Clinical trials: Cardiovascular Function
Obesity
Whole Body Vibration and External Load Exercise Training on Cardiovascular and Autonomic Function in Obese Individuals
Obesity is directly related to arterial dysfunction and negatively associated to muscle strength. High-intensity resistance exercise is the favored modality to offset muscle weakness, yet, adverse effects on arterial function…
- Trial name
- NCT02679898
- Testing
- Unloaded-Whole Body Vibration (WBVT), Loaded-Whole Body Vibration (WBVT)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Florida State University
Atherosclerotic Cardiovascular Diseases, Endothelial Dysfunction
TB-500 (Thymosin Beta 4 17-23 Fragment) for Cardiovascular Biomarkers in Stable ASCVD
This fictional study is an example of a ClinicalTrials.gov-style record. It describes a Phase 1/2 trial evaluating the safety and tolerability of TB-500 (a 17-23 fragment of thymosin beta 4) versus placebo in adults with stable…
- Trial name
- TBRIDGE-CV (NCT07487363)
- Testing
- TB-500
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Hudson Biotech
Stroke
Mirror Therapy Versus PNF on LE Function in Stroke
Many rehabilitation strategies are being implemented to treat stroke. Constraint-induced movement therapy and robotics are two potentially useful treatment options for rehabilitation.
- Trial name
- NCT05948384
- Testing
- PNF
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Cognitive Impairment, Stroke
Strategy Training on Improving Executive Functions in Persons Following Acquired Brain Injury
About two-third individuals with acquired brain injury (ABI) experience cognitive impairments. Deficits in executive functions is one of the most prevalent cognitive impairments following ABI which result in decline of recovery…
- Conditions
- Cognitive Impairment, Stroke, Acquired Brain Injury
- Trial name
- NCT04033952
- Testing
- Strategy Training
- Where
- 3 sites in Taiwan
- Volunteers
- 180 people
- Sponsor
- Taipei Medical University
Stroke
Effectiveness of Soft Robotic Glove Versus EMS on Hand Function and Quality of Life in Stroke Survivors (RCT)
This study will evaluate the effectiveness of soft robotic gloves versus electrical muscle stimulation (EMS) in improving hand function and quality of life in stroke survivors.
- Trial name
- NCT06739733
- Testing
- SRG, EMS
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Superior University
Heart Failure
Intra-coronary Versus Intramyocardial Application of Enriched CD133pos Autologous Bone Marrow Derived Stem Cells
This is a pilot study comparing the effect of intra-coronary versus intramyocardial application of enriched CD133pos autologous bone marrow derived stem cells for improving left ventricular function in chronic ischemic…
- Trial name
- AlsterMACS (NCT01337011)
- Testing
- autologous CD133pos stem cell application
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Asklepios proresearch
Heart Failure
Study to Evaluate the Safety, Tolerability and Pharmacokinetics of AMG 986 Administered Orally to Healthy Volunteers and Participants With Severely Impaired Renal Function
A study to assess the safety, tolerability, and pharmacokinetics of AMG 986 given orally as a single dose to healthy participants and participants with severely impaired kidney function.
- Trial name
- NCT03318809
- Testing
- AMG 986
- Where
- 4 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Amgen
Endothelial Dysfunction
Combustion Derived Air Pollution and Vascular Function
Air pollution is a major cause of cardiovascular morbidity and mortality. The components of air pollution responsible and the mechanisms through which they might mediate these harmful effects remain only partially understood.
- Trial name
- NCT00775099
- Testing
- Forearm Vascular Study, Badimon Chamber
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Transcatheter Aortic Valve Implantation, Physiological Pacing
Physiological vs Right Ventricular Pacing in Patients With Normal Ventricular Function Post-TAVI
Single-center randomized trial in patients with pacing indication (AV block) after TAVI (transfemoral aortic valve implantation) and LVEF> 50%, that aims to study the percentage of patients who improve at 12 months in a combined…
- Conditions
- Transcatheter Aortic Valve Implantation, Physiological Pacing, Right Ventricular Pacing, AV Block
- Trial name
- PHYS-TAVI (NCT04482816)
- Testing
- Physiological pacing, Right ventricular pacing
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- Josep Lluis Mont Girbau
Stroke
Tele-Rehabilitation Study for People With a History of Stroke
Stroke results in long-term disability for many people, and particularly for survivors of stroke who have cognitive impairments.
- Trial name
- NCT02724813
- Testing
- Cognitive Orientation to Occupational Preformance (COOP)
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Baycrest
Psoriasis, Psoriatic Arthritis
SystemIc iNflammation and Microvascular diSease PreventIon in psoRiatic diseasE
This is a single-label open-arm mechanistic clinical study recruiting patients with psoriasis or psoriatic arthritis with elevated cardiovascular risk.
- Conditions
- Psoriasis, Psoriatic Arthritis, Cardiovascular Risk Factor
- Trial name
- INSPIRE (NCT04417114)
- Testing
- Rosuvastatin
- Sponsor
- Brigham and Women's Hospital
HIV, Acquired Immunodeficiency Syndrome
Evaluating an Exercise Program to Reduce Cardiovascular Risk Factors in Children Infected With HIV
People infected with HIV are now living longer lives because of the use of highly active antiretroviral therapy (HAART). However, HAART medications have been shown to increase the risk of cardiovascular disease and metabolic…
- Conditions
- HIV, Acquired Immunodeficiency Syndrome, Cardiovascular Diseases
- Trial name
- NCT00908284
- Testing
- Exercise Program, Control Group
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Miami
Acute Heart Failure With Reduced Ejection Fraction, Decompensation; Heart, Congestive
The FOCUS-ADHF Registry
Acute heart failure (AHF) represents a significant clinical and economic burden due to its impact on patients' quality of life, poor prognosis, and high healthcare costs.
- Conditions
- Acute Heart Failure With Reduced Ejection Fraction, Decompensation; Heart, Congestive, Regurgitation, Mitral
- Trial name
- FOCUS-ADHF (NCT06726109)
- Where
- 4 sites in Belgium, Italy
- Volunteers
- 600 people
- Sponsor
- ASL Città di Torino
Acute Coronary Syndrome
Comparison of Ticagrelor vs. Prasugrel on Inflammation, Arterial Stiffness, Endothelial Function, and Circulating Endothelial Progenitor Cells in Diabetic Patients With Non-ST Elevation Acute Coronary Syndrome (NSTE-ACS) Requiring Coronary Stenting
To investigate pleiotropic effects of ticagrelor in addition to its antiplatelet effects in type 2 diabetic patients with non-ST elevation acute coronary syndrome by measuring inflammatory markers, circulating number of…
- Trial name
- NCT02487732
- Testing
- Ticagrelor, Prasugrel
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Korea University Anam Hospital
Pulmonary Hypertension
The Study Of CT Scans and Echo Parameters in Patients With PAH
Current standard of the diagnosis and monitoring of PHNT requiring combination of invasive and non-invasive tests. The goal of the study is to correlate data from CT scans, echocardiograms, right heart catheterization, PFTs…
- Trial name
- NCT00625963
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Northwell Health
Stroke, Stroke Rehabilitation
COMPERATIVE EFFECTS of CONSTRAINT- INDUCED MOVEMENT THERAPY and MIRROR THERAPY on FUNCTIONAL AMBULATION and QUALITY of LIFE in CHRONIC STROKE PATIENTS
Stroke is a global health issue as this happens when the blood flow to the brain is disrupted or reduced, depriving the brain tissue of sugar and oxygen.
- Conditions
- Stroke, Stroke Rehabilitation, Mirror Therapy, Quality of Life (QOL)
- Trial name
- NCT06807814
- Testing
- Constraint-Induced Movement Therapy (CIMT)), Mirror Therapy
- Where
- Pakistan
- Volunteers
- 56 people
- Sponsor
- University of Lahore
Diastolic Heart Failure
Pedometer-Based Walking Intervention in Patients With Chronic Heart Failure With Preserved Ejection Fraction
A multicenter randomized controlled trial, with follow-up at 6 and 12 months. Physically inactive participants with chronic heart failure with preserved or mid-range ejection fraction will be randomly assigned to intervention or…
- Trial name
- NCT03041376
- Testing
- Walking intervention
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- Charles University, Czech Republic
Heart Failure - NYHA II - IV, Left Bundle Branch Area Pacing
REstoration of SYNChronous Cardiac Function Due to Physiologic cArdiac Pacing Modalities With Clinical Endpoints
The goal of this observational study is to evaluate the long-term clinical outcomes of physiologic cardiac resynchronization therapy (CRT) using conduction system pacing strategies compared with conventional biventricular CRT in…
- Conditions
- Heart Failure - NYHA II - IV, Left Bundle Branch Area Pacing, Left Bundle Branch Block, Intraventricular Conduction Delay
- Trial name
- RESYNC-PACE (NCT07684547)
- Testing
- Physiologic cardiac resynchronization using conduction system pacing and selective LV lead optimization.
- Where
- Hungary
- Volunteers
- 50 people
- Sponsor
- University of Pecs
Arthritis, Rheumatoid, Spondylitis, Ankylosing
Heart Function in Rheumatoid Arthritis and Ankylosing Spondylitis Pre and Post-TNF Blocker
The purpose of this study is to determine possible alterations in cardiac function in patients with Rheumatoid Arthritis and Ankylosing Spondylitis under anti-TNF therapy, without clinical heart disfunction at baseline, using…
- Trial name
- NCT01072058
- Testing
- TNF blockers (infliximab, adalimumab, etanercept)
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- University of Sao Paulo
Hypercholesterolemia
Replacement of Saturated Fat in Dairy on Total Cholesterol
The consumption of milk and dairy products is recognised as an essential part of a healthy diet as it represents an important source of key micro- and macronutrients.
- Trial name
- RESET (NCT02089035)
- Testing
- MUFA-rich dairy products (UHT milk, cheese and butter), Conventional dairy products (UHT milk, cheese, butter)
- Where
- United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Reading