Clinical trials: Cardiac Arrest Circulatory
Cardiac Arrest, Hypothermia
Follow up After Survived Therapy With Mild Induced Hypothermia (MIH) After Restoration of Spontaneous Circulation (ROSC)
Sudden cardiac arrest (SCA) remains one of the major leading causes of death. Cognitive deficits are common in survivors of SCA.
- Trial name
- NCT01083069
- Where
- Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Cardiac Arrest
Remote Ischemic Conditioning to Enhance Resuscitation (RICE) Pilot
Following resuscitation from out-of-hospital cardiac arrest (OHCA), reperfusion injury can cause cell damage in the heart and brain.
- Trial name
- NCT04265807
- Testing
- Active Remote Ischemic Conditioning
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Washington
Endotracheal Intubation, Cardiac Arrest
Double Lumen Tube Intubation
The aim of this study was to compare time, success rates of different double-lumen tubes in intubation in a standardized manikin model.
- Trial name
- DLETI (NCT02295657)
- Testing
- standard double-lumen tube, VivaSight Double Lumen Tube
- Where
- Poland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- International Institute of Rescue Research and Education
Coronary Artery Disease, Myocardial Infarction
Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in Europe
The "EUropean Comparative Effectiveness Research to assess the use of primary prophylacTic Implantable Cardioverter Defibrillators (EU-CERT-ICD)" is a modular research project to study the effectiveness of prophylactic ICDs in a…
- Conditions
- Coronary Artery Disease, Myocardial Infarction, Dilated Cardiomyopathy, Implantable Defibrillator User
- Trial name
- EU-CERT-ICD (NCT02064192)
- Where
- 42 sites in Belgium, Bulgaria and 14 more
- Volunteers
- 2,285 people
- Sponsor
- University Medical Center Goettingen
Intubation Complication, Cardiopulmonary Arrest
IntuBrite Versus Macintosh for Endotracheal Intubation in Out of Hospital Cardiac Arrest
a randomized, parallel, non-blinded trial in a single Emergency Mdeical Service in Poland within a group of 34 ground ambulances crews, comparing time and first pass success (FPS) for endotracheal intubation (ETI) in DL using the…
- Trial name
- NCT05607836
- Testing
- IntuBrite intubation, Macintosh laryngoscope
- Where
- Poland
- Volunteers
- 86 people
- Sponsor
- Medical University of Lodz
Sudden Death, Cardiac, Myocardial Scarring
Cardiac Magnetic Resonance - PROgnostic HEart Scar for Sudden Cardiac Death Prediction StudY
The purpose of this observational study is to investigate whether myocardial scar characteristics assessed by cardiac magnetic resonance (CMR) can predict the risk of out-of-hospital sudden cardiac death (SCD) after myocardial…
- Conditions
- Sudden Death, Cardiac, Myocardial Scarring, Myocardial Infarction (MI)
- Trial name
- NCT07137936
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Beijing Anzhen Hospital
Cardiac Arrest, Cardiopulmonary Resuscitation
Circulation Improving Resuscitation Care (CIRC)
During resuscitation of out of hospital cardiac arrest patients the use of a mechanical chest compression device Autopulse will improve survival compared to manual compressions.
- Trial name
- CIRC (NCT00597207)
- Testing
- AutoPulse, Manual
- Where
- 5 sites in United States, Austria and 1 more
- Volunteers
- 4,231 people
- Sponsor
- Zoll Medical Corporation
Cardiac Arrest
Resuscitative Endovascular Balloon Occlusion of the Aorta in Non-traumatic Out of Hospital Cardiac Arrest
The primary aim of this trial is to assess the efficacy of resuscitative endovascular balloon occlusion of the aorta (REBOA) as an adjunct treatment to advanced cardiovascular life support (ACLS) in patients with out-of-hospital…
- Trial name
- REBOARREST (NCT04596514)
- Testing
- REBOA, usual procedure according to guidelines
- Where
- 11 sites in Denmark, Italy and 1 more
- Volunteers
- 200 people
- Sponsor
- St. Olavs Hospital
Cardiac Arrest, Sudden, Cardiopulmonary Arrest
The Success Rate of Cardiopulmonary Resuscitation in Patients Experiencing In-hospital Cardiac Arrest
Cardiac arrest causes the heart to stop functioning to maintain circulation that provides oxygen to the brain. The global incidence of cardiac arrest is 50 to 60 per 100,000 people per year.
- Conditions
- Cardiac Arrest, Sudden, Cardiopulmonary Arrest, Cardiopulmonary Failure, In-hospital Cardiac Arrest
- Trial name
- NCT04786860
- Testing
- CPR
- Where
- 2 sites in Indonesia
- Volunteers
- 415 people
- Sponsor
- Udayana University
Cardiac Arrest
Improving Defibrillation Pad Position
Manufacturer's diagrams showing defibrillation pad positioning (as used on public access defibrillators) are anatomically incorrect and are likely to lead to poor position of defibrillation pads, with reduced defibrillation…
- Trial name
- NCT03476720
- Testing
- Pad positioning according to a manufacturer's diagram
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Anomalous Coronary Artery Origin, Anomalous Coronary Artery Arising from the Opposite Sinus
New Patient-specific Functional Assessment of the Anomalous Aortic Origin of Coronary Arteries.
Anomalous Aortic Origin of the Coronary Arteries (AAOCA) is a rare congenital disease that may cause sudden death in young subjects.
- Conditions
- Anomalous Coronary Artery Origin, Anomalous Coronary Artery Arising from the Opposite Sinus, Anomalous Coronary Artery Course, Anomalous Coronary Artery with Aortic Origin and Course Between the Great Arteries
- Trial name
- NECESSARY (NCT05159791)
- Testing
- Invasive coronary blood flow assessment and simulations and fluid dynamic patient specific simulation
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS Policlinico S. Donato
Sudden Cardiac Death
Ovatio DR and VR Implantable Cardioverter Defibrillators Post-approval Study
The purpose of this post-approval study is to confirm the safety and effectiveness of Ovatio DR and VR ICDs
- Trial name
- Post-Ovatio (NCT00586378)
- Testing
- Ovatio DR and Ovatio VR
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- ELA Medical, Inc.
Cardiac Arrest (CA)
Effectiveness of a Communication Training Program in Improving the Handling of Calls for Suspected Cardiac Arrest at SAMU-Centre 15.
Each year, France's emergency response services-the SAMU (15) and the fire department (18)-handle 31 million and 19 million calls, respectively.
- Trial name
- COM-ARM (NCT07776990)
- Testing
- Multifaceted intervention including 4 components
- Where
- 10 sites in France
- Volunteers
- 987 people
- Sponsor
- University Hospital, Grenoble
Cardiac Arrest, Hypothermia
COOL-Trial: Outcome With Invasive and Non-invasive Cooling After Cardiac Arrest
Sudden cardiac arrest (SCA) remains one of the major leading causes of death. Cognitive deficits are common in survivors of SCA.
- Trial name
- COOL (NCT00843297)
- Testing
- Coolgard, ArcticSun, Conventional treatment
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- University of Leipzig
Ventricular Arrhythmias and Cardiac Arrest
Epicardial Ablation in Brugada Syndrome to Prevent Sudden Death
A total of 150 patients will be randomized to perform catheter ablation or not in a 2:1 fashion in selected patients with Brugada-related symptoms (Ablation+ICD arm 105 patients vs ICD only 45 patients).
- Trial name
- NCT03294278
- Testing
- ablation plus ICD
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- IRCCS Policlinico S. Donato
Avalanche, Landslide, or Mudslide, Asphyxia; Immersion
Efficacy and Pathophysiological Implications of a New Asphyxiation Delaying Device
Survival of fully buried avalanche victims depends in major part on a triad of hypoxia, hypercapnia, and hypothermia and therefore decreases rapidly after complete burial.
- Trial name
- SAFEBACK (NCT05779540)
- Testing
- Safeback SBX
- Where
- Italy
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Institute of Mountain Emergency Medicine
Cardiac Arrest, Post-cardiac Arrest Care
Neuroprotection Bundles For Comatose Survivors Following Cardiac Arrest
The investigators designed LAPTOPS to determine the effectiveness of a goal-directed neuroprotection bundles of active management including body temperature,PaCO2,PaO2,position,Blood glucose ,blood sodium,Blood pressure and…
- Trial name
- LAPTOPS (NCT06992843)
- Testing
- Goal-directed care bundle for neuroprotection, Usual Care
- Where
- China
- Volunteers
- 1,008 people
- Sponsor
- Xiangya Hospital of Central South University
Cardiac Arrest
RACE-CARS - RAndomized Cluster Evaluation of Cardiac ARrest Systems
RACE-CARS is a real-world cluster-randomized trial designed to evaluate a multifaceted community and health systems intervention aimed to improve outcomes of out-of-hospital cardiac arrest.
- Trial name
- NCT04660526
- Testing
- Rapid cardiac arrest recognition that triggers immediate priority EMS/first responder dispatch by 911 operators, Systematic bystander resuscitation instruction by 911 operators, Comprehensive community training of lay people in CPR and AED use.
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Duke University
Cardiac Arrest
CCSV - Post Market Clinical Follow-up Study
The main goal of this observational study is the evaluation of Chest Compression Synchronized Ventilation (CCSV) regarding oxygenation in terms of PaO2 assessed by routine blood gas analysis, hemodynamic effects, 30-day outcome…
- Trial name
- NCT06836908
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Medical University of Vienna
Heart Arrest
Resuscitation Outcomes Consortium (ROC) Prehospital Resuscitation Using an Impedance Valve
The purpose of this study is to look at two different treatments during a cardiac arrest that occurs outside of the hospital and whether either or both treatments will increase the number of people who live to hospital discharge.
- Trial name
- NCT00394706
- Testing
- Impedance Threshold Device (ITD), Analyze early, Analyze later
- Where
- 9 sites in United States, Canada
- Volunteers
- 11,738 people
- Sponsor
- University of Washington
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