Clinical trials: Cardiovascular Morbidity
Diabetic Kidney Disease
Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and the Clinical Diagnosis of Diabetic Kidney Disease
The purpose of this study was to evaluate whether oral finerenone (study drug), in addition to standard daily therapy, is effective and safe in treating patients with type 2 diabetes mellitus and diabetic kidney disease, when…
- Trial name
- FIGARO-DKD (NCT02545049)
- Testing
- Finerenone (BAY94-8862)
- Where
- 975 sites in United States, Argentina and 46 more
- Volunteers
- 7,352 people
- Sponsor
- Bayer
Coronary Artery Disease
TEAM-Project: Trial on the Effect of Anesthetics on Morbidity and Mortality
Volatile anesthetics may provide some protection from myocardial ischemia, an effect called anesthetic preconditioning. In patients undergoing coronary artery bypass surgery, this preconditioning effect resulted in better cardiac…
- Trial name
- NCT00286585
- Testing
- Inhalational anesthetic, Intravenous anesthetic, propofol
- Where
- 3 sites in Switzerland
- Volunteers
- 385 people
- Sponsor
- University Hospital, Basel, Switzerland
Shock, Sepsis
Single Dose Enteral Tranexamic Acid in Critically Ill Patients
The premise of this study is that enteral tranexamic acid will help to maintain small bowel integrity, which is often compromised by critical illness due to inadequate cardiovascular perfusion (i.e., shock), and that maintenance…
- Conditions
- Shock, Sepsis, Hypotension, Critical Illness
- Trial name
- NCT01683747
- Testing
- Tranexamic Acid, Control Intervention (Carrier fluid only)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- San Diego Veterans Healthcare System
Periodontitis, Adult
Effects of Antibiotic Therapy on the Short and Long-term Results of Periodontitis Treatments
Antibiotics are currently used in periodontology to specifically target the most pathogenic bacteria in subgingival biofilms and to improve treatments.
- Trial name
- PERIODONTITIS (NCT05065034)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Strasbourg, France
Hyperglycaemia (Non Diabetic), Enteral Feeding Intolerance
Hyperglycemia in Patients with Stroke and Indication of Enteral Nutrition
The purpose of this study is to evaluate the effect of a specific nutritional formula for diabetics on the development of hyperglycemia in patients with recent non-diabetic stroke who require admission and enteral nutritional…
- Conditions
- Hyperglycaemia (Non Diabetic), Enteral Feeding Intolerance, Stroke
- Trial name
- GlyENStroke (NCT03422900)
- Testing
- Diabetes-Specific enteral formula, Standard formula
- Where
- Spain
- Volunteers
- 52 people
- Sponsor
- Endocrinology and Clinical Nutrition Research Center, Spain
Carotid Atherosclerosis, Regional Anaesthesia Morbidity
Ultrasound-guided Intermediate Cervical Block Versus Superficial Cervical Block for Carotid Endarterectomy (CERVECHO)
The aim of this prospective, randomised, controlled study is to compare the efficacy of ultrasound-guided intermediate cervical block to superficial block for carotid endarterectomy.
- Trial name
- CERVECHO (NCT01742845)
- Testing
- Ultrasound-guided administration of ropivacaine 4.75 mg/ml, landmark based superfical ropivacaine 4.75 mg/ml injection
- Where
- France
- Volunteers
- 86 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Stroke
Akershus Early Mobilisation in Stroke Study
Treatment in stroke units compared with treatment in general medical wards reduces the odds of being dead or disabled. Little is known about which components of acute stroke care that is responsible for this benefit.
- Trial name
- AKEMIS (NCT00832351)
- Testing
- Mobilisation
- Where
- Norway
- Volunteers
- 65 people
- Sponsor
- University Hospital, Akershus
Pregnancy Complications, Pregnancy, High Risk
Active Pregnancy Against COVID-19
Historically and traditionally, the recommendations related to physical exercise during pregnancy have been based more on moral or cultural issues than on scientific evidence.
- Conditions
- Pregnancy Complications, Pregnancy, High Risk, Pregnancy Induced Hypertension, Newborn Morbidity
- Trial name
- ACPREGCOV (NCT04563065)
- Testing
- Exercise program, Healthy lifestyle advise
- Where
- 2 sites in Spain
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Universidad Politecnica de Madrid
Hyperthyroidism, Cardiovascular Diseases
Follow-up Study of the RAI-Treated Hyperthyroid Patients
Previous studies of hyperthyroid patients suggest that they remain at increased risk of cardiovascular morbidity after restoring euthyroidism.
- Conditions
- Hyperthyroidism, Cardiovascular Diseases, Atrial Fibrillation
- Trial name
- NCT00471458
- Where
- Finland
- Volunteers
- 5,222 people
- Sponsor
- Tampere University
Chest Wall Tumor, Breast Cancer
Pharmacologic Therapies to Mitigate Radiation- Associated Heart Disease
Radiation therapy is an essential treatment for tumors in the chest area, including breast, lung, esophageal, mediastinal cancers, and spine metastases.
- Conditions
- Chest Wall Tumor, Breast Cancer, Lung Cancer, Esophageal Cancer
- Trial name
- NCT07685938
- Testing
- Atorvastatin and Lisinopril
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Hypertension, Ischemic Heart Disease
A Morbidity-Mortality and Remodeling Study With Valsartan
The JIKEI HEART Study has been designed to investigate whether concomitant treatment with valsartan, an angiotensin II receptor blocker (ARB), in addition to conventional treatment, will improve the prognosis of 3000 Japanese…
- Conditions
- Hypertension, Ischemic Heart Disease, Congestive Heart Failure
- Trial name
- NCT00133328
- Testing
- valsartan
- Where
- Japan
- Volunteers
- 3,000 people
- Sponsor
- Jikei University School of Medicine
Asthma
The Effect of Long Term Inhaled Corticosteroids on the Risk of Cardiovascular Morbidities
Cardiovascular disease is a major cause of morbidity and mortality worldwide. It is the second leading cause of death in Hong Kong. The disease burden is huge and effective control measures should target at prevention level.
- Trial name
- NCT00959257
- Where
- 4 sites in Hong Kong
- Volunteers
- 1,394 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Heart Failure
GISSI-HF- Effects of n-3 PUFA and Rosuvastatin on Mortality-Morbidity of Patients With Symptomatic CHF
INTRODUCTION While pharmacological treatments specifically targeted to the cardio-circulatory system have been largely investigated, scanty controlled data are available concerning the role of dietary and metabolic approaches in…
- Trial name
- NCT00336336
- Testing
- n-3 PUFA, Rosuvastatin
- Where
- 337 sites in Italy, Switzerland
- Volunteers
- 6,975 people
- Sponsor
- Gruppo di Ricerca GISSI
Brain Injuries, Congenital Heart Disease
Protecting Brains and Saving Futures - the PBSF Protocol
Background: Multiple neonatal disorders are associated with risks of neurological injury. Thus, management of these infants should involve a coordinated approach to permit early diagnosis with improved clinical care.
- Conditions
- Brain Injuries, Congenital Heart Disease, Newborn Morbidity, Intraventricular Hemorrhage
- Trial name
- PBSF (NCT03786497)
- Where
- 2 sites in Brazil
- Volunteers
- 2,268 people
- Sponsor
- Protecting Brains Saving Futures
Hypertension in Pregnancy, Obstetrical Complications
Gestational Hypertension and Preeclampsia Blood Pressure (BP) Treatment Goals Less Than 140/90 vs. Less Than 160/110 mmHg: The GOALPOST Trial
This is a phase-III multi-center open-label randomized clinical trial of 4,120 individuals between 23 weeks, 0 days and 35 weeks, 6 days gestation with gestational hypertension or preeclampsia without severe features randomized…
- Trial name
- GOALPOST (NCT07746271)
- Testing
- Anti-hypertensive medication titrated to a BP goal of <140/90 mmHg, Usual Care: Anti-hypertensive medication for BP ≥160/110 mmHg titrated to a goal of < 160/110 mmHg
- Where
- 14 sites in United States
- Volunteers
- 4,120 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Heart Failure，Congestive
RELieving Increasing oEdema Due to Heart Failure
This trial will investigate the potential for patiromer-facilitated use of higher doses of mineralocorticoid antagonists in addition to standard care (compared to standard care alone) to improve congestion, well-being and…
- Trial name
- RELIEHF (NCT04142788)
- Testing
- Patiromer
- Where
- 11 sites in United Kingdom
- Volunteers
- 19 people
- Sponsor
- NHS Greater Glasgow and Clyde
Cardiovascular Disease
Tolerance of "on Line" Hemodiafiltration in Chronic Renal Failure Patients
The aim of this study is to appreciate the tolerance of "on line" hemodiafiltration and its impact on morbidity and cardiovascular risk factors in chronic renal failure patient.
- Trial name
- on-line-HDF (NCT01327391)
- Testing
- On line Hemodiafiltration, Hemodialysis
- Where
- France
- Volunteers
- 415 people
- Sponsor
- University Hospital, Montpellier
Cardiovascular Mortality
Factors Influencing Cardiovascular Prognosis
The purpose of this study is to identify risks for cardiovascular events in a follow up period of 10 years.
- Trial name
- Pythia-GR (NCT00973206)
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Prostate Cancer, Metabolic Syndrome
Akkermansia Muciniphilia and Metabolic Side Effects of ADT
The overriding objectives of this study are: 1. Primary outcomes: 1. To confirm that administration of oral acetate increases the proportion of A.
- Conditions
- Prostate Cancer, Metabolic Syndrome, Obesity, Cardiovascular Morbidity
- Trial name
- NCT05802121
- Testing
- Apple Cider Vinegar
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Western University
Microcirculation
Evaluation of Different Priming Solutions Effects on Microcirculation, Oxidative Stress and Morbidity in Cardiovascular Surgery Patients
Single-centre prospective randomized study will be included the patients who undergo elective cardiovascular surgery. Preoperative fluid deficit will be calculated by the formula as starvation period X 4 X weight.
- Trial name
- Acibadem (NCT02501681)
- Testing
- priming solution during cardiovascular surgery
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Frisius Medisch Centrum