Clinical trials: Cardiac Resynchronization Therapy
Cardiomyopathy (Ischemic or Non-Ischemic)
DNA/RNA Analysis of Blood and Skeletal Muscle in Patients Undergoing Cardiac Resynchronization Therapy (CRT)
Genes expressing inflammatory cytokines (TNF- alpha, IL1 etc) and genes involved in apoptosis (Caspase 3, Bax, Bcl-2, Fas) are dysregulated in the skeletal muscles of the patients who have muscle wasting and decreased exercise…
- Trial name
- Medusa PH (NCT00600392)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Duke University
Long QT Syndrome, Wide QRS Complexes
ECG Signal Collection From Long QT Syndrome, Wide QRS Complexes, Heart Failure, and Cardiac Resynchronization Patients
The purpose of this study is to collect surface electrograms from standard and several non-standard configurations in patients with long QT syndrome, heart failure, cardiac resynchronization therapy or wide QRS during a routine…
- Conditions
- Long QT Syndrome, Wide QRS Complexes, Heart Failure, Cardiac Resynchronisation
- Trial name
- NCT00399412
- Testing
- subcutaneous ICD
- Where
- United Kingdom
- Volunteers
- 86 people
- Sponsor
- Boston Scientific Corporation
Heart Failure at NYHA Stage III or IV, Non Responders to Resynchronization
LVAD in Non Cardiac Transplant Candidates and Non Responders to Resynchronization
The prognosis for heart failure patients is bleak for the advanced stages of the disease, with a reported 6-month mortality rate of almost 50% in patients treated with chronic inotropic therapy.
- Conditions
- Heart Failure at NYHA Stage III or IV, Non Responders to Resynchronization, Non Candidates for Transplantation
- Trial name
- CHECKMATE (NCT01126944)
- Testing
- heart mate II
- Where
- 4 sites in France, Germany
- Sponsor
- Rennes University Hospital
Heart Failure, Systolic, Left Bundle Branch Block
Acute Hemodynamic Effects of Pacing the His Bundle in Heart Failure
Cardiac resynchronization therapy (CRT) with biventricular pacing (BVP) is indicated for patients with low ejection fraction and persistent symptoms of heart failure despite medical therapy and a wide QRS-complex, preferably with…
- Conditions
- Heart Failure, Systolic, Left Bundle Branch Block, Wide QRS Complex
- Trial name
- HEPA-His (NCT04701112)
- Testing
- Temporary His bundle pacing
- Where
- Sweden
- Volunteers
- 2 people
- Sponsor
- Region Skane
Heart Failure, Diabetes Mellitus, Type 2
BIO-2-HEART: Identification of Biomarkers in T2DM and Heart Failure
The primary aim of the current study is a better understanding of the role of Type 2 Diabetes Mellitus (T2DM) in heart failure and, in particular, changes in cardiac metabolism, which may contribute to heart failure.
- Trial name
- BIO-2-HEART (NCT03323216)
- Testing
- 6-minute walk test, Study specific questionnaire, Blood collection
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- RWTH Aachen University
Heart Failure
Assessing the Capability of Cardiogoniometry (CGM) to Detect Changes in Cardiac Resynchronisation Therapy Device Settings
Some patients with heart failure require treatment called cardiac-resynchronisation therapy (CRT) which involves putting a pacemaker into the heart to make both ventricles (the lower chambers of the heart) contract together…
- Trial name
- HF-CGM (NCT02803879)
- Testing
- Cardiogoniometry
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Cardiac Resynchronization Therapy, Heart Failure
Comparison of Epicardial Versus Conventional Lead Placement in Cardiac Resynchronization Therapy
The primary goal of this study is to evaluate the use of robotically -assisted device leads as a primary strategy for heart resynchronization.This trials aims to compare transvenous lead placement with robotic lead placement for…
- Trial name
- REVERT (NCT01302470)
- Testing
- Primary epicardial placement of left ventricular lead, Transvenous placement of left ventricular lead
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Adult Congenital Heart Disease
Real-World Data on the Effects of Cardiac Resynchronization Therapy in Adult Patients With Congenital Heart Disease
This study aims to evaluate the real-world effects of cardiac resynchronization therapy (CRT) in adult patients with congenital heart disease (ACHD).
- Trial name
- RECORD-CHD (NCT06969924)
- Testing
- Cardiac resynchronization therapy
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Leiden University Medical Center
Atrial Fibrillation (AF), Heart Failure
AV Nodal Ablation With Conduction System Pacing Versus Cardiac Resynchronization for Symptomatic Heart Failure Patients With Atrial Fibrillation
The goal of this clinical trial is to learn if conduction system pacing works as well as cardiac resynchronization therapy (CRT) post atrioventricular (AV) node ablation in adult patients with symptomatic heart failure and atrial…
- Conditions
- Atrial Fibrillation (AF), Heart Failure, Cardiac Pacing
- Trial name
- APAF-CSP (NCT07604727)
- Testing
- Conduction System Pacing, Cardiac resynchronization therapy
- Where
- 23 sites in France, Germany and 2 more
- Volunteers
- 292 people
- Sponsor
- University Medical Center Groningen
Heart Failure, Left-Sided Heart Failure
Trajectory Changes of Coronary Sinus Lead Tip and Cardiac Resynchronization Therapy Outcome
In chronic systolic heart failure patients submitted to cardiac resynchronization therapy, the study aims at assessing whether geometric variations in coronary sinus lead tip trajectory throughout the cardiac cycle acutely…
- Conditions
- Heart Failure, Left-Sided Heart Failure, Ventricular Dysfunction
- Trial name
- TRAJECTORIES (NCT02340546)
- Testing
- cardiac resynchronization therapy
- Where
- 7 sites in Italy
- Volunteers
- 119 people
- Sponsor
- Corrado Tomasi
Heart Failure
Quartet Lead and Resynchronization Therapy Options
The purpose of this Clinical Trial is to determine the percentage of patients whose hemodynamic response improves with the different configurations offered by the new Quartet® left ventricular lead, as a result of its four…
- Trial name
- QUARTO (NCT01295840)
- Testing
- Cardiac Resynchronization Therapy Defibrillator
- Where
- Spain
- Volunteers
- 51 people
- Sponsor
- Abbott Medical Devices
Cardiac Resynchronization Therapy
MAGNET CRT Feasibility - Efficiency of LV Lead Placement Comparing Conventional vs. Magnetic Guidance
Magnetic navigation will permit delivery of the LV lead tip to a prospectively defined location more efficiently and in a higher proportion of patients than is possible with manual navigation.
- Trial name
- NCT00370474
- Testing
- Bi-ventricular lead placement
- Where
- 6 sites in United States
- Volunteers
- 27 people
- Sponsor
- Stereotaxis
Congestive Heart Failure, Cardiac Resynchronization Therapy
Improvement in Clinical Outcomes in Heart Failure Patients With ICDs That Practice Meditation
This is a trial to examine the effects of meditation on the incidence of ventricular arrhythmias and the psychological profiles in patients with implanted cardiac defibrillators. We wish to test the following hypotheses: 1.
- Trial name
- NCT00611260
- Testing
- Vipassana Meditation practice and instruction, Standard Medical Care
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of California, Davis
Compare Two Programming Modalities for CRT Devices in Heart Failure Patients With an Indication for Cardiac Resynchronization Therapy
Multi Point Pacing vs. Conventional STUDY PROTOCOL
The Purpose of this study is to compare two programming modalities for CRT devices in Heart Failure patients with an indication for Cardiac Resynchronization Therapy
- Trial name
- CRT-MPP (NCT04334018)
- Testing
- conventional CRT, MPP CRT
- Where
- 6 sites in France, Monaco
- Sponsor
- CMC Ambroise Paré
Sympathetic Innervation, Chronic Heart Failure
Sympathetic Innervation of the Heart and Cardiac Resynchronization Therapy(CRT)
The purpose of this study is to assess whether baseline sympathetic innervation in patients with chronic heart failure (CHF) is predictive for response to cardiac resynchronization therapy (CRT).
- Trial name
- PET-CRT (NCT00567645)
- Where
- Netherlands
- Sponsor
- University Medical Center Groningen
Heart Failure
InSync III Marquis Model 7279 Cardioverter Defibrillator Cardiac Resynchronization System
People who have a dangerously fast heart beat, or whose heart is at risk of stopping beating, may be in need of an electronic device called an implantable cardioverter defibrillator (ICD).
- Trial name
- NCT00271232
- Testing
- Cardiac resynchronization therapy
- Where
- 34 sites in United States
- Volunteers
- 238 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Left Ventricular Dyssynchrony
Rest/Stress Quantification Of Left Ventricular Dyssynchrony By 3D Gated Blood Pool D-SPECT
Cardiac Resynchronization Therapy (CRT) is an established treatment for patients with advanced heart failure and left ventricular dyssynchrony (LVD). Too many patients do not clinically improve with CRT.
- Trial name
- NCT01390532
- Testing
- 3D Blood-Pool Gated SPECT (BPGS) with a new designed cardiac imaging camera (DSPECT, Spectrum Dynamics®, Ceasaria, Israel)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Clermont-Ferrand
Congenital Heart Defects
Assessing the Hemodynamic Benefits of Cardiac Resynchronization Therapy in Children Following Open-Heart Surgery
Malformations of the heart (congenital heart disease) are the most common congenital birth defects, occurring in about 1% of children.
- Trial name
- NCT00397514
- Testing
- Congenital Heart Surgery Patients
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- University of British Columbia
Heart Failure, Central Sleep Apnea
Cardiac Resynchronisation Therapy in Combination With Overdrive Pacing in the Treatment of Central Sleep Apnea in CHF
The primary objective of this study is to compare the Apnea- Hypopnea Index in HF patients with concomitant CSA, after 12 weeks of CRT alone to CRT in combination with one night of overdrive pacing.
- Trial name
- Morpheus (NCT00551499)
- Testing
- CRT + AOP
- Where
- 2 sites in Germany
- Volunteers
- 44 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Heart Failure
Endocardial Pacing in On-table Non-responders in Cardiac Resynchronization Therapy
The purpose of this study is to determine whether left ventricular endocardial pacing exhibits a greater acute hemodynamic response during biventricular pacing in patients who do not show this response to standard cardiac…
- Trial name
- NCT01193712
- Testing
- temporary left ventricular endocardial pacing
- Where
- Netherlands
- Sponsor
- Catharina Ziekenhuis Eindhoven