Clinical trials: Carrier State
Meningioma, Boron Neutron Capture Therapy
A Study of the Boron Neutron Capture Therapy (BNCT) Using B10 L-BPA in Recurrent Meningioma
This Phase I/II study, titled 'A Study to Evaluate the Safety and Efficacy of Boron Neutron Capture Therapy (BNCT) Using B10 L-BPA as a Boron Carrier in Recurrent Meningioma', aims to assess the efficacy of B10 L-BPA with BNCT in…
- Trial name
- NCT06668987
- Testing
- B10 L-BPA Injection
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- Heron Neutron Medical Corp.
HIV Infections
A Phase I Study of the Safety and Pharmacokinetics of Recombinant Human CD4-Immunoglobulin G (rCD4-IgG) Administered by Intravenous Bolus Injection in Combination With Oral Zidovudine in Patients With AIDS and AIDS-Related Complex
To determine the safety profile of recombinant human CD4-immunoglobulin G (CD4-IgG) and zidovudine (AZT) combination therapy in patients with AIDS or AIDS-related complex (ARC); to assess pharmacokinetic (blood level) properties…
- Trial name
- NCT00000976
- Testing
- CD4-IgG, Zidovudine
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
brca1 Mutation Carrier, brca2 Mutation Carrier
Studying Breast Cancer Risk in Women Who Are BRCA1/BRCA2 Mutation Carriers
RATIONALE: Studying samples of DNA in the laboratory from women who are BRCA1/BRCA2 mutation carriers may help doctors learn more about cancer and identify biomarkers related to cancer.
- Conditions
- brca1 Mutation Carrier, brca2 Mutation Carrier, Breast Cancer
- Trial name
- NCT00897455
- Testing
- DNA analysis, mutation analysis, polymorphism analysis
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Gynecologic Oncology Group
Enterobacteria Infections
Can the Relative Fecal Abundance of BLSE and the Digestive Microbiota be Predictive of the Risk of Infection in a Carrier Patient?
Among Enterobacteriaceae, the production of beta-lactamases (ESBLs) is the leading cause of multi-resistance. The first cases of ESBL-producing Enterobacteriaceae (E-ESBL) infections were described in the 1980s and subsequently…
- Trial name
- COPROBLSE2 (NCT04699981)
- Testing
- Control (Patients colonized rectally with ESBL-producing enterobacteria without antibiotic pressure), Case (Patients colonized rectally with ESBL-producing enterobacteriaceae, with antibiotic pressure)
- Where
- 4 sites in France
- Volunteers
- 200 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Neuroendocrine Tumors, Heart Failure
Phase I Study of the Safety, Distribution, and Radiation Dosimetry of Ultratrace Iobenguane 123I-mIBG
The goal of this proposal is to produce and test high specific activity Ultratrace iobenguane I 123 in normal human volunteers.
- Trial name
- mIBG (NCT01730417)
- Testing
- no carrier added metaiodobenzylguanidine
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Bennett Chin
Coronary Artery Disease
Safety and Efficacy Study of the Svelte Drug-Eluting Coronary Stent Delivery System
A prospective, randomized, active-control, multi-center clinical trial comparing the safety and efficacy of the Svelte Drug-Eluting Coronary Stent Integrated Delivery System (IDS) to that of the commercially available Resolute…
- Trial name
- DIRECT II (NCT01788150)
- Testing
- Coronary Stenting
- Where
- 18 sites in Belgium, Czechia and 5 more
- Volunteers
- 159 people
- Sponsor
- Svelte Medical Systems, Inc.
Vitamin B 12 Deficiency
Assessing the Efficacy of Different Carrier Systems in Oral Vitamin B12 Supplementation
Vitamin B12, a vital nutrient, plays a crucial role in red blood cell formation, neurological function, and DNA synthesis. Deficiency in B12 can lead to anemia, neurological symptoms such as tingling or numbness, and cognitive…
- Trial name
- NCT06376591
- Testing
- Vit B12
- Where
- Pakistan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Liaquat University of Medical & Health Sciences
brca1 Mutation Carrier, brca2 Mutation Carrier
Fenretinide in Preventing Ovarian Cancer in Participants Who Are at High Risk for Developing Ovarian Cancer and Planning to Undergo Surgery to Remove the Ovaries
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming, growing, or coming back. The use of fenretinide may prevent ovarian cancer.
- Conditions
- brca1 Mutation Carrier, brca2 Mutation Carrier, Ovarian Cancer
- Trial name
- NCT00098800
- Testing
- fenretinide
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Arizona
Leishmaniasis, Cutaneous
ASYMPTOMATIC CARRIER OF LEISHMANIA INFANTUM, MEDISERRANEAN VISCERAL LEISHMANIOSIS AGENT: STUDY OF IMMUNE RESPONSE -
Leishmaniasis is considered by the WHO as emerging and uncontrolled diseases. They are the second leading cause of death and the fourth leading cause of morbidity in tropical diseases.
- Trial name
- Asymptoleish (NCT03303898)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Inherited Genetic Conditions
Preconception Carrier Screening at the Erasmus MC
Rationale A recent advisory report by the 'Health Council' has recommended that all prospective parents should have the opportunity to undergo preconception carrier screening.
- Trial name
- NCT06543784
- Where
- Netherlands
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Coronary Artery Disease
The Direct III Post Market Study
The primary objective of this multicenter, single-arm, observational study is to evaluate the feasibility of a systematic direct stenting strategy with the Svelte SLENDER IDS Sirolimus-Eluting Coronary Stent-on-a-Wire Integrated…
- Trial name
- Direct III (NCT02693158)
- Where
- 8 sites in Netherlands
- Volunteers
- 440 people
- Sponsor
- Svelte Medical Systems, Inc.
Streptococcus B Carrier State Complicating Pregnancy
Group B Streptococcal Carrier State Prevalence Among Arab Pregnant Women in Northern Israel District
The incidence of early neonatal GBS (group B Streptococcus) infection in the Nazareth Hospital through the years 2006-2013 has been higher compared to the national average.
- Trial name
- GBS (NCT02528890)
- Testing
- vaginal/anal swab for GBS from all participants
- Where
- Israel
- Volunteers
- 196 people
- Sponsor
- The Nazareth Hospital, Israel
Transplant; Complication, Failure
Evaluation at 5 and 10 Years of Renal Transplant Patients
5 and 10 years follow-up of the oxyop study.
- Trial name
- OXYOP 5 and 10 (NCT05469906)
- Where
- France
- Volunteers
- 116 people
- Sponsor
- University Hospital, Brest
Glioblastoma, Glioma, Malignant
Monocyte Antigen Carrier Cells for Newly Diagnosed GBM
The primary purpose of this study is to determine the maximum tolerated dose (MTD) of MT-201-GBM (pp65CMV antigen monocytes) that will be administered to patients newly diagnosed with a type of brain tumor called glioblastoma…
- Trial name
- DEMAND (NCT04741984)
- Testing
- MT-201-GBM monocyte vaccine
- Sponsor
- Michael Gunn
Liver Dysfunction
The Effect of Compound Herbal Formula (RHD-1) on HBV Carrier With Abnormal Liver Function
The aim of the study is to examine whether the compound herbal formula (RHD-1) is effective on HBV Carrier With Abnormal Liver Function.
- Trial name
- NCT01338714
- Testing
- Compound Herbal Formula (RHD-1), dilute RHD-1
- Where
- Taiwan
- Volunteers
- 58 people
- Sponsor
- Taipei City Hospital
Ornithine Transcarbamylase Deficiency
Study to Characterize Rate of Ureagenesis in Patients With Ornithine Transcarbamylase (OTC) Deficiency
The objectives of the study are to characterize urea production rates in patients with OTC, characterize the association of rate of ureagenesis and disease severity in OTC patients, characterize the association of rate of…
- Trial name
- NCT04717453
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Ultragenyx Pharmaceutical Inc
BRCA1 Mutation Carrier, BRCA2 Mutation Carrier
Veliparib in Treating Patients With Persistent or Recurrent Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
This phase II trial studies how well veliparib works in treating patients with epithelial ovarian, fallopian tube, or primary peritoneal cancer that has come back or does not respond to treatment.
- Conditions
- BRCA1 Mutation Carrier, BRCA2 Mutation Carrier, Ovarian Epithelial Tumor, Recurrent Fallopian Tube Carcinoma
- Trial name
- NCT01540565
- Testing
- Laboratory Biomarker Analysis, Veliparib
- Where
- 153 sites in United States
- Volunteers
- 52 people
- Sponsor
- National Cancer Institute (NCI)
Genetic Predisposition, Carrier, Gestational
Prevalence of Carriers of Genetic Diseases in the Mexican Jewish Community
The Jewish Population is at an increased risk for genetic diseases, especially autosomal recessive, thus, screening should be done to determine carrier status of several genetic diseases.
- Trial name
- NCT04307719
- Where
- Mexico
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Anahuac University
Retinitis Pigmentosa
Clinical and Genetic Findings in Patients With PRPF31-associated Retinitis Pigmentosa
Retrospective chart review study to elucidate the genotype and phenotype of patients with PRPF31-associated retinitis pigmentosa and asymptomatic carriers of the respective variant(s)
- Trial name
- NCT06368375
- Where
- Germany
- Volunteers
- 87 people
- Sponsor
- University Hospital Tuebingen
Mastitis, Staphylococcus Aureus
Staphylococcus Aureus Carrier Status in Breastfeeding Mothers and Infants and the Risk of Lactation Mastitis
Lactation (breastfeeding) mastitis is an acute infection of the milk ducts of the breastfeeding woman. Staphylococcus aureus (S. aureus) is the infectious germ most commonly associated with lactation mastitis.
- Conditions
- Mastitis, Staphylococcus Aureus, Staphylococcal Infections
- Trial name
- NCT00620984
- Where
- United States
- Volunteers
- 557 people
- Sponsor
- State University of New York - Upstate Medical University