Clinical trials: Cardiac Output
Cardiac Surgery
Evaluation of Cardiac Hemodynamic Modifications During Temporary Left Atrial Appendage Occlusion
The left atrium appendage (LAA) is a remnant of the original embryonic left atrium formed during the third week of gestation. LAA is believed to function as a decompression chamber during left ventricular systole and other…
- Trial name
- NCT02814851
- Testing
- Transesophageal echocardiogram, Thermistor-tipped catheter, Pressure/volume catheter
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Brugmann University Hospital
Anesthesia, Hemodynamic Instability
Anesthetic Guidance of Depth of Anesthesia and Indirect Cardiac Output Monitoring in Thoracic Surgery
Patients undergoing thoracotomy in thoracic surgery are prone to have complications of delayed recovery from general anesthesia and perioperative instable hemodynamics due to the relatively invasive procedures and patient's…
- Conditions
- Anesthesia, Hemodynamic Instability, Postoperative Respiratory Complication
- Trial name
- NCT04414228
- Testing
- M-Entropy guidance of anesthesia depth, ProAQT in guiding goal-directed hemodynamic therapy
- Where
- Taiwan
- Volunteers
- 76 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Preeclampsia
Ephedrine, Phenylephrine and Metaraminol Effects on Maternal Cardiac Output, Uterine Blood Flow and Fetal Circulation
It is a prospective clinical trial with random distribution that intends to investigate maternal and fetal effects of ephedrine, phenylephrine and metaraminol during cesarean delivery in patients with pre-eclampsia.
- Trial name
- NCT02245191
- Testing
- Ephedrine, Phenylephrine, Metaraminol
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
Cardiac Output, Hemodynamic Optimization
Hemodynamic Effects of Two Modalities of Alveolar Recruitment Maneuvers - ICU Patients
The objective of this study was to investigate the hemodynamic effects of two alveolar recruitment maneuver strategies in critical care patients with acute respiratory distress syndrome.
- Conditions
- Cardiac Output, Hemodynamic Optimization, Monitoring Blood Pressure, Stroke Volume
- Trial name
- CHARM-ICU (NCT05365854)
- Testing
- Alveolar Recruitment Maneuver (ARM)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Clermont-Ferrand
Cardiac Output
FIO2 Influences SvO2 Interpretation and Fick-based Cardiac Output Assessment
In this study, the investigators sought to clarify the influence of FIO2 levels on the variables in the Fick equation and then assessed the influence of each variable on the accuracy of Fick-CO measurements in patients undergoing…
- Trial name
- NCT04265924
- Testing
- fraction of inspired oxygen (FIO2)
- Volunteers
- 50 people
- Sponsor
- Chang Gung Memorial Hospital
Acute Heart Failure, Low Output Heart Failure
Postcardiotomy Venoarterial Extracorporeal Membrane Oxygenation
Cardiac surgery can be not infrequently complicated by cardiac low-output syndrome due to critical preoperative conditions such as cardiogenic shock, poor left ventricular function and severe myocardial ischemia.
- Conditions
- Acute Heart Failure, Low Output Heart Failure, Cardiac Output, Low, Extracorporeal Membrane Oxygenation
- Trial name
- PC-ECMO (NCT03508505)
- Testing
- Venoarterial extracorporeal oxygenation
- Where
- Finland
- Volunteers
- 1,000 people
- Sponsor
- Turku University Hospital
Heart Failure With Reduced Ejection Fraction HFrEF
Translational and Clinical Aspects of Metabolic, Anabolic and Endothelial Dysfunction in Heart Failure
In patients with HF cardiac output, metabolism and endothelial function will be studied during and after treatment with ghrelin infusion
- Trial name
- MetAnEnd-HF (NCT05277415)
- Testing
- Ghrelin
- Volunteers
- 31 people
- Sponsor
- Lars Lund
Cardiopulmonary Exercise Test, Hypertrophic Cardiomyopathy
Exercise Oxygen Kinetic and Cardiac Output in Hypertrophic Cardiomyopathy
Fatigue and dyspnea that reduce exercise performance are common symptoms in patients with hypertrophic cardiomyopathy. Since the cause of this functional limitation has not yet been described, this study aims to evaluate the…
- Conditions
- Cardiopulmonary Exercise Test, Hypertrophic Cardiomyopathy, Cardiac Output Measurement
- Trial name
- NCT05754489
- Where
- 3 sites in Italy
- Volunteers
- 90 people
- Sponsor
- Centro Cardiologico Monzino
Cardiac Output, Low
Effects of Inspiratory Flow Waveforms on Preload
The clinical usefulness of inspiratory flow pattern manipulation during mechanical ventilation remains unclear. The aim of this study was to investigate the effects of different inspiratory flow waveforms, i.e.
- Trial name
- NCT01892696
- Testing
- varying inspiratory flow waveforms
- Where
- Tunisia
- Volunteers
- 60 people
- Sponsor
- Military Hospital of Tunis
Cardiac Output,Low, Hemodynamic Instability
Cardiac Output Changes in Cesarean Section
Since 2011, phenylephrine was recommended as the preferred drug to maintain blood pressure in obstetric anesthesia.Phenylephrine, an α adrenoceptor agonist, can induce peripheral vasoconstriction to maintain blood pressure, while…
- Conditions
- Cardiac Output,Low, Hemodynamic Instability, Obstetrical Complication of Anesthesia
- Trial name
- NCT02759510
- Testing
- Norepinephrine, Phenylephrine
- Volunteers
- 106 people
- Sponsor
- RenJi Hospital
Cardiac Failure
Near Infrared Spectroscopy (NIRS) for Heart Failure Assessment.
It is routine practice for a cardiologist to perform a battery of tests to assess the degree of heart failure. The purpose of this study is to establish a non-invasive method to reliably predict cardiac output state in real-time…
- Trial name
- NCT01577810
- Testing
- Near Infrared Spectroscopy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Phoenix Children's Hospital
Congestive Heart Failure, Low Cardiac Output
Losartan in Decompensated Heart Failure
The dual blockade of the renin-angiotensin-aldosterone system with an angiotensin-converting enzyme inhibitor and an angiotensin-receptor blocker used together in heart failure patients has been demonstrated to be beneficial.
- Trial name
- NCT01857999
- Testing
- Losartan
- Where
- Brazil
- Volunteers
- 21 people
- Sponsor
- InCor Heart Institute
Atrial Fibrillation, Left Ventricular Failure
Non-invasive Blood Pressure and Cardiac Output Measurement by Using Applanation Tonometry
To evaluate and to validate accuracy, precision and trending ability of blood pressure and cardiac output measurement by applanation tonometry in cardiological patients having: atrial fibrillation severe impaired leftventricular…
- Conditions
- Atrial Fibrillation, Left Ventricular Failure, Left Ventricular Impaired Function, Aortic Valve Stenosis
- Trial name
- NCT02444104
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Healthy Volunteers
The Relationship Between Cardiac Output and Microvascular Visceral Blood Flow
Although major surgery is often required to treat abdominal problems, there is a significant risk of death or complication following these operations.
- Trial name
- NCT02167178
- Testing
- Administration of 0.9% NaCl solution, Measurement of stroke volume, Measurement of microvascular blood flow
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Hemodynamic Monitoring
Evaluation of the UltraTrac System as a Non-Invasive Monitor of Hemodynamic Parameters
This study will test the use of the UltraTrac™ system, a small, noninvasive device that uses electrodes on the skin and a small ultrasound sensor to provide measurements of cardiac function in a wide of subjects.
- Trial name
- NCT07862608
- Testing
- Noninvasive Hemodynamic Monitoring System
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- AcQumen Medical, Inc.
Hemodynamic Instability, Cardiac Output, High
Individualized Perioperative Hemodynamic Goal-directed Therapy in Major Abdominal Surgery (iPEGASUS-trial)
To evaluate the impact of perioperative, algorithm driven, hemodynamic therapy based on individualized fluid and cardiac output optimization on postoperative moderate and severe complications in patients undergoing major…
- Conditions
- Hemodynamic Instability, Cardiac Output, High, Peroperative Complication
- Trial name
- iPEGASUS (NCT03021525)
- Testing
- Individualized Goal Directed Therapy, Control Group
- Where
- 7 sites in Germany, Italy and 1 more
- Volunteers
- 380 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Cardiac Diseases Requiring Surgery
Correlation of Estimated Continuous Cardiac Output (esCCO) and TEE in Pediatric Cardiac Surgery
The purpose of this study is to determine the measuring accuracy of the truly non-invasive method estimated continuous cardiac output (esCCO) against the reference method transesophageal echocardiography in pediatric cardiac…
- Trial name
- NCT01865994
- Where
- Germany
- Volunteers
- 44 people
- Sponsor
- Heidelberg University
Sepsis, Shock
Assessment of Transcutaneous Oxygen Tension/Oxygen Challenge Test in Intensive Care Unit (ICU) Patients
The lack of subcutaneous partial pressure of oxygen (PO2) rise in response to high fraction of inspired oxygen (FiO2), called the "oxygen challenge test (OCT)", was associated with higher morbidity and mortality in human…
- Trial name
- ICUPtO2OCT (NCT01174966)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
ICU, Pulmonary Artery Catheter (PAC)
The HIgh-fidelity Hydraulic couPling Upper-arm Cuff Assessment of Limits, Safety, and Effectiveness (HIPULSE) Trial (Cardiac Output Study)
The purpose of this study is to compare cardiac output (CO), fluid responsiveness, and related measurements between the Philips AMC and PAC (Swan-Ganz) in ICU or surgical patients.
- Conditions
- ICU, Pulmonary Artery Catheter (PAC), Swan-Ganz Catheter
- Trial name
- CO (NCT06895603)
- Testing
- Philips Advanced Monitoring Cuff (AMC)
- Where
- 2 sites in United States, Germany
- Volunteers
- 75 people
- Sponsor
- Philips Clinical & Medical Affairs Global
Spinal Anesthesia, Pregnancy
Ephedrine vs Phenylephrine - ECG Changes
ECG changes during caesarean section are common. Incidence of ST depression on the ECG is up to 81% in some studies. Although this may indicate inadequate oxygen supply to the heart muscle (myocardial ischaemia) many other…
- Trial name
- NCT01243970
- Testing
- Phenylephrine, Ephedrine
- Where
- United Kingdom
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University College London Hospitals