Clinical trials: Cardiotoxicity
HER2-positive Breast Cancer, HER2+ Breast Cancer
HER2HEART-US: Prevention of Cardiotoxicity in Breast Cancer Patients Receiving HER2-directed Therapy
Ten to 15% of patients with breast cancer are HER2 positive, with treatment focused on targeting the HER2 receptor. Although these treatments are generally well tolerated, they are associated with an increased risk of…
- Trial name
- NCT06844669
- Testing
- Carvedilol, Empagliflozin
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Washington University School of Medicine
Breast Cancer, Hematologic Malignancy
Global Cardio Oncology Registry
G-COR is the first Global Prospective Cardio-Oncology Registry. It is a multinational, multicenter prospective observational cohort registry, with the goal of collecting clinical, laboratory, imaging, demographic, and…
- Conditions
- Breast Cancer, Hematologic Malignancy, Immune Checkpoint Inhibitor-Related Myocarditis, Cardiotoxicity
- Trial name
- G-COR (NCT05598879)
- Testing
- anonymized data collection during programmed surveillance clinical follow up
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- The Cleveland Clinic
Anthracycline-induced Cardiotoxicity, Lymphoma
Sotagliflozin as Prevention of Anthracycline-Related Cardiotoxicity
This project aims to determine the benefits of the dual SGLT1/2 inhibition as prophylactic treatment to prevent anthracycline-related cardiotoxicity.
- Conditions
- Anthracycline-induced Cardiotoxicity, Lymphoma, Chemotherapy, Cardiotoxicity
- Trial name
- SPARTACUS (NCT07572175)
- Testing
- Sotagliflozin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cardiotoxicity, Anthracycline-induced Cardiotoxicity
Serial Cardiac Magnetic Resonance Imaging (CMR) With Contrast Agents and Biomarker Analysis for the Detection of Cardiotoxicity Under Anthracycline-containing Cancer Therapy
The goal of the trial is the early detection of cardiotoxicity in patients treated with anthracycline-based chemotherapy. Current diagnostics, such as troponin T, NT-pro-BNP, electrocardiogram, and echocardiography, are not able…
- Trial name
- CMR-Onko (NCT07528586)
- Testing
- CMR based measurement of cardiotoxicity, biosampling for scientific research in study-specific biobank
- Where
- Germany
- Volunteers
- 93 people
- Sponsor
- Robert Bosch Gesellschaft für Medizinische Forschung mbH (RBMF)
Cancer Therapy-Related Cardiac Dysfunction, Heart Failure
Risk Stratification of Cancer Therapy-Related Cardiac Dysfunction Using AI-Enhanced Electrocardiography
This study investigates the use of AI-enhanced electrocardiogram (ECG) for risk stratification of cancer therapy-related cardiac dysfunction (CTRCD) before the initiation of cancer therapy.
- Conditions
- Cancer Therapy-Related Cardiac Dysfunction, Heart Failure, Left Ventricular Dysfunction
- Trial name
- NCT07515859
- Testing
- No intervention (retrospective observational study)
- Where
- South Korea
- Volunteers
- 31,486 people
- Sponsor
- Yonsei University
Prostate Cancer, Cardiotoxicity
Mechanisms, Predictors, and Social Determinants of Cardiotoxicity in Prostate Cancer
This is an observational study for patients with prostate cancer that will be treated with Androgen Deprivation Therapy. The study will help the investigators learn more about how these medications affect the heart and how those…
- Conditions
- Prostate Cancer, Cardiotoxicity, Drug-Related Side Effects and Adverse Reactions, Cardiovascular Diseases
- Trial name
- PCT (NCT05096338)
- Testing
- Social Determinants of Health
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Cardiotoxicity, Heart Failure
ML Score Prediction of Cardiotoxicity in Cancer Patients Receiving Anthracycline Chemotherapy or HER2-Targeted Therapies
Cancer treatments have improved substantially over the past decades, but some effective therapies such as anthracyclines and HER2-targeted agents are associated with severe cardiovascular adverse effects, including heart failure.
- Conditions
- Cardiotoxicity, Heart Failure, Neoplasms, Breast Neoplasms
- Trial name
- ML-CardioTox (NCT07191730)
- Where
- France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Caen
Childhood Cancer Survivors, Cardiotoxicity
Impact of Exercise Intensity on Cardiac Health in Young Adult Survivors of Childhood Cancer: The PULSE Trial
This trial aims to evaluate the impact of exercise intensity on cardiac health in young adult survivors of childhood cancer previously treated with anthracyclines.
- Conditions
- Childhood Cancer Survivors, Cardiotoxicity, Cardiovascular Diseases, Anthracycline-induced Cardiotoxicity
- Trial name
- PULSE (NCT07442578)
- Testing
- HIIT Exercise Program, MICT Exercise Program
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Dana-Farber Cancer Institute
Non-small Cell Lung Cancer, Cardiac Toxicity
Evaluation of Impedance Cardiography for Assessing Hemodynamic Shifts in Patients With LA-NSCLC During Treatment.
This study aimed to investigate the role of impedance cardiography (ICG) in evaluating hemodynamic changes during the 6-minute walk test (6MWT) in patients with locally advanced non-small cell lung cancer (LA-NSCLC) who underwent…
- Trial name
- NCT06277388
- Testing
- Impedance cardiography
- Where
- China
- Volunteers
- 231 people
- Sponsor
- Sun Yat-sen University
Breast Cancer, Doxorubicin Induced Cardiotoxicity
Effect of Montelukast on Doxorubicin Induced Cardiotoxicity in Breast Cancer
This is a prospective, randomized (1:1) controlled trial that will be carried out on 50 patients who are candidate to evaluate the effect of montelukast on doxorubicin induced cardiotoxicity after 4 cycles of AC.
- Trial name
- NCT05959889
- Testing
- AC protocol, Montelukast
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Damanhour University
Multiple Myeloma, Shortness of Breath
Dyspnea and Cardiotoxicity in Multiple Myeloma Patients Who Receive Carfilzomib
This study will explore why some multiple myeloma patients who receive carfilzomib (an anti-cancer medication) experience shortness of breath while others do not.
- Conditions
- Multiple Myeloma, Shortness of Breath, Dyspnea, Cardiotoxicity
- Trial name
- NCT04827563
- Testing
- EndoPAT, Blood Pressure Cuff, Echocardiogram
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Chicago
Chemotherapy-induced Cardiotoxicity, Breast Cancer
Grape Polyphenols for Prevention of Chemotherapy-Induced Cardiotoxicity
This pilot randomized clinical study aims to evaluate the cardioprotective effects of a grape polyphenol concentrate in patients receiving anthracycline- and/or trastuzumab-based chemotherapy.
- Trial name
- NCT07419711
- Testing
- Grape Polyphenol Concentrate
- Volunteers
- 120 people
- Sponsor
- Nazarbayev University
Cardiotoxicity
Artificial Intelligence for Reconstruction of Echocardiography Studies
To investigate the clinical utility of both 3D and 2D artificial intelligence reconstruction echocardiography (V-echo and L-echo) assessment against conventional echocardiography and clinical cardiovascular magnetic resonance…
- Trial name
- AIRES (NCT07093918)
- Testing
- V-echo, L-echo
- Volunteers
- 120 people
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
Leukemia, Lymphoma
Cardiovascular Effects of CART Cell Therapy
This is an observational study aiming to prospectively define the rate of occurrence, natural history and progression of cardiac dysfunction in adults, and to identify the patients at high risk of developing cardiovascular…
- Conditions
- Leukemia, Lymphoma, Cardiotoxicity, Risk Factor, Cardiovascular
- Trial name
- CVE-CART (NCT04026737)
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Breast Cancer, Cardiotoxicity
Cardiotoxicity in Breast Cancer Patients Treated With Proton or Photon Radiotherapy: A RadComp Companion Study
This is a companion study to the "Pragmatic Randomized Trial of Proton vs Photon Therapy for Patients with non-Metastatic Breast Cancer Receiving Comprehensive Nodal Radiation: A Radiotherapy Comparative Effectiveness (RadComp)…
- Trial name
- NCT04361240
- Testing
- Proton vs Photon Radiation
- Where
- 6 sites in United States
- Volunteers
- 172 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Breast Neoplasms
Role of Sodium-glucose Linked Transporter 2 (SGLT2) and Its Inhibitor Over CARdiotoxicity Induced by Anthracyclines and Breast Cancer Tumorigenesis SCARA-B
In the context of breast cancer, in case of an indication for chemotherapy, anthracycline-based protocols make it possible to improve the overall survival of patients most at risk.
- Trial name
- SCARA-B (NCT06443645)
- Testing
- Anthracycline
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Paul Strauss
Thoracic Cancer, Left Sided Breast Cancer
Hyperpolarized Carbon 13-Based Metabolic Imaging to Detect Radiation-Induced Cardiotoxicity
Patients enrolled in the study will receive standard of care adjuvant or definitive breast, chest wall or thoracic radiation therapy.Cardiac mitochondrial dysfunction is a hallmark of radiation-induced cardiac injury.
- Trial name
- NCT04044872
- Testing
- [1-13C]pyruvate along with MRI imaging
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Texas Southwestern Medical Center
Cardiotoxicity
Early Identification of Cardivascular Damage Induced by Chemotherapy and Antineoplastic Treatments in Pediatric Age
To test whether the implementation of new diagnostic techniques (ultrasonography, speckle tracking, vascular stiffness study, cardiac MRI, and histologic studies) allows in CAYA (Childern, Adolescents, and Young Adults) cancer…
- Trial name
- PREDICT (NCT07382141)
- Testing
- Parameters of vascular stiffness
- Where
- 5 sites in Italy
- Volunteers
- 400 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Breast Cancer, Disability Physical
Breast cancEr, FITness and ExeRcise for Heart Health: The BE-FITTER Study
The chemotherapy medications used for breast cancer treatment are important for achieving a cure, but a potential side effect is that they can cause a decline in functional capacity (reduced exercise tolerance and impaired…
- Conditions
- Breast Cancer, Disability Physical, Heart Failure, Cardiotoxicity
- Trial name
- BE-FITTER (NCT06595147)
- Testing
- Structured Exercise Training, Group-based Yoga and Stretching
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Alberta
Breast Cancer, Radiotherapy
BRAVE-HEART: Breast Cancer Radiotherapy Using Active Breathing Coordinator to aVoid Exposure of HEART
The BRAVE-HEART trial is an ambispective, observational, non-randomized study conducted at Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Policlinico San Matteo (Pavia, Italy).
- Trial name
- BRAVE-HEART (NCT07299812)
- Testing
- Breast Radiotherapy with or without Deep Inspiration Breath Hold (DIBH)
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia