Clinical trials: Carbohydrate Metabolism
Diabetes Mellitus, Type 2, Pre-diabetes
Dietary Intervention in Type-2 Diabetes and Pre-Diabetes
The primary purpose of this research is to demonstrate the therapeutic effects of implementing a well-formulated low carbohydrate lifestyle program over 2 years in patients with type 2 diabetes, pre-diabetes, and metabolic…
- Conditions
- Diabetes Mellitus, Type 2, Pre-diabetes, Metabolic Syndrome
- Trial name
- NCT02519309
- Testing
- Virta Program
- Where
- United States
- Volunteers
- 465 people
- Sponsor
- Virta Health
Obesity
The Safety and Efficacy of Low and High Carbohydrate Diets
This study will compare the safety and effectiveness of a low carbohydrate diet (Atkins Diet) with a high carbohydrate diet (conventional USDA diet).
- Trial name
- NCT00143936
- Testing
- Low- Carbohydrate -Atkins Diet, Low Calorie Diet
- Where
- 3 sites in United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Temple University
Critical Illness
Glycemic Index Variation During Low-carbohydrate Enteral Formula With and Without Fructose in Critically Ill Patients
Hyperglycemia is a known risk factor for mortality in critically ill patients. Most of these patients receive enteral feeding. There is controversy about ideal carbohydrate composition of these diets.
- Trial name
- NCT03003507
- Testing
- Enteral Formula With Fructose, Enteral Formula Without Fructose
- Volunteers
- 25 people
- Sponsor
- Hospital Moinhos de Vento
Type 2 Diabetes Mellitus
A Nurse-Led Digital Coaching Program to Improve Blood Sugar Control in Adults With Type 2 Diabetes
The goal of this clinical trial is to learn whether ChronoCoach, a nurse-led multidisciplinary digital coaching program, improves blood sugar control and self-management in adults with type 2 diabetes attending primary health…
- Trial name
- ChronoCoach (NCT07916584)
- Testing
- ChronoCoach, Usual diabetes care
- Where
- Bahrain
- Volunteers
- 160 people
- Sponsor
- Alexandria University
Type 1 Diabetes
Low cArbohydraTe dIeT and aUtomated Insulin Delivery System for Type 1 DiabetEs
This is a randomized, controlled study in people living with type 1 diabetes using an automated insulin delivery (AID) system. Participants will be assigned to a control diet (45% carbohydrate) or a low carb diet (25%…
- Trial name
- LATITUDE (NCT05449678)
- Testing
- Low-carb diet
- Volunteers
- 38 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Dyslipidemia, Obesity, Abdominal
Effects of Almond Intake on Atherogenic Lipoprotein Particles
Increased abdominal adiposity is a key feature of metabolic syndrome, which describes a cluster of cardiovascular disease (CVD) risk factors that also includes insulin resistance, high blood pressure and an atherogenic…
- Trial name
- NCT01792648
- Testing
- Standard reference diet, Almond supplemented diet, Low carbohydrate reference diet
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Mucopolysaccharidosis III-B
A Long-term Follow-up Study of Patients With MPS IIIB Treated With ABO-101
This is a multicenter, non-interventional, long-term follow-up (LTFU) study in participants who have been treated with ABO-101 in a prior trial.
- Trial name
- NCT04655911
- Testing
- ABO-101
- Where
- 3 sites in United States, France and 1 more
- Volunteers
- 1 people
- Sponsor
- Abeona Therapeutics, Inc
Gestational Diabetes Mellitus (GDM)
Carbohydrate Restriction for Gestational Diabetes Mellitus
There is evidence that controlling total amount of carbohydrates is a strategy for controlling glucose levels in diabetes mellitus.
- Trial name
- LO-CA (NCT00911404)
- Testing
- Low CHO, High CHO diet
- Where
- Spain
- Volunteers
- 152 people
- Sponsor
- Hospital Arnau de Vilanova
Obesity and Overweight
Reduction in Consumption of Sweetened Beverages on Weight, Body Composition and Blood Pressure in Young Adults
The impact of reduction in consumption of caloric and no caloric sweetened beverages on: weight body composition blood pressure young adults
- Trial name
- NCT02347267
- Testing
- Caloric and non-caloric SSBS reduction, Caloric SSBS reduction
- Where
- Mexico
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Type 1 Diabetes
Low Carbohydrate Versus Mediterranean Diet in Adolescents With Type 1 Diabetes
The goal of this clinical trial is to compare the effect of low carbohydrate diet versus Mediterranean diet on blood sugar values in adolescents with type 1 diabetes.
- Trial name
- NCT05872711
- Testing
- Low carbohydrate diet
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
Hurler Syndrome, Inherited Metabolic Disorder
BPX-501 T Cells Infused Post Stem Cell Transplant in Pediatrics With Non-Malignant Disorders Ineligible for BPU004 Study
Providing access of BPX-501 gene modified T cells and rimiducid to pediatric patients who do not meet the eligibility criteria of the BP-U-004 study.
- Conditions
- Hurler Syndrome, Inherited Metabolic Disorder, Lysosomal Storage Disorder, Metachromatic Leukodystrophy
- Trial name
- NCT03639844
- Testing
- rivogenlecleucel, rimiducid
- Where
- 2 sites in United States
- Sponsor
- Bellicum Pharmaceuticals
Mucopolysaccharidosis VI
Open-Label Study of Efficacy and Safety of Recombinant Human N-acetylgalactosamine 4-sulfatase in Patients With MPS VI
The purpose of the study is evaluate the efficacy, safety, and pharmacokinetics of weekly intravenous infusions of 1 mg/kg recombinant human N-acetylgalactosamine 4-sulfatase (rhASB) in patients diagnosed with…
- Trial name
- NCT00048711
- Testing
- N-acetylgalactosamine 4-sulfatase
- Where
- United States
- Sponsor
- BioMarin Pharmaceutical
Glycogen Storage Disease Type II Late Onset, Pompe Disease (Late-onset)
Safety and Efficacy of Avalglucosidase Alfa in Patients With Non-classic Pompe Disease Aged ≥ 5 Years
The goal of this clinical trial is to study the efficacy and safety of treatment with avalglucosidase alfa in patients with late onset Pompe disease that previously deteriorated on alglucosidase alfa.
- Conditions
- Glycogen Storage Disease Type II Late Onset, Pompe Disease (Late-onset), Pompe Disease Late-Onset, Pompe's Disease Juvenile Onset
- Trial name
- AVA (NCT07652814)
- Testing
- Avalglucosidase Alfa
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- Iris Plug
Pompe Disease
Pregnancy and Birth Outcome in Women With Pompe Disease
This study explores the outcome and effect of pregnancy on Pompe Disease. The results are expected to guide clinicians in counseling and care of women with Pompe disease, who are planning to become pregnant, and during the…
- Trial name
- NCT01556516
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- O & O Alpan LLC
Glucosephosphate Dehydrogenase Deficiency, Favism
A Test to Predict the Hemolytic Potential of Drugs in G6PD Deficiency
This study will evaluate a new and safe testing method for identifying medicines that can cause problems in glucose-6-phosphate dehydrogenase (G6PD) deficient individuals.
- Trial name
- NCT00076323
- Testing
- Primaquine
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Institute of Research (WRAIR)
Lactose Intolerance
Evaluation of GIMate Handheld Hydrogen Breath Monitor for Diagnosis of Lactose Malabsorption
The goal of this study is to assess the performance of the Vivante Health GIMate Breathalyzer device in diagnosing lactose malabsorption.
- Trial name
- NCT04754724
- Testing
- GIMate, H2 Check
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Vivante Health
Obesity
Considering Patient Diet Preferences to Optimize Weight Loss
Obesity is increasingly common and can lead to decreased quality of life, increased medical and psychiatric illness, high health care costs, and early mortality.
- Trial name
- DietChoice (NCT01152359)
- Testing
- Choice, Control
- Where
- United States
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Pompe Disease (Late-onset), Glycogen Storage Disease Type II (GSD-II)
A Placebo-Controlled Study of Safety and Effectiveness of Myozyme (Alglucosidase Alfa) in Patients With Late-Onset Pompe Disease
Pompe disease (also known as glycogen storage disease Type II) is caused by a deficiency of a critical enzyme in the body called acid alpha-glucosidase (GAA).
- Conditions
- Pompe Disease (Late-onset), Glycogen Storage Disease Type II (GSD-II), Acid Maltase Deficiency Disease, Glycogenosis 2
- Trial name
- NCT00158600
- Testing
- alglucosidase alfa
- Where
- 8 sites in United States, France and 1 more
- Volunteers
- 90 people
- Sponsor
- Genzyme, a Sanofi Company
Overweight and Obesity, Type IIb Hyperlipidaemia
Low Carbohydrate Diet - Effect on Plasma Lipids and Metabolic Markers
Low carbohydrate diet may influence the plasma lipid levels.
- Conditions
- Overweight and Obesity, Type IIb Hyperlipidaemia, Hypercholesterolemia Aggravated
- Trial name
- NCT01476436
- Testing
- Low carbohydrate dietary advice, Continue usual diet
- Where
- 2 sites in Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Postprandial Hyperglycemia, Hyperinsulinemia
Effect of a Sugar Replacement on Blood Glucose Levels in Healthy Adults
Diabetes and cardiovascular disease account for millions of deaths per year. One of the risk factors for both conditions is high blood sugar, particularly after eating (postprandial hyperglycaemia).
- Trial name
- SURE-BloG (NCT06714552)
- Testing
- Galacto-Oligosaccharide, Glucose
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
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