Clinical trials: Cardiac Imaging Techniques
Fabry Disease
Therapeutic Implications of CMR Low Native T1 in Non-treated Non-hypertrophic Females With Fabry Disease (FD)
Females with Fabry disease are characterized by variable phenotypes regarding time of onset, severity of symptoms and progression of disease due to the random inactivation of X chromosome leading to a cellular mosaic of mutated…
- Trial name
- NATI-Fab (NCT07872852)
- Testing
- Decision tree for initiating treatment
- Where
- 12 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Bordeaux
Myocardial Ischemia
Quantitative Myocardial Perfusion Reserve by Cardiovascular Magnetic Resonance
The purpose of this study is to validate a full-automated post-processing software for quantitative perfusion of the myocardium with magnetic resonance imaging.
- Trial name
- NCT02723747
- Testing
- myocardial perfusion with magnetic resonance imaging
- Where
- Sweden
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Tetralogy of Fallot
Cardiac Function Under Stress for Early Detection of the Right Ventricular Insufficiency After Repair of Tetralogy of Fallot
Summary: The investigators aim to identify markers of right ventricular dysfunction in patients with severe pulmonary regurgitation following repair of Tetralogy of Fallot, that allow prediction of the optimal timing of the…
- Trial name
- NCT00564993
- Testing
- Dobutamin
- Where
- 11 sites in Germany
- Volunteers
- 53 people
- Sponsor
- Competence Network for Congenital Heart Defects
Ischemic Stroke, Cardioembolic Stroke
Diagnostic Yield of Cardiac CT to Detect Cardiac Thrombi in Acute Ischemic Stroke: an Individual Patient Data Meta-Analysis
The aim of the AIS of HEARTS registry is to establish a database to collect, maintain and provide accessible individual patient data from international cohorts and to provide pooled analyses about the yield and value of cardiac…
- Conditions
- Ischemic Stroke, Cardioembolic Stroke, Thrombus, Cardiac CT
- Trial name
- AIS of HEARTS (NCT07165093)
- Where
- Netherlands
- Volunteers
- 3,940 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Aortic Valve Disorder
Novel Cardiac Imaging Prognostic Markers of Clinical Outcome in Patients With Chronic Aortic Regurgitation
Severe aortic regurgitation is a common valvular heart disease with prevalence of approximately 1%, affecting rather younger patients.
- Trial name
- MOLLI-GLS-Hx (NCT02910349)
- Where
- 5 sites in Belgium, Czechia
- Volunteers
- 129 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Sickle Cell Disease
Relationship Between Abnormal Myocardial Perfusion and Diastolic Dysfunction in Sickle Cell Disease Using PET
There is limited information on what causes injury to the heart in individuals with Sickle Cell Disease (SCD). Researchers in this study want to see if decreased blood flow to the heart during stress could be causing the heart…
- Trial name
- NCT05583721
- Testing
- [13N]NH3, Lexiscan, Positron emission tomography
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Coronary Artery Disease
ADVANCE MPI 2: Study of Regadenoson Versus Adenoscan® in Patients Undergoing Myocardial Perfusion Imaging (MPI)
Adenoscan® (adenosine) is an approved pharmacological stress agent indicated as an adjunct to thallium-201 myocardial perfusion scintigraphy in patients unable to exercise adequately.
- Trial name
- NCT00208312
- Testing
- Regadenoson, Adenosine
- Where
- United States
- Volunteers
- 787 people
- Sponsor
- Gilead Sciences
CHD - Congenital Heart Disease
Ultrafast Ultrasound Imaging in Pediatric Cardiology
About 13 in 1000 children are born with heart disease. Current tools poorly assess heart filling in children, limiting treatment.
- Trial name
- NCT07255144
- Testing
- Cardiac Ultrafast Ultrasound
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Bordeaux
Myocardium; Injury, Coronary Artery Disease
Minimal Invasive Imaging of Coronary Artery Disease in Patients With Asymptomatic Myocardial Injury After Major Non-cardiac Surgery.
This is a cross-sectional pilot study to assess coronary artery disease with minimal invasive techniques in patients with asymptomatic troponin elevation after noncardiac surgery.
- Trial name
- AMI-NCS (NCT01960309)
- Testing
- Minimal invasive cardiac imaging
- Where
- Netherlands
- Volunteers
- 70 people
- Sponsor
- UMC Utrecht
Psoriasis, Atherosclerosis
The Early Detection and Progression of Subclinical Atherosclerosis in Psoriasis
The goal of this observational study is to identify new molecular and imaging markers associated with the presence of atherosclerosis and its progression in psoriasis.
- Trial name
- EDSAP (NCT05858099)
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Congenital Heart Disease
Analysis of Cerebral Perfusion Using Head Ultrasound and Multisource Detector Near Infrared Spectroscopy (NIRS) Imaging
The purpose of this study is to use an experimental diagnostic tool(NIRS), combined with a known screening tool (cranial ultrasound), to analyze and evaluate cerebral blood flow and oxygenation, and determine if abnormal…
- Trial name
- NCT01082536
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Congenital Heart Defect
Post-market Clinical Follow-up Study With Magnetic Resonance Imaging Conditional Guide Wire
This is post-market clinical follow-up study on 25 consecutive patients in two centers to evaluate the safety and performance of magnetic resonance imaging conditional guide wire and the acceptability of identified risks in the…
- Trial name
- MRWIREPMCF (NCT02493634)
- Testing
- pressure gradient measurement, MRWire
- Where
- 3 sites in Germany, United Kingdom
- Volunteers
- 25 people
- Sponsor
- Nano4Imaging GmbH
Bradycardia
INGENIO MRI/ FINELINE II Pacing System Data Collection in Patients Undergoing MRI
The INFINITE MRI Study is a prospective, non-randomized, multicenter, single arm study aimed at collecting data on ImageReady™ MR Conditional Pacing System (consisting of an INGENIO™ MRI or ADVANTIO™ MRI pacemaker with FINELINE™…
- Trial name
- INFINITE-MRI (NCT01890512)
- Where
- 2 sites in Netherlands
- Volunteers
- 20 people
- Sponsor
- Boston Scientific Corporation
Coronary Artery Disease
Myocardial Flow Reserve and 99mTc-DTPA Cardiac Dynamic SPECT
New CZT-based SPECT cameras are potentially capable of dynamic 3-D acquisition. Preliminary results suggested that dynamic acquisitions could allow the assessment of myocardial flow reserve using 99mTc-labelled perfusion tracers.
- Trial name
- Flow-Heart (NCT02844686)
- Testing
- Cardiac SPECT
- Volunteers
- 20 people
- Sponsor
- University Hospital, Caen
Coronary Artery Disease
OPtical Frequency Domain Imaging Versus INtravascular Ultrasound in Percutaneous Coronary InterventiON - OPINION Imaging
This study is the sub-study of OPINION Trial. (UMIN000010580) The aim of this study is to evaluate how Optical frequency domain imaging (OFDI) or Intravascular Ultrasound (IVUS) imaging technology influence to the Percutaneous…
- Trial name
- NCT01873222
- Testing
- OFDI-guided PCI & IVUS, IVUS-guided PCI & OFDI
- Where
- Japan
- Volunteers
- 106 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Atrial Septal Defects
Percutaneous Closure of Atrial Septal Defects in Children: Integration of 3D Echocardiography and Fluoroscopy Imaging.
The interventional catheterization allows the percutaneous treatment of congenital heart diseases as the atrial septal defect (ASD). The examination is guided by the X-rays with stochastic side effects worrying at the child's.
- Trial name
- CIA3DNAVIGATOR (NCT02529111)
- Testing
- "Echonavigator" software
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Toulouse
Ventricular Tachycardia, Myocardial Infarction
Peri-Procedural Transmural Electrophysiological (EP) Imaging of Scar-Related Ventricular Tachycardia
Ventricular tachycardia (VT) contributes to over 350,000 sudden deaths each year in the US. Malignant VTs involve an electrical "short circuit" in the heart, formed by narrow channels of surviving tissue inside myocardial scar.
- Trial name
- ECGI-VT (NCT03713866)
- Testing
- EP Imaging and Testing
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- John Sapp
Cardiac Resynchronization Therapy, Magnetic Resonance Imaging (MRI)
MRI Assessment of Patient Suitability for Cardiac Resynchronization Therapy (CRT)
The goals of this project are to: 1) explore the potential use of magnetic resonance imaging (MRI) data for improved prediction of response to cardiac resynchronization (CRT), and 2) use the MRI-derived data together with a…
- Trial name
- NCT02728336
- Testing
- Cardiac MRI
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Transthyretin Amyloid Cardiomyopathy
Retinal Fundus Imaging and OCT Imaging for Ocular Detection of ATTR-CM
This multicenter pilot study will enroll adult participants with a confirmed clinical diagnosis of transthyretin amyloid cardiomyopathy (ATTR-CM) and heart failure (HF) controls with documentation within the past 2 years that…
- Trial name
- NCT07690436
- Where
- 20 sites in United States, Germany and 3 more
- Volunteers
- 500 people
- Sponsor
- AstraZeneca
Cardiac
Improve Nuclear Medicine Heart Imaging, Compare MRI Results With Single Photon Emission Computed Tomography Imaging
The purpose of this study is to compare the MRI results with the new SPECT image reconstruction method, this study will allow us to determine whether a new more accurate method of looking at the heart by nuclear study can be used…
- Trial name
- NCT00639704
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- State University of New York - Upstate Medical University
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