Clinical trials: Cardiac Output,Low
Cardiac Output, Low, Coronary Arterial Disease
Post-Induction Low Cardiac Output Syndrome in Coronary Artery Bypass Graft Surgery
Hemodynamic change after induction of general anesthesia is usually judged from mean arterial pressure. Pressure, however, is a surrogate for flow, and the two can separate: cardiac output may fall while arterial pressure remains…
- Conditions
- Cardiac Output, Low, Coronary Arterial Disease, Anesthesia, General
- Trial name
- PiLCOs (NCT07810621)
- Testing
- routine clinical monitoring, observed only
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 103 people
- Sponsor
- Ataturk University
Coronary Heart Disease, Congestive Heart Failure
Standard Drug Therapy vs. Implanted Defibrillator for Primary Prevention of Sudden Cardiac Death
Recent ACC/AHA/ESC guidelines recommend prophylactic ICD implantation in most patients with coronary heart disease and LVEF < 40%.
- Conditions
- Coronary Heart Disease, Congestive Heart Failure, Ventricular Dysfunction, Low Cardiac Output
- Trial name
- SMART-ICD (NCT00524862)
- Testing
- Optimized medical therapy, Implantable Cardioverter Defibrillator
- Where
- 10 sites in Canada
- Volunteers
- 5,000 people
- Sponsor
- Unity Health Toronto
Burns
Cardiac Output Monitoring in Burn Patients
The purpose of this study is to describe the use of non-invasive cardiac output monitors (NICOM) in patients with burn injuries and to develop a protocol for NICOM in a burn unit.
- Trial name
- NCT02404597
- Testing
- NICOM (non-invasive cardiac output monitor)
- Where
- United States
- Sponsor
- Emory University
Ventricular Fibrillation, Ventricular Tachycardia
Understanding Outcomes With the EMBLEM™ S-ICD in Primary Prevention Patients With Low Ejection Fraction
This study assesses the 18-month incidence of inappropriate shocks in subjects implanted with the EMBLEM Subcutaneous Implantable Defibrillator (S-ICD) for primary prevention of sudden cardiac death.
- Conditions
- Ventricular Fibrillation, Ventricular Tachycardia, Low Cardiac Output
- Trial name
- UNTOUCHED (NCT02433379)
- Testing
- EMBLEM S-ICD System
- Where
- 110 sites in United States, Belgium and 11 more
- Volunteers
- 1,173 people
- Sponsor
- Boston Scientific Corporation
Congenital Cardiovascular Defects, Low Cardiac Output Syndrome
Levosimendan in Congenital Cardiac Surgery
Many pediatric patients undergoing cardiac surgery under cardiopulmonary bypass for repair of complex congenital malformations, require inotropic support for low cardiac output syndrome.
- Trial name
- NCT00695929
- Testing
- Levosimendan, Milrinone
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Hemodynamic Instability, Anesthesia, General
Hemodynamics During Induction of General Anesthesia With Medium or Low Remifentanil Doses.
In this trial the investigators want to examine if there is any difference in hemodynamic stability during induction when comparing two low and a medium remifentanil dose and keeping propofol induction dose at about 2.0 mg/kg.
- Conditions
- Hemodynamic Instability, Anesthesia, General, Anesthesia, Intravenous
- Trial name
- RH (NCT03861377)
- Testing
- Remifentanil R2, Remifentanil R4, Remifentanil R8
- Where
- Norway
- Volunteers
- 99 people
- Sponsor
- Helse Fonna
Low Cardiac Output
Efficacy, Safety of Hypertonic Lactate Soln. as Fluid Resuscitation Compared With Ringer's Lactate in Post-CABG Pats
Prospective, randomized, open-label study to assess the efficacy and safety of hypertonic lactate solution, compared to Ringer's Lactate as fluid resuscitation to maintain hemodynamic stability in post-coronary artery bypass…
- Trial name
- NCT00529490
- Testing
- Hypertonic lactate, Ringer's lactate
- Where
- Indonesia
- Volunteers
- 230 people
- Sponsor
- Innogene Kalbiotech Pte. Ltd
Cardiac Output, Low
Spanish Randomized Clinical Trial to Compare Levosimendan Versus Placebo in Postoperative Cardiac Surgery (SPARTANS)
Low cardiac output Syndrome (LCOS) is a complication that appears in approximately 20% of cardiac surgeries with extracorporeal circulation.
- Trial name
- SPARTANS (NCT04179604)
- Testing
- Levosimendan
- Where
- 9 sites in Spain
- Volunteers
- 300 people
- Sponsor
- María de los Ángeles Tena Pajuelo
Congenital Heart Disease
NIRS Predict Low Cardiac Output State in Neonates and Infants in Cardiac Surgery
Neonates and infants that have cardiac surgery with cardiopulmonary bypass (CPB) for congenital heart disease are at great risk for experiencing life-threatening low cardiac output syndrome (LCOS) in the first 24 hours after…
- Trial name
- NCT01849120
- Testing
- EQUANOX Advance 8004CB sensor
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Mayo Clinic
Heart Failure Low Output, Heart Failure
The Prelieve Trial - Pilot Study to Assess Safety and Efficacy of a Novel Atrial Flow Regulator (AFR) in Heart Failure Patients
This study aims to investigate safety and efficacy of the Occlutech® AFR device in patients with HFrEF (Heart failure with reduced ejection fraction) and HFpEF (Heart failure with preserved ejection fraction)
- Trial name
- PRELIEVE (NCT03030274)
- Testing
- Occlutech AFR device
- Where
- 26 sites in Belgium, Germany and 1 more
- Volunteers
- 106 people
- Sponsor
- Occlutech International AB
End Stage Renal Failure on Dialysis, Body Fluid Retention
Changes in Volumetric Hemodynamic Parameters Induced by Fluid Removal on Hemodialysis
Changes in volumetric hemodynamic parameters and fluid overload (Cardiac Index,Stroke Volume, Thoracic Fluid Content, Systemic Vascular Resistance) were measured using a impedance cardiography (ICG) (CardioScreen 1000 …
- Conditions
- End Stage Renal Failure on Dialysis, Body Fluid Retention, Impedance, Cardiac Output, Low
- Trial name
- CI/HD (NCT02485782)
- Testing
- CardioScreen 1000 - Haemodynamic Measurement System, Medis, BCM- Body Composition Monitor, Fresenius Medical Care, SCHILLER, BR-102 plus, Ambulatory Blood Pressure Monitoring System
- Where
- Poland
- Volunteers
- 48 people
- Sponsor
- Medical University of Warsaw
Cardiac Output, Low
Cardiac Index Changes With Ephedrine, Phenylephrine, Ondansetron and Norepinephrine During Spinal Anesthesia
The purpose of the study is to evaluate the cardiac output changes after an intravenous bolus of ephedrine, phenylephrine, ondansetron or norepinephrine during a spinal anesthetic for a cesarean delivery.
- Trial name
- EPhON (NCT03421860)
- Testing
- cardiac output changes with "ephedrine", cardiac output changes with "phenylephrine", cardiac output changes with "ondansetron"
- Where
- Tunisia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
Systolic Hypertension, Pregnancy Related
Effect of Labetalol, Atenolol, and Nifedipine on Maternal Hemodynamics Measured by ICG in Early Pregnancy
The purpose of the research is to characterize the effect of labetalol, atenolol, and nifedipine on maternal hemodynamics early in pregnancy.
- Conditions
- Systolic Hypertension, Pregnancy Related, Diastolic Hypertension, Cardiac Output, Low
- Trial name
- NCT04755764
- Testing
- Labetalol, Atenolol, Nifedipine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Marshall University
Heart Disease
Assessment of Cardiac Function and Anesthesia Depth in Patients Undergoing Cardiac Surgery
The SHAPE study is a prospective, randomized study evaluating changes in cardiac function in adult patients undergoing cardiac surgery with cardiopulmonary bypass.
- Trial name
- SHAPE (NCT07770269)
- Testing
- BIS-guided anesthesia: BIS 45-55, BIS-guided anesthesia: BIS 30-35
- Where
- Greece
- Volunteers
- 70 people
- Sponsor
- AHEPA University Hospital
Cardiac Output, Low, Cardiac Output, High
Echo FLOW Versus (Non-)Invasive Haemodynamics
Rationale: Diligent fluid management is instrumental to improve postoperative outcome, cost and quality of care. Objective: To determine the accuracy of brachial, femoral and carotid blood flow measurement with ultrasound…
- Trial name
- EFLOW (NCT04593797)
- Testing
- carotid blood flow measurement with ultrasound
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Congenital Heart Disease, Brain Injuries
Autologous Umbilical Cord Blood Treatment of Neonate With CHD
The aim of the study is to evaluate the feasibility and safety and efficacy of collecting and infusing autologous umbilical cord blood (UCB) in newborn infants with hypoplastic left heart syndrome (HLHS) and transposition of…
- Conditions
- Congenital Heart Disease, Brain Injuries, Low Cardiac Output Syndrome, Neonatal Disorder
- Trial name
- NCT03558269
- Testing
- Autlogous UCB infusion
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center
Cardiac Output, High, Cardiac Output, Low
Pulse Contour Analysis and Tissue Oxymetry in Changing Vascular Tone
The purpose of this study is to compare changes of minimally invasive arterial pulse contour cardiac output with changes of intermittent and continuous thermodilution cardiac output by pulmonary artery catheter in hemodynamic…
- Conditions
- Cardiac Output, High, Cardiac Output, Low, Vasodilation, Vasoconstriction
- Trial name
- NCT00583687
- Testing
- Vigileo TM / Flotrac TM (Minimally invasive cardiac output system consisting of arterial line sensor and cardiac output monitor), Passive leg raising, Volume challenge / Change of vasoactive drugs or inotropics
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cardiac Output, Low
Comparison Between NICOM-Cheetah and Flotrac-Vigileo for Cardiac Output Monitoring.
Cardiac output (CO) monitoring is an important tool in critically ill patients with haemodynamic instability. Traditionally, this has been accomplished using the pulmonary artery catheter (PAC).
- Trial name
- NCT03394768
- Testing
- No additional intervention
- Where
- Singapore
- Volunteers
- 26 people
- Sponsor
- Changi General Hospital
Liver Transplantation, End-stage Liver Disease (ESLD)
Restrictive Fluid Management In Liver Transplantation (REFIL) - Pilot
Hypothesis: A Canadian multicentre clinical trial is feasible. Study Design: Multicenter internal pilot parallel arm randomized controlled trial.
- Trial name
- REFIL-1 (NCT05647733)
- Testing
- Low splanchnic blood volume restrictive fluid management strategy, Optimized cardiac output liberal fluid management strategy, Phlebotomy
- Where
- 4 sites in Canada
- Volunteers
- 138 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Cardiac Output, Low, Cardiac Output, High
Non-invasive Continuous Cardiac Output Monitoring in Preterm Infants Study
This is an observational study in newborn term and preterm infants. The study will validate if non-invasive continuous cardiac output monitoring is feasible in newborn infants, if normative values can be constructed and what is…
- Conditions
- Cardiac Output, Low, Cardiac Output, High, Blood Pressure
- Trial name
- NICCOM (NCT04064177)
- Testing
- NICAS cardiac output monitor
- Where
- United Kingdom
- Volunteers
- 148 people
- Sponsor
- Imperial College Healthcare NHS Trust