Clinical trials: Cardioprotection
Coronary Artery Bypass Graft Triple Vessel, Apoptotic DNA Damage
Remote Ischemic Preconditioning of Human Myocardium
The investigators aim to definitively show if human myocardium can be remotely preconditioned. In the writings there are no experiments that would prove that the remote preconditioning protocol effects on the higher protection of…
- Trial name
- NCT01994707
- Testing
- Remote ischemic preconditioning
- Where
- Poland
- Volunteers
- 134 people
- Sponsor
- Medical University of Silesia
Coronary Artery Bypass Surgery
Nitrite Mediated Cardioprotection During Coronary Artery Bypass Surgery
The purpose of this study is to determine whether sodium nitrite administration 24 hours prior to or during coronary artery bypass surgery protects the heart better from lack of blood flow which occurs as part of this type of…
- Trial name
- NCT01098409
- Testing
- sodium nitrite, 0.9% sodium chloride
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Coronary Artery Bypass Graft Surgery, Myocardial Ischemia
A Safety and Efficacy Study to Confirm the Cardioprotective Effects of MC-1 in Patients Undergoing High-Risk CABG
The purpose of this study is to determine the effect of MC-1 on the combined incidence of cardiovascular death and nonfatal myocardial infarction (MI) up to and including 30 days following coronary artery bypass graft (CABG)…
- Conditions
- Coronary Artery Bypass Graft Surgery, Myocardial Ischemia, Reperfusion Injury
- Trial name
- NCT00402506
- Testing
- (MC-1) Pyridoxal 5'-phosphate
- Where
- 2 sites in United States, Canada
- Volunteers
- 3,000 people
- Sponsor
- Medicure
Myocardial Infarction
Effect of METOprolol in CARDioproteCtioN During an Acute Myocardial InfarCtion. The METOCARD-CNIC Trial.
The purpose of this study is to test whether early pre-reperfusion metoprolol administration in patients suffering and acute myocardial infarction might reduce the size of myocardial necrosis.
- Trial name
- METOCARD-CNIC (NCT01311700)
- Testing
- Injectable (i.v.) metoprolol tartrate (up to 15 mg).
- Where
- 12 sites in Spain
- Volunteers
- 221 people
- Sponsor
- Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III
Recovery From Sedation, Sevoflurane Consumption
Inhalative Sedation in ICU With Sevoflurane Via Anaesthetic Conserving Device Compared to Propofol
The evaluation of the presented study will work on the practicability of inhalative sedation on the ICU, potential benefits and limitations of the ACD system in a postoperative sedated patient population in comparison to a…
- Conditions
- Recovery From Sedation, Sevoflurane Consumption, Renal Function, Hepatic Function
- Trial name
- NCT00586118
- Testing
- Sevoflurane, Propofol
- Volunteers
- 120 people
- Sponsor
- Klinikum Ludwigshafen
ST-segment Elevation Myocardial Infarction (STEMI)
Effect of Remote Ischemic Conditioning in Heart Attack Patients
New treatments are required to improve health outcomes in patients with ischemic heart disease. This is especially so in developing countries such as Mauritius in which optimal therapy for acute myocardial infarction may not be…
- Trial name
- ERIC-LYSIS (NCT02197117)
- Testing
- Remote ischemic conditioning, Control
- Where
- 5 sites in Mauritius
- Volunteers
- 519 people
- Sponsor
- University College, London
Diabetes Mellitus, Coronary Artery Bypass
Remote Ischemic Preconditioning in Type 2 Diabetic Patients Undergoing CABG
This randomized, double-blind, prospective clinical trial aims to investigate the effect of remote ischemic preconditioning (RIPC) on myocardial protection in patients with type 2 diabetes mellitus undergoing elective coronary…
- Conditions
- Diabetes Mellitus, Coronary Artery Bypass, Remote Ischaemic Conditioning
- Trial name
- NCT06977230
- Testing
- Remote Ischemic Preconditioning
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Muğla Sıtkı Koçman University
Transplant; Failure, Heart, Cardiac Allograft Vasculopathy
Impact of SGLT2 Inhibitors in Heart Transplant Recipients
The goal of this clinical trial is to test if SGLT2 inhibitors could prevent or delay the development of Cardiac Allograft Vasculopathy (CAV) post-heart transplantation (TxC).
- Conditions
- Transplant; Failure, Heart, Cardiac Allograft Vasculopathy, Rejection Heart Transplant
- Trial name
- NCT06147271
- Testing
- SGLT2i
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Universidade Federal do Ceara
Coronary Artery Bypass Graft Surgery, Myocardial Ischemia
MEND-CABG (MC-1 to Eliminate Necrosis and Damage in Coronary Artery Bypass Graft Surgery)
The purpose of this study is to determine whether MC-1 is effective and safe in reducing cardiovascular and neurological events in patients undergoing high-risk coronary artery bypass surgery
- Conditions
- Coronary Artery Bypass Graft Surgery, Myocardial Ischemia, Reperfusion Injury, Myocardial Revascularization
- Trial name
- NCT00157716
- Testing
- (MC-1) Pyridoxal-5'-phosphate
- Where
- 2 sites in United States, Canada
- Volunteers
- 900 people
- Sponsor
- Medicure
Coronary Artery Disease
Aroxxen® Inhalation for Cardioprotection After Elective PCI With Stent Implantation
This is an open-label, randomized, multicenter Phase II clinical study designed to evaluate the cardioprotective effect, to determine the optimal dosages and duration of inhalation, and to assess the clinical safety of the…
- Trial name
- NCT07397351
- Testing
- Aroxxen
- Where
- Russia
- Volunteers
- 180 people
- Sponsor
- Research Institute of Geroprotective Technologies
STEMI, Myocardial Reperfusion Injury
Effect of Remote Ischaemic Conditioning on Clinical Outcomes in STEMI Patients Undergoing PPCI (CONDI2/ERIC-PPCI)
The purpose of this study is to determine whether remote ischemic conditioning can reduce cardiac death and hospitalization for heart failure at 12 months in patients presenting with a ST-elevation myocardial infarction and…
- Trial name
- NCT02342522
- Testing
- Remote ischemic conditioning, Control
- Where
- 35 sites in Denmark, Serbia and 2 more
- Volunteers
- 5,413 people
- Sponsor
- University College, London
Coronary Heart Disease, Cardiovascular Diseases
Comparison Between Propofol and Inhalational Anaesthetic Agents on Cardiovascular Outcomes Following Cardiac Surgery
The objective of this research proposal is to find out whether comparing the two different anaesthetic maintenance techniques (Propofol vs volatile anaesthetics) in adult patients undergoing heart surgery is practical for the…
- Trial name
- COPIA (NCT04039854)
- Testing
- Isoflurane, Sevoflurane or Desflurane, Propofol
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- King's College Hospital NHS Trust
Hemodialysis, Cardioprotection
Exercise Preconditioning to Protect Against Dialysis-induced Cardiac Injury
The goal of this study is to determine what happens to the heart muscle contraction when people cycle before their hemodialysis treatment.
- Trial name
- NCT06735378
- Testing
- Intradialytic Cycling
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Angina Pectoris
Adenosine Cardioplegia; Improved Cardioprotection?
60 elective patients for CABG will be included to receive either standard hyperkalemic cardioplegia (St.Thomas Hospital Solution No I) or cardioplegia where supranormal potassium is replaced with 1.2 mM adenosine.
- Trial name
- NCT01123525
- Testing
- Adenosine
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- University Hospital of North Norway
Cardiotoxicity
Cardioprotection Effect of Linagliptin
1. Background and Rationale Breast cancer is one of the most common malignancies affecting women worldwide and represents a major health burden in Egypt.
- Trial name
- Linagliptin (NCT07852546)
- Testing
- Doxorubicin, Empaglifloz 5 mg orally once daily
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Tanta University
Ischemic Preconditioning
Study on the Cardioprotection and Humoral Mechanism of Limb Ischemia Preconditioning
Numerous studies Have shown that limb ischemic preconditioning can protect vital organs (including the heart) from ischemia-reperfusion injury,which has a broad application prospect.But its mechanism is still unclear.
- Trial name
- NCT01118000
- Testing
- limb ischemia preconditioning
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Myocardial Infarction, Reperfusion Injury, Myocardial
Trans-coronary Cooling and Dilution for Cardioprotection During Revascularisation for ST-elevation Myocardial Infarction
A heart attack (myocardial infarction) occurs when an artery supplying blood to the heart is suddenly blocked resulting in damage to the heart muscle.
- Trial name
- STEMI-Cool (NCT06128993)
- Testing
- Transcoronary cooling and dilution, Standard of care
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Myocardial Injury, Myocardial Ischemia
PeRiOperaTivE CardioproTection With Ivabradine in Non-cardiac Surgery
Perioperative myocardial injury (PMI) after non-cardiac surgery (NCS), i.e. the elevation of postoperative troponin, occurs in nearly 20% of patients older than 45 years undergoing NCS and is independently and strongly associated…
- Trial name
- PROTECTIN (NCT04436016)
- Testing
- Ivabradine
- Where
- Switzerland
- Volunteers
- 78 people
- Sponsor
- University Hospital, Geneva
Breast Cancer, Cardiotoxicity
Cardiotoxicity Prevention in Breast Cancer Patients Treated With Anthracyclines and/or Trastuzumab
The aim of the study is to analyze the protective impact on the cardiac damage of beta blockers and ACE inhibitors for breast cancer patients treated with anthracyclines-based chemotherapy with or without trastuzumab.
- Trial name
- SAFE (NCT02236806)
- Testing
- Bisoprolol, Ramipril
- Where
- Italy
- Volunteers
- 262 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Coronary Heart Disease
Effect of Remote Ischaemic Preconditioning on Clinical Outcomes in CABG Surgery
Coronary heart disease (CHD) is the leading cause of death in the UK, accounting for 124,000 deaths (2006) and costing the UK economy over £7.9 billion a year.
- Trial name
- ERICCA (NCT01247545)
- Testing
- Remote ischaemic preconditioning, Control
- Where
- 28 sites in United Kingdom
- Volunteers
- 1,612 people
- Sponsor
- University College, London