Clinical trials: Cancer, completed
Adjuvant, Chemotherapy
Drug Delivery and Toxicities of Adjuvant Chemotherapy in Resected NCSLC
There are limited numbers of retrospective studies showing the effectiveness of adjuvant chemotherapy over observation in resected lung cancers.
- Conditions
- Adjuvant, Chemotherapy, Lung, Cancers
- Trial name
- NCT00484016
- Volunteers
- 45 people
- Sponsor
- Washington University School of Medicine
Chemotherapy-induced Thrombocytopenia
To Evaluate Thrombosis Risk in Chemotherapy Patients With Solid Tumors Who Receiving Thrombocytopenia Treatment
Chemotherapy-induced thrombocytopenia (CIT) is a common hematological toxicity in patients with solid tumors undergo chemotherapy, which can increase the risk of bleeding, prolong hospital stay, increase medical costs, and even…
- Trial name
- NCT05688306
- Testing
- Recombinant Human Interleukin-11 for Injection
- Where
- China
- Volunteers
- 3,494 people
- Sponsor
- Liaoning Cancer Hospital & Institute
Breast Cancer
Analyzing a New Mechanism in Response to Tamoxifen Therapy in Breast Cancer Patients
This study will help to understand the interaction between estrogen receptor-alpha (ER alpha) and tumor suppressor protein p53 as well as impact on patient tumor gene expression in response to the hormonal therapy Tamoxifen.
- Trial name
- NCT01027416
- Testing
- Tamoxifen
- Where
- 2 sites in United States
- Volunteers
- 59 people
- Sponsor
- Roswell Park Cancer Institute
Pancreatic Cancer
Study of Ruxolitinib in Pancreatic Cancer Patients
The purpose of this study was to determine whether ruxolitinib added to capecitabine is effective in improving the overall survival of patients with metastatic pancreatic cancer.
- Trial name
- RECAP (NCT01423604)
- Testing
- Capecitabine, Ruxolitinib
- Where
- 39 sites in United States
- Volunteers
- 136 people
- Sponsor
- Incyte Corporation
Carcinoma, Non-Small-Cell Lung, Non-Small Cell Lung Cancer
Study Assessing Safety, Pharmacokinetics and Efficacy of CC-223 With Either Erlotinib or Oral Azacitidine in Advanced Non-Small Cell Lung Cancer
The main purpose of this first study combining an investigational dual mTOR inhibitor, CC-223, with other agents (erlotinib or the investigational agent, oral azacitidine) is to establish a maximum tolerated dose level for each…
- Trial name
- NCT01545947
- Testing
- CC-223, erlotinib, CC-223, oral azacitidine
- Where
- 9 sites in United States, Spain
- Volunteers
- 76 people
- Sponsor
- Celgene
Lung Diseases, Carcinoma, Non-Small-Cell Lung
Atezolizumab Plus Induction Chemotherapy Plus CT-radiotherapy. (APOLO)
Open-label, non-randomized, phase II multi-centre controlled clinical trial. 51 non-resectable stage IIIA-IIIB non-small cell lung cancer patients will be enrolled in this trial to evaluate the efficacy of the treatment…
- Conditions
- Lung Diseases, Carcinoma, Non-Small-Cell Lung, Stage IIIA Non-small Cell Lung Cancer, Stage IIIB Non-small Cell Lung Cancer
- Trial name
- APOLO (NCT04776447)
- Testing
- Carboplatin, Placlitaxel, Atezolizumab
- Where
- 22 sites in Spain
- Volunteers
- 38 people
- Sponsor
- Fundación GECP
Breast Cancer
Gene Therapy Plus Chemotherapy in Treating Patients With Breast Cancer
Phase I trial to study the effectiveness of gene therapy plus chemotherapy in treating patients who have breast cancer. Inserting the p53 gene into a person's cancer cells may improve the body's ability to fight cancer or make…
- Trial name
- NCT00004038
- Testing
- Ad5CMV-p53 gene, chemotherapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Cancer Institute (NCI)
Liver Cancer, Pain Postoperative
Parecoxib Versus Celecoxib Versus Oxycodone in Pain Control for Transcatheter Chemoembolization Procedure
This phase III, randomized, prospective clinical study, aiming to compare the analgesic effects of celecoxib, parecoxib, and oxycodone in patients with inoperable hepatic carcinoma undergoing TACE procedure in postoperative pain…
- Trial name
- NCT03059238
- Testing
- Celecoxib 200mg oral capsule, parecoxib sodium, controlled-release oxycodone
- Where
- China
- Volunteers
- 213 people
- Sponsor
- Sun Yat-sen University
Cancer
Study of Theliatinib (HMPL-309) in Patients With Advanced Solid Tumor
First-in-human study is conducted to assess the maximum tolerated dose (MTD) and dose-limiting toxicity(DLT), safety and tolerability, pharmacokinetics (PK), and preliminary anti-tumor activity of Theliatinib .
- Trial name
- NCT02601248
- Testing
- Theliatinib
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Hutchison Medipharma Limited
Ovarian Neoplasms, Breast Neoplasms
A Phase I Safety Study of a Cancer Vaccine to Treat HLA-A2 Positive Advanced Stage Ovarian, Breast and Prostate Cancer
To determine the safety and immunogenicity profile of two (2) different doses of the vaccine DPX-0907 to treat breast, ovarian and prostate cancer.
- Conditions
- Ovarian Neoplasms, Breast Neoplasms, Prostatic Neoplasms
- Trial name
- NCT01095848
- Testing
- DPX-0907 consists of 7 tumor-specific HLA-A2-restricted peptides, a universal T Helper peptide, a polynucleotide adjuvant, a liposome and Montanide ISA51 VG
- Where
- 5 sites in United States
- Volunteers
- 23 people
- Sponsor
- ImmunoVaccine Technologies, Inc. (IMV Inc.)
Colorectal Cancer, Colorectal Disorders
Reducing Colonoscopies in Patients Without Significant Bowel Disease
Investigating people with bowel symptoms uses a test that detects traces of blood in the stools, the FIT test. There are many possible reasons for positive tests. A few people have cancer.
- Conditions
- Colorectal Cancer, Colorectal Disorders, Colorectal Adenoma, Colorectal Polyp
- Trial name
- RECEDE (NCT04516785)
- Testing
- FIT and VOC
- Where
- 4 sites in United Kingdom
- Volunteers
- 1,181 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Neuroendocrine Tumor, Gastrointestinal Neoplasm
A Study of XmAb®18087 in Subjects With NET and GIST
This is a Phase 1, multiple dose, ascending dose escalation study; to define a MTD/RD and regimen consisting of a first "priming" dose and escalated subsequent doses of XmAb18087; to describe safety and tolerability; to assess PK…
- Trial name
- NCT03411915
- Testing
- XmAb18087
- Where
- 16 sites in United States
- Volunteers
- 62 people
- Sponsor
- Xencor, Inc.
Colorectal Cancer
Korean Red Ginseng in Treating Patients With Fatigue Caused by Chemotherapy for Colorectal Cancer
Korean Red Ginseng may improve fatigue in healthy subject. It is not yet known whether Korean Red Ginseng is effective compared with a placebo in chemotherapy.
- Trial name
- KRG (NCT02039635)
- Testing
- Korean Red Ginseng
- Where
- South Korea
- Volunteers
- 438 people
- Sponsor
- Korea Ginseng Corporation
Sintilimab and Anlotinib in Combination With Chemotherapy
Sintilimab and Anlotinib Combined With Chemotherapy in Neoadjuvant Treatment of Resectable Esophageal Cancer
The study focused on patients with T2-4NxM0 resectable esophageal carcinoma. Neoadjuvant treatment involved administering anlotinib (10 mg orally, once a day, 2 weeks on and 1 week off) for anti-angiogenesis and sintilimab (200…
- Trial name
- NCT06015035
- Testing
- Sintilimab and anlotinib in combination with chemotherapy
- Where
- 2 sites in China
- Volunteers
- 17 people
- Sponsor
- Tang-Du Hospital
Cancer, Chronic Lymphocytic Leukemia (CLL)
A Study of the Safety and Efficacy of Venetoclax for Participants With Chronic Lymphocytic Leukemia (CLL) Used in Routine Clinical Practice
This observational study will evaluate the safety and effectiveness of Venetoclax used in routine clinical practice for participants diagnosed with chronic lymphocytic leukemia (CLL).
- Trial name
- NCT04178317
- Where
- 13 sites in South Korea
- Volunteers
- 14 people
- Sponsor
- AbbVie
Prostate Cancer
Evaluation of Safety and Feasibility of OGX-011 in Combination With 2nd-line Chemotherapy in Patients With HRPC
This study is for patients with cancer of the prostate gland that has metastasized or spread outside the prostate to other parts of the body.
- Trial name
- NCT00327340
- Testing
- custirsen (OGX-011)/mitoxantrone, custirsen (OGX-011)/docetaxel
- Where
- 10 sites in Canada
- Volunteers
- 70 people
- Sponsor
- Achieve Life Sciences
Skin Cancer
Using Technology to Scale-Up an Occupational Sun Protection Policy Program
Comprehensive approaches that combine sun protection policy and education for outdoor workers can reduce their risk for skin cancer by reducing their exposure to solar ultraviolet radiation on the job.
- Trial name
- SSW-T (NCT03278340)
- Testing
- Sun Safe Workplaces - Technology, Sun Safe Workplaces -In Person
- Where
- 2 sites in United States
- Volunteers
- 2,644 people, healthy volunteers welcome
- Sponsor
- Klein Buendel, Inc.
Polycystic Ovary Syndrome, Metabolic Syndrome
Metabolic Syndrome in PCOS: Precursors and Interventions
The purpose of this study is to investigate the metabolic effects of anti-androgens and oral contraceptive pills (OCPs), compared with placebo, in the treatment of women with PCOS.
- Trial name
- NCT00442689
- Testing
- flutamide, ethinyl estradiol 35 mcg and drospirenone 3 mg
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Northwestern University
Autoimmune Diseases, Cancer
The Biodistribution of 1-L-(2 Deoxy-2,- 18 Fluoroarabinofuranosyl) Cytosine ([18F]L-FAC) in Healthy Subjects and Patients With Cancer, Autoimmune and Inflammatory Diseases
The purpose of this study is to determine the biodistribution of a new agent 1-L-(2 deoxy-2,-18fluoroarabinofuranosyl) cytosine non-invasively in healthy humans and to evaluate whether it can be used to image cancer, autoimmune…
- Trial name
- NCT01180868
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Jonsson Comprehensive Cancer Center
Shoulder Pain, Breast Cancer
Physiotherapy in Women With Peripheral Persistent Pain Following Breast Cancer Treatment
The aim of this study is to determine the effectiveness of a multimodal physiotherapy intervention including scapula exercises in addition to deep dry needling and neurodynamic techniques versus scapula exercises only versus…
- Trial name
- NCT02735668
- Testing
- Shoulder Conventional Exercises, Multimodal Physiotherapy, Scapular exercises
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- University of Alcala
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