Clinical trials: Cardiovascular Adaption
Hypertension, Elevated Blood Pressure
Blood Pressure Following Isometric Exercise in Inactive Adults
This study investigates how isometric exercise training (IET) affects blood pressure in physically inactive adults. Isometric exercise involves sustained muscle contractions without movement-for example, pushing against a fixed…
- Conditions
- Hypertension, Elevated Blood Pressure, Sedentary Lifestlye
- Trial name
- BELIEF-BP (NCT06937164)
- Testing
- Isometric Exercise Training (IET), Expectation-Enhancing Informational Framing
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Canterbury Christ Church University
Pre-Eclampsia, Vascular Diseases
Mechanisms of Pregnancy Vascular Adaptations
The investigators will collect omental tissue (research surgical excision) and placental tissue (standard of care clinical delivery) from both preeclamptic and non-preeclamptic women during their c-section and use these samples…
- Trial name
- NCT03806283
- Testing
- Omental Biopsy
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Hypertension
Blood Pressure and Cardiac Autonomic Adaptations to Isometric Exercise Training
A randomized, sham-controlled intervention measuring the effects of isometric exercise training (IET) on blood pressure and cardiac autonomics.
- Trial name
- NCT05025202
- Testing
- Isometric exercise training
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Canterbury Christ Church University
Transcranial Direct Current Stimulation, Ankle
Investigating the Effects of Transcranial Direct Current Stimulation to Different Brain Regions on Ankle Tracking Motor Learning, Motor Adaptation, and Brain Connectivity in Healthy Middle-aged and Older Adults and Patients With Subcortical Stroke
Ankle control is essential to safe over-ground navigation for humans. Middle- aged and older adults and patients with stroke whose ankle control is poor often lose their balance or fall.
- Conditions
- Transcranial Direct Current Stimulation, Ankle, Motor Learning, Adaptation
- Trial name
- tDCS (NCT06556043)
- Testing
- cM1 transcranial direct current stimulation, cPPC transcranial direct current stimulation, iCBM transcranial direct current stimulation
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Healthy, Healthy Subjects (HS)
Static Stretching Reshapes Post-RT Recovery
This experimental study investigates the acute cardiovascular and local recovery to a single session of resistance training, with and without additional static stretching, compared with a resting control condition.
- Conditions
- Healthy, Healthy Subjects (HS), Cardiovascular Adaption, Stretching
- Trial name
- NCT07649785
- Testing
- Resistance Training, Resistance training + Static Stretching
- Where
- Italy
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Palermo
Motor Learning and Physiological Adaptation
Effects of Active Upper-Limb Exoskeleton Training in Simulated Hyper-Gravity on Fine Motor Performance, Brain-Muscle Connectivity, Cardiovascular System and Stress Responses in Real Hyper-Gravity
The aim of the study presented here is to assess the effects of exoskeleton training on performance in a real hypergravity situation.
- Trial name
- EGOS (NCT07278245)
- Testing
- Training with an exoskeleton
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Centre National d'Etudes Spatiales
Psychological Adaptation
Problem-solving: A Stroke Caregiver Early Intervention
Intervention studies for stroke caregivers (CG's) during early caregiving are few and have met with limited success. The Post-Stroke Rehabilitation Clinical Practice Guidelines (1995) recommend sensitivity to the adverse effects…
- Trial name
- CPSI (NCT01141738)
- Testing
- Caregiver Problem-Solving Intervention, Wait List Control
- Where
- 4 sites in United States
- Volunteers
- 362 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Right Ventricular Hypertrophy, d-TGA
Right Ventricular Hypertrophy After Atrial Switch and Cardiovascular Magnetic Resonance (CMR) Findings
Systemic RV hypertrophy and impaired systolic function occur after atrial switch (AS) in d-transposition of the great arteries (d-TGA). Echocardiography has limitation in the assessment of the right ventricle (RV).
- Trial name
- NCT01430897
- Where
- Germany
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Ascites, Blunt Abdominal Trauma
Telesonography Adaptation and Use to Improve the Standard of Patient Care Within a Dominican Community
The role of teleradiology has far reaching implications for the health of remote and underserved populations. The ability to coordinate radiographic evaluation and diagnosis from a distance has the potential to raise the standard…
- Conditions
- Ascites, Blunt Abdominal Trauma, Cholelithiasis, Cholecystitis
- Trial name
- NCT00591968
- Testing
- SonoSite Titan portable ultrasound coupled with email telediagnosis
- Where
- Dominican Republic
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Edward Via Virginia College of Osteopathic Medicine
Arthritis, Rheumatoid, Activities of Daily Living
Adaptation of EDAQ Into Turkish, Examining The Reliability and Validity For People With RA
The aim of the study is to adapt the Evaluation of Daily Activity Questionnaire into Turkish language, and to examine the reliability and validity for people with rheumatoid arthritis.
- Trial name
- NCT05244824
- Testing
- Adaptation into Turkish, Examining The Reliability and Validity for People with RA
- Where
- Turkey (Türkiye)
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Hypoxia, Sleep Apnea
Intermittent Hypoxia 2: Cardiovascular and Metabolism
The purpose of this study is to compare cardiovascular physiological adaptation to intermittent hypoxia (IH) of nonobese healthy subjects. The exposure will be two periods of two weeks (IH versus exposure "placebo hypoxia").
- Conditions
- Hypoxia, Sleep Apnea, Obstructive Sleep Apnea
- Trial name
- IH2 (NCT02058823)
- Testing
- Valsartan, Amlodipine
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Healthy
Dose Adaptation to Offset the Interaction Between Ticagrelor and Ritonavir by Population-based PK Modeling
Ticagrelor is a new generation antiplatelet agent with higher efficacy as compared to clopidogrel and prasugrel in treatment of patients with moderate and high ischemic risks.
- Trial name
- NCT02435563
- Testing
- ticagrelor 180 mg administrated alone, Ticagrelor adjusted dose + ritonavir 100mg
- Where
- Switzerland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Hypertension, Menopause
8 Weeks of L-CIT Supplementation and LIRET on Vascular Function in Hypertensive Postmenopausal Women
The overall objective of this project is to bring forth evidence that L-Citrulline (L-CIT) supplementation and low intensity resistance exercise training (LIRET) alone and combined will improve vascular function and muscle…
- Trial name
- NCT05227781
- Testing
- L-Citrulline
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Stroke
Virtual Reality Augmented Gait Adaptation in Stroke Survivors
The major problem in stroke survivors that is being addressed in this research project is walking asymmetry, i.e., difference between the legs during walking (e.g. steps on the more affected side are longer than the other).
- Trial name
- NCT03787693
- Testing
- VR - Virtual Reality
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Stroke
Validation and Standardisation of a Pool of Simplified Evaluation Aimed to the Diagnoses of Aphasic Disorders and Adapted to the Patients Suffering an Acute Phase of Stroke
Every year in France, from 100 000 to 145 000 people are affected by a stroke. 75% patients survived with aftereffects, in particular aphasic disorders.
- Trial name
- BESTA-AVC (NCT02548481)
- Testing
- BESTA scale
- Where
- France
- Volunteers
- 395 people, healthy volunteers welcome
- Sponsor
- University Hospital, Limoges
Exercise
Importance of Blood Volume and Its Interaction With Cardiovascular Adaptations
The present project aims to investigate the interaction between training-induced blood volume expansion (plasma- and red blood cell volume responses), central as well as peripheral cardio-vascular adaptations.
- Trial name
- NCT05191979
- Testing
- Exercise regiment (aerobic exercise on bike)
- Where
- 2 sites in Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Medication Non-adherence
Improving Adherence and Outcomes by Artificial Intelligence-Adapted Text Messages
Uncontrolled hypertension is a major cause of morbidity and mortality and many patients fail to take their antihypertensive medication as prescribed.
- Trial name
- AIM@BP (NCT02454660)
- Testing
- SMS (Text messages)
- Where
- 2 sites in United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Circulatory Failure in Newborn Infants
NeoAdapt 1: A Study of Circulatory Adaptation of Newborn Infants After Birth
The current definitions of neonatal shock/circulatory failure are outdated and inaccurate. This makes the development of evidence based protocols for its treatment very difficult.
- Trial name
- NCT02047916
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Brighton and Sussex University Hospitals NHS Trust
Stroke, Frailty
Pilot of Cognitive Stimulation Therapy for Pre-frail Stroke Survivors
Frailty is described as a type of vulnerability where one can struggle to recover fully from things that can put stress on one\'s body, e.g., cold weather or bronchitis.
- Conditions
- Stroke, Frailty, Carers
- Trial name
- NCT06733103
- Testing
- Stroke Cognitive Behavioural Therapy
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Cardiovascular Diseases, Metabolic Disorders
Chinese Migrant Population Health Cohort
The Chinese Migrant Population Health Cohort is a prospective, multi-center study jointly initiated by Professor Yong Ji, President of Harbin Medical University, and Academician Guoqiang Chen, President of Hainan Medical…
- Conditions
- Cardiovascular Diseases, Metabolic Disorders, Ageing and Geriatric Health, Climate Adaptation
- Trial name
- NCT07124949
- Testing
- No intervention
- Where
- China
- Volunteers
- 26,000 people, healthy volunteers welcome
- Sponsor
- Jinwei Tian