Clinical trials: Cataract Extraction
Irvine-Gass Syndrome
Treatment of Macular Edema After Cataract Surgery with Subconjunctival Aflibercept
This research study is being conducted to determine the safety and tolerability of subconjunctival injections of aflibercept in the treatment of pseudophakic cystoid macular edema that has not responded well to first-line…
- Trial name
- ACME (NCT03396861)
- Testing
- Aflibercept
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Tufts Medical Center
Cataract, Mydriasis
Subconjunctival Atropine and Intracameral Epinephrine for Pupil Dilation in Phacoemulsification
Mydriatic eye drops are routinely used before phacoemulsification but they are not free of drawbacks. Several alternatives were tried to overcome their limitations.
- Conditions
- Cataract, Mydriasis, Adverse Drug Event
- Trial name
- NCT03638726
- Testing
- Atropine sulfate and epinephrine, Topical cyclopentolate and phenylephrine
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Dar El Oyoun Hospital
Inflammation, Pain
Efficacy and Safety of RX-10045 Ophthalmic Solution for Ocular Inflammation and Pain in Cataract Surgery
The primary objective of this study is to assess the efficacy and safety of 2 concentrations of RX-10045 ophthalmic solution, 0.05% and 0.1%, compared to placebo for the treatment of ocular inflammation and pain in subjects…
- Conditions
- Inflammation, Pain, Cataract
- Trial name
- NCT02329743
- Testing
- RX-10045
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- A.T. Resolve SARL
Cataract
Dexmedetomidine Versus Midazolam for Peribulbar Block
50 patients of both sexes, ages 18 to 75, who were scheduled for cataract surgery and had physical status I or II according to the American Society of Anesthesiologists were included in this study.
- Trial name
- peribulbar (NCT06784843)
- Testing
- Dexmedetomidine as an adjuvant to local anesthesia for peribulbar block, Midazolam as an adjuvant to local anesthesia for peribulbar block
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Suez Canal University
Cataract
Visual Function of Enhanced Monofocal Intraocular Lenses
Comparison of the visual function of two enhanced monofocal intraocular lenses after cataract surgery
- Trial name
- NCT07262021
- Testing
- enhanced monofocal IOL
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Vienna Institute for Research in Ocular Surgery
POCD - Postoperative Cognitive Dysfunction
Cognitive Dysfunction After Cataract Surgery
Cataract surgery is commonly performed in elderly patients who are at high risk for developing postoperative cognitive dysfunction.
- Trial name
- NCT04730596
- Testing
- Ketamine, Dexmedetomidine, Normal saline
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Cataract, Presbyopia Correction
Night Driving After Trifocal Versus Monofocal IOL Implantation
This prospective observational cohort study will compare night-driving visual difficulty and visual disturbances after bilateral implantation of an Alcon trifocal intraocular lens or an Alcon monofocal intraocular lens in adults…
- Trial name
- TriIOL (NCT07755189)
- Testing
- AcrySof IQ PanOptix TFNT00 Trifocal Intraocular Lens, Alcon Monofocal Intraocular Lens
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Jin Yang
Pediatric Cataract, IOL Implantation
Myopia Progression Control Using Atropine 0.05% After Pediatric Cataract Surgery And Intraocular Lens Implantation Surgery
Myopic shift remains a debilitating and unpredictable adverse event following pediatric cataract surgery. While research exploring peripheral myopic defocus for post-cataract surgery myopia prevention shows promising results, the…
- Conditions
- Pediatric Cataract, IOL Implantation, Myopia Progression
- Trial name
- NCT07364370
- Testing
- Atropine Eye drops
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Dry Eye Syndromes
Evaluation Of Vision Recovery And Comfort Index In Patients With Borderline/Mild Dry Eyes Undergoing FLACS With Premium IOL
This is a prospective, open-label, single-center, randomized, head-to-head, investigator-sponsored clinical study. It aims to investigate the vision recovery and patient comfort in borderline/mild dry eye disease patients…
- Trial name
- ENHANCE (NCT04863742)
- Testing
- Dextenza 0.4Mg Ophthalmic Insert, Prednisolone Acetate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Sight Medical Doctors PLLC
Cataract Surgery
The PanOptix Trifocal IOL: A Study of Patient Satisfaction, Visual Disturbances, and Uncorrected Visual Performance
Prospective survey study of patients who previously underwent cataract surgery with the Alcon PanOptix or PanOptix Toric intraocular lens in both eyes.
- Trial name
- NCT04146961
- Testing
- Alcon PanOptix or PanOptix Toric IOL
- Where
- 3 sites in United States
- Volunteers
- 59 people
- Sponsor
- Research Insight LLC
Cataract, Presbyopia
Visual Results of the Acrysof IQ Vivity Toric Extended Vision Intraocular Lens
The main goal of this study is to evaluate real-world visual outcomes, rotational stability, and patient reported visual disturbances with a non-diffractive extended vision presbyopia and astigmatism correcting intraocular lens…
- Conditions
- Cataract, Presbyopia, Corneal Astigmatism
- Trial name
- NCT04652037
- Testing
- Acrysof IQ Vivity Toric Extended Vision Intraocular Lens Implantation
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Cataract
Ocular Biometrics in a French Population
The investigators aimed to study ocular biometrics parameters and their association with age, gender and the prevalence of high myopia in a population of cataract surgery candidates in the South of France.
- Trial name
- NCT04992403
- Where
- France
- Volunteers
- 11,650 people
- Sponsor
- University Hospital, Montpellier
Cataract Extraction, Cataract
Clinical Study to Evaluate the Efficacy and Tolerability of an Anti-inflammatory/Antibiotic Treatment Following Ocular Cataract Extraction
Cataract is an ophthalmic disease that usually affects the elderly population. Cataract surgery with phaco-emulsification is now the most frequently performed intraocular surgical procedure in the developed world.
- Trial name
- NCT02973880
- Testing
- NETILDEX™ ophthalmic gel, NETILDEX™ eye drops solution
- Where
- 7 sites in Germany, Italy and 1 more
- Volunteers
- 180 people
- Sponsor
- SIFI SpA
Corneal Disease
Automated Lamellar Keratectomy in Symptomatic Patients With Bullous Keratopathy
To relieve pain in patients with symptomatic bullous keratopathy (BK) until keratoplasty and in patients without visual prediction.
- Trial name
- ALKSBK (NCT00654888)
- Testing
- ALK (automated lamellar keratectomy), Mitomycin
- Volunteers
- 28 people
- Sponsor
- Federal University of São Paulo
Cataract
Mapracorat Ophthalmic Suspension for the Treatment of Ocular Inflammation Following Cataract Surgery
The objective of this clinical study is to compare the safety and efficacy of Mapracorat Ophthalmic Suspension, 3% to vehicle for the treatment of postoperative inflammation and pain following cataract surgery.
- Trial name
- NCT01230125
- Testing
- Mapracorat, Vehicle
- Where
- United States
- Volunteers
- 311 people
- Sponsor
- Bausch & Lomb Incorporated
Cataract, Inflammation
Evaluation of BOL-303242-X Versus Vehicle for the Treatment of Inflammation Following Cataract Surgery
This clinical study is being conducted to identify the most effective drug concentration and dose frequency of BOL-303242-X (Mapracorat) ophthalmic suspension, for the treatment of inflammation following cataract surgery.
- Trial name
- NCT00905450
- Testing
- BOL-303242-X, Vehicle for BOL-303242-X
- Where
- United States
- Volunteers
- 415 people
- Sponsor
- Bausch & Lomb Incorporated
Cataract, Glaucoma
Comparison of Phaco-Trabeculectomy and MSICS-Trab in Cataract and Glaucoma Patients
The goal of this interventional study is to compare the outcomes of two surgical techniques, Phaco-Trabeculectomy and Manual Small Incision Cataract Surgery (MSICS) with Trabeculectomy, in patients with coexisting cataract and…
- Trial name
- NCT06739343
- Testing
- PHACO-Trabeculectomy, MSICS-Trabeculectomy
- Where
- Nigeria
- Volunteers
- 122 people
- Sponsor
- Emeka John Dingwoke
Adverse Events
ReSure Sealant Post Approval Study
This is a prospective multicenter observational post-approval registry study that will collect post-approval data relative to the incidence of pre-specified Adverse Ocular Events for cataract surgery patients treated with the…
- Trial name
- Clinical PAS (NCT02310815)
- Testing
- ReSure Sealant
- Volunteers
- 626 people
- Sponsor
- Ocular Therapeutix, Inc.
Dry Eye
Effect of Re-esterified Triglyceride (rTG) Form Omega-3 Supplements on Dry Eye Following Cataract Surgery
To evaluate the clinical outcomes of the systemic re-esterified triglyceride (rTG) form of omega-3 fatty acids in patients with dry eye symptoms after cataract surgery
- Trial name
- NCT04411615
- Testing
- Omega 3
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Ocular Infections
Effectiveness of Liposomial Ozonized-Oil for Cataract Surgery
Evaluation of the antimicrobial efficacy of a liposomal ozone-based solution (OZODROP®) , vs placebo in 200 patients undergoing cataract surgery by phacoemulsification .
- Trial name
- NCT04087733
- Testing
- OZODROP
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Molise