Clinical trials: Cardiovascular Diseases (CVD)
Coronary Artery Disease, Diabetes
Clinical Trial of Abluminus DES+ Sirolimus Eluting Stent Versus Everolimus-eluting DES
The objective of the study is to compare angiographic and clinical performance of Abluminus DES+ versus Everolimus-eluting DES in patients with diabetes mellitus.
- Trial name
- NCT03399994
- Testing
- device implantation during coronary angioplasty
- Where
- 6 sites in Italy
- Volunteers
- 137 people
- Sponsor
- Fondazione Evidence per Attività e Ricerche Cardiovascolari ONLUS
Heart Failure
Treating Heart Failure With hiPSC-CMs
Heart failure has a high morbidity and mortality because the heart is one of the least regenerative organs in the human body. Drug treatments for heart failure manage symptoms but do not restore lost myocytes.
- Trial name
- NCT05223894
- Testing
- hiPSC-CM therapy, Control
- Where
- China
- Volunteers
- 20 people
- Sponsor
- HELP Therapeutics Co., Ltd.
Heart Failure
Open-label Extension Study to Evaluate Long-term Safety of Sacubitril/Valsartan in Pediatric Patients With HF
The purpose of this study was to evaluate long-term safety and tolerability and to provide post-trial access to sacubitril/valsartan to eligible participants who successfully completed CLCZ696B2319 (PANORAMA-HF) core study Part 2…
- Trial name
- NCT03785405
- Testing
- sacubitril/valsartan
- Where
- 79 sites in United States, Argentina and 25 more
- Volunteers
- 216 people
- Sponsor
- Novartis Pharmaceuticals
Intracerebral Hemorrhage
Retrospective Study of Intracerebral Hemorrhage Patients in Hospital Parc Taulí
This is a retrospective observational study to investigate the clinical, analytical and neuroimaging data generated during routine clinical management of intracerebral hemorrhage.
- Trial name
- NCT04877405
- Testing
- No intervention
- Where
- Spain
- Volunteers
- 137 people
- Sponsor
- Universitat Autonoma de Barcelona
Stroke, Stroke Sequelae
Novel Wrist Sensor System to Promote Hemiparetic Arm Use in Home Daily Life of Chronic Stroke Survivors
The proposed study is a two-arm randomized clinical trial designed to assess the effects of the StrokeWear system on clinical outcomes over a period of 6-months in chronic stroke survivors.
- Conditions
- Stroke, Stroke Sequelae, Hemiparesis;Poststroke/CVA
- Trial name
- NCT05626894
- Testing
- StrokeWear Motor and Behavioral Intervention, Usual Care
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Spaulding Rehabilitation Hospital
Postoperative Cognitive Dysfunction, Postoperative Delirium
Neuroimaging Combining Biomarkers for Identifying Long-term Cognitive Dysfunction and Delirium
Postoperative Cognitive Dysfunction(POCD) is commonly seen in cardiac surgery, which may lead to poor pognosis. Cerebral small vessel disease(CVSD) is refer as the main resource of delirium among elderly people.
- Conditions
- Postoperative Cognitive Dysfunction, Postoperative Delirium, Cerebral Small Vessel Diseases, Covert Postoperative Stroke
- Trial name
- NeuroIDEA (NCT05594966)
- Testing
- multimodal MRI
- Where
- China
- Volunteers
- 211 people
- Sponsor
- RenJi Hospital
Abdominal Compartment Syndrome
Relation Between Intrabdominal Pressure and Collapsibility Index of Inferior Vena Cava Before and After Fluid Therapy
This study assess the relation between intra abdominal pressure and collapsibility index of inferior vena cava in emergency bedside ultrasonography before and after fluid therapy.
- Trial name
- NCT01553422
- Testing
- Fluid therapy (Saline Normal)
- Where
- Iran
- Volunteers
- 82 people
- Sponsor
- Isfahan University of Medical Sciences
Acute Ischemic Stroke
Sublingual Edaravone Dexborneol for Inter-hospital Transfer Acute Ischemic Stroke (SLEDAIS)
This is a multicenter, randomized, double-blind, placebo-controlled clinical trial (SLEDAIS) involving 1,040 patients with acute ischemic stroke (AIS) who require inter-hospital transfer for potential endovascular therapy.
- Trial name
- SLEDAIS (NCT07682922)
- Testing
- Edaravone dexborneol sublingual tablet
- Where
- China
- Volunteers
- 1,040 people
- Sponsor
- Xinqiao Hospital of Chongqing
Blood Pressure, Low Back Pain
Therapeutic Mechanisms of Epidural Spinal Cord Stimulation
The purpose of this study in patients undergoing routine care epidural spinal cord stimulation (SCS) is to determine 1) whether SCS reduces arterial blood pressure (BP) in patients which chronic low back pain and hypertension, 2)…
- Conditions
- Blood Pressure, Low Back Pain, Hypertension
- Trial name
- NCT05556902
- Testing
- Permanent Epidural Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Alabama at Birmingham
Ventricular Arrhythmia, Cardiomyopathies
ElectroPhySiological Characterization Of the Arrhythmia Substrate for Sudden Cardiac Death PrEdiction
EP-SCOPE is a prospective, multicentric, non-randomized pilot study that aims to estimate the risk of life-threatening ventricular arrhythmia through use of advanced electrophysiological studies in patients with ischemic or…
- Conditions
- Ventricular Arrhythmia, Cardiomyopathies, Left Ventricular Ejection Fraction Less Then or Equal to 50percent
- Trial name
- EP-SCOPE (NCT07020702)
- Testing
- Implantation of an ICD
- Where
- 3 sites in France
- Volunteers
- 210 people
- Sponsor
- University Hospital, Bordeaux
Plasma Cell Myeloma
A Prospective, Non-interventional, Multinational, Observational Study With Isatuximab in Patients With Relapsed and/or Refractory Multiple Myeloma (RRMM)
Primary Objective: To assess the effectiveness, in terms of overall response rate (ORR) of isatuximab patients with RRMM in routine clinical practice, within 12 months To assess other effectiveness parameters such as progression…
- Trial name
- IONA-MM (NCT04458831)
- Testing
- isatuximab SAR650984, Pomalidomide, Dexamethasone
- Where
- 129 sites in United States, Argentina and 19 more
- Volunteers
- 583 people
- Sponsor
- Sanofi
Coronary Artery Disease
Decision Variability Between Different Heart Teams for Complex Coronary Artery Diseases
The purposes of this study are 1) to explore the variability of decisions between different heart teams in complex coronary artery disease; 2) to evaluate the reasons of the discrepancy in decision making.
- Trial name
- NCT04217031
- Testing
- No intervention
- Where
- China
- Volunteers
- 101 people
- Sponsor
- China National Center for Cardiovascular Diseases
Obesity, Cardiovascular Diseases
Motivation Makes the Move!
This study evaluates the effect and usability of mobile and cloud technology -based intervention on lifestyle modification in 18-40 year obese and overweight subjects.
- Conditions
- Obesity, Cardiovascular Diseases, Physical Conditioning
- Trial name
- MoMaMo! (NCT02686502)
- Testing
- Lifestyle
- Where
- 2 sites in Finland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Ischemic Stroke, Carotid Stenosis
Radial Versus Femoral Access For Carotid Artery Stenting
Background: For moderate to severe carotid artery atherosclerotic stenosis, in the past decades, carotid artery stenting (CAS) has been an alternative to carotid endarterectomy (CEA) for the treatment of carotid artery stenosis.
- Conditions
- Ischemic Stroke, Carotid Stenosis, Cerebral Revascularization, Carotid Artery Diseases
- Trial name
- RACE-CAS (NCT05416853)
- Testing
- Carotid Artery Stenting (CAS)
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Coronary Heart Disease
Varenicline Versus Transdermal Nicotine Patch for Smoking Cessation in Patients With Coronary Heart Disease
The purpose of this study is to determine if a new drug, varenicline, for smoking cessation is more effective than the standard nicotine replacement therapy aide currently used, "the patch" among smokers hospitalized with…
- Trial name
- NCT00959972
- Testing
- Varenicline, Transdermal Nicotine Patch
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Psoriasis, Arthritic Psoriasis
Evaluation of Adipokines and Fat Tissue in Psoriasis and Psoriatic Arthritis
Body composition analysis and especially body fat distribution in regions of interest (android and in particular intra-abdominal region) provides some information on the risk of cardiovascular disease.
- Trial name
- ADIPSO (NCT02849795)
- Testing
- bone densitometry, questionnaires, biological analyses
- Where
- France
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Cardiovascular Diseases
Smart Wearable Insights to Prevent Exacerbations and Recurrence - Rehabilitation Study: SWIPER-REHAB
Aims of the study: To measure the rate of completion of a digital cardiac rehabilitation programme at Imperial College Healthcare NHS Trust (ICHNT) To measure the health economic impact of a digital cardiac rehabilitation…
- Trial name
- SWIPER-REHAB (NCT06011395)
- Testing
- Smartwatch, Imperial Healthy Hearts app
- Where
- United Kingdom
- Volunteers
- 1,800 people
- Sponsor
- Imperial College London
Atrial Fibrillation
The Efficacy of Single Coil Defibrillation Leads for Internal Cardioversion of Atrial Fibrillation
This study seeks to determine the efficacy of single coil defibrillation leads for cardioversion of persistent atrial fibrillation.
- Trial name
- NCT03164395
- Testing
- Internal Cardioversion, External Cardioversion
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Kentucky
Chronic Obstructive Pulmonary Disease, Pulmonary Hypertension
A Mechanistic Study of Inhaled Nitric Oxide in COPD
There is a lack of effective treatments for chronic obstructive pulmonary disease (COPD) complicated with pulmonary hypertension.
- Trial name
- NCT05785195
- Testing
- Nitric Oxide Generation and Delivery System
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Ting YANG
Anxiety, Hypertension
Anxiety-mediated Impairments in Large Elastic Artery Function and the Autonomic Nervous System
The goal of this study is to evaluate the effectiveness of a short-term (4 weeks) pharmacological blockade of sympathetic nerve activity (clonidine) on anxiety symptoms, vascular function, inflammation, muscle sympathetic nerve…
- Trial name
- ATLAS (NCT03109795)
- Testing
- Clonidine Pill, Hydrochlorothiazide
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Iowa
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