with cataracts.
- Trial name
- ARCUATAS (NCT05053620)
- Testing
- Calculation of the arcuate intrasomal incisions
- Where
- Spain
- Volunteers
- 22 people
- Sponsor
- OFTALVIST (Oftalmología Vistahermosa S.L)
Cataract Surgery Incision Leak
ReSure Sealant Pivotal Study
This is a randomized multicenter study to evaluate the safety and effectiveness of ReSure Sealant compared to sutures for preventing incision leakage within the first 7 days of cataract surgery.
- Trial name
- NCT01498224
- Testing
- ReSure Sealant, Sutures
- Where
- United States
- Volunteers
- 488 people
- Sponsor
- Ocular Therapeutix, Inc.
Ocular Inflammation and Pain
Phase II Study Evaluating Safety/Efficacy of OTX-DP for Treatment of Ocular Inflammation and Pain After Cataract Surgery
To evaluate the safety and efficacy of OTX-DP as a sustained release drug (dexamethasone) depot when placed in the canaliculus of the eyelid for the treatment of ocular inflammation and pain in subjects who have undergone…
- Trial name
- NCT01666210
- Testing
- OTX-DP (Dexamethasone punctum plug)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Ocular Therapeutix, Inc.
Cataract Extraction
A Study of Ketorolac for the Treatment of Inflammation and Pain Associated With Cataract Surgery
This is a 16 day study to evaluate the safety and efficacy of ketorolac eye drops for the treatment of inflammation and pain associated with cataract surgery
- Trial name
- NCT00521456
- Testing
- ketorolac eye drops
- Where
- United States
- Volunteers
- 263 people
- Sponsor
- Allergan
Cataract Surgery
A Prospective Multicenter Study To Assess The Clinical Outcomes Of Current Phacoemulsification Approach To Cataract Extraction Versus The Micor System Device
The purpose of this research study is to evaluate the clinical outcomes of current phacoemulsification approaches to cataract extraction involving high-frequency thermogenic energy versus the use of the MICOR System device using…
- Trial name
- NCT05729477
- Testing
- miCOR System, Phaco Subject Cohort
- Where
- 6 sites in United States
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- Carl Zeiss Meditec, Inc.
Cataract, Inflammation
Mapracorat Ophthalmic Suspension, 3% for the Treatment of Ocular Inflammation and Pain Following Cataract Surgery
The objective of this clinical study is to compare the safety and efficacy of mapracorat ophthalmic suspension, 3% with its vehicle for the treatment of postoperative inflammation and pain following cataract surgery.
- Conditions
- Cataract, Inflammation, Surgery
- Trial name
- NCT01591161
- Testing
- Mapracorat
- Where
- United States
- Volunteers
- 369 people
- Sponsor
- Bausch & Lomb Incorporated
Cataract
Safety and Efficacy of FLACS With the FEMTO LDV Z8 Laser Compared to Conventional Cataract Surgery in Chinese Patients
This trial will be designed as a multi-center randomized non-inferiority clinical trial to demonstrate safety and efficacy of the FEMTO LDV Z8 laser for cataract surgery in a Chinese population in China compared to the…
- Trial name
- Z8CAT01 (NCT03953053)
- Testing
- Femtosecond Laser Assissted Cataract Surgery
- Where
- Switzerland
- Volunteers
- 132 people
- Sponsor
- Ziemer Ophthalmic Systems AG
Cataract Extraction
Assessment of the Concentrations of Besifloxacin, Moxifloxacin, or Gatifloxacin in the Aqueous Humor of Subjects
This study is being conducted to assess the concentration of besifloxacin, moxifloxacin, or gatifloxacin in aqueous humor samples collected following topical instillation of the associated formulation in subjects undergoing…
- Trial name
- NCT00824070
- Testing
- Besifloxacin hydrochloride, moxifloxacin hydrochloride, gatifloxacin
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Bausch & Lomb Incorporated