Clinical trials: Cardiovascular (CV) Risk
Atrial Fibrillation, Obstructive Sleep Apnea
OSA and CV Outcomes in Patients With High Risk AF
The POACH study is part of the Cardiosleep research program. It is a prospective, observational, multicentre study conducted in Singapore. The recruitment target is 1365 patients.
- Trial name
- POACH (NCT04005508)
- Testing
- Overnight sleep study
- Where
- Singapore
- Volunteers
- 1,365 people
- Sponsor
- National University of Singapore
Cardiovascular Health Risk Communication, Cardiovascular (CV) Risk
Breast Artery Calcification (BAC) and Female Cardiovascular Disease
The investigators are recruiting women with and without Breast Artery Calcification (BAC) on their mammograms. Each participant in the study will undergo bloodwork at a Northwell Health lab, a cardiac CT scan, and fill out some…
- Conditions
- Cardiovascular Health Risk Communication, Cardiovascular (CV) Risk, Cardiovascular Disease Prevention
- Trial name
- NCT07809932
- Testing
- Cardiac CT Scan, Bloodwork
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Cardiovascular Diseases, Coronary Artery Disease
Evaluation Using ClearView in Determining Association to the Cardiac Risk Factors
The objective of this study is to explore the relationship between the ClearView scan results and a variety of cardiovascular risk indicators such as the Coronary Calcium Score, Framingham Risk Factors, Reynolds Risk Score, and…
- Trial name
- Cardiac-CV (NCT01740739)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Epic Research & Diagnostics, Inc.
Type 1 Diabetes (T1D)
Circadian Mechanisms, Glucose, and CV Risks in T1D
People with type 1 diabetes are disproportionately affected by cardiovascular disease (CVD). Short and irregular sleep have been associated with cardiovascular risk in this population.
- Trial name
- NCT06624046
- Testing
- Sleep stability intervention
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Illinois Chicago
Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD)
The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)
The main purpose of this study is to determine if retatrutide can significantly lower the incidence of serious heart-related complications or prevent the worsening of kidney function.
- Trial name
- NCT06383390
- Testing
- Retatrutide
- Where
- 742 sites in United States, Argentina and 25 more
- Volunteers
- 10,000 people
- Sponsor
- Eli Lilly and Company
Cardiovascular (CV) Risk, Physical Activities
The Effect of Physical Activity on Cardiovascular Disease Risk Awareness and Self-Worth in Young Women
The main purpose of this study was to reveal the self-worth perceptions of women who regularly participate in physical activity and to investigate the effect of physical activity on self-worth perception and cardiovascular risk…
- Trial name
- NCT07137182
- Testing
- 8-week physical activity program
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Karamanoğlu Mehmetbey University
HIV, Hypercholesterolemia
Analysis on the Risk of Cardiovascular Events in HIV- Infected Subjects Treated With LPV/r Based HAART Regimen vs. an EFV Based Regimen
The objective of this study is to evaluate changes in Framingham score (from low to moderate, from moderate to high) based on changes in lipid profile and other parameters from baseline to 48 weeks of HAART in naïve patients or…
- Conditions
- HIV, Hypercholesterolemia, Dyslipidemia
- Trial name
- NCT01705873
- Where
- Argentina
- Volunteers
- 300 people
- Sponsor
- Helios Salud
Atherosclerosis
The Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy Trial
This study will test whether darapladib can safely lower the chances of having a cardiovascular event (such as a heart attack or stroke) in people with coronary heart disease.
- Trial name
- STABILITY (NCT00799903)
- Testing
- Darapladib
- Where
- 650 sites in United States, Argentina and 37 more
- Volunteers
- 15,828 people
- Sponsor
- GlaxoSmithKline
Heart Diseases, Diabetes Mellitus, Type 2
Behavior Change Intervention for Cardiovascular Risk Reduction Among People Experiencing Homelessness
This single-arm trial of the Cardiovascular Risk Reduction Among People Experiencing Homelessness (CV-Homes) intervention alone (n=8) will test the perception and feasibility of anticipated study procedures.
- Conditions
- Heart Diseases, Diabetes Mellitus, Type 2, Pre-diabetes, Hypertension
- Trial name
- CV-Homes (NCT06025721)
- Testing
- Cardiovascular Risk Homeless Support
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Katherine Vickery
Cardiovascular (CV) Risk
Neqpiaput Iinruugut (Our Food Is Medicine): A Tribally Driven Food Sovereignty Intervention to Reduce Heart Disease Risk in Alaska Native Adults
This study Neqpiaput Iinruugut ("Our Food is Medicine"), will test if a tribally designed Indigenous food sovereignty intervention can lower the risk of coronary heart disease in Alaska Native adults ages 18 to 65 years old.
- Trial name
- Food is Med (NCT07897838)
- Testing
- Neqpiaput linruugut (Our Food is Medicine)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Alaska Fairbanks
Breast Cancer, Cardiovascular (CV) Risk
Multicenter Cardiac Decision Impact Study in People With Breast Cancer
Background: Breast cancer is the most common cancer in women, and advances in early detection and treatment have led to steadily improved survival rates. Today, nearly 80% of breast cancer survivors are over 50 years of age.
- Conditions
- Breast Cancer, Cardiovascular (CV) Risk, Coronary Artery Calcifications
- Trial name
- CarDI (NCT07703033)
- Testing
- Measuring coronary artery calcifications (Agatston score) using routine radiotherapy planning CT scans and communicating the associated risk of cardiovascular disease to the patient.
- Where
- 5 sites in Denmark, Germany and 2 more
- Volunteers
- 1,000 people
- Sponsor
- UMC Utrecht
Coronary Disease, Cardiovascular Diseases
Examining How Heart Disease Risk Factors Affect Healthy Aging (The Chicago Healthy Aging Study [CHAS])
Heart disease is the leading cause of death in the United States and is responsible for 30% of all deaths in the United States. This study will examine how risk factors for heart disease in young and middle aged people affect…
- Trial name
- CHAS (NCT00626379)
- Where
- United States
- Volunteers
- 1,395 people
- Sponsor
- Northwestern University
Secondary Prevention, CHD
National Tunisian Clinical Registry on CardioVascular Secondary Prevention Clinical
A non-interventional, national longitudinal multicenter study of CV secondary prevention in Tunisia
- Conditions
- Secondary Prevention, CHD, CV Risk
- Trial name
- NATURE STOP-CH (NCT07034274)
- Where
- Tunisia
- Volunteers
- 7,284 people
- Sponsor
- Dacima Consulting
Type 2 Diabetes, Cardiovascular Complication
Study on the Predictive Value of High-sensitivity Cardiac Troponin I, N-terminal Pro-B-natriuretic Peptide, and Soluble Suppression of Tumorigenesis-2 for Mortality and the Development of Cardiovascular Events in Patients With Type 2 Diabetes (Diabetes-CV)
The Diabetes-CV study is an observational study designed to assess the prognostic value of serum cardiac damage markers high-sensitivity cardiac troponin I (hs-cTnI), N-terminal pro-B-natriuretic peptide (NT-proBNP), and soluble…
- Trial name
- Diabetes-CV (NCT06902857)
- Where
- Italy
- Volunteers
- 964 people
- Sponsor
- Istituto Nazionale di Ricovero e Cura per Anziani
Hypercholesterolemia, Atherosclerotic Cardiovascular Diseases
Evaluation of Long-Term Safety and Tolerability of ETC-1002 in High-Risk Patients With Hyperlipidemia and High CV Risk (CLEAR Harmony)
The purpose of this study is to see if ETC-1002 (bempedoic acid) is safe and well-tolerated versus placebo in patients with high cardiovascular risk and elevated LDL cholesterol that is not adequately controlled by their current…
- Trial name
- NCT02666664
- Testing
- ETC-1002
- Where
- 104 sites in United States, Canada and 4 more
- Volunteers
- 2,230 people
- Sponsor
- Esperion Therapeutics, Inc.
Perimenopause, Menopause
CARAMEL Observational Study
CARAMEL is a project funded by the European Commission under the Horizon Europe programme. Its aim is to develop a personalized prevention approach based on state-of-the-art artificial intelligence models for cardiovascular risk…
- Conditions
- Perimenopause, Menopause, Cardiovascular (CV) Risk, Women (Between 30 to 60 Years Old)
- Trial name
- CARAMEL-OS (NCT07695376)
- Where
- 6 sites in Colombia, Croatia and 3 more
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Biogipuzkoa Health Research Institute
Physical Activities, Cardiovascular (CV) Risk
Physical Inactivity Among Patients With Cardiovascular Risk
The goal of this clinical trial is to learn if newly developed intervention package works to improve physical activity level among patients with intermediate cardiovascular risk factors.
- Conditions
- Physical Activities, Cardiovascular (CV) Risk, Empowerment
- Trial name
- INSPIRE-PA (NCT07440056)
- Testing
- INSPIRE-PA intervention study arm
- Where
- Sri Lanka
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- University of Colombo
Cystic Fibrosis (CF), Cardiovascular (CV) Risk
Heart and Blood Vessels Health in People With Cystic Fibrosis
Cystic fibrosis (CF) is a disease that affects over 11,000 people in the UK. It is a genetic condition that affects many organs including the lungs, pancreas, kidneys and liver.
- Conditions
- Cystic Fibrosis (CF), Cardiovascular (CV) Risk, Flow-mediated Dilation Evaluation of the Brachial Artery, Pulse Wave Analysis
- Trial name
- CHi-CF (NCT07692594)
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
Hypertension,Essential
Association Between Coronary Flow Reserve and BH4 Levels in High CV Risk
To determine if there is a relationship between coronary flow reserve (CFR) and platelet/plasma BH2 and BH4 levels in patients with high cardiovascular risk .
- Trial name
- NCT03841383
- Testing
- Echo stress dipyridamole
- Where
- 2 sites in Italy
- Volunteers
- 55 people
- Sponsor
- IRCCS San Raffaele
Coronary Artery Disease
Family Atherosclerosis Counseling and Testing Project
Family history of early atherosclerotic disease in a first-degree relative [(FDR) sibling, parent or child] is an important risk factor for coronary artery and/or vascular disease.
- Trial name
- NCT00387595
- Sponsor
- University of British Columbia