Clinical trials: Cardio-Renal Syndrome
Cardio-Renal Syndrome
Adequate Hydration Therapy Combined With Intravenous Infusion of Isosorbide Dinitrate Prevention for CIN
Patients at moderate and high risk for contrast induced nephropathy (CIN) should receive sufficient hydration before application of contrast to prevent CIN, but hydration could obviously increase the preload for congestive heart…
- Trial name
- NCT02718521
- Testing
- Hydration Combined With Intravenous Infusion of Isosorbide Dinitrate, Visipaque, 0.9% sodium chloride fluid administration
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Chinese PLA General Hospital
Acute Decompensated Heart Failure
Assessment of Biomarkers and Cardiorenal Syndrome in Acute Decompensated Heart Failure With Vasodilator Therapy
The purpose of this study is to determine whether Nesiritide is more effective than nitroglycerin in modifying inflammatory and neurohormonal biomarkers without renal toxicity when proper infusion duration is administered.
- Trial name
- ABC-HFT (NCT00842023)
- Testing
- Nesiritide, Nitroglycerin
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Western University of Health Sciences
Cardiorenal Syndrome, Acute Decompensated Heart Failure
Biomonitoring and Cardiorenal Syndrome in Heart Failure(BIONICS-HF) Trial
The purpose of this study is to evaluate the ability of a non-invasive monitor that measures how much fluid is in the body as well as various blood tests for their ability to predict worsening kidney function in patients with…
- Trial name
- BIONICS-HF (NCT01570153)
- Where
- 2 sites in United States, Italy
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Cardiac Failure, Renal Failure
Protocolized Diuretic Strategy in Cardiorenal Failure
This research study is a randomized clinical trial to evaluate if taking diuretics (medications that increase urine production and help with fluid removal from the body) in a standardized fashion (using a guideline for adjusting…
- Conditions
- Cardiac Failure, Renal Failure, Kidney Failure
- Trial name
- ProDiuS (NCT01921829)
- Testing
- Protocolized Diuretic Strategy
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Kelly V. Liang, MD
Chronic Heart Failure, Cardio-Renal Syndrome
A Prospective, Multicenter, Randomized, Blinded, Sham-controlled, Feasibility Study of Renal Denervation in Patients With Chronic Heart Failure
The renin-angiotensin-aldosterone axis has been found to be a key system involved in heart failure disease progression and it may be inhibited by renal sympathetic denervation.
- Trial name
- RE-ADAPT-HF (NCT04947670)
- Testing
- Renal arteriography followed by renal denervation
- Where
- Germany
- Volunteers
- 4 people
- Sponsor
- Universität des Saarlandes
Acute Kidney Injury, Cardio-Renal Syndrome
Cardiac MRI for the Detection of Myocardial Injury Following Acute Kidney Injury
The aim of this clinical prospective study is to assess structural and functional myocardial changes in patients after acute kidney injury (Cardiorenal syndrome type 3) and intensive care stay by multiparametric cardiac MRI.
- Conditions
- Acute Kidney Injury, Cardio-Renal Syndrome, Cardiomyopathies
- Trial name
- NCT05034588
- Testing
- Cardiac magnetic resonance scan
- Where
- 2 sites in Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital, Bonn
Cardio-Renal Syndrome
Nitrates In Combination With Hydralazine in cardiorEnal Syndrome (NICHE) Study
This is a single-blind, randomised, clinical trial assessing the efficacy of Hydralazine and Isosorbidedinitrate combination (oral agents) in HF patients with renal dysfunction.
- Trial name
- NICHE (NCT02343393)
- Testing
- Hydralazine, Isosorbide Dinitrate
- Where
- 3 sites in Singapore
- Volunteers
- 100 people
- Sponsor
- National University Hospital, Singapore
Tricuspid Regurgitation, Tricuspid Valve Insufficiency
Evaluation of the Impact of Interventional Treatments for Symptomatic, Severe Tricuspid Valve Insufficiency on Renal Integrity and Function, as Well as on Physical Function and Activity in Older Adults.
The hypothesis is that renal function will improve following tricuspid valve intervention. A reduction in renal biomarkers is also expected.
- Conditions
- Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Cardio-Renal Syndrome, Frailty
- Trial name
- TriRenGe (NCT07464106)
- Testing
- Transcatheter edge-to-edge repair (TEER)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Robert Bosch Medical Center
Glycocalyx, Cardio-Renal Syndrome
Damage and Renal Clearance of Glycocalyx in Cardiac Surgery
The glycocalyx is a component of the vascular endothelium that currently plays a relevant role in the modified Starling theory. The manipulation of the heart during cardiac surgery stimulates the release of the natriuretic atrial…
- Trial name
- GlycoCarSur (NCT04332952)
- Where
- Mexico
- Volunteers
- 21 people
- Sponsor
- Miguel Ayala León
Cardiorenal Syndrome, Heart Failure
Venous Ultrasound Guided Organ Decongestion in Patients Hospitalized with Acute Decompensated Heart Failure
The purpose of this study is to assess the feasibility, safety and effectiveness of VExUS guided organ decongestion compared to standard of care in patients hospitalized with acute decompensated heart failue (ADHF).
- Conditions
- Cardiorenal Syndrome, Heart Failure, Acute Kidney Injury, Acute Decompensated Heart Failure
- Trial name
- VExOUS-ADHF (NCT06714409)
- Testing
- VExUS guided decongestion
- Where
- Norway
- Volunteers
- 180 people
- Sponsor
- Oslo University Hospital