Clinical trials: Cardiac Arrest Circulatory
Arrhythmia, Sudden Cardiac Death
Electrophysiological Phenotyping Of Patients at Risk of Ventricular Arrhythmia and Sudden Cardiac Death
Obesity, rheumatoid arthritis (RA) and gene-specific dilated cardiomyopathy (DCM) are common medical conditions. Small-scale studies have shown that these are associated with proarrhythmic changes on 12-lead electrocardiogram…
- Conditions
- Arrhythmia, Sudden Cardiac Death, Cardiomyopathy, Dilated, Obesity
- Trial name
- EPORVA (NCT03910725)
- Testing
- Electrocardiographic imaging
- Where
- 2 sites in United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Cardiac Arrest
Pediatric Resuscitation With Feedback CPR Devices
The aim of this study was to compare the TrueCPR feedback device (with metronome) to standard basic life support (BLS) in terms of the quality of single rescuer pediatric resuscitation.
- Trial name
- PRFD (NCT02281903)
- Testing
- The TrueCPR feedback device, Standard BLS
- Where
- Poland
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- International Institute of Rescue Research and Education
Cardiac Arrest
Compression Is Life In Cardiac Arrest - Quality Study (CILICA-QS)
Context: Chest compressions quality is known to be essential in cardiopulmonary resuscitation. Despite a known harmful effect of chest compressions interruptions, current guidelines still recommend provider switch every 2…
- Trial name
- CILICA-QS (NCT03140202)
- Testing
- CPRmeter (feedback device) with feedback, CPRmeter (feedback device) without feedback
- Where
- France
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Code Status Discussions With Medical In-patients
Checklist-guided Shared Decision-making for Code Status Discussions in Medical Inpatients.
This cluster-randomized, multicenter trial is designed to investigate the effect of checklist-guided shared decision-making including decision aids and communication of expected outcome on patients' decision regarding their code…
- Trial name
- NCT03872154
- Testing
- Checklist-guided shared decision-making
- Where
- Switzerland
- Volunteers
- 2,663 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Quality of Cardio-pulmonary Resuscitation
Registry of Laypeople's CPR Performance
The aim of the registry is to collect laypeople's performance after a BLS/AED course carried out with the use of feedback devices.
- Trial name
- NCT03185260
- Where
- 5 sites in Italy, Switzerland
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Pavia nel Cuore
Intubation, Cardiac Arrest
ETI During Spinal Trauma
The aim of this study was to compare time, success rates of different tracheal tubes (standard tube and ETView VivaSight SL) for intubation with an immobilized cervical spine in a standardized manikin model.
- Trial name
- NCT02295631
- Testing
- Standard tracheal tube, ETView VivaSight SL
- Where
- Poland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- International Institute of Rescue Research and Education
Critical Illness, Cardiac Arrest
Swecrit Biobank - Blood Samples From Critically Ill Patients and Healthy Controls
Blood samples are collected and stored in a biobank for later analysis of circulating substances in peripheral blood and genetic variations in patients with severe critical illness and risk of death.
- Conditions
- Critical Illness, Cardiac Arrest, Sepsis, Influenza
- Trial name
- SWECRIT (NCT04974775)
- Testing
- Blood collection, Blood collection, serial sampling
- Where
- 4 sites in Sweden
- Volunteers
- 8,500 people, healthy volunteers welcome
- Sponsor
- Skane University Hospital
Resuscitation, Cardiac Arrest (CA)
Comparison of Different Chest Compression Techniques in Infant Resuscitation
In this prospective, single-center, randomized, self-controlled crossover manikin simulation study, participitants performed 2 minutes of single-rescuer CPR (30:2 compression-to-ventilation ratio) with each of the four techniques…
- Trial name
- NCT07698340
- Testing
- Two-Finger (2F) Technique, Three-Finger (3F) Technique, Heel-of-One-Hand (HOH) Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Simulation, Education
Use of an Observer Tool to Improve Learning Outcomes for Cardiac Arrest Management
Only approximately 10.4% of patients with out-of-hospital cardiac arrest (OHCA) survive their initial hospitalization. The very early management of cardiac arrest is indeed considered an extremely important criterion to improve…
- Trial name
- NCT05187299
- Testing
- observer tool
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Université Paris-Sud
Cardiac Arrest (CA)
Hand vs. Foot Chest Compressions in Simulation
Cardiopulmonary resuscitation (CPR) is essential in the management of cardiorespiratory arrest (CA) to improve survival rates. High-quality chest compressions are the primary intervention to maintain circulation and oxygenation…
- Trial name
- NCT07074080
- Testing
- Performing chest compressions on a mannequin using the foot, Performance of standard chest compressions with the upper limbs.
- Where
- Spain
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Out-Of-Hospital Cardiac Arrest
International Termination of Resuscitation Practices
Neither the international nor the interregional variation in survival following OHCA is fully understood, but may rely on multiple factors such as: organization of the Emergency Medical Service (EMS) system bystander…
- Trial name
- NCT05029180
- Testing
- Termination of resuscitation
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Cardiomyopathies, Cardiac Arrest
AI-powered ECG Analysis Using Willem™ Software in High-risk Cardiac Patients (WILLEM)
WILLEM is a multi-center, prospective and retrospective cohort study. The study will assess the performance of a cloud-based and AI-powered ECG analysis platform, named Willem™, developed to detect arrhythmias and other abnormal…
- Conditions
- Cardiomyopathies, Cardiac Arrest, Cardiac Arrhythmias, Sudden Cardiac Death
- Trial name
- WILLEM (NCT05890716)
- Testing
- AI-powered ECG analysis to detect cardiac arrhythmic episodes
- Where
- 13 sites in Netherlands, Spain
- Volunteers
- 5,342 people, healthy volunteers welcome
- Sponsor
- Idoven 1903 S.L.
Stable Angina, Myocardial Infarction
Heart Rate and Cardiovascular Diseases Prognosis in People With Stable Coronary Artery Disease
The Cardiovascular disease research using Linked Bespoke studies and Electronic Records (CALIBER) e-health database was the data resource for this study.
- Conditions
- Stable Angina, Myocardial Infarction, Coronary Heart Disease, Heart Failure
- Trial name
- NCT02244853
- Where
- United Kingdom
- Volunteers
- 51,703 people, healthy volunteers welcome
- Sponsor
- University College, London
Sudden Cardiac Arrest
AI-guided Prediction and Treatment of Cardiac Arrest
Sudden cardiac arrest is a major health problem, and most people don't survive. One big reason is that even if resuscitation is successful, people commonly have recurrent cardiac arrests (rearrest).
- Trial name
- NCT07452016
- Testing
- Machine learning-guided cardiac arrest prediction device
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- MetroHealth Medical Center
Safety Issues, Communication
Personal Protective Equipment Affect Team Performance During Medical Emergencies
Safety of healthcare professionals working in high-risk environments is of upmost importance. Personal protective equipment (PPE) may affect the performance of individuals and teams by altering their senses, manual skills and…
- Conditions
- Safety Issues, Communication, Cardiopulmonary Arrest
- Trial name
- PPE-TEAM (NCT04742426)
- Testing
- WHO recommended PPE, Super-safe setup
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Roman Sýkora
Cardiac Arrest
Intra-Arrest-Ventilation in Human Cadavers
The study investigates the influence of non-synchronized bag-device-ventilation and intermittent positive pressure ventilation (IPPV), as recommended in the current resuscitation guidelines of the European Resuscitation Concil…
- Trial name
- NCT06306898
- Testing
- Endotracheal Intubation, Laryngeal tube, Laryngeal mask
- Where
- Germany
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Gerrit Jansen
Airway Aspiration, Cardiopulmonary Arrest
The Impact of Soiled Airway Management on CPR Quality
Regurgitation is an adverse event common during cardiopulmonary resuscitation (CPR) and occurs in 20%-32% of patients experiencing out-of-hospital cardiac arrest (OHCA).
- Trial name
- NCT05278923
- Testing
- SALAD simulation device
- Where
- Taiwan
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Cardiac Arrest
Videolaryngoscopy During Child Intubation
We hypothesized that the video-laryngoscopes are beneficial for intubation of pediatric manikins while performing CPR. In the current study, we compared effectiveness of three video-laryngoscopes and Macintosh (MAC) laryngoscopes…
- Trial name
- NCT02289664
- Testing
- MAC, Coopdech, CoPilot
- Where
- Poland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- International Institute of Rescue Research and Education
Arrest, Bone
Anabolic Steroid and Propranolol in Paediatric Burn
propranolol and anabolic steroids have a role in pediatric burn patients and their combined effects are to be studied here. They decrease the catabolic response to burn trauma and minimize the duration of growth arrest hence…
- Conditions
- Arrest, Bone, Development, Growth
- Trial name
- NCT05805553
- Testing
- Propranolol, Nandrolone Decanoate
- Where
- Pakistan
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- King Edward Medical University
Cardiac Arrest
Effectiveness of Pediatric Intubation
We hypothesized that the Venner videolaryngoscope (A.P. Advance™) is beneficial for intubation of pediatric manikins while performing CPR. In the current study, we compared effectiveness of the Venner videolaryngoscope (A.P.
- Trial name
- PETI (NCT02289651)
- Testing
- Venner, Miller
- Where
- Poland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- International Institute of Rescue Research and Education