Clinical trials: Cardiovascular Function
HIV-1-infection, Metabolic Syndrome
Assessing Virologic Success and Metabolic Changes in Patients Switching From a TDF to TAF Containing Antiretroviral Therapy Regimen
Switching patients with HIV infection from tenofovir disoproxil fumarate (TDF) to a tenofovir alafenamide (TAF) based drug regimen can provide many safety benefits including preserving bone mineral density and kidney function.
- Conditions
- HIV-1-infection, Metabolic Syndrome, Cardiovascular Diseases, Weight Gain
- Trial name
- NCT03646370
- Testing
- Tenofovir Alafenamide
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Thomas Jefferson University
Obesity, Diabetes Mellitus, Type 2
School-Based Program On Metabolic Disease
Mexico occupies the first place worldwide in childhood obesity. Its urban and indigenous communities present different levels of westernization which have triggered different epidemiological diseases.
- Conditions
- Obesity, Diabetes Mellitus, Type 2, Cardiovascular Function, Kidney Diseases
- Trial name
- NCT03768245
- Testing
- Health Education and Physical activity program, Nutrition Program
- Where
- Mexico
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado
Menopause, Cardiac Function Impaired
Effects of Exercise Training on Cardiovascular Health in Middle-aged Women
The hypothesis of the present study is that physical training can oppose detrimental changes in cardiovascular and metabolic health associated with estrogen loss after menopause.
- Conditions
- Menopause, Cardiac Function Impaired, Cardiovascular Diseases, Blood Platelet Disorders
- Trial name
- NCT02135575
- Testing
- Spinning
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Metabolic Disease, Immune Function
Omega 3 and Fibre Intervention Study to Improve Metabolic Health
Metabolic syndrome represents a major health burden worldwide affecting 20-30% of the population. This clustering of abnormalities that confers an increased risk of cardiovascular disease and type 2 diabetes mellitus, is the…
- Conditions
- Metabolic Disease, Immune Function, Cardiovascular Diseases, Systemic Inflammation
- Trial name
- NCT03442348
- Testing
- Omega 3 fatty acid, Inulin fibre
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Body Composition, Visceral Obesity
Dysfunctional Adiposity and Glucose Impairment
This is a large and comprehensively phenotyped cohort with fasting glycaemia where the predictive value of body composition and anthropometric measures of total and central fat distribution for postprandial carbohydrate…
- Conditions
- Body Composition, Visceral Obesity, Carbohydrate Intolerance, Obesity, Abdominal
- Trial name
- DICAMANO (NCT03506581)
- Volunteers
- 853 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Cardiovascular Function
Investigation of the Influence of Gender on Cardiovascular Function
Inflammation is a key initiating and damaging factor in many illnesses including infection, arthritis and cancer but also of particular relevance to this study in diseases of the heart and blood vessels (i.e.
- Trial name
- NCT01582321
- Testing
- Typhoid vaccine, Cantharidin
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Sleep Apnea, Obstructive, Continuous Positive Airway Pressure
Endothelial Dysfunction, Monocyte Activation, and Vasculopathy in Patients With Obstructive Sleep Apnea (OSA) and Effect of 6-month CPAP Treatment
This purpose of this study is to 1. Determine the change in endothelial dependent vascular reactivity and vascular properties 2. Determine the changes in monocytes activation 3. Determine the change in pro-inflammatory status 4.
- Conditions
- Sleep Apnea, Obstructive, Continuous Positive Airway Pressure, Endothelium, Inflammation
- Trial name
- NCT01312168
- Testing
- Therapeutic CPAP, Subtherapeutic CPAP
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Female Infertility Due to Diminished Ovarian Reserve, Menopausal Syndrome
Cohort Study to Evaluate Ovarian Function
The study will collect the clinical and biological data of the patients, the investigators could further analyse and identify the risk factors and optimize clinical treatment method.
- Conditions
- Female Infertility Due to Diminished Ovarian Reserve, Menopausal Syndrome, Sexual Function and Fertility Disorders, Cardiovascular Diseases
- Trial name
- NCT02294500
- Where
- China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Shixuan Wang
Cardiovascular Disease Risk in HIV Patients, Endothelial Function
Cardiovascular Risk in HIV Patients on Antiretroviral Therapy Therapy: The MHEART Study
CVD accounts for 15% of all deaths in Malawi. Both HIV and ART are risk factors for CVD through direct toxic and inflammatory cardiovascular effects. (44,45).
- Trial name
- MHEART (NCT02401269)
- Testing
- Aspirin
- Where
- Malawi
- Volunteers
- 91 people
- Sponsor
- University of Pittsburgh
Cardiovascular Disease, Endothelial Function
Olive Oil and Cardiovascular Health
The purpose of this study is to conduct a double-blind, randomized controlled trial (RCT), to determine if six month supplementation of olive oil can improve the health of the blood vessels and improve long term health of the…
- Trial name
- NCT01983943
- Testing
- Hydroxytyrosol, the active ingredient in olive oil., Nutrition counseling, Endopat
- Where
- United States
- Sponsor
- Mayo Clinic
Cardiovascular Health, Immune Function
Effects of the Consumption of California Walnuts on Cardiovascular Health
The purpose of this study is to determine the effects of the 4-week consumption of California walnuts on vascular function and immune health in postmenopausal women of ages 50-70.
- Trial name
- NCT01235390
- Testing
- Walnuts
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Cardiovascular Function, Gene Expression
Effect of a Polyphenol-rich Cocoa Extract on Peripheral Blood Mononuclear Cells Gene Expression
It has been evidenced that chocolate and cocoa consumption increase vasodilation and reduce blood pressure. However, the mechanisms implicated in these effects have not been elucidated yet.
- Trial name
- NCT01681394
- Testing
- Polyphenol-rich cocoa extract, Chocolate cream
- Where
- Spain
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Technological Centre of Nutrition and Health, Spain
Triglyceride Metabolism, Cardiovascular Function
Ability of Grape Seed Proanthocyanidins to Reduce Postprandial Triglycerides in Humans
Grape seed proanthocyanidins have been reported to possess a hypotriglyceridemic effect after an acute or chronic consumption in rodents.
- Trial name
- NCT01688154
- Testing
- 35 mg/Kg of grape seed proanthocyanidins extract (2 capsules), 2 empty capsules
- Where
- 2 sites in Spain
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Technological Centre of Nutrition and Health, Spain
Endothelial Dysfunction, Endothelial Function
Cycling, Air Pollution and Health
Introduction: Cycling is currently promoted at the municipal, provincial and national level as a form of active transportation that increases physical activity while at the same time reducing traffic congestion, traffic-related…
- Conditions
- Endothelial Dysfunction, Endothelial Function, Cardiovascular Physiological Phenomena
- Trial name
- CAPaH (NCT01708356)
- Testing
- Cycling on a residential route
- Where
- Canada
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Cardiovascular Mortality, Cardiac Function
Intervention With Selenium and Q10 on Cardiovascular Mortality and Cardiac Function in the Elderly Population in Sweden
The dietary supplements selenium and Q10 has been evaluated in a double blind placebo-controlled study in an elderly Swedish population.
- Trial name
- KiSel-10 (NCT01443780)
- Testing
- Selenium and ubiquinon (Q10) combined
- Where
- Sweden
- Volunteers
- 443 people, healthy volunteers welcome
- Sponsor
- University Hospital, Linkoeping