Clinical trials: Cardiovascular-Kidney-Metabolic Syndrome
Chronic Myeloproliferative Disorders, Leukemia
506U78 in Treating Patients With Hematologic Cancer and Kidney or Liver Impairment
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of 506U78 in treating patients who have hematologic cancer…
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00004239
- Testing
- Compound 506U78
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Leukodystrophy, White Matter Disease
The Myelin Disorders Biorepository Project
The Myelin Disorders Biorepository Project (MDBP) seeks to collect and analyze clinical data and biological samples from leukodystrophy patients worldwide to support ongoing and future research projects.
- Conditions
- Leukodystrophy, White Matter Disease, Leukoencephalopathies, 4H Syndrome
- Trial name
- MDBP (NCT03047369)
- Where
- 23 sites in United States
- Volunteers
- 12,000 people
- Sponsor
- Children's Hospital of Philadelphia
Cradiovascular-kidney-liver-metabolic (CKLM) Syndrome, Cardiovascular-kidney-metabolic Syndrome
Swiss Cardiovascular-Kidney-Liver-Metabolic (CKLM) Registry
The aim of this clinical and exploratory Swiss Cardiovascular-Kidney-Liver-Metabolic (CKLM) Registry is to establish high quality prevalence and incidence database for Cardiovascular-Kidney-Metabolic (CKM) syndrome, its major…
- Trial name
- NCT07084688
- Where
- Switzerland
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Night Eating Syndrome, Metabolic Syndrome
Cardiorenal and Metabolic Effects of Nighttime Eating
In this study, the investigators are trying to find out of the effect of nighttime eating on metabolism, cardiorenal, hormonal and circadian rhythm, and a study was conducted to examine the effects of diseases that are quite…
- Conditions
- Night Eating Syndrome, Metabolic Syndrome, Cardiorenal Syndrome, Sleep Disorder
- Trial name
- NCT06588088
- Testing
- Dietary
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Koc University Hospital
CKM
Community-Based Time-Restricted Eating and Health Education for Adults With Stage 1-2 Cardiovascular-Kidney-Metabolic Syndrome in Can Tho City
This study evaluates the effectiveness of a community-based intervention for adults aged 30 years and older with stage 1-2 cardiovascular-kidney-metabolic syndrome who do not currently have an indication for pharmacotherapy in…
- Trial name
- CKM (NCT07722338)
- Testing
- 10-Hour Time-Restricted Eating With Health Education and Behavioral Support
- Where
- Vietnam
- Volunteers
- 200 people
- Sponsor
- Can Tho University of Medicine and Pharmacy
Arterial Hypertension, Heart Rhythm Disorders
Screening for Cardiac and Cardiac-associated Pathology Using Single-channel Electrocardiogram
It is a prospective, controlled, single-center, observational, non-randomized study. The study is planned to include at least 4000 patients 18 years old and older in the training sample and 1000 patients over 18 years old in the…
- Conditions
- Arterial Hypertension, Heart Rhythm Disorders, Valvular Heart Diseases, Heart Failure
- Trial name
- NCT07396792
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Electrolyte Disturbances, Subarachnoid Hemorrhage
Electrolyte and Fluid Disturbances in Subarachnoid Hemorrhage and Traumatic Brain Injury
During the course of their acute illness patients with subarachnoid hemorrhage and severe traumatic brain injury often develop disturbances in their fluid balance and electrolyte homeostasis.
- Conditions
- Electrolyte Disturbances, Subarachnoid Hemorrhage, Traumatic Brain Injury, Natriuretic Peptides
- Trial name
- NCT01313975
- Where
- Switzerland
- Volunteers
- 85 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hypoxic-Ischemic Encephalopathy, Sepsis
Continous Renal Replacement Therapy With the CARPEDIEM® in a French National Cohort of 25 Neonates and Small Infants
Historically, CKRT and hemodialysis were performed in small infants and newborns with devices developed for adults with high rates of complications and mortality.
- Conditions
- Hypoxic-Ischemic Encephalopathy, Sepsis, Kidney Diseases, Metabolic Disease
- Trial name
- NCT05495607
- Testing
- CARPEDIEN
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Cardiovascular Diseases (CVD), Chronic Kidney Disease
Study on Construction of Whole Lifecycle Cohort, Big Data Management and Clinical Prognosis of Cardio-Renal-Metabolic (CKM) Syndrome
This is a single-center observational registry study aiming to establish a structured clinical and multimodal imaging database for cardiovascular-kidney-metabolic (CKM) populations and to support lifecycle follow-up and outcome…
- Conditions
- Cardiovascular Diseases (CVD), Chronic Kidney Disease, Metabolic Diseases, Cardiovascular-kidney-metabolic Syndrome
- Trial name
- CKM-LCBP (NCT07547098)
- Where
- China
- Volunteers
- 8,000 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Hypertension, Type 2 Diabetes
Multi-Organ Denervation With the iRF System to RedUce Sympathetic Drive
The objective of the study is to evaluate the safety of multi-organ denervation using the Integrated Radio Frequency (iRF) Denervation System. and to understand any potential improvement in hypertension and glycemic control.
- Conditions
- Hypertension, Type 2 Diabetes, Metabolic Syndrome
- Trial name
- MODUS (NCT04917393)
- Testing
- iRF System Multi-organ Denervation, Control Procedure
- Where
- 2 sites in Georgia
- Volunteers
- 45 people
- Sponsor
- Metavention
Hypertension (HTN), CKD - Chronic Kidney Disease
Community Health Worker Nutrition Self-Management Support for Cardio-Kidney-Metabolic Health
This study tests whether adding CHW support to usual nutrition care helps adults with type 2 diabetes, hypertension, or chronic kidney disease manage their diet and health.
- Conditions
- Hypertension (HTN), CKD - Chronic Kidney Disease, Cardio-Renal Syndrome, Food Insecurity
- Trial name
- INTEGRATE-CHW (NCT07918508)
- Testing
- INTEGRATE-CHW, Usual Care
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Florida International University
Hypertension, Type 2 Diabetes Mellitus
Nanshan Elderly Cohort Study
Objective: The Nanshan Elderly Cohort Study (NECS) aims to investigate the nutritional, as well as other environmental and genetic factors of chronic diseases, such as cardio-metabolic diseases.
- Conditions
- Hypertension, Type 2 Diabetes Mellitus, Cardiovascular Diseases, Stroke
- Trial name
- NECS (NCT03569735)
- Where
- 2 sites in China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Hypertension, Metabolic Syndrome
Evaluation of the Integrated Radio Frequency Denervation System for the Treatment of Hypertension
The objective of the study is to evaluate the safety of renal denervation using the iRF System and to understand any potential improvement in hypertension.
- Trial name
- RADAR (NCT04740723)
- Testing
- iRF System Renal Denervation
- Where
- 2 sites in Georgia
- Volunteers
- 30 people
- Sponsor
- Metavention
Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome
Sunitinib Malate in Treating HIV-Positive Patients With Cancer Receiving Antiretroviral Therapy
This phase I trial studies the side effects and the best dose of sunitinib malate in treating human immunodeficiency virus (HIV)-positive patients with cancer receiving antiretroviral therapy.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Acute Undifferentiated Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
- Trial name
- NCT00890747
- Testing
- sunitinib malate, pharmacological study, laboratory biomarker analysis
- Where
- 11 sites in United States
- Volunteers
- 42 people
- Sponsor
- National Cancer Institute (NCI)
Kidney Disease, Chronic, Transplant Complication
Plant-based Diet for Kidney Transplant Recipients
The goal of this clinical trial is to evaluate cardiometabolic and inflammatory parameters in kidney transplant recipients after transitioning to a plant-based diet (PBD).
- Conditions
- Kidney Disease, Chronic, Transplant Complication, Hypertension, Diabetes Mellitus
- Trial name
- NCT06186843
- Testing
- Plant-based diet
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- George Washington University
Adenine Phosphoribosyltransferase Deficiency, AH Amyloidosis
National Registry of Rare Kidney Diseases
The goal of this National Registry is to is to collect information from patients with rare kidney diseases, so that it that can be used for research.
- Conditions
- Adenine Phosphoribosyltransferase Deficiency, AH Amyloidosis, AHL Amyloidosis, AL Amyloidosis
- Trial name
- RaDaR (NCT06065852)
- Where
- United Kingdom
- Volunteers
- 35,000 people
- Sponsor
- UK Kidney Association
Morbid Obesity, Chronic Kidney Disease (Stage 3-4)
Metabolic Status and Risk of Chronic Kidney Disease in French Overseas Populations With Morbid Obesity (OBECAMcohort).
Morbid obesity is defined by a body mass index (BMI) ≥ 40 kg/m2 or > 35 if there is at least one comorbidity (hypertension, diabetes, hypercholesterolemia, joint pain, obstructive sleep apnea syndrome, etc.) Morbid obesity…
- Trial name
- OBECAMcohort (NCT07830030)
- Where
- Guadeloupe
- Volunteers
- 480 people
- Sponsor
- Clinique
Coronary Artery Disease, End Stage Renal Disease
Coronary Revascularization in Patients On Dialysis in China-Retrospective Registry
Coronary artery disease (CAD) is the leading cause of death in end-stage renal disease (ESRD) patients requiring dialysis. There are limited data on clinical characteristics, treatment strategies and outcomes in this special…
- Conditions
- Coronary Artery Disease, End Stage Renal Disease, Dialysis
- Trial name
- CRUISE-R (NCT05841082)
- Where
- China
- Volunteers
- 1,249 people
- Sponsor
- China-Japan Friendship Hospital
Cancer
Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain
This is a phase III, randomized, double-blind, placebo-controlled, multicenter study of the clinical response to fentanyl sublingual spray as a treatment for breakthrough cancer pain.
- Trial name
- NCT00538850
- Testing
- Fentanyl sublingual spray
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- INSYS Therapeutics Inc
Attention Deficit Disorder With Hyperactivity, Asthma
Study of an Intervention to Improve Problem List Accuracy and Use
The aim of this study is to identify patients with problem list gaps and intervene to correct these gaps by creating clinical decision support interventions that alert providers to likely problem list gaps and offer clinicians…
- Conditions
- Attention Deficit Disorder With Hyperactivity, Asthma, COPD, Breast Cancer
- Trial name
- MAPLE (NCT01105923)
- Testing
- MAPLE
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Brigham and Women's Hospital