Clinical trials: Cardioversion
Atrial Fibrillation
Edoxaban vs. Warfarin in Subjects Undergoing Cardioversion of Nonvalvular Atrial Fibrillation (NVAF)
The purpose of this study is to compare edoxaban to warfarin (with enoxaparin, if needed). It will see if edoxaban prevents stroke and other blood clotting problems as well and as safely as warfarin.
- Trial name
- ENSURE-AF (NCT02072434)
- Testing
- Edoxaban, Warfarin, Enoxaparin
- Where
- 228 sites in United States, Austria and 17 more
- Volunteers
- 2,199 people
- Sponsor
- Daiichi Sankyo
Sudden Cardiac Death
'Effect of CRT on Defibrillation Threshold Estimates' Study
The purpose of this prospective study is to evaluate the effect of cardiac resynchronization therapy (CRT) on the defibrillation threshold (DFT) estimates in cardiac resynchronization therapy defibrillators (CRT-D) patients.
- Trial name
- NCT00626093
- Testing
- Cardiac Resynchronization Therapy - Defibrillator (CRT-D)
- Where
- 2 sites in United States
- Volunteers
- 77 people
- Sponsor
- Abbott Medical Devices
Arrhythmia, Quality of Life
Psychosomatic Effects of Implantable Cardioverter Defibrillator With Home Monitoring Function (QUANTUM)
Quality of life (QOL) and psychological well-being of patients with implantable cardioverter-defibrillators (ICDs) are significantly influenced by the experience of shock therapies.
- Trial name
- NCT00325221
- Testing
- HM on, HM Off
- Where
- 7 sites in Austria, Germany and 1 more
- Volunteers
- 148 people
- Sponsor
- Biotronik SE & Co. KG
Atrial Fibrillation (AF)
RECURrence of Atrial Fibrillation After Cardioversion of Patients Randomized to Dapagliflozin or Usual Care
The goal of this clinical trial is to learn if drug dapagliflozin, a sodium-glucose transport-2 inhibitor, works to treat atrial fibrillation in adults.
- Trial name
- RECUR-AF (NCT07187570)
- Testing
- Dapagliflozin 10 mg once daily
- Where
- 7 sites in Sweden
- Volunteers
- 1,600 people
- Sponsor
- Region Stockholm
Left Atrial Appendage Thrombi
Detection of Left Atrial Appendage (LAA) Thrombus: Comparison of Cardiac Magnetic Resonance Imaging and Transesophageal Echocardiogram
The purpose of this study is to compare Cardiac Magnetic Resonance (CMR) Imaging with transesophageal echocardiography (TEE) in detecting the presence of LAA thrombi in men and women with atrial fibrillation presenting for…
- Trial name
- NCT00797576
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Gundersen Lutheran Medical Foundation
Atrial Fibrillation, Atrial Flutter
Double Blind Placebo COntrolled Dose Ranging studY of the eFficacy and safEty of SSR149744c 300 or 600 mg for the Conversion of Atrial Fibrillation / fluttEr
Double blind study to assess versus placebo the efficacy of SSR149744C for the conversion of atrial fibrillation/flutter to sinus rhythm at the time of the planned electrical cardioversion.
- Trial name
- CORYFEE (NCT00232310)
- Testing
- CELIVARONE (SSR149744C)
- Where
- 9 sites in United States, Canada and 7 more
- Volunteers
- 150 people
- Sponsor
- Sanofi
Atrial Fibrillation
Canakinumab for the Prevention of Recurrences After Electrical Cardioversion: CONVERT-AF
The purpose of this study is to test the efficacy of a single injection of Canakinumab on AF recurrences within 6 months after electrical cardioversion in patients with persistent AF.
- Trial name
- CONVERT-AF (NCT01805960)
- Testing
- Canakinumab
- Where
- 5 sites in Germany, Switzerland
- Volunteers
- 24 people
- Sponsor
- University Hospital, Basel, Switzerland
Ventricular Arrythmia
A Randomised Trial of S-ICD Implantation With and Without Defibrillation Testing
This study will test the hypothesis that implantation of a subcutaneous implantable cardioverter defibrillator (S-ICD) without performing a defibrillation test is non-inferior to S-ICD implant with a defibrillation test with…
- Trial name
- PRAETORIAN-DFT (NCT03495297)
- Testing
- ommitence of defibrillation testing
- Where
- 32 sites in United States, Germany and 2 more
- Volunteers
- 965 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Atrial Fibrillation
Atrial Fibrillation Recurrence Following Cardioversion: the Role of Clinical Factors and Alpha Defensin Levels
Atrial fibrillation and inflammation are strongly correlated. The aim of this study is to evaluate whether inflammation markers (alpha Defensin) predict maintenance of sinus rhythm following cardioversion.
- Trial name
- NCT04155879
- Testing
- Colchicine Tablets, Cardioversion
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Hillel Yaffe Medical Center
Intracranial Embolism
Electrical Cardioversion of Recent Onset Atrial Fibrillation - Silent Thromboembolic Events, Reverse Atrial Remodeling
The purpose of this study is to study the effects of transthoracic electrical cardioversion for restoration of sinus rhythm in patients who present with recent onset atrial fibrillation, with regard to new silent cerebral…
- Trial name
- ECAF-STAR (NCT02955004)
- Testing
- Electrical cardioversion
- Where
- 3 sites in Sweden
- Volunteers
- 43 people
- Sponsor
- Uppsala University Hospital
Cardiomyopathy, Heart Failure
Evaluating Myocardial Injury for Defibrillation Threshold Testing Methods for ICD Implantation
The objective of this study is to evaluate myocardial injury, if any, as quantified by cardiac markers (Troponin-T) in defibrillation threshold (DFT) testing during implantation of implantable cardioverter defibrillators (ICDs)…
- Conditions
- Cardiomyopathy, Heart Failure, Cardiac Arrhythmia
- Trial name
- ULV (NCT02111993)
- Testing
- Standard Defibrillation Testing, Upper Limit of Vulnerability Testing
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Diego
Cardioversion
Myocardial Injury Following Elective Direct Current Cardioversion for Atrial Arrhythmias
Researchers are trying to determine if heart injury occurs in subjects who undergo direct current cardioversion.
- Trial name
- NCT04151966
- Testing
- Blood sample collection
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Mayo Clinic
Cardiac Arrest, Identify of Electrocadiac Rhythm
Identification of Ventricular Fibrillation and Optimization of Defibrillation During CPR
It's so important to recognize ventricular fibrillation in cardiac arrest and defibrillation early. At the same time Research findings have identified high-quality CPR with minimum interruption is critical to the success of…
- Trial name
- IVFOD (NCT02952105)
- Where
- China
- Volunteers
- 90 people
- Sponsor
- The First Affiliated Hospital of Henan University of Science and Technology
Atrial Fibrillation Fluttering
Ankle - Brachial Index Measurement in Atrial Fibrillation
Consecutive patients with atrial fibrillation will be admitted to the hospital for electrical cardioversion. Ankle brachial index will be measured three times with oscillometric method and three times with doppler method.
- Trial name
- AFABI (NCT02986282)
- Testing
- ABI measurement using both doppler and oscillometric method
- Volunteers
- 115 people
- Sponsor
- Medical University of Warsaw
Ventricular Arrythmia
Non-vascular ICD Electrode Configuration Feasibility Study
This study is designed to evaluate the energy requirements of two different Nonvascular ICD (NV-ICD) electrode configurations for achieving successful defibrillation of ventricular arrhythmias.
- Trial name
- NCT04809701
- Testing
- Temporary implantation of defibrillation coils and pulse generator, Defibrillation following induction of VA (Configuration A first), Defibrillation following induction of VA (Configuration B first)
- Where
- 3 sites in Chile, Czechia and 1 more
- Volunteers
- 30 people
- Sponsor
- Abbott Medical Devices
Sudden Cardiac Death
POWER (Pulse Width Optimized Waveform Evaluation Trial)
The objective of this study is to compare the ULV (Upper Limit of Vulnerability)/DFT (Defibrillation Threshold) efficacy between the 2.5, 3.5 and 4.5 ms membrane time constant based biphasic defibrillation waveforms.
- Trial name
- NCT00311181
- Testing
- Implantable Cardioverter Defibrillator (ICD), Cardiac Resynchronization Therapy (CRT-D)
- Where
- 2 sites in United States
- Volunteers
- 217 people
- Sponsor
- Abbott Medical Devices
Atrial Fibrillation
Study of Normal Conditions of Use, Dosing, and Safety of Intravenous (IV) Administration of Vernakalant (MK-6621-049)
This non-interventional prospective study is a post-authorization safety study (PASS) of vernakalant conducted to collect information about normal conditions of use and appropriate dosing, and to quantify possible medically…
- Trial name
- NCT01370629
- Testing
- Vernakalant
- Where
- 6 sites in Austria, Denmark and 4 more
- Volunteers
- 2,015 people
- Sponsor
- Correvio International Sarl
Atrial Fibrillation, Atrial Flutter
Left Atrial Thrombus on Transesophageal Echocardiography
The aim of the study is to assess the prevalence of left atrial thrombus in patients with atrial fibrillation (AF) or atrial flutter (AFI), in whom transesophageal echocardiography is performed before AF/AFl cardioversion or…
- Conditions
- Atrial Fibrillation, Atrial Flutter, Transesophageal Echocardiography, Ablation
- Trial name
- LATTEE (NCT03591627)
- Testing
- Transesophageal echocardiography
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Medical University of Warsaw
Atrial Fibrillation
The Efficacy of Single Coil Defibrillation Leads for Internal Cardioversion of Atrial Fibrillation
This study seeks to determine the efficacy of single coil defibrillation leads for cardioversion of persistent atrial fibrillation.
- Trial name
- NCT03164395
- Testing
- Internal Cardioversion, External Cardioversion
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Kentucky
Atrial Fibrillation
Efficacy and Safety of Electrical Versus Pharmacological Cardioversion in Early Atrial Fibrillation
The optimal strategy to restore sinus rhythm in patients with atrial fibrillation (AF) of less than 48 hours' duration is still controversial.
- Trial name
- NCT00933634
- Testing
- electrical cardioversion, propafenone
- Where
- Italy
- Volunteers
- 247 people
- Sponsor
- Valduce Hospital