Clinical trials: Cardiovascular Biomarkers
Stroke, Acute, Gait, Hemiplegic
Biomarkers of Independent Walking Post-Stroke
Prediction of walking recovery after stroke can inform patient-centered care and support discharge planning. The accuracy of current prediction models is limited, however, due to small study designs and narrow predictors…
- Trial name
- NCT05004389
- Testing
- MRI, blood draw, Clinical assessments
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Vermont
Breast Cancer, Heart Failure
Carvedilol Effect in Preventing Chemotherapy - Induced Cardiotoxicity
The purpose of this study is to evaluate if carvedilol can prevent the cardiotoxicity after chemotherapy in breast cancer.
- Conditions
- Breast Cancer, Heart Failure, Cardiotoxicity
- Trial name
- Ceccy (NCT01724450)
- Testing
- Carvedilol
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- University of Sao Paulo
Pulmonary Embolism
Pulmonary Embolism in Pregnancy: Biomarkers and Clinical Predictive Models
Objective: To evaluate whether trimester specific d-dimer levels and brain natriuretic protein (BNP), along with the modified Wells score (MWS), is a useful risk stratification tool to exclude pregnant women at low-risk of…
- Trial name
- NCT02709174
- Testing
- blood draw
- Volunteers
- 59 people
- Sponsor
- Wake Forest University Health Sciences
Hypertension, Pregnancy-Induced
Kidney Injury Biomarkers in Preeclampsia
we found different pattern of podocyte glycoproteins and kidney injury biomarkers in urine specimens between preeclampsia and pregnancy complicated with chronic hypertention compared with normotensive pregnant controls.abnormally…
- Trial name
- NCT03217916
- Testing
- Elisa assay of podocyte glycoprotein in urine
- Volunteers
- 40 people
- Sponsor
- Woman's Health University Hospital, Egypt
Cardiovascular Diseases
Identification of New Biomarkers for the Prediction of Cardiovascular Events
The main goal of this project is to constitute a collection of biological samples, obtained through the clinical activity of the Centre for Screening and Prevention of Atherosclerosis at Toulouse University Hospital, managing…
- Trial name
- CDPA-Biobank (NCT04809506)
- Testing
- additional blood samples
- Where
- France
- Volunteers
- 1,500 people
- Sponsor
- University Hospital, Toulouse
Obstructive Sleep Apnea
Effect of CPAP on Biomarkers in Patients With OSA
CPAP, the standard treatment for Obstructive sleep apnea syndrome (OSAS) that reduces sleep fragmentations and neurocognitive deficit in OSAS may also have a key role in reduction of cardiovascular, mortality risks in the same…
- Trial name
- CPAP (NCT01138865)
- Testing
- AutoSet Spirit--Wash--Modified-AutoSet Spirit, Modified-AutoSet Spirit--Wash-AutoSet Spirit
- Where
- India
- Volunteers
- 100 people
- Sponsor
- All India Institute of Medical Sciences
Atrial Fibrillation, Insulin Resistance
Insulin Resistance as a Predictor of Pulsed Field Ablation Success in Atrial Fibrillation (HOMA-PULSE)
This study investigates whether insulin resistance, a metabolic condition where the body's cells respond poorly to insulin, can predict the success of atrial fibrillation (AF) ablation using pulsed field ablation (PFA)…
- Conditions
- Atrial Fibrillation, Insulin Resistance, Catheter Ablation, Artificial Intelligence
- Trial name
- HOMA-PULSE (NCT07551947)
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- Nemocnice AGEL Trinec-Podlesi a.s.
Myocardial Infarction
RElevance of Biomarkers for Future Risk of Thromboembolic Events in UnSelected Post-myocardial Infarction Patients
The study is an open, single center, observational study at the Cardiology Dept at Uppsala University Hospital. The number of patients included will be 410.
- Trial name
- REBUS (NCT01102933)
- Where
- Sweden
- Volunteers
- 425 people
- Sponsor
- Uppsala University
Covid19, Angiogenesis
Endothelial Damage and Angiogenesis Biomarkers During COVID-19
Severe SARS-CoV-2 disease is characterized by a progressive hypoxemic respiratory failure. Autopsies from these patients show severe endothelial damage with extensive vascular thrombosis, microangiopathy, and occlusion of…
- Conditions
- Covid19, Angiogenesis, Endothelial Dysfunction, Cardiovascular Morbidity
- Trial name
- NCT04609332
- Testing
- Endothelial damage and angiogenic biomarkers
- Where
- Chile
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Chile
Vascular Disease, Peripheral, Thromboprophylaxis
Heparin-Binding Protein and Heparins
Heparin-Binding protein is a protein from primary and secretory granluae of white blood cells. It is released when white blood cells become activated and has been advocated as a biomarker for sepsis.
- Conditions
- Vascular Disease, Peripheral, Thromboprophylaxis, Cardiovascular Diseases
- Trial name
- HepHep (NCT04146493)
- Testing
- Blood samples for Heparin-binding protein measurement
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Halla Halldorsdottir
Atrial Fibrillation
Biomarkers in Patients Undergoing Atrial Fibrillation Ablation
The investigators aim to find biomarkers to determine the success of pulmonary vein isolation for the treatment of atrial fibrillation.
- Trial name
- NCT03388333
- Testing
- Catheter Ablation
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Hypertension Disorders in Pregnancy, Gestational Hypertension
Vascular Biomarkers Predictive of the Progression From Hypertensive Disorders in Pregnancy to Preeclampsia in Pregnant Women
Hypertension during pregnancy remains a leading cause of maternal and fetal morbidity and mortality. The frequency (5 to 10% of pregnancies) and potential severity of these diseases, both for the mother and the child, are reasons…
- Conditions
- Hypertension Disorders in Pregnancy, Gestational Hypertension, Pre-Eclampsia
- Trial name
- BIOVASC-PreHTA (NCT04520048)
- Testing
- Determination of the UEMP levels, Aortic central pressure and the carotid-femoral pulse wave velocity, Vascular biomarker assay
- Where
- 3 sites in France
- Volunteers
- 110 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Stroke, Arm Motor Recovery
Repetitive Arm Training + FES on Upper Extremity Motor Recovery in Sub-acute Stroke Survivors
Rehabilitation restores functions and reduces disabilities due to diseases sequelae. The relationship between intensity of rehabilitation and clinical outcomes, recently emphasized, has generated a great interest for…
- Trial name
- NCT02267798
- Testing
- conventional therapy, arm training combined with FES
- Where
- 2 sites in Italy
- Volunteers
- 64 people
- Sponsor
- University Hospital of Ferrara
Coronary Artery Calcification, Coronary Artery Disease
MAP-Calcification: MicroRNAs as Potential Biomarkers for Coronary Artery Calcification
Coronary artery disease (CAD) remains the leading cause of mortality in the UK with an estimated 80,000 fatalities in 2010. Coronary artery calcification (CAC) is associated with atherosclerotic plaque burden and cardiovascular…
- Conditions
- Coronary Artery Calcification, Coronary Artery Disease, Osteoporosis, Osteopenia
- Trial name
- NCT01992848
- Testing
- Venous blood sampling, 4-day food diary, 1 week UV dosimeter
- Where
- 2 sites in United Kingdom
- Volunteers
- 45 people
- Sponsor
- University of Surrey
Sleep Disorders, Circadian Rhythm
Circadian Phase Adjustment and Improvement of Metabolic Control in Night Shift Workers
EuRhythDia II is a multicenter, randomized, double-blind controlled study. The rationale of EuRhythdia is to explore the effects of 12 weeks of timed melatonin treatment on circadian rhythm, metabolic control and cardiovascular…
- Trial name
- NCT02108353
- Testing
- Melatonin 2mg
- Where
- 3 sites in Germany, Italy
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Infertility, Hyperstimulation Syndrome, Ovaian
Vascular Cell Activation, Cell-Derived Microparticles and In Vitro Fertilisation, and In Vitro Fertilisation
Introduction: Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic phenomenon, poorly understood and difficult to predict, complicating intense ovarian stimulation cycle.
- Conditions
- Infertility, Hyperstimulation Syndrome, Ovaian, Thrombosis
- Trial name
- PREDHSO (NCT03051230)
- Volunteers
- 50 people
- Sponsor
- Poissy-Saint Germain Hospital
Arrhythmia
Comprehensive Biomarker ProfiliNg in PatieNts With VEntriCular TachyCardia, PremAtuRe VEntricular Contractions, and AVNRT
To systematically evaluate multiple biomarkers in patients ventricular tachycardia (VT), premature ventricular contractions (PVC), atrioventricular nodal reentrant tachycardia (AVNRT) undergoing catheter ablation to elucidate…
- Trial name
- CONNECT-CARE (NCT07389928)
- Volunteers
- 200 people
- Sponsor
- University of Luebeck
Acute Ischemic Stroke, Reperfusion Injury
Wet and Dry Biomarkers to Predict Secondary Injury in Stroke: From Bench to Bedside - The NIMBLE Study
Infarct growth (IG), Hemorrhagic Transformation (HT) and Cerebral Edema (CE) can be considered pivotal phenomena of clinical deterioration following an acute ischemic stroke.
- Conditions
- Acute Ischemic Stroke, Reperfusion Injury, Cerebral Edema, Hemorrhagic Transformation Due to Acute Stroke
- Trial name
- NIMBLE (NCT07422636)
- Where
- Italy
- Volunteers
- 213 people
- Sponsor
- University of Florence
Psoriasis, Cardiovascular Diseases
Serum Lipid Levels and Other Biomarkers of Cardiovascular Disease in Patients With Psoriasis
Psoriasis patients are known to be at increased risk for heart disease. This may be due to the increased prevalence of cardiovascular disease risk factors in this population, including high blood pressure, diabetes, obesity, and…
- Conditions
- Psoriasis, Cardiovascular Diseases, Dyslipidemia
- Trial name
- NCT01019200
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- George Washington University
Dyspnea, Heart Failure
The Triple A Initiative Study ("Aktionsbündnis Akute Atemnot")
Acute dyspnea is a common chief complaint of patients presenting to the emergency department. Patients with acute dyspnea display a high mortality rate.
- Trial name
- NCT02049853
- Testing
- NTproBNP measurement with point of care device "Cobash232" in the POCT group
- Where
- 6 sites in Germany
- Volunteers
- 67 people
- Sponsor
- Prof. Dr. Michael Christ