Clinical trials: Cardiovascular Physiological Phenomena
n-3 Polyunsaturated Fatty Acids
N-3 Polyunsaturated Fatty Acids Enriched Chicken Meet and Cardiovascular Function
Evidence from multiple experimental, epidemiological, and clinical studies indicate that n-3 polyunsaturated fatty acids (n-3 PUFAs) may exert their cardiovascular (CV) protective effect, at least in part, by improving vascular…
- Trial name
- NCT05725486
- Testing
- N-3 PUFAs Chicken Meet, Regular Chicken Meet
- Where
- Croatia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Obesity, Pre-hypertension
Whole Body Vibration Combined With L-citrulline Supplementation on Cardiovascular Function and Body Composition
Arterial dysfunction contributes to the development of cardiovascular disease (CVD), which is currently afflicting millions of individuals.
- Conditions
- Obesity, Pre-hypertension, Hypertension
- Trial name
- NCT02143817
- Testing
- L-citrulline supplementation, Whole Body Vibration Training
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Florida State University
n-3 Polyunsaturated Fatty Acids, Selenium
Enriched QUARTET® Hen Eggs and Cardiovascular Function
Role of oxidative stress in the development of cardiovascular diseases is well known and extensively investigated, because of its direct effects on vascular function, but also on the activation of the immune response.
- Conditions
- n-3 Polyunsaturated Fatty Acids, Selenium, Vitamin E, Lutein
- Trial name
- NCT04564690
- Testing
- QUARTET® hen eggs (enriched in n-3 PUFA, selenium, vitamin E and lutein), Regular hen eggs
- Where
- Croatia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Cardiac Arrhythmia, Blood Pressure
The Effect of Energy Drink Ingredients on Cardiovascular Function in Men and Women 18-39 Years Old
1. Statement of the research question: Does the caffeine in energy drinks interact with other ingredients to affect cardiovascular function in healthy male and female adults after exercise? 2.
- Trial name
- EEDICF (NCT04149717)
- Testing
- Energy Drink Ingredients and Exercise
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Duquesne University
Pain, Hypoxia
Effects of Walking Apnea at High Lung Volume on Hypoalgesia, Cardiovascular Function and Respiratory Function
The aim of this randomized controlled study is to explore the hypoalgesic response of a 6 minutes of intermittent walking apneas training session at high lung volume in healthy subjects; also, as secondary objectives, to analyze…
- Conditions
- Pain, Hypoxia, Hypercapnia, Apnea
- Trial name
- NCT06158282
- Testing
- Voluntary apnoea
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centro Universitario La Salle
Sleep Disorders, Circadian Rhythm
Circadian Phase Adjustment and Improvement of Metabolic Control in Night Shift Workers
EuRhythDia II is a multicenter, randomized, double-blind controlled study. The rationale of EuRhythdia is to explore the effects of 12 weeks of timed melatonin treatment on circadian rhythm, metabolic control and cardiovascular…
- Trial name
- NCT02108353
- Testing
- Melatonin 2mg
- Where
- 3 sites in Germany, Italy
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Cardiovascular Function in EMTs
Vascular Function and Oxidative Stress in Emergency Medical Responders
The goal of this clinical trial is to characterize blood vessel function and oxidative stress (a harmful condition that damages cells and tissues) in emergency medical technicians (EMTs).
- Trial name
- VF-EMT (NCT06985394)
- Testing
- Antioxidant cocktail
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Obesity
Beige Fat, Energy, and the Natriuretic Peptide System
Obese individuals experience an increased risk of cardiovascular and metabolic diseases. Evidence from genetic studies indicate that the natriuretic peptide (NP) system may protect against these diseases.
- Trial name
- NCT04357964
- Where
- 2 sites in United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Obesity, Diabetes Mellitus, Type 2
School-Based Program On Metabolic Disease
Mexico occupies the first place worldwide in childhood obesity. Its urban and indigenous communities present different levels of westernization which have triggered different epidemiological diseases.
- Conditions
- Obesity, Diabetes Mellitus, Type 2, Cardiovascular Function, Kidney Diseases
- Trial name
- NCT03768245
- Testing
- Health Education and Physical activity program, Nutrition Program
- Where
- Mexico
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado
Cardiovascular Function, Cardiorespiratory Fitness
Effects of Exercise Snacks and Sprint Interval Training in Overweight Adults
Exploring the efficacy and acceptability of exercise snacks (ES) and sprint interval training (SIT) could provide time-efficient, low-barrier alternatives for individuals, especially those who, due to 'lack of time, environment…
- Trial name
- NCT06849453
- Testing
- Exercise snacks group, Sprint interval training group
- Where
- China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Beijing Sport University
Metabolic Syndrome
Ketone Esters for Appetite, Cognition, and Cardiovascular Function in Individuals With Obesity and Insulin Resistance
The goal of this single-blind randomized placebo-controlled trial is to test the effects of an oral ketone supplement on appetite, cognition, metabolism, and cardiovascular function in individuals with obesity and insulin…
- Trial name
- NCT05651243
- Testing
- Ketone Ester Supplement
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Southern Mississippi
Healthy
The Effects of Low Dose Ketamine on Cardiovascular Function
Low dose ketamine is used for pain management and for the treatment of anxiety and depression. Prior studies on low dose ketamine have noted short-term (minutes to hours) increases or decreases in blood pressure.
- Trial name
- NCT04429685
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Periodontal Disease, Atherosclerosis
Assess the Effect of Treating Periodontal Disease on Cardiovascular Function in Young Adults
We propose to examine a population of Native Americans who have had little or no dental care, and to determine if periodontal disease is associated with early signs of vascular dysfunction or systemic inflammation.
- Trial name
- NCT01376791
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Cardiovascular Function, Gene Expression
Effect of a Polyphenol-rich Cocoa Extract on Peripheral Blood Mononuclear Cells Gene Expression
It has been evidenced that chocolate and cocoa consumption increase vasodilation and reduce blood pressure. However, the mechanisms implicated in these effects have not been elucidated yet.
- Trial name
- NCT01681394
- Testing
- Polyphenol-rich cocoa extract, Chocolate cream
- Where
- Spain
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Technological Centre of Nutrition and Health, Spain
Aging, Blood Pressure
Coconut Sugar Lowers Blood Pressure and Arterial Stiffness in Middle-aged and Older Adults
The goal of this intervention is to determine the efficacy of coconut sap powder (CSP) to lower arterial stiffness and blood pressure in middle-aged and older adults.
- Conditions
- Aging, Blood Pressure, Arterial Stiffness
- Trial name
- NCT05645991
- Testing
- Coconut Sap Powder (CSP)
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Ball State University
Type 2 Diabetes
Effect of Aerobic Interval Training on Cardiovascular Function in Type 2 Diabetes
The study objectives are: 1. To compare cardiovascular function in type 2 diabetes patients vs. healthy controls. 2. To compare the effect of 8 weeks of aerobic interval training versus continuous moderate exercise on…
- Trial name
- NCT01883258
- Testing
- High intensity aerobic interval training, Continuous moderate intensity exercise
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- University of Florida
Early Menopause, Menopause
Influence of Early Menopause on Sympathetic Activation and Cardiovascular Function in Older Women
Women who enter menopause early are at a greater risk for developing cardiovascular disease later in life as compared to women with normal onset of menopause.
- Trial name
- NCT03692572
- Testing
- Nitrate supplementation
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Women, Aging
Beta3-adrenergic Receptors and Cardiovascular Function in Aging Women
To determine if vascular beta3 adrenergic receptors are present and functional in aging women and can be targeted to attenuate sympathetic vasoconstriction and enhance vascular function in aging women.
- Conditions
- Women, Aging, Menopause
- Trial name
- NCT07674680
- Testing
- Gemtesa
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Pain, Hypoxia
Effects of Static Apnea at Low Lung Volume on Hypoalgesia, Cardiovascular Function and Respiratory Function
The aim of this randomized controlled study is to explore the hypoalgesic response of a 6 minutes of intermittent static apneas training session at low lung volume in healthy subjects; also, as secondary objectives, to analyze…
- Conditions
- Pain, Hypoxia, Hypercapnia, Apnea
- Trial name
- NCT06158256
- Testing
- Voluntary apnoea
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centro Universitario La Salle
Single-ventricle, Fontan Circulation
Venous Compression in Fontan
The aim of this study is to investigate whether venous compression garments increase exercise stroke volume in patients with Fontan circulation. To address this aim, we will test the following hypotheses: 1.
- Trial name
- NCT07220226
- Testing
- Lower extremity compression garments, Without compression garments
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center