Clinical trials: Carbohydrate
Non-small Cell Lung Cancer Stage IIIB/IV, Non-small Cell Lung Cancer Metastatic
Metformin and Carbohydrate Restriction With Platinum Based Chemotherapy In Stage IIIB/IV Non-Squamous Non-Small Cell Lung Cancer (NS-NSCLC)
Metformin is thought to activate AMP-activated protein kinase (AMPK), a major sensor of cellular energy levels and a key enzyme limiting cellular growth during times of cellular stress.
- Conditions
- Non-small Cell Lung Cancer Stage IIIB/IV, Non-small Cell Lung Cancer Metastatic, Nonsquamous Nonsmall Cell Neoplasm of Lung
- Trial name
- METRO (NCT02019979)
- Testing
- metformin, carbohydrate restricted diet
- Where
- 4 sites in United States
- Volunteers
- 14 people
- Sponsor
- Beth Israel Medical Center
Frenulum Breve
Analgesia in Lingual Frenulotomy in the Newborn
Ankyloglossia (tongue-tie) is a congenital anomaly characterized by a short lingual frenulum that limits the physiological tongue movement and occurs with an estimated prevalence between 4 and 10% of the newborns.
- Trial name
- RE-GLU (NCT04440462)
- Testing
- Sugar and water solution, Sterile water
- Where
- Italy
- Volunteers
- 72 people
- Sponsor
- IRCCS Burlo Garofolo
Morquio Disease, MPS - Mucopolysaccharidosis
Pregnancy With Morquio Syndrome - What Are Patients' Perspectives and Has ERT Changed Them?
The present study seeks to interview women with Morquio A and Morquio B syndrome, to explore their concerns surrounding pregnancy and the impact of ERT on their perspectives, in comparison with the control group of Morquio B…
- Trial name
- MorqPreg (NCT03150069)
- Testing
- Interview
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Emory University
Carbohydrate Mouth-rinse on Time Trial Performance
Carbohydrate Mouth-rinse
Several studies have reported that carbohydrate (CHO) ingestion can improve performance during exercise of short duration (less than 60 min).
- Trial name
- CHO rinse (NCT01527266)
- Testing
- Carbohydrate drink
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Recurrent Miscarriage
Walking and Dietary Modification for Recurrent Early Miscarriages
This study is part of a big one aiming to evaluate how lifestyle interventions during pregnancy affect obstetric results, neonatal metabolism and the intelligence of the offspring (study not yet completed).
- Trial name
- W&D (NCT03023137)
- Testing
- Walking & dietary modification
- Where
- Brazil
- Volunteers
- 480 people
- Sponsor
- Hospital dos Servidores do Estado do Rio de Janeiro
Pompe Disease
Safety/Tolerability/Pharmacokinetic (PK)/Pharmacodynamics (PD) Study of BMN701 in Patients With Late-Onset Pompe Disease
A Phase 1/2, open-label, multicenter, multiple dose escalation study of BMN 701 administered by intravenous infusion every 2 weeks over a 24-week treatment period to patients with late-onset Pompe disease.
- Trial name
- NCT01230801
- Testing
- BMN 701
- Where
- 10 sites in United States, Australia and 3 more
- Volunteers
- 22 people
- Sponsor
- BioMarin Pharmaceutical
Diabetes Mellitus, Type 1
Optimizing Metabolic Control in Type 1 Diabetes - The Automatic Bolus Calculator Flash Study
This study aims to compare the effect of flash glucose monitoring (FGM) with traditional self-monitoring of blood glucose (SMBG) with or without carbohydrate counting and automated bolus calculation, in patients with type 1…
- Trial name
- NCT03682237
- Testing
- Carbohydrate counting, automated bolus calculation, Flash glucose monitoring (FGM)
- Where
- Denmark
- Volunteers
- 184 people
- Sponsor
- Steno Diabetes Center Copenhagen
Obesity, Gastric Emptying
Gastric Volume After Ingestion of Carbohydrate Drink vs Water in Obese Volunteers
This randomized crossover study compares gastric residual volume after ingestion of carbohydrate drinks and water in obese volunteers.
- Trial name
- NCT05827029
- Testing
- Preopertive drink
- Where
- Thailand
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Prince of Songkla University
Food Preferences
Online Study of the Effects of Sugary Drink Warning Labels on Consumption
The aim of this study is to determine the degree to which sugar-sweetened beverages (SSB) warning labels increase consumers' knowledge about the potential health harms of SSBs and reduce SSB purchases and consumption.
- Trial name
- NCT05079477
- Testing
- Exposure to sugar-sweetened beverage warning labels, Exposure to calorie information
- Where
- United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Body Composition, Visceral Obesity
Dysfunctional Adiposity and Glucose Impairment
This is a large and comprehensively phenotyped cohort with fasting glycaemia where the predictive value of body composition and anthropometric measures of total and central fat distribution for postprandial carbohydrate…
- Conditions
- Body Composition, Visceral Obesity, Carbohydrate Intolerance, Obesity, Abdominal
- Trial name
- DICAMANO (NCT03506581)
- Volunteers
- 853 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Cancer, Diarrhea
CASAD for Severe Diarrhea in the Emergency Department
The goal of this clinical research study is to learn if calcium alumina-silicate (CASAD) can help to stop your diarrhea. Researchers also want to know if this drug can help decrease the duration of your diarrhea.
- Trial name
- NCT02018653
- Testing
- Calcium Alumina-Silicate (CASAD), Questionnaire
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- M.D. Anderson Cancer Center
Mucopolysaccharidosis IVA, Morquio A Syndrome
Efficacy and Safety Study of BMN 110 for Morquio A Syndrome Patients Who Have Limited Ambulation
The primary objective of this study is to evaluate the effect of 2.0 mg/kg/week BMN 110 in a patient population that has limited ambulation, in a period of up to 144 weeks.
- Conditions
- Mucopolysaccharidosis IVA, Morquio A Syndrome, MPS IVA
- Trial name
- NCT01697319
- Testing
- BMN 110
- Where
- 7 sites in United States, Germany and 1 more
- Volunteers
- 16 people
- Sponsor
- BioMarin Pharmaceutical
Mucopolysaccharidoses
A Cross-specialty Collaboration Platform for Mucopolysaccharidosis Confirmative Diagnosis
In this study the investigators is aimed to establish the MPS screening algorithm for high risk patients who had medical history of previous surgical repair or presence of inguinal and/or umbilical hernia with combination of any…
- Trial name
- NCT03017677
- Volunteers
- 100 people
- Sponsor
- Mackay Memorial Hospital
High Enteral Protein Nutrition, Muscle Breakdown
The Basel Enteral High Protein Study
The objective of this study is to compare the difference in daily protein intake of critically ill patients in two standardized enteral nutrition formulas (20% versus 33% percent) with the same caloric density of 1.2 kcal/ml.
- Conditions
- High Enteral Protein Nutrition, Muscle Breakdown, Autophagy
- Trial name
- NCT02678325
- Testing
- Standardized high protein enteral nutrition, Standardized normal protein enteral nutrition
- Where
- Switzerland
- Volunteers
- 25 people
- Sponsor
- University Hospital, Basel, Switzerland
Mucopolysaccharidoses, Progressive Pseudorheumatoid Dysplasia
Pediatric Arthropathy Beyond Inflammation: Clinical Spectrum and Diagnostic Approach at Assiut University Children Hospital
To identify the most common underlying causes of non-inflammatory arthropathy in children presenting to Assiut University Children Hospital for through clinical evaluation, laboratory testing, and imaging, in order to improve…
- Conditions
- Mucopolysaccharidoses, Progressive Pseudorheumatoid Dysplasia, Farber Disease, Osteogenesis Imperfecta
- Trial name
- NCT07173010
- Volunteers
- 35 people
- Sponsor
- Assiut University
Obesity, Hypertension
Effectiveness of a Low Carbohydrate Diet Versus a High Carbohydrate Diet in Promoting Weight Loss and Improved Health
This study will examine the effects of a low carbohydrate diet versus a high carbohydrate diet on weight loss.
- Trial name
- NCT00200720
- Testing
- Atkins diet (low carbohydrate diet), DASH diet (high carbohydrate diet)
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- Kaiser Permanente
SEDC, Hypochondrogenesis
A Natural History Study in Children With a Type II Collagen Disorder With Short Stature
There are relatively few data available on type II collagen disorders, and evidence is lacking on the disease course in relation to symptoms and development of complications, the level of actual disease burden over time as well…
- Conditions
- SEDC, Hypochondrogenesis, Semd, Strudwick Type, Kniest Dysplasia
- Trial name
- ROCKET (NCT05408715)
- Testing
- Natural History Study
- Where
- 2 sites in France, Spain
- Volunteers
- 60 people
- Sponsor
- Innoskel
Starvation
Effects of Glutamine on Gastric Emptying
Surgical patients are usually starved for 8 hours before operation in order to ensure the stomach is empty and thus reduce the chances of vomiting during the anaesthetic.
- Trial name
- NCT00943020
- Testing
- Nutricia PreOp nutritional supplement, Lipid, Glutamine
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Glycogen Storage Disease Type II, Pompe's Disease
China Post-approval Commitment (PAC) Study of Avalglucosidase Alfa in Participants With IOPD
This is a single group, 52-week treatment, Phase 4, open-label, single-arm study to assess the safety and efficacy of avalglucosidase alfa IV infusion in male and female Chinese participants with IOPD who are treatment-naïve or…
- Trial name
- NCT06666413
- Testing
- Avalglucosidase alfa
- Where
- China
- Volunteers
- 13 people
- Sponsor
- Genzyme, a Sanofi Company
Hyperoxaluria
Hydroxyproline Influence on Oxalate Metabolism
Primary hyperoxaluria is an inborn error of metabolism that results in marked overproduction of oxalate by the liver. The excess oxalate causes kidney failure and can cause severe systemic disease due to oxalate deposition in…
- Trial name
- NCT02038543
- Testing
- Hydroxyproline and Leucine
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Mayo Clinic