Clinical trials: Cardiac Surgery With Cardiopulmonary Bypass
Right Ventricular Impaired Function, Hypovolemia
Comparison of the Effects of an Hypertonic Solution With Ringer Lactate on Right Ventricular Function Following Cardiac Surgery
This study is a phase III, randomized, controled, parallel groups, single blinded, clinical trial that aims at comparing the improvement of right ventricular function after administration of a hypertonic solution versus Ringer…
- Trial name
- SUCCESS (NCT02782520)
- Testing
- Ringer Lactate (10ml/kg) fluid expansion, Hypertonic saline (3ml/kg) fluid expansion
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Grenoble
Acute Kidney Injury Cardiac Surgery
Renal Near-Infrared Spectroscopy Monitoring and Postoperative Acute Kidney Injury in Cardiac Surgery
This prospective observational study aims to evaluate the effectiveness of renal near-infrared spectroscopy (NIRS) monitoring in predicting postoperative acute kidney injury (AKI) in patients undergoing elective cardiac surgery…
- Trial name
- RENAL-CPB-NIRS (NCT07582393)
- Where
- Turkey (Türkiye)
- Volunteers
- 113 people
- Sponsor
- SERAY TÜRKMEN
Postoperative Cognitive Dysfunction
Comparison of Postoperative Outcome After Sevoflurane and Propofol Anaesthesia
As the investigators know, postoperative cognitive dysfunction (POCD) is a fairly well-documented clinical phenomenon, which affect patients' short-term and long-term outcome.
- Trial name
- NCT02931877
- Testing
- sevoflurane, propofol
- Where
- 3 sites in China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Xinqiao Hospital of Chongqing
Cardiopulmonary Bypass
Cerebral Perfusion Monitoring With Transpharyngeal Ultrasonography
This prospective observational pilot study investigates transpharyngeal ultrasonography (TPU) as an additional neuromonitoring strategy to assess cerebral perfusion during on-pump cardiovascular surgery.
- Trial name
- TP-Echo (NCT01828411)
- Testing
- Transpharyngeal ultrasonography, Duplex sonography
- Where
- Switzerland
- Volunteers
- 32 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Emergence Delirium, Postoperative Delirium
Verification of a New Predictive Delirium Score in Adults With Elective Cardiac Valve or Bypass Surgery With Perioperative Use of a Heart-lung Machine; a Monocentric Pilot Observational Study
Basics (state of scientific knowledge): Delirium is an acute disturbance of consciousness and attention that develops over a short period of time and fluctuates in severity.
- Trial name
- MO-FA2-(TB) (NCT07276503)
- Volunteers
- 100 people
- Sponsor
- University Hospital Tuebingen
Acute Lung Injury
Inflammatory Genetic Polymorphism and Acute Lung Injury After Cardiac Surgery
Acute lung injury is a common complication of cardiac surgery with cardiopulmonary bypass, and it is significantly related to prolonged postoperative recovery, hospital stays and medical cost.
- Trial name
- NCT00826072
- Where
- China
- Volunteers
- 107 people
- Sponsor
- Changhai Hospital
Hypertrophic Obstructive Cardiomyopathy
Esmolol for Myocardial Protection in Hypertrophic Obstructive Cardiomyopathy
Perioperative blockage of beta-adrenoreceptors is widely used in cardiac and non-cardiac surgery to reduce the rate of cardiovascular complications.
- Trial name
- NCT05073094
- Testing
- Esmolol
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Cardiopulmonary Bypass
Cefazolin Dosing in Children Undergoing Cardiac Surgery With Cardiopulmonary Bypass
Pharmacokinetics of cefazolin in children undergoing cardiac surgery.
- Trial name
- CEFA (NCT02749981)
- Testing
- blood and tissue sampling
- Volunteers
- 56 people
- Sponsor
- University Hospital, Ghent
Valvular Heart Disease, Aortic Disease
Effect of Anesthetics on CD39 and CD73 After Open-heart Surgery
CD39 and CD73 was known protein expressed on surface of Th1 and Th17 cell and modulate immune related reaction. Cardiopulmonary bypass (CPB) can induce inflammatory reaction during cardiac surgery, and induce immunosuppression.
- Trial name
- NCT02136979
- Testing
- Propofol, Sevoflurane
- Where
- South Korea
- Volunteers
- 2 people
- Sponsor
- Konkuk University Medical Center
Coronary Artery Disease
SMART Trial Longitudinal Follow-Up:Off-Pump Versus On-Pump Coronary Artery Bypass Surgery
The purpose of this study is to determine completeness of revascularization, graft patency, clinical outcomes, health-related quality of life and costs in 200 initial trial participants at > 5 years post surgery who had heart…
- Trial name
- NCT00209053
- Testing
- Coronary Artery Bypass
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Emory University
Systemic Inflammatory Response Syndrome (SIRS), Cardiac Surgical Procedures
Electroacupuncture at ST36 for Reducing Postoperative Inflammation After Cardiac Surgery With Cardiopulmonary Bypass
Cardiac surgery using cardiopulmonary bypass can trigger a marked systemic inflammatory response and may contribute to postoperative organ dysfunction and delayed recovery.
- Conditions
- Systemic Inflammatory Response Syndrome (SIRS), Cardiac Surgical Procedures, Postoperative Complications (Cardiopulmonary)
- Trial name
- EAST36-CPB (NCT07795112)
- Testing
- Electroacupuncture at Bilateral ST36, Acupuncture Without Electrical Stimulation at Bilateral ST36
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Sir Run Run Shaw Hospital
Cardiovascular Disease, Renal Insufficiency, Acute
Acetylcysteine Against Acute Renal Insult During Cardiopulmonary Bypass.
The purpose of this study is to determine whether N-acetylcysteine is effective in the prophylaxis of post-cardiopulmonary bypass acute renal impairment.
- Conditions
- Cardiovascular Disease, Renal Insufficiency, Acute, Cardiopulmonary Bypass
- Trial name
- NCT00190034
- Testing
- N-Acetylcysteine 600mg/tab
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Far Eastern Memorial Hospital
Coronary Artery Disease
A Study of Hemopure® to Enhance Tissue Preservation During Cardiopulmonary Bypass Surgery
The purpose of this study is to determine if Hemopure® will enhance tissue preservation during Cardiopulmonary Bypass surgery.
- Trial name
- NCT00301535
- Testing
- HBOC-201 (hemoglobin glutamer-250 bovine)
- Where
- 3 sites in Greece, South Africa and 1 more
- Volunteers
- 60 people
- Sponsor
- Biopure Corporation
Cardiac Surgery With Cardiopulmonary Bypass, Complete Serum Phosphorus Measure
Serum Phosphatemia Predictive Marker for AKI Diagnosis After Cardiac Surgery
Cardiac surgery associated acute kidney injury is an independent factor of morbidity and mortality . Despite its delayed elevation, serum creatinine (Cr) remains the goal standard to diagnose AKI.
- Conditions
- Cardiac Surgery With Cardiopulmonary Bypass, Complete Serum Phosphorus Measure, Complete Serum Creatinine Measure
- Trial name
- PhosphoIRA (NCT02900313)
- Testing
- cardiac surgery
- Where
- France
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Right Heart Failure, Open-heart Surgery
Levosimendan in Patients With Impaired Right Ventricular Function Undergoing Cardiac Surgery
Perioperative right ventricular (RV) function is an important determinant of postoperative outcomes after cardiac surgery. Perioperative RV dysfunction increases the need for perioperative inotropic support, prolongs intensive…
- Trial name
- NCT05063370
- Testing
- Levosimendan, Standard Care
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Cardiac Surgery With Cardiopulmonary Bypass, Acute Mesenteric Ischemia
Perioperatively Assessed Biomarker I-FABP Level for Prediction of Acute Mesenteric Ischemia and Its Correlation With Acute Kidney Injury, Followed by Extracorporeal Circulation (aMIKI)
Acute mesenteric ischemia (AMI) is a severe condition that might occur after cardiovascular surgery. Several risk factors for AMI, such as multimorbidity, the use of vasopressors, and an increase in inflammatory markers have been…
- Conditions
- Cardiac Surgery With Cardiopulmonary Bypass, Acute Mesenteric Ischemia, Acute Kidney Injury, Non-Occlusive Mesenteric Ischaemia
- Trial name
- aMIKI (NCT06365827)
- Testing
- observational study
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University of Giessen
Acute Kidney Injury, Cardiac Surgery
Transcutaneous Auricular Vagus Nerve Stimulation for Preventing Acute Kidney Injury in Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass
Acute kidney injury (AKI) is a common complication after cardiac surgery using cardiopulmonary bypass, leading to longer hospital stays and worse outcomes. Effective preventive therapies are lacking.
- Conditions
- Acute Kidney Injury, Cardiac Surgery, Cardiopulmonary Bypass
- Trial name
- NCT07549243
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation
- Where
- China
- Volunteers
- 152 people
- Sponsor
- Sir Run Run Shaw Hospital
Cardiac Surgery, Cardiopulmonary Bypass
Benefits of GIK in Cardiac Surgery Patients
The purpose of this study is to evaluate the effects of modified glucose - insulin - potassium (GIK) therapy in cardiac surgery patients undergoing cardiopulmonary bypass (CPB).
- Trial name
- NCT01516138
- Testing
- GIK, Control
- Where
- China
- Volunteers
- 930 people
- Sponsor
- Xijing Hospital
Cardiac Surgery, Cardiopulmonary Bypass
Clinical Trial Comparing Heparin and Protamine Fixed and Titrated Doses in Cardiac Surgery With Cardiopulmonary Bypass
There are currently several schemes described for anticoagulation with heparin and its reversal with protamine during cardiac surgery with CPB.
- Conditions
- Cardiac Surgery, Cardiopulmonary Bypass, Anticoagulation
- Trial name
- NCT01267487
- Testing
- Heparin fixed doses, PO continuous infusion of Protamine, Heparin and protamine titration
- Where
- Brazil
- Volunteers
- 240 people
- Sponsor
- SANE-Society of Anesthesiology
Cardiac Disease, Blood Transfusion
Predicting CSA-AKI With ACTA-PORT Score
In the scope of this study, it will be determined whether the ACTA-PORT (Association of Cardiothoracic Anesthetists perioperative risk of blood transfusion) scoring system can predict the incidence of events in other organ…
- Conditions
- Cardiac Disease, Blood Transfusion, Acute Kidney Injury
- Trial name
- NCT06484907
- Where
- Turkey (Türkiye)
- Volunteers
- 467 people
- Sponsor
- Ankara City Hospital Bilkent