Clinical trials: Cardiovascular Abnormalities
Tricuspid (Valve); Deformity
Changes in the Tricuspid Valve Complex Induced by Mitral Valve Annuloplasty
The purpose of this study is to evaluate the impact of isolated mitral valve annuloplasty on the geometry and the function of the tricuspid valve complex.
- Trial name
- NCT02357862
- Testing
- Mitral Valve Annuloplasty
- Volunteers
- 22 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Abnormalities, Hyperlipidemia
Study of the Effects of Blackcurrant Extract and Omega-3 Fats on the Health of the Heart and Blood Vessels
Background: Heart disease is the leading cause of death in the United States. Eating fruits and vegetables with chemicals called flavonoids may protect against heart disease and improve blood flow to the heart.
- Conditions
- Abnormalities, Hyperlipidemia, Cardiovascular Disease, Arteriosclerosis
- Trial name
- NCT02019680
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Nursing Research (NINR)
Abnormalities, Cardiovascular
Development of New Software Capabilities for Use With Cardiovascular Magnetic Resonance Imaging
This Protocol is intended to facilitate development and testing of new cardiovascular MRI software capabilities by UC Davis Research Faculty, as well as to facilitate the evaluation of new software capabilities provided by GE and…
- Trial name
- CVMRI (NCT00593541)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Cancer, Cardiovascular Disease
NCGENES: North Carolina Clinical Genomic Evaluation by NextGen Exome Sequencing
This study is part of a larger consortium project investigating the validity and best use of next-generation sequencing (in particular, whole exome sequencing, or WES) in clinical care.
- Conditions
- Cancer, Cardiovascular Disease, Neurologic Dysfunction, Congenital Abnormalities
- Trial name
- NCGENES (NCT01969370)
- Testing
- Experimental
- Where
- United States
- Volunteers
- 645 people
- Sponsor
- University of North Carolina, Chapel Hill
Bone Diseases, Metabolic, Acid-Base Imbalance
The Effect of Potassium Bicarbonate on Bone and Several Physiological Systems During Immobilisation
Mainly due to the absence of gravitational forces in weightlessness, astronauts suffer from an increased bone loss- negatively affecting health and vitality during a mission.
- Conditions
- Bone Diseases, Metabolic, Acid-Base Imbalance, Muscular Atrophy, Sprains and Strains
- Trial name
- NUC (NCT01509456)
- Testing
- Potassium Bicarbonate
- Where
- Germany
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- DLR German Aerospace Center
Cardiovascular Abnormalities
Postoperative Canadian Oral Anticoagulation Self-management (Post-COAGS) Trial
This study will measure the efficacy and safety of an early postoperative anticoagulation self-management program, using the CoaguChek S device, in patients undergoing mechanical valve replacements.
- Trial name
- NCT00468702
- Testing
- CoaguChek S
- Where
- Canada
- Sponsor
- Hoffmann-La Roche
Cardiovascular Abnormalities
A Study of Immunological Biomarkers as Predictors of Cardiovascular Events
Cardiovascular disease linked to atherosclerosis (e.g. infarcts, cerebro-vascular accidents) are one of the main causes of mortality in the general population.
- Trial name
- BIOKID (NCT02894060)
- Testing
- blood tests
- Where
- France
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Cardiovascular Abnormalities
Efficacy and Safety of the Mammalian Target of Rapamycin (mTor Rapamycin) Inhibitor in Vascular Malformations
The phosphatidylinositol 3-kinase (PI3Kinase)/Protein Kinase B (AKT)/mammalian target of rapamycin (mTor) pathway plays a role on the development and the lymphatic-vascular organisations.
- Trial name
- vasca-LM (NCT01811667)
- Testing
- Sirolimus
- Where
- Belgium
- Volunteers
- 19 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Cancer, Congenital Anomalies
Estimating the Global Need for Palliative Care for Children
A cross-sectional analysis of prevalence data from a stratified sample of 23 countries used to estimate the global need for palliative care for children aged 0-19 years.
- Conditions
- Cancer, Congenital Anomalies, Cardiovascular Disease, HIV
- Trial name
- NCT02553148
- Testing
- Need for children's palliative care
- Where
- United States
- Volunteers
- 18,837,613 people, healthy volunteers welcome
- Sponsor
- International Children's Palliative Care Network
Cardiovascular Abnormalities
Evaluation of the Cardiac Effects of a Novel Food Ingredient in Healthy Male Subjects
This study evaluates if a single oral dose of 150 mg of the novel food ingredient (AME001, R,R-monatin) does not have an effect on the Fridericia-corrected QT ECG interval (QTcF) exceeding 10 milliseconds (msec).
- Trial name
- NCT02616913
- Testing
- R,R-monatin, Moxifloxacin
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Cargill
Cardiovascular Abnormalities
Magnevist® Injection Enhanced MRA Compared to Non Contrast MRA for the Detection of Structural Abnormalities of the Aortic Arch and Cerebral Branches
The purpose of this study is to look at the safety (what are the side effects) and efficacy (how well does it work) of Magnevist (the study drug) used for MRI of the aortic arch and cerebral branches.
- Trial name
- NCT00310609
- Testing
- Gadopentetate dimeglumine (Magnevist)
- Volunteers
- 123 people
- Sponsor
- Bayer
Obesity, Cardiovascular Abnormalities
Effects of Weight Loss on Cardio-respiratory Function
Obesity is a medical problem of epidemic proportions and is associated with high mortality. Obesity has significant effects on the cardiovascular system, producing structural cardiovascular changes including myocardial…
- Trial name
- NCT01410487
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- NYU Langone Health
Cardiovascular Abnormalities, Weightlessness
Electroacupuncture is Effective in Cardiac Deconditioning Induced by Head-down Bed Rest
To investigate the changes of cardiovascular function during short-term simulated weightlessness after electroacupuncture (EA) treatment．
- Trial name
- NCT02300207
- Testing
- electronic acupuncture treatment instrument
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Air Force Military Medical University, China
Cardiovascular Abnormalities, Vascular Diseases
Characterization of Slow Coronary Flow
Description of the phenomena "Slow Coronary Flow" (SCF), according to the data that has been collected from patients hospitalized with specific criteria.
- Trial name
- NCT02025101
- Where
- Israel
- Volunteers
- 90 people
- Sponsor
- Hillel Yaffe Medical Center
Bone Diseases, Metabolic, Acid-Base Imbalance
Short Term Bed Rest Study: Evaluation of the Use of Artificial Gravity, Induced by Short-arm Centrifugation
Randomized cross-over design with 10 male subjects and 3 campaigns to test whether the negative effects of bed rest (6º head-down tilt) on the various systems of the body and the consequences to health of simulated weightlessness…
- Conditions
- Bone Diseases, Metabolic, Acid-Base Imbalance, Muscular Atrophy, Sprains and Strains
- Trial name
- SAG (NCT01820702)
- Testing
- Defined Training Programme
- Where
- Germany
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- DLR German Aerospace Center
Disorders of the Autonomic Nervous System, Cardiovascular Abnormalities
Electrocardiographic Autonomic Function Measures in Mechanically Ventilated Patients
This research proposal has two main objectives. The first is to increase understanding of the underlying physiological interactions that occur between the cardiovascular, pulmonary, and ANS during transition between positive…
- Conditions
- Disorders of the Autonomic Nervous System, Cardiovascular Abnormalities, Respiratory Disorders
- Trial name
- NCT00844935
- Where
- United States
- Sponsor
- University of California, San Francisco
Transplantation, Kidney, Cardiovascular Abnormalities
CEC/EPC and Cardiovascular Risk in Renal Transplant Recipients
We believe that certain cells in the human body (Circulating Endothelial Cells and Endothelial Progenitor Cells) are related to risk of cardiovascular disease.
- Conditions
- Transplantation, Kidney, Cardiovascular Abnormalities, Cardiovascular Diseases
- Trial name
- CEC (NCT00365833)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Florida
Cardiovascular Abnormalities
Thoracoscopic Vascular Rings Chart Review
The purpose of this study is to review the use of diverticulopexy, and collect data regarding the ease of the procedure and the overall outcome.
- Trial name
- NCT00229853
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Children's Healthcare of Atlanta
Type 2 Diabetes Mellitus, Cardiovascular Abnormalities
Curcumin for Type 2 Diabetic Patients
There are evidence that there is an association between insulin resistance and prolonged hyperinsulinemia or hyperglycemia in Type 2 diabetic patients.
- Trial name
- NCT01052597
- Testing
- curcumin
- Where
- Thailand
- Volunteers
- 200 people
- Sponsor
- Srinakharinwirot University
Cardiovascular Abnormalities, Kidney Failure
Renal Function in Adults With Congenital Heart Disease.
Impaired kidney function is associated with a poor outcome in patients with heart failure but it is not known of this is the case for patients who have been born with their heart condition (congenital heart disease).
- Trial name
- NCT00807274
- Where
- United Kingdom
- Volunteers
- 1,200 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust