Clinical trials: Cardiovascular Prevention, open to volunteers
Multiple Myeloma, Fall Risk Factors
Fall Risk Assessment and an Exercise Intervention for Prevention of Falls in Multiple Myeloma Patients
Approximately one third of the population over the age of 65 falls at least once a year. The risk of falling is in increased in older patients with tumor diseases.
- Conditions
- Multiple Myeloma, Fall Risk Factors, Strength Training Effects, Balance Training Effects
- Trial name
- Myfall (NCT07044427)
- Testing
- Strength and balance training in combination with a treadmill-based pertubation intervention
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital Heidelberg
Breast Cancer Risk, Cardiovascular Disease Risk
The RISC Registry--Risk Informed Screening Registry
Chronic diseases such as heart disease, cancer, and diabetes are the leading causes of death and disability in the United States. Six in ten adults have one chronic disease; 4 in 10 have two or more.
- Conditions
- Breast Cancer Risk, Cardiovascular Disease Risk, Cardiometabolic Risk, Diabetes
- Trial name
- RISC (NCT05848856)
- Testing
- Breast Cancer, Cardiometabolic, Cardiovascular Risk Screening and Follow up
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Precision Health Equity Initiative
Maternal Cardiometabolic Health, Infertility
St Mary's Assisted Reproductive Technology and Cardiometabolic Health: Modifiable Targets for Multimorbidity Prevention (START-HEALThY)
The main causes of death in women are conditions affecting the heart and blood vessels (cardiovascular disease, CVD). Women who have difficulties getting pregnant (infertility) may be at increased risk, but the reasons for this…
- Conditions
- Maternal Cardiometabolic Health, Infertility, Assisted Reproductive Technology, Cardiovascular Health
- Trial name
- START-HEALThY (NCT07173569)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Isolated Noncompaction of the Ventricular Myocardium
Risk Stratification and Early Prevention Strategies for Non-compaction of Ventricular Myocardium (CAPTAIN)
This study intends to retrospectively-prospectively enroll NVM patients from multiple centers to establish a natural population cohort of NVM patients.
- Trial name
- NCT06504056
- Testing
- Diagnosis of NVM
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Peripheral Neuropathy, Multiple Myeloma, Neoplasms
Fenofibrate Role in the Prophylaxis From Peripheral Neuropathy Induced by Bortezomib, Lenalidomide and Dexamethasone (VRd) Protocol in the Treatment of Patients With Multiple Myeloma (MM)
This study aims at evaluating the possible beneficial role of Fenofibrate in attenuating the peripheral neuropathy associated with bortezomib (velcade), lenalidomide (revlimid), and dexamethasone (VRd) regimen in newly diagnosed…
- Trial name
- VRd MM Fibrate (NCT07025005)
- Testing
- Bortezomib + Lenalidomide + Dexamethasone + Fenofibrate 160 mg tablet, Bortezomib + Lenalidomide + Dexamethasone
- Where
- 2 sites in Egypt
- Volunteers
- 44 people
- Sponsor
- Tanta University
Heart Failure, Acute Heart Failure
Pharmacological Optimization in Prevention in Heart Failure: A Sex-gap?
The goal of this clinical trial is to learn whether a rapid and intensive optimization of heart failure medications in women can improve outcomes after hospitalization for heart failure.
- Conditions
- Heart Failure, Acute Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF), Heart Failure With Preserved Ejection Fraction (HFPEF)
- Trial name
- PopS-HF (NCT07295522)
- Testing
- Guideline-Directed Medical Therapy (GDMT)
- Where
- 12 sites in Italy
- Volunteers
- 368 people
- Sponsor
- IRCCS Policlinico S. Donato
Suicidal Behaviour Disorder
Prevention of Suicidal Behavior Through the VIGILANS Protocol: the Restoration of Social Connection Hypothesis
The World Health Organization (WHO) estimates, with 800,000 annual deaths, that suicide is the second leading cause of death in people aged 10 to 44 and thus recognizes suicide prevention as a public health priority.
- Trial name
- RECONEX (NCT05227183)
- Testing
- The virtual version of the Social stress task : V-TSST
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Montpellier
Radial Artery Occlusion
Comparison of the Systematic Versus the Selective Use of Heparin for the Prevention of Radial Artery Occlusion
Randomized study comparing the systematic use of heparin (standard of care) against an elective use of heparin to prevent radial artery occlusion after a percutaneous catheterization using a dual-artery compression system.
- Trial name
- EASY-Heparin (NCT06981624)
- Testing
- No heparin
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- Olivier F. Bertrand
Cardiovascular Risk Factors, Insulin Resistance
Pilot Validation of the STELA Preventive Medicine Platform to Reduce Modifiable Health Risk Factors in Adults (CPM-STELA)
This study evaluates a comprehensive digital health platform called STELA, developed at the Center for Preventive Medicine (CPM) of AGEL Hospital Trinec-Podlesi in Czechia.
- Conditions
- Cardiovascular Risk Factors, Insulin Resistance, Obesity, Dyslipidemias
- Trial name
- CPM-STELA (NCT07551960)
- Testing
- STELA Digital Preventive Medicine Platform, Comprehensive Preventive Health Assessment
- Where
- Czechia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nemocnice AGEL Trinec-Podlesi a.s.
Stroke, Neurological Diseases or Conditions
Development and Efficacy of a Novel, Cost-Effective Gait Training Device Utilized at Home for Stroke Survivors
This pilot, parallel-group randomized controlled trial will evaluate the feasibility, safety, usability, and preliminary efficacy of the Rise\&Walk InHome (RWH), a novel robotic gait training device designed for home use after…
- Conditions
- Stroke, Neurological Diseases or Conditions, Hemiparesis;Poststroke/CVA, Gait Disorders, Neurologic
- Trial name
- NCT07250425
- Testing
- Rise&Walk InHome by Healing Innovations
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Healing Innovations
Cardiovascular Disease
Awareness of Risk Factors and Perception of Cardiovascular Risk in Secondary Prevention Among Women and Men
The present research project aims to assess, through a survey, awareness of general and sex/gender-specific cardiovascular risk factors, as well as the perception of the risk of developing further cardiovascular diseases, among…
- Trial name
- CORPS-CV (NCT07521436)
- Testing
- No intervention
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Acute Decompensated Heart Failure, Acute Myocardial Infarction
Using an Intervention Adapted to the Health Literacy Level to Improve Adherence to Medical Recommendations
Health literacy is the ability to access, understand, evaluate and apply information in order to communicate with health professionals and understand health instructions but also, promote, maintain and improve health throughout…
- Trial name
- ILIADE (NCT03951467)
- Testing
- Interventional educational toolkit specific to low Health Literacy patients, designed with patients and health professionals.
- Where
- 4 sites in France
- Volunteers
- 300 people
- Sponsor
- Hospices Civils de Lyon
Breast Cancer, Heart Failure
CardioPROTECTion with Dapagliflozin in Breast Cancer Patients Treated with AnthrAcycline - PROTECTAA TRIAL
The purpose of this study is to evaluate the effect of dapagliflozin on the incidence of cancer therapeutics-related cardiac dysfunction in patients with breast cancer receiving anthracycline treatment.
- Trial name
- PROTECTAA (NCT06304857)
- Testing
- Dapagliflozin
- Where
- 3 sites in Poland
- Volunteers
- 188 people
- Sponsor
- 4th Military Clinical Hospital with Polyclinic, Poland
Anemia, Iron Deficiencies
Postoperative Intravenous Ferric Derisomaltose for Prevention of Long-term Anemia After Cardiac Surgery
Postoperative anemia is highly prevalent among patients undergoing cardiac surgery and is associated with delayed functional recovery, increased morbidity, and impaired long-term outcomes.
- Conditions
- Anemia, Iron Deficiencies, Iron Deficiency Anemia, Cardiac Surgery
- Trial name
- NCT07238972
- Testing
- Ferric derisomaltose
- Where
- South Korea
- Volunteers
- 180 people
- Sponsor
- Yonsei University
Heavy Smokers, Lung Cancer Screening
Akershus Cardiac Examination (ACE) 5 Study
Individuals with extensive smoking history have 2- to 3-fold increased risk of dying prematurely compared to age- and gender-matched peers.
- Conditions
- Heavy Smokers, Lung Cancer Screening, Cardiovascular Risk Profile, Cardiovascular Disease Prevention
- Trial name
- ACE5 (NCT07301489)
- Testing
- Lung Cancer Screening Plus Program, Standard of Care
- Where
- Norway
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Akershus
Obsessive Compulsive Disorder (OCD), Lifestyle (Sedentary Behavior and Physical Activity)
A Lifestyle Intervention to Reduce Cardiometabolic Risk Factors in Individuals With Obsessive-compulsive Disorder
The overall aim of this study is to evaluate the efficacy and cost-effectiveness of a lifestyle intervention to improve lifestyle habits and reduce cardiometabolic risk factors in individuals with obsessive-compulsive disorder…
- Trial name
- LIFT (NCT07206212)
- Testing
- A group-based lifestyle intervention for individuals with OCD, Medical and lifestyle advice
- Where
- Sweden
- Volunteers
- 108 people
- Sponsor
- Karolinska Institutet
Cancer Related Cardiovascular Toxicity
Detection and Prevention of Cancer-Related Cardiovascular Toxicity Registry
This study is being done in order to assess the cardiovascular events known as cardiovascular toxicity of chemotherapy agents and radiotherapy protocols in cancer subjects to identify risk prediction, prevention and treatment of…
- Trial name
- NCT06086132
- Testing
- Prospective validation of the HFA-ICOS risk score in a subset of subjects with newly diagnosed breast cancer and undergoing treatment with anthracyclines analogues with or without radiotherapy
- Where
- 5 sites in Italy, North Macedonia and 1 more
- Volunteers
- 10,000 people
- Sponsor
- University of Bologna
Venous Thromboembolism (VTE), Deep Vein Thrombosis (DVT)
Extended Prophylactic Anticoagulation Following Spinal Surgery for Metastatic Disease
People who have surgery on their spine to treat cancer that has spread (metastatic disease) have a high chance of developing dangerous blood clots in the legs or lungs.
- Conditions
- Venous Thromboembolism (VTE), Deep Vein Thrombosis (DVT), Pulmonary Embolism (PE), Spine Metastasis
- Trial name
- NCT07713875
- Testing
- Apixaban
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- James Bayley
Sarcoma, Soft Tissue Sarcoma
LMWH vs Aspirin for VTE Prophylaxis in Orthopaedic Oncology
Aspirin and low molecular weight heparin (LMWH) are both commonly employed pharmacologic methods of venous thromboembolism (VTE) prophylaxis after orthopaedic surgery.
- Conditions
- Sarcoma, Soft Tissue Sarcoma, Bone Sarcoma, Bone Metastases
- Trial name
- NCT03244020
- Testing
- Aspirin 325mg, Enoxaparin 40Mg/0.4mL Prefilled Syringe
- Where
- 10 sites in United States
- Volunteers
- 2,868 people
- Sponsor
- Massachusetts General Hospital
Serious Mental Illness, Type 2 Diabetes
MetSense Pilot and Feasibility
People with serious mental illness have high risk for type 2 diabetes due to multiple risk factors, including the metabolic side effects of psychotropic medications that are used to treat these conditions.
- Trial name
- MetSenseP&F (NCT07264062)
- Testing
- MetSense Risk Flag, Usual Care
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Kaiser Permanente