Clinical trials: Cancer Surveillance
Lynch Syndrome
Study Aiming to Test Whether Non-invasive Liquid Biopsies Can Safely Reduce Invasive Surveillance Methods in Lynch Syndrome
Lynch syndrome is an inherited genetic predisposition that increases the risk of developing several types of cancer, particularly colon and rectal cancers (colorectal cancer), as well as cancer of the uterine lining (endometrial…
- Trial name
- PREDI-LYNCH (NCT07360834)
- Testing
- INVITRO DIAGNOSTIC TESTS AND COLONOSCOPY
- Where
- 9 sites in Croatia, Czechia and 7 more
- Volunteers
- 2,000 people
- Sponsor
- UNICANCER
Breast Cancer, Breast Cancer - Infiltrating Ductal Carcinoma
Percutaneous Cryoablation for the Treatment of Breast Cancer
The goal of this clinical trial is to study cryoablation as a treatment for selected adults with localized breast cancer. Cryoablation uses very low temperatures to destroy the tumor through thin needles placed through the skin…
- Trial name
- CRYSTAL (NCT07775014)
- Testing
- Ultrasound-Guided Percutaneous Cryoablation
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Ospedale Cottolengo
Breast Cancer-related Subclinical Lymphedema
Subclinical Lymphedema Treatment Study
Primary Objective To compare the effectiveness of 2 treatment protocols for patients with breast cancer-related subclinical lymphedema identified through bioimpedance spectroscopy, L-dex scores Secondary Objectives To determine…
- Trial name
- SLT (NCT03292198)
- Testing
- 20-30 mmHg compression sleeve and gauntlet, Manual Lymphatic Drainage
- Where
- United States
- Volunteers
- 267 people
- Sponsor
- Mercy Research
Prostate Cancer
European Multicenter Validation of PCaVision: A Head-to-Head Diagnostic Accuracy Study Comparing Multiparametric Transrectal Ultrasound to MRI for Clinically Significant Prostate Cancer Detection
The goal of this clinical trial is to learn if a new ultrasound-based imaging method (PCaVision) can accurately detect clinically significant prostate cancer in adult men (18 years and older) who are either undergoing initial…
- Trial name
- PCaVISTA (NCT06935487)
- Testing
- transrectal ultrasound of prostate (TRUS) with AI software algorithm, MRI prostate
- Where
- 10 sites in France, Germany and 4 more
- Volunteers
- 806 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Metastatic Colorectal Cancer ctDNA Surveillance
Using ctDNA Methylation to Monitor Metastatic Colorectal Cancer Treatment (PROMET)
Multi-center observational clinical study to evaluate the application value of ctDNA methylation monitoring in efficacy assessment and relapse prediction in patients diagnosed with recurrence or metastatic colorectal cancer…
- Trial name
- NCT07283575
- Testing
- Plasma ctDNA methylation profiling
- Where
- China
- Volunteers
- 497 people
- Sponsor
- Fudan University
Barrett Esophagus
"Using Dilute Vinegar to Find Changes in Cells During Endoscopy for Patients With Barrett's Oesophagus" (The ABBA Study)
Problem statement Barrett's oesophagus is a pre-cancerous condition affecting 375,000 people in the U.K. There is a 0.5-3% yearly risk of progressing to oesophageal cancer, from which only 5% of patients will survive for 5 years…
- Trial name
- ABBA (NCT02407392)
- Testing
- Acetic Acid, Non targeted quadrantic biopsies
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Portsmouth Hospitals NHS Trust
Surveillance Endoscopy for Colorectal Cancer, Artificial Intelligence
Surveillance Modified by Artificial Intelligence in Endoscopy (SMARTIE)
Evaluation of an artificial intelligence system for polyp detection (CADe)
- Conditions
- Surveillance Endoscopy for Colorectal Cancer, Artificial Intelligence, Polyps of Colon, CADe
- Trial name
- SMARTIE (NCT05006092)
- Testing
- ENDOMIND
- Where
- Germany
- Volunteers
- 1,149 people, healthy volunteers welcome
- Sponsor
- Wuerzburg University Hospital
Rectal Cancer
IMMUNOlogical Microenvironment in REctal Adenocarcinoma Treatment.
Background The current management on rectal cancer based on TNM staging has some limitations. In locally advanced rectal cancer after neoadjuvant therapy the persistence of a complete response to therapy cannot be accurately…
- Trial name
- IMMUNOREACT2 (NCT04917263)
- Testing
- Immunohistochemistry, Flow citometry, Trascriptome analysis
- Where
- Italy
- Volunteers
- 544 people
- Sponsor
- University of Padova
Liver Cirrhosis
Annual MRI Versus Biannual US for Surveillance of Hepatocellular Carcinoma in Liver Cirrhosis
The investigators will investigate the usefulness of biannual ultrasonography versus annual non-contrast magnetic resonance imaging for surveillance of hepatocellular carcinoma in single arm patients.
- Trial name
- MAGNUS-HCC (NCT02551250)
- Testing
- annual noncontrast MRI, biannual ultrasonography
- Where
- 6 sites in South Korea
- Volunteers
- 211 people
- Sponsor
- JOON-IL CHOI
Prostate Cancer
A Post-marketing Surveillance to Assess Safety of Abiraterone Acetate (Zytiga) in Indian Participants With Metastatic, Castration Resistant Prostate Cancer
The purpose of this study is to evaluate the safety of abiraterone acetate in Indian participants with metastatic, castration-resistant prostate cancer who have been prescribed abiraterone acetate as per locally approved…
- Trial name
- NCT02608359
- Testing
- Abiraterone Acetate
- Where
- 3 sites in India
- Sponsor
- Johnson & Johnson Private Limited
Localized Prostate Carcinoma, Stage I Prostate Cancer AJCC v8
Testosterone Replacement Therapy for the Treatment of Low Testosterone in Hypogonadal Men With Localized Prostate Cancer on Active Surveillance
This phase IV trial studies the effects of testosterone replacement therapy (TRT) on treatment outcomes in hypogonadal men with prostate cancer that has not spread to other parts of the body (localized) and who are on active…
- Conditions
- Localized Prostate Carcinoma, Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8, Stage III Prostate Cancer AJCC v8
- Trial name
- NCT06733350
- Testing
- Biopsy of Prostate, Biospecimen Collection, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Roswell Park Cancer Institute
Bladder Cancer
Evaluation of the PhageTech Virus BioResistor
To evaluate the effectiveness of the PhageTech Virus BioResistor to detect bladder cancer biomarkers.
- Trial name
- NCT04756284
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- PhageTech, Inc.
Barrett's Esophagus
Surveillance and Image-Guided Biopsy of the Esophagus Using an OFDI Capsule
The purpose of this research is to test the feasibility, sensitivity, and specificity of the marking Optical Frequency Domain Imaging (OFDI) capsule for diagnosing Barrett's Esophagus (BE).
- Trial name
- NCT02422433
- Testing
- OFDI Capsule Marking
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Massachusetts General Hospital
Colon Cancer
Vitamin D and Screening Colonoscopy or Polyp Surveillance
The investigators will recruit DoD beneficiaries 18 years or older, that have been referred for a screening colonoscopy or polyp surveillance (or had one in the last 2 weeks), and have no previous diagnosis of colorectal cancer.
- Trial name
- VitDColon (NCT02269332)
- Testing
- Screening Colonoscopy
- Where
- United States
- Volunteers
- 298 people
- Sponsor
- Mike O'Callaghan Military Hospital
Colorectal Cancer
Surveillance of Metabolic Parameters in Patients With Colorectal Cancer
A prospective, single center, cohort study for surveillance of metabolic parameters in patients who will receive chemotherapy after surgical resection of colorectal cancer
- Trial name
- SPRING (NCT02700555)
- Where
- South Korea
- Volunteers
- 23 people
- Sponsor
- Kangbuk Samsung Hospital
Prostate Cancer, Prostatic Neoplasms
Exercise for Tumor Suppressive Impact in Men With Prostate Cancer at High-Risk of Progression on Active Surveillance: The REMOVE Trial
The purpose of this study is to determine whether a 12-week, home-based, virtually supervised exercise program will slow cancer progression of prostate cancer among men with prostate cancer at high-risk of progression undergoing…
- Trial name
- NCT05918263
- Testing
- High-Intensity Interval Training Exercise Program
- Where
- 4 sites in United States
- Volunteers
- 68 people
- Sponsor
- Fred Hutchinson Cancer Center