Clinical trials: Cardiovascular Physiological Phenomena
Cardiovascular Diseases
Exploring the Effects of Aquatic Exercise on Cardiovascular Function in Older Adults
Cardiovascular ageing is implicated in the development of cardiovascular disease (CVD). Aquatic exercise is being considered as a co-adjuvant form of rehabilitation, but there is limited evidence for its cardiovascular…
- Trial name
- ACELA (NCT04308057)
- Testing
- Aquatic exercise
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sheffield Hallam University
Cardiovascular Function, Gene Expression
Effect of a Polyphenol-rich Cocoa Extract on Peripheral Blood Mononuclear Cells Gene Expression
It has been evidenced that chocolate and cocoa consumption increase vasodilation and reduce blood pressure. However, the mechanisms implicated in these effects have not been elucidated yet.
- Trial name
- NCT01681394
- Testing
- Polyphenol-rich cocoa extract, Chocolate cream
- Where
- Spain
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Technological Centre of Nutrition and Health, Spain
Women, Aging
Beta3-adrenergic Receptors and Cardiovascular Function in Aging Women
To determine if vascular beta3 adrenergic receptors are present and functional in aging women and can be targeted to attenuate sympathetic vasoconstriction and enhance vascular function in aging women.
- Conditions
- Women, Aging, Menopause
- Trial name
- NCT07674680
- Testing
- Gemtesa
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Cardiovascular Disease (CVD), Elevated Cardiovascular Risk
Sacha Inchi-CoQ10 Supplementation and Cardiovascular Health
The goal of this clinical trial is to learn if Sacha Inchi-CoQ10 supplementation can improve cardiovascular health in adults who have an increased risk of cardiovascular disease.
- Conditions
- Cardiovascular Disease (CVD), Elevated Cardiovascular Risk, Endothelial Dysfunction
- Trial name
- Sacha-Q10 (NCT07792005)
- Testing
- Sacha-Q10 Plus
- Volunteers
- 60 people
- Sponsor
- Hospital Pengajar Universiti Putra Malaysia
Aging, Blood Pressure
Coconut Sugar Lowers Blood Pressure and Arterial Stiffness in Middle-aged and Older Adults
The goal of this intervention is to determine the efficacy of coconut sap powder (CSP) to lower arterial stiffness and blood pressure in middle-aged and older adults.
- Conditions
- Aging, Blood Pressure, Arterial Stiffness
- Trial name
- NCT05645991
- Testing
- Coconut Sap Powder (CSP)
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Ball State University
Obesity, Diabetes Mellitus, Type 2
School-Based Program On Metabolic Disease
Mexico occupies the first place worldwide in childhood obesity. Its urban and indigenous communities present different levels of westernization which have triggered different epidemiological diseases.
- Conditions
- Obesity, Diabetes Mellitus, Type 2, Cardiovascular Function, Kidney Diseases
- Trial name
- NCT03768245
- Testing
- Health Education and Physical activity program, Nutrition Program
- Where
- Mexico
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado
Preeclampsia
Study of Maternal and Fetal Cardiovascular Function in Hypertensive States of Pregnancy
The pharmacological treatment strategy is then tailored to the underlying hemodynamic phenotype of each patient. That is, rather than applying a one-size-fits-all treatment for all patients, therapy is tailored to the specific…
- Trial name
- CARDIAC-OAT (NCT06858345)
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia
Long COVID Symptoms
Using Enhanced External Counterpulsation to Recover Cardiovascular Function for Patient of Chronic Diseases
The goal of this clinical trial is to learn whether enhanced external counterpulsation (EECP) therapy can improve cardiopulmonary function and symptoms in adults with long COVID.
- Trial name
- NCT07492953
- Testing
- enhanced external counterpulsation
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- National Defense Medical Center, Taiwan
Stroke, Hemiplegia
Cardiovascular Function in Sub Maximal Exercise and Performance in Three Daily Activity Tests After Stroke
The purpose of this study is to explore the relationship between cardiovascular function of persons with post stroke conditions and their performance in three field tests.
- Trial name
- NCT01396746
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Hillel Yaffe Medical Center
Exercise, Cardiovascular Function, Fatigue, Muscular Power
Physiological Responses to Maximal 4-s Sprint Interval Cycling
The optimal recovery duration depends on the intensity of exercise and in the present study the intensity was maximal power for 4-s while cycling an 'Inertial Load' ergometer (ILE).
- Trial name
- NCT04448925
- Testing
- inertial-load exercise (ILE)
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Healthy Adults
Statins Against Bushfire Smoke
The goal of this clinical trial is to test whether statins can protect the heart and brain from the biological stress and inflammatory responses caused by breathing bushfire smoke in healthy adult volunteers aged 18-64 years.
- Trial name
- SABS (NCT07462715)
- Testing
- Atorvastatin
- Where
- Australia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Menzies Institute for Medical Research
Down Syndrome, Obstructive Sleep Apnea Syndrome
Obstructive Sleep Apnea and Neurocognitive and Cardiovascular Function in Children With Down Syndrome
Many individuals with Down syndrome (DS) have breathing problems during sleep. This is called obstructive sleep apnea syndrome (OSAS).
- Trial name
- TRIO (NCT01808508)
- Testing
- Continuous positive airway pressure
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Children's Hospital of Philadelphia
Cardiovascular Diseases, Pre-Eclampsia Onset Less Than 37 Weeks (Diagnosis)
Postnatal Enalapril to Improve Cardiovascular fUnction Following Preterm Pre-eclampsia
This is a double blind randomised controlled feasibility study investigating the effect of postnatal enalapril on cardiovascular function in women who have had preterm pre-eclampsia.
- Trial name
- PICk-UP (NCT03466333)
- Testing
- Enalapril Maleate
- Where
- United Kingdom
- Volunteers
- 118 people
- Sponsor
- Manchester University NHS Foundation Trust
Pain, Hypoxia
Effects of Static Apnea at Low Lung Volume on Hypoalgesia, Cardiovascular Function and Respiratory Function
The aim of this randomized controlled study is to explore the hypoalgesic response of a 6 minutes of intermittent static apneas training session at low lung volume in healthy subjects; also, as secondary objectives, to analyze…
- Conditions
- Pain, Hypoxia, Hypercapnia, Apnea
- Trial name
- NCT06158256
- Testing
- Voluntary apnoea
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centro Universitario La Salle
Diastolic Dysfunction
MitoQ Supplementation and Cardiovascular Function in Healthy Men and Women
In this pilot study, the investigators will determine whether supplementation with a mitochondrial-targeted antioxidant (Mitoquinone (MitoQ)) improves mitochondrial function, left ventricular diastolic and vascular function.
- Trial name
- NCT03586414
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Cardiac Arrhythmia, Blood Pressure
The Effect of Energy Drink Ingredients on Cardiovascular Function in Men and Women 18-39 Years Old
1. Statement of the research question: Does the caffeine in energy drinks interact with other ingredients to affect cardiovascular function in healthy male and female adults after exercise? 2.
- Trial name
- EEDICF (NCT04149717)
- Testing
- Energy Drink Ingredients and Exercise
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Duquesne University
Mechanical Ventilation
Acute Effects of Open and Closed Suction Systems in Mechanically Ventilated Patients
Seventy-one patients in intensive care were randomized for initial treatment with open suction systems or closed suction systems in a cross-over design.
- Trial name
- NCT03256214
- Testing
- Closed suction system, Open suction system
- Volunteers
- 71 people
- Sponsor
- University of Sao Paulo
Reduction of Blood Pressure in Hypertensive Patients., Improvement of Cardiovascular Autonomic Control.
Effects of Inspiratory Muscle Training on Cardiovascular Function in Hypertension.
The purpose of this study is to determine inspiratory muscle training effects on blood pressure, functional capacity and quality of life in hypertensive patients.
- Conditions
- Reduction of Blood Pressure in Hypertensive Patients., Improvement of Cardiovascular Autonomic Control., Improvement of Functional Capacity., Improvement of Quality of Life.
- Trial name
- TREMVEN (NCT01250444)
- Testing
- Inspiratory Muscle Training
- Where
- Brazil
- Volunteers
- 14 people
- Sponsor
- Federal University of Health Science of Porto Alegre
Type 2 Diabetes
Evaluating the Effects of a Study Medication on Exercise Function in Type 2 Diabetes
People who are overweight or who have type 2 diabetes mellitus (T2DM) have higher levels of certain fats in their blood. The blood vessels and heart of most of these individuals do not work normally and people with T2DM also have…
- Trial name
- AcT2 (NCT01580813)
- Testing
- Acipimox
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Colorado, Denver
Airway Disease
Nitrate Supplementation During Final Examination Stress
The purpose of the present study is to explore the effects of a dietary nitrate supplement on immunity, mood, cardiovascular activity, and lung function during and following final exam stress in both healthy and asthmatic…
- Trial name
- NCT03159273
- Testing
- Beetroot Juice Group
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Southern Methodist University