Clinical trials: Cannabis Use Disorder
Cannabis Use, Tobacco Use Disorder
N-Acetylcysteine for Smoking Cessation in Tobacco and Cannabis Co-Use
Tobacco and cannabis co-use is a common and growing public health problem, especially in states that have legalized cannabis. There are no pharmacologic treatments for co-occurring tobacco and cannabis use.
- Conditions
- Cannabis Use, Tobacco Use Disorder, Drug Use Disorder
- Trial name
- NAC_CUD-TUD (NCT04627922)
- Testing
- N-Acetyl cysteine, Cognitive behavioral therapy (CBT)
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Ellen Herbst
Pain, Cannabis
Enhancing Medication-based Analgesia in Humans- STUDY 2
This is a single-group, within-subject, double-blind, double-dummy, placebo and active-controlled study evaluated whether the FDA-approved cannabinoid cannabidiol (CBD; Epidiolex) would enhance analgesia, subjective reports, and…
- Conditions
- Pain, Cannabis, Opioid Use
- Trial name
- NCT04036968
- Testing
- Within-subject test of blinded study medications
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cannabis, Marijuana Use
Developing and Strengthening Cannabis Warnings: Warning Message Testing
The purpose of this activity is to identify promising cannabis warning messages from different themes. Participants will be adults who live in the United States, including both people who use cannabis and those who do not use…
- Trial name
- NCT07699198
- Testing
- Constituents, Cognitive Functioning, Cardiovascular Health
- Where
- United States
- Volunteers
- 1,750 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Cannabis Use Disorder
Pilot Testing the Check Up
We propose to pilot test an adapted version of the Teen Marijuana Check Up (TMCU) for persistent cannabis users with first episode psychosis (FEP) in Coordinated Specialty Care (CSC).
- Trial name
- NCT04624074
- Testing
- Teen Marijuana Check Up
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Maryland, Baltimore
HIV, Depression
Stress and Pain in People Living With HIV
This is a basic human experimental study utilizing 4 groups of individuals with and without HIV and complex morbidities of cannabis use disorder and major depression who will participate in 2 sessions of the Yale Pain Stress Task…
- Conditions
- HIV, Depression, Cannabis Use Disorder, Stress
- Trial name
- HIV Stress (NCT06784908)
- Testing
- Yale Pain Stress Task (YPST)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcohol Use Disorder (AUD), Alcoholism
Role of Pavlovian Mechanisms for Control Over Substance Use
During the first funding period (1st FP), the investigators developed a novel full Pavlovian-to-instrumental transfer (PIT) task that allows assessing both, general and specific PIT to investigate whether specific PIT differs…
- Conditions
- Alcohol Use Disorder (AUD), Alcoholism, Substance Use Disorders, Cannabis Use Disorder
- Trial name
- ReCoDe (NCT06701487)
- Testing
- fMRI imaging (BOLD), sMRI (structure), Pavlovian-to-instrumental transfer (PIT) paradigm
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Technische Universität Dresden
Crohn Disease, Inflammatory Bowel Diseases
Cannabidiol Usage as an Adjunct Therapy for Crohn's Disease
To date, few studies have assessed the efficacy and safety of Cannabinoids, compounds derived from the Cannabis plant, in patients with Crohn's disease.
- Conditions
- Crohn Disease, Inflammatory Bowel Diseases, Cannabis
- Trial name
- NCT03467620
- Testing
- Cannabidiol
- Sponsor
- University of Illinois at Chicago
Schizophrenia, Schizoaffective Disorder
Controlled Trial of Brexpiprazole For The Treatment of Co-occurring Schizophrenia and Substance Use Disorder
The proposed study is a 4-site, 12-week, novel, feasibility, investigation of patients who have co-occurring diagnoses of schizophrenia and current substance use disorder (alcohol, cocaine, heroin, or cannabis).
- Conditions
- Schizophrenia, Schizoaffective Disorder, Substance Use Disorders
- Trial name
- NCT03526354
- Testing
- Brexpiprazole, Treatment as Usual
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Massachusetts, Worcester
Melanoma
Evaluating the Effects of Cannabis Use and Circulating Cannabinoids on Tumor Infiltrating Lymphocytes in Malignant Melanoma
The goal of this proposal is to determine how cannabinoid use affects the tumor immune microenvironment (TME) of melanoma by correlating TILs with reported cannabinoid use and circulating plasma cannabinoids.
- Trial name
- NCT05520294
- Testing
- High-performance liquid chromatography-tandem mass spectrometry assays
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Colorado, Denver
Cannabis Use, Sleep
Cannabis Effects on Sleep, Circadian Rhythms, and Light Sensitivity in Young Adults
The goal of this study is to learn how cannabis use and discontinuation affect sleep, circadian rhythms, and sensitivity to light. The main questions it aims to answer are: 1.
- Conditions
- Cannabis Use, Sleep, Circadian Rhythm
- Trial name
- CASCILS (NCT06743373)
- Testing
- Cannabis Discontinuation
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Post Traumatic Stress Disorder, Cannabis Use
Warrior CARE: Cannabis Behavioral Health
This study is a randomized, controlled clinical trial to examine the therapeutic potential of cannabinoids for treating veterans with PTSD and suicidal ideation.
- Conditions
- Post Traumatic Stress Disorder, Cannabis Use, Suicide, Veterans
- Trial name
- CBH (NCT06381180)
- Testing
- Tetrahydrocannabinol, Cannabidiol
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Wayne State University
Cannabis
Feasibility Trial of rTMS for Cannabis Use Disorder
This small pilot trial will recruit 10 cannabis use disordered participants and apply 20 sessions of rTMS in conjunction with a two session Brief Marijuana Dependance Counseling treatment paradigm.
- Trial name
- NCT03538288
- Testing
- rTMS
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Medical University of South Carolina
Cannabis Use Disorder, Moderate, Cannabis Use Disorder, Severe
Tirzepatide in the Treatment of Cannabis Use Disorder
Cannabis is the most commonly used psychoactive substance in Canada. A sub-group of cannabis users develop Cannabis Use Disorder (CUD).
- Trial name
- NCT07671248
- Testing
- Tirzepatide
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- McMaster University
Marijuana Use
Improving Brief Marijuana Interventions With a Behavioral Economic Supplement
The purpose of this study is to evaluate the efficacy of a Substance-Free Activity Session (SFAS) as a supplement to a brief motivation intervention (BMI) in reducing marijuana use and drug-related consequences in college student
- Trial name
- BLUE-J (NCT02837315)
- Testing
- Brief Motivational Intervention (BMI), Substance-Free Activity Session (SFAS), Relaxation Session
- Where
- United States
- Volunteers
- 133 people
- Sponsor
- University of Memphis
Sexual Pain Disorders
Cannabis Suppositories and Mindful Compassion Online Groups for Sexual Functioning
Research aim: To determine how an online mindful-compassion intervention adjunct with cannabis suppositories might reduce vaginal pain during sexual intimacy among women post-gynaecological cancer treatment.
- Trial name
- NCT06607835
- Testing
- Mindful- compassion, Mindful-compassion and cannabis suppositories
- Where
- United Kingdom
- Volunteers
- 83 people
- Sponsor
- London Metropolitan University
Marijuana Use Disorder
Effects of Smoked Marijuana on Risk Taking and Decision Making Tasks
The purpose of this study is to investigate the effects of smoked marijuana on both risk taking and decision making tasks.
- Trial name
- NCT00373399
- Testing
- Inactive Marijuana (0% THC), Low THC marijuana (1.8 %THC), High THC marijuana (3.9% THC)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Cannabis Use Disorder, Pregnancy Related
Maternal Marijuana Use and Fetal and Infant Outcome
Marijuana and cannabis-containing products are growing in popularity and availability in the United States, and use during pregnancy has increased dramatically.
- Trial name
- NCT04266314
- Testing
- Maternal-fetal monitoring, NICU Network Neurobehavioral Scale
- Where
- United States
- Sponsor
- Johns Hopkins University
Alcohol Abuse, Cannabis Abuse
Trial of Computerized SBI to Reduce Teen Alcohol Use
The goal of this project is to test the effectiveness of a computer-facilitated alcohol screening and brief intervention (c-ASBI) system for 12- to 18-year-old primary care patients in a multi-site, randomized comparative…
- Conditions
- Alcohol Abuse, Cannabis Abuse, Nicotine Dependence
- Trial name
- NCT01784627
- Testing
- c-ASBI
- Where
- 6 sites in United States
- Sponsor
- Boston Children's Hospital
Depression, Cannabis Use Disorder
The Neural Underpinnings of Depression and Cannabis Use in Young People Living With HIV
To elucidate mechanisms of substance use disorders (SUD) and comorbid mental illnesses in people living with HIV (PLWH), the study team seeks to investigate reward and pain circuitry in cannabis use and depression comorbidity…
- Conditions
- Depression, Cannabis Use Disorder, HIV
- Trial name
- NCT05453513
- Testing
- MRI Study
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- University of Miami
Cannabis Use Disorder, Bipolar Disorder
Effects of Cannabis Abstinence on Symptomology and Cognition in Bipolar Disorder
The objective of this study is to assess the changes in symptoms and cognition that occur after a 28-day abstinence period in patients with comorbid Cannabis Use Disorder (CUD) and Bipolar (Type I or II) disorder.
- Conditions
- Cannabis Use Disorder, Bipolar Disorder, Cognition
- Trial name
- NCT03629106
- Testing
- Weekly Behavioral Coaching Session
- Where
- Canada
- Sponsor
- Centre for Addiction and Mental Health