Clinical trials: Cardiac Remodeling, Atrial
Heart Failure, Patients Undergoing CRT-D Device Implantation
Reverse Electrical Remodeling of Native Conduction in Cardiac Resynchronization Therapy
Cardiac resynchronization therapy with pacemaker alone, or in combination with a cardioverter-defibrillator, prolongs life and decreases risk of heart failure exacerbation in patients with low ejection fraction and wide QRS.
- Trial name
- RER-CRT (NCT01924221)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Johns Hopkins University
Heart Valve Incompetence, Atrial Fibrillation, Persistent
In-depth Characterization of Atriogenic Secondary Tricuspid Regurgitation Due to Atrial Fibrillation
1050 patients with persistent/permanent atrial fibrillation (AF) will be studied using conventional and advanced (three-dimensional and deformation imaging) echocardiography.
- Trial name
- ASTRA (NCT05749107)
- Testing
- Echocardiography, Proteomic analyses
- Where
- 2 sites in Italy
- Volunteers
- 1,050 people
- Sponsor
- Istituto Auxologico Italiano
Atrial Fibrillation
Effect of Structural Remodeling on Scar Formation as Assessed by DE-MRI of the Left Atrium
The purpose of this study is to evaluate the impact of pre-ablation fibrosis on scar formation in the left atrium of the heart. This will be assessed by delayed enhancement magnetic resonance imaging and will be looked at in…
- Trial name
- RADAR (NCT01187914)
- Volunteers
- 40 people
- Sponsor
- University of Utah
Atrial Fibrillation
Reappraisal of Atrial Fibrillation: RACE-V - Work Package 5
In the proposed study the investigators aim to clarify the relative contribution of these different mechanisms to the progression of atrial fibrillation (AF).
- Trial name
- RACE V- WP 5 (NCT03124576)
- Testing
- Implantable loop recorder
- Where
- Netherlands
- Volunteers
- 380 people
- Sponsor
- Academisch Ziekenhuis Maastricht
Atrial Fibrillation (AF)
Unipolar Voltage Mapping for Personalized Atrial Fibrillation Ablation
Atrial fibrillation (AF) is a common heart rhythm disorder. While catheter ablation is an effective treatment, many patients still experience AF recurrence after the procedure.
- Trial name
- UNIQS-AF (NCT07630857)
- Testing
- Unipolar QS-Potential Guided Catheter Ablation, Conventional Pulmonary Vein Isolation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- China National Center for Cardiovascular Diseases
Atrial Fibrillation, Atrial Remodeling
High-density Mapping-guided bOx Isolation and subsTrate Ablation
This study evaluates the efficacy of high-density mapping guided atrial substrate ablation for persistent atrial fibrillation. 1/5 of the patients with persistent atrial fibrillation undergo pulmonary veins isolation, 2/5 of them…
- Trial name
- HOT (NCT03998956)
- Testing
- CPVI, CPVI+BOX, CPVI+BOX+SUB
- Volunteers
- 200 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Atrial Fibrillation
Flecainide-Short Long Study (Flec-SL)
A randomized trial to test the hypothesis that short-term pharmacological reversal of electrical remodeling after cardioversion is equally efficient to prevent recurrent atrial fibrillation as standard long-term antiarrhythmic…
- Trial name
- NCT00215774
- Testing
- Flecainide
- Volunteers
- 760 people, healthy volunteers welcome
- Sponsor
- Atrial Fibrillation Network
ASD2(Secundum Atrial Septal Defect)
Dapagliflozin and Right Heart Recovery After ASD Device Closure
The aim of this study is to evaluate the clinical and echocardiographic influence of dapagliflozin on right ventricular reverse remodeling in adult patients following successful transcatheter Atrial Septal Defect (ASD) device…
- Trial name
- NCT07823972
- Testing
- trans catheter device closure
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Assiut University
Stiffness, Aortic, Cardiac Remodeling, Ventricular
Study of the Aorta Adaptations to Exercise in Triathletes During Sports Season (CoATri)
Regular sustained physical activity creates a cardiac remodelling : it is athlete's heart. In our preliminary work published in 2016, the investigators demonstrated in a small population of triathletes that there is also a…
- Conditions
- Stiffness, Aortic, Cardiac Remodeling, Ventricular, Vascular Remodeling, Magnetic Resonance Imaging, Functional
- Trial name
- CoATri (NCT03356301)
- Testing
- Cardiac MRI, Applanation tonometry
- Where
- France
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Aortic Valve Stenosis, Heart Failure
Left Atrial Volume Index in Asymptomatic Aortic Stenosis
Aortic stenosis results in increased filling pressures of the heart. Size and function of the left atrium may be a marker for more advanced heart disease (heart failure) in patients with severe aortic stenosis, not presenting any…
- Trial name
- LAVIAS (NCT02395107)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
Persistent Atrial Fibrillation, Atrial Fibrillation (AF)
Atrial Remodeling After PFA Substrate Modification for Persistent AF (PeAF)
Atrial fibrillation (AF) is associated with both electrical and structural remodeling of the left atrium. While successful catheter ablation has been shown to reverse some aspects of atrial remodeling, the impact of pulsed-field…
- Conditions
- Persistent Atrial Fibrillation, Atrial Fibrillation (AF), Atrial Remodeling, Pulsed Field Ablation
- Trial name
- NCT07675395
- Testing
- Pulsed-Field Ablation with FARAWAVE Catheter System
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Cardiopulmonary Failure, Myocardial Infarction (MI)
COR-INSIGHT: Optimizing Cardiovascular and Cardiopulmonary Outcomes with AI-Driven Multiplexed Indications Using COR ECG Wearable
The COR-INSIGHT trial aims to evaluate the effectiveness of Peerbridge COR advanced ambulatory ECG wearables (COR 1.0 and COR 2.0) in accurately and non-invasively detecting cardiovascular and cardiopulmonary conditions using…
- Conditions
- Cardiopulmonary Failure, Myocardial Infarction (MI), Heart Decompensation, Heart Failure
- Trial name
- COR-INSIGHT (NCT06763549)
- Testing
- SUBPROTOCOL A, SUBPROTOCOL B, SUBPROTOCOL C
- Where
- United States
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Atrial Fibrillation, Cardiac Remodeling, Atrial
Effect of ARNI in Patients With Persistent AF and Enlarged Left Atrium After Catheter Ablation
The purpose of this clinical randomized trial is to evaluate the efficacy and safety of Sacubitril/Valsartan compared with ARB in improving cardiac remodeling in patients With Enlarged Left Atrium Diameter and Persistent AF.
- Conditions
- Atrial Fibrillation, Cardiac Remodeling, Atrial, Sacubitril/Valsartan
- Trial name
- APART-AF (NCT03791723)
- Testing
- Sacubitril-Valsartan, Valsartan
- Volunteers
- 90 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Sick Sinus Syndrome
Imaging Cardiac Electrical Remodeling With Electrocardiogram Imaging (ECGI)
A consequence of chronic RV pacing is a process of electrical remodeling that alters myocardial repolarization to reflect the altered depolarization induced by the RV lead.
- Trial name
- NCT00785564
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Washington University School of Medicine
Atrial Fibrillation
Stepwise Strategy for Treatment of Atrialfibrillation Substrate Study
Electrical/pharmacological cardioversion improves structural remodeling of left atrium. We hypothesized that radiofrequency ablation surgery for atrial fibrillation has a higher success rate and a lower recurrence rate of atrial…
- Trial name
- SAFE (NCT07129564)
- Testing
- treatment react
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Yuehui Yin
Atrial Fibrillation (AF), Arrhythmia
Computed Tomography of Pulse-Field Ablation
Radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF) reduces left atrial (LA) volume post-ablation, a phenomenon termed reverse atrial remodeling, indicative of successful reversal of atrial cardiomyopathy…
- Trial name
- CT-PFA (NCT07395089)
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Dilated Cardiomyopathies, Idiopathic, Heart Failure, Systolic
Pulse Reduction On Beta-blocker and Ivabradine Therapy
Heart failure with reduced left ventricular ejection fraction (HFrEF) is the most common form of chronic heart failure in subjects ≤ 75 years of age.
- Conditions
- Dilated Cardiomyopathies, Idiopathic, Heart Failure, Systolic, Ventricular Remodeling, Electrical Remodeling
- Trial name
- PROBE-IT (NCT02973594)
- Testing
- Ivabradine
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- University of Colorado, Denver
Myocardial Remodeling
Aldosterone Blockade to Prevent Myocardial Remodeling In Patients With Controlled Essential Hypertension
The goal of this project is to investigate the effects that the addition of aldosterone blockade with eplerenone will have on the progression of diastolic dysfunction in patients with controlled essential hypertension.
- Trial name
- Aldosterone (NCT00980031)
- Testing
- Eplerenone, Lactose Tablet
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Creighton University
Intracranial Embolism
Electrical Cardioversion of Recent Onset Atrial Fibrillation - Silent Thromboembolic Events, Reverse Atrial Remodeling
The purpose of this study is to study the effects of transthoracic electrical cardioversion for restoration of sinus rhythm in patients who present with recent onset atrial fibrillation, with regard to new silent cerebral…
- Trial name
- ECAF-STAR (NCT02955004)
- Testing
- Electrical cardioversion
- Where
- 3 sites in Sweden
- Volunteers
- 43 people
- Sponsor
- Uppsala University Hospital
Atrial Fibrillation (AF)
Finerenone After Catheter Ablation to Reduce Atrial Fibrillation Recurrence
Atrial fibrillation (AF) is a common heart rhythm disorder associated with stroke, heart failure, and increased mortality. Catheter ablation with pulmonary vein isolation (PVI) is an effective rhythm-control strategy, but 20-30%…
- Trial name
- FINE-CA (NCT07799519)
- Testing
- Finerenone
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Cheng-Kung University Hospital