Clinical trials: Cardiopulmonary Resuscitation
Heart Arrest
Combined Vasopressin, Methylprednisolone, and Epinephrine for Inhospital Cardiac Arrest
A randomized controlled trial did not show benefit of vasopressin versus epinephrine in inhospital cardiac arrest. Preceding laboratory data suggest that combined vasopressin and epinephrine ensure long-term survival and…
- Trial name
- NCT00411879
- Testing
- Vasopressin, Epinephrine, and Steroids
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University of Athens
Pediatric Cardiac Arrest (Simulated), Cardiopulmonary Resuscitation, Simulation Training
Effect of Bed Height on Chest Compression Quality and Provider Biomechanics During Pediatric CPR Simulation
High-quality chest compressions are critical for outcomes after pediatric cardiac arrest, yet rescuer ergonomics and bed height may adversely affect compression quality and fatigue.
- Conditions
- Pediatric Cardiac Arrest (Simulated), Cardiopulmonary Resuscitation, Simulation Training, In-Hospital Cardiac Arrest, Rescuer Fatigue During CPR
- Trial name
- NCT07329842
- Testing
- Fixed Standard Bed Height (58 cm), Anthropometry-Based Bed Height (Patella Midpoint), Anthropometry-Based Bed Height (Lower One-Third Patella-ASIS)
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Ventilation During Cardiopulmonary Resuscitation
Lung Ventilation During Cardiopulmonary Resuscitation
The authors to measure passive tidal volumes generated during external chest compressions in order to determine whether chest compressions alone without any mechanical ventilatory support in cardiopulmonary resuscitation can…
- Trial name
- NCT02420483
- Testing
- Cardiopulmonary resuscitation chest compressions
- Where
- Greece
- Volunteers
- 25 people
- Sponsor
- University of Thessaly
Heart Diseases, Heart Valve Diseases
Acute Kidney Injury After Cardiac Surgery
The study aims to identify the Following: - 1. incidence and mortality of cardiac Surgery associated -AKI based on the new consensus diagnostic systems of KDIGO (Kidney Disease Improving Global Outcomes). 2.
- Conditions
- Heart Diseases, Heart Valve Diseases, Heart Shock, Cardiac Disease
- Trial name
- NCT05079724
- Testing
- Cardiac Surgery
- Volunteers
- 200 people
- Sponsor
- Assiut University
Cardiac Arrest, Sudden Cardiac Death
Treatment of Ventricular Tachyarrhythmias Refractory To Shock With Beta Blockers: The SHOCK and BLOCK Trial
The purpose of this research study is to evaluate the effectiveness of metoprolol, a "beta blocker," in treating patients in the hospital with a cardiac arrest. It will be given intravenously (given into a vein).
- Conditions
- Cardiac Arrest, Sudden Cardiac Death, Ventricular Fibrillation, Tachycardia, Ventricular
- Trial name
- Shock n Block (NCT00401882)
- Testing
- Epinephrine, Metoprolol
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- David Haines, MD
Cardiac Arrest
RACE-CARS - RAndomized Cluster Evaluation of Cardiac ARrest Systems
RACE-CARS is a real-world cluster-randomized trial designed to evaluate a multifaceted community and health systems intervention aimed to improve outcomes of out-of-hospital cardiac arrest.
- Trial name
- NCT04660526
- Testing
- Rapid cardiac arrest recognition that triggers immediate priority EMS/first responder dispatch by 911 operators, Systematic bystander resuscitation instruction by 911 operators, Comprehensive community training of lay people in CPR and AED use.
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Duke University
Low-Dose High-Frequency CPR Training
Low-Dose, High-Frequency CPR Training in Pediatric Emergency Nurses
Life-threatening conditions such as respiratory failure, shock, and cardiac arrest require rapid recognition and timely intervention in pediatric emergency settings.
- Trial name
- LDHF CPR Peds (NCT07508085)
- Testing
- Low-Dose High-Frequency CPR Training, Massed CPR Training
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ankara University
Cardiopulmonary Arrest, DNR-orders
Resuscitation Outcomes in the Netherlands Flashmob Questionnaire
The aim of this study is to gain insight in patients' experiences regarding do not resuscitate conversations and decisions. A multicentre flash mob investigation will be conducted in which data will be obtained over the course of…
- Trial name
- ROUTINE-F (NCT03807206)
- Testing
- Questionnaire
- Where
- 12 sites in Netherlands
- Volunteers
- 1,136 people
- Sponsor
- Erasmus Medical Center
Cardiac Arrest
A Comparison of CPR Outcomes Between Traditional and Endomorphic Manikins With and Without Equipment
The study's research design is a randomized experiment. 50 emergency responders (emergency medical responders, emergency medical technicians, advanced emergency medical technicians, and paramedics) will be recruited for this…
- Trial name
- NCT04283214
- Testing
- Cardiopulmonary Resuscitation
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- North Dakota State University
Out-Of-Hospital Cardiac Arrest, Emergencies
Livestreaming From Smartphones as a Supplement to Emergency Calls
The aim of the study is to analyse if live video as a supplement to emergency calls can improve medical dispatchers' situation awareness and enhance the assistance they provide including provision of pre-hospital resources.
- Conditions
- Out-Of-Hospital Cardiac Arrest, Emergencies, Unconscious
- Trial name
- NCT04061187
- Where
- Denmark
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Emergency Medical Services, Capital Region, Denmark
Resuscitation, Extra Corporeal Life Support
PERCEPTION - Super-Early Neuroprognostication in eCPR Patients
Background Extracorporeal cardiopulmonary resuscitation (eCPR) is a rescue therapy for a selected group of patients. Extracorporeal membrane oxygenation (ECMO) is initiated to bypass the cardiac system and bridge time to…
- Conditions
- Resuscitation, Extra Corporeal Life Support, ECMO, Extracorporeal Cardiopulmonary Resuscitation
- Trial name
- PERCEPTION (NCT07584187)
- Testing
- Automated Pupillometry, continuous near-infrared spectroscopy (cNIRS)
- Where
- Austria
- Volunteers
- 45 people
- Sponsor
- Medical University of Vienna
Out-of-hospital Cardiac Arrest
Application of Mechanical Cardiopulmonary Resuscitation Devices and Their Value in Out-of-hospital Cardiac Arrest: A Retrospective Analysis of the German Resuscitation Registry
The aim of this study was to analyse a large CPR database, the German Resuscitation Registry, to evaluate potential benefits of mechanical CPR devices over manual CPR in adult cardiac arrest victims.
- Trial name
- NCT02932124
- Testing
- mechanical chest compression device
- Volunteers
- 19,609 people
- Sponsor
- German Resuscitation Registry
Cardiac Arrest, Cardiopulmonary Resuscitation
Quantitative Measurement of Cardiopulmonary Resuscitation (CPR) During In Hospital Cardiac Arrest
The design of this protocol is a prospective observational study to objectively measure the rate, depth and quality of chest compressions and ventilations delivered during cardiac arrest in the Pediatric Intensive Care Unit…
- Trial name
- Q-CPR (NCT00628693)
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Children's Hospital of Philadelphia
Pediatric Advanced Life Support (PALS)
Comparing the Effectiveness of Large Language Model-Based and Video-Based Refresher Education on Knowledge Retention After Simulation-Based Pediatric Cardiopulmonary Resuscitation Training: A Six-Month Follow-Up Study
This study aims to compare the effectiveness of large language model (LLM)-based refresher education and video-based refresher education for maintaining knowledge and performance after simulation-based Pediatric Advanced Life…
- Trial name
- NCT07783932
- Testing
- LLM-Based Refresher Education, Video-Based Refresher Education
- Where
- South Korea
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Heart Arrest
Resuscitation Outcomes Consortium (ROC) Prehospital Resuscitation Using an Impedance Valve
The purpose of this study is to look at two different treatments during a cardiac arrest that occurs outside of the hospital and whether either or both treatments will increase the number of people who live to hospital discharge.
- Trial name
- NCT00394706
- Testing
- Impedance Threshold Device (ITD), Analyze early, Analyze later
- Where
- 9 sites in United States, Canada
- Volunteers
- 11,738 people
- Sponsor
- University of Washington
Airway Aspiration, Cardiopulmonary Arrest
The Impact of Soiled Airway Management on CPR Quality
Regurgitation is an adverse event common during cardiopulmonary resuscitation (CPR) and occurs in 20%-32% of patients experiencing out-of-hospital cardiac arrest (OHCA).
- Trial name
- NCT05278923
- Testing
- SALAD simulation device
- Where
- Taiwan
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Cardiac Arrest
Assessing CPR Quality During In-Hospital Cardiac Arrest
Using an investigational monitor/defibrillator that passively records CPR quality parameters, including chest compression rate and depth and ventilation rate and volume, we are prospectively recording CPR quality during…
- Trial name
- NCT00228293
- Testing
- investigational monitor/defibrillator with CPR feedback
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Chicago
Cardiac Arrest
Aminophylline in Bradyasystolic Cardiac Arrest
The purpose of this study is to evaluate the effect of aminophylline in patients with out-of-hospital bradyasystolic cardiac arrest.
- Trial name
- NCT00312273
- Testing
- Aminophylline (250mg IV +/- a second dose of 250mg IV)
- Where
- Canada
- Volunteers
- 966 people
- Sponsor
- Vancouver General Hospital
Cardiac Arrest
Multifaceted Intervention for Increasing Performance of CPR by Laypersons in Out-of-hospital Cardiac Arrest
Cardiac arrest (CA) early recognition is essential in order to rapidly activate emergency services and for bystanders to begin cardiopulmonary resuscitation (CPR).
- Trial name
- DISPATCH (NCT03633370)
- Testing
- Multifaceted intervention including 3 components
- Where
- 15 sites in France
- Volunteers
- 2,481 people
- Sponsor
- University Hospital, Grenoble
Cardiac Arrest
Sustained Inflation and Chest Compression vs 3:1 C:V Ratio in Asphyxiated Newborns
Newborn infants who require cardiopulmonary resuscitation at birth receive chest compression using a 3-Compression to 1-Ventilation (3:1 C:V) ratio.
- Trial name
- SUR1VE-2 (NCT06577818)
- Testing
- CC+SI (Chest compression during sustained inflation), 3:1 C:V (3:1 Compression:Ventilation ratio)
- Where
- Canada
- Volunteers
- 554 people
- Sponsor
- University of Alberta